Mitochondrial fumarate reductase as a target of chemotherapy: From parasites to cancer cells

Biochimica et Biophysica Acta - General Subjects

Volumn 1820, Issue 5, 2012, Pages 643-651

  Sakai, Chika ^a   Tomitsuka, Eriko ^a,b   Esumi, Hiroyasu ^b   Harada, Shigeharu ^c   Kita, Kiyoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Ascaris suum; Complex II; Drug target; Hypoxia; Mitochondrial fumarate respiration; Type II flavoprotein subunit

Indexed keywords

ANTINEOPLASTIC AGENT; ATPENIN A5; FLUTOLANIL; FUMARATE REDUCTASE; NAFUREDIN; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

ASCARIS SUUM; ASPERGILLUS NIGER; BINDING SITE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CANCER THERAPY; CARCINOGENESIS; CITRIC ACID CYCLE; DISEASE ASSOCIATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HAEMONCHOSIS; HUMAN; MALIGNANT NEOPLASTIC DISEASE; METABOLIC DISORDER; MITOCHONDRIAL RESPIRATION; MUTATIONAL ANALYSIS; NEMATODE LIFE CYCLE STAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RESPIRATORY CHAIN; REVIEW; STRUCTURE ACTIVITY RELATION; TYPE I FP GENE; TYPE II FP GENE;

ADULT; ANIMALS; ANTIPARASITIC AGENTS; ENERGY METABOLISM; HUMANS; MITOCHONDRIA; MULTIENZYME COMPLEXES; NEOPLASMS; PARASITES; SUCCINATE DEHYDROGENASE;

ASCARIS SUUM; ASPERGILLUS NIGER; HAEMONCHUS CONTORTUS; OVIS ARIES; VERMES;

EID: 84859424299     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2011.12.013     Document Type: Review

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