Synthesis and biological evaluation of benzoisothiazole derivatives possessing N,N-dimethylformimidamide group as 5-HT 6 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 8, 2012, Pages 2707-2712

  Yoo, Euna ^a   Hayat, Faisal ^a   Rhim, Hyewhon ^b   Park Choo, Hea Young ^a  

^a Ewha Womans University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

5 HT 6 receptor antagonists; Benzoisothiazole; N,N dimethylformimidamide; Sulfonamide

Indexed keywords

AMIDE; BENZISOTHIAZOLE DERIVATIVE; CALCIUM; ISOTHIAZOLE DERIVATIVE; N' (5 (BIPHENYL 4 YLSULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL) N,N DIMETHYLFORMIMIDAMIDE; N' (6 AMINOBENZO[D]ISOTHIAZOL 2 YL) N,N DIMETHYLFORMIMIDAMIDE; N,N (5 AMINOBENZO[D]ISOTHIAZOL 3 YL) N,N DIMETHYLFORMIMIDAMIDE; N,N DIMETHYL N' (5 (2,6 DIFLUOROPHENYLSULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 (4 CHLOROPHENYLSULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 (4 FLUOROPHENYLSULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 (4 ISOPROPYLPHENYLSULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 (4 METHYLPHENYLSULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 (4 NITROPHENYLSULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 (NAPHTHALENE 1 SULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 (NAPHTHALENE 2 SULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 (PHENYLSULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 (QUINOLINE 8 SULFONAMIDO)BENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (5 NITROBENZO[D]ISOTHIAZOL 3 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (6 (NAPHTHALENE 1 SULFONAMIDO)BENZO[D]THIAZOL 2 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (6 (NAPHTHALENE 2 SULFONAMIDO)BENZO[D]THIAZOL 2 YL)FORMIMIDAMIDE; N,N DIMETHYL N' (6 NITROBENZO[D]ISOTHIAZOL 2 YL)FORMIMIDAMIDE; N,N DIMETHYLFORMIMIDAMIDE; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FORMAMIDES; HEK293 CELLS; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 84859428852     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.020     Document Type: Article

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