Influence of conformationally restricted pyrimidines on the activity of 10-23 DNAzymes

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 8, 2012, Pages 2581-2586

  Robaldo, Laura ^a   Izzo, Franco ^b   Dellafiore, María ^a   Proietti, Cecilia ^b   Elizalde, Patricia V ^b   Montserrat, Javier M ^a,c   Iribarren, Adolfo M ^a,d  

^a INSTITUTO DE INVESTIGACIONES EN INGENIERÍA GENÉTICA Y BIOLOGÍA MOLECULAR   (Argentina)

^b INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^c INSTITUTO DE CIENCIAS   (Argentina)

^d UNIVERSIDAD NACIONAL DE QUILMES   (Argentina)

Author keywords

2 C Methylnucleosides; Deoxyribozymes; DNA structures; DNAzymes; Modified nucleosides

Indexed keywords

2' DEOXY 2' C METHYL PYRIMIDINE DERIVATIVE; 2' DEOXY 2' C METHYLCYTIDINE; 2' DEOXY 2' C METHYLURIDINE; 2' METHYLCYTIDINE; DEOXYRIBOZYME; PYRIMIDINE DERIVATIVE; SHORT HAIRPIN RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CATALYSIS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; NUCLEIC ACID SYNTHESIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; BIOCATALYSIS; CELL PROLIFERATION; DNA, CATALYTIC; DNA, SINGLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; MOLECULAR CONFORMATION; PYRIMIDINES; STAT3 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84859423623     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.047     Document Type: Article

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