Challenges in urine bioanalytical assays: Overcoming nonspecific binding

Bioanalysis

Volumn 2, Issue 9, 2010, Pages 1573-1586

  Ji, Allena Ji ^a,b   Jiang, Zhiping ^a,c   Livson, Yuliya ^b,c   Davis, Jennifer Ann ^b,d   Chu, Jasper Xuegong ^b,c   Weng, Naidong ^e  

^a XENOBIOTIC LABORATORIES INC   (United States)

^b PFIZER INC   (United States)

^c Novartis Pharmaceuticals Corp ^*

^d NOVARTIS PHARMA AG   (Switzerland)

^e JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 2 HYDROXY 1 PROPANESULFONIC ACID; BETA CYCLODEXTRIN; BOVINE SERUM ALBUMIN; DIMETHYL SULFOXIDE; DODECYL SULFATE SODIUM; DODECYLBENZENESULFONIC ACID; POLYSORBATE 20; QUATERNARY AMMONIUM DERIVATIVE;

ACCURACY; ADSORPTION KINETICS; ANALYTIC METHOD; ANALYTICAL ERROR; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; BLOOD ANALYSIS; CLINICAL PROTOCOL; DRUG ADSORPTION; DRUG DETERMINATION; DRUG URINE LEVEL; INSTRUMENT VALIDATION; INTERMETHOD COMPARISON; LABORATORY DIAGNOSIS; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONLINEAR SYSTEM; PH MEASUREMENT; PROCESS DEVELOPMENT; QUALITY CONTROL; SEQUENTIAL INJECTION ANALYSIS; SODIUM URINE LEVEL; SOLID PHASE EXTRACTION; SOLUBILITY; STORAGE TEMPERATURE; THERMOSTABILITY; URINALYSIS; URINARY EXCRETION; ADSORPTION; ANIMAL; ARTIFACT; CALIBRATION; CATTLE; HUMAN; METHODOLOGY; PHARMACOKINETICS; STANDARD;

ADSORPTION; ANIMALS; ARTIFACTS; CALIBRATION; CATTLE; HUMANS; NONLINEAR DYNAMICS; PHARMACOKINETICS; QUALITY CONTROL; URINALYSIS;

EID: 79952499962     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.10.114     Document Type: Article

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