Advances in the treatment of basal cell carcinoma: Hedgehog inhibitors

Seminars in Oncology

Volumn 39, Issue 2, 2012, Pages 139-144

  Kudchadkar, Ragini ^a   Lewis, Karl ^b   Gonzalez, Rene ^b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BMS 833923; CYCLOPAMINE; ERISMODEGIB; ERIVEDGE; FLUOROURACIL; HEDGEHOG INHIBITOR; IMIQUIMOD; ITRACONAZOLE; PLACEBO; PROTEIN INHIBITOR; PROTEIN P53; PROTEIN PATCHED 1; SMO INHIBITOR; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG; VISMODEGIB; XL 139;

ADVANCED CANCER; ALOPECIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BASAL CELL CARCINOMA; CANCER INCIDENCE; CANCER MORTALITY; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RISK; CHEMOSURGERY; DYSGEUSIA; FATIGUE; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; MEDULLOBLASTOMA; METASTASIS; MUSCLE CRAMP; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TREATMENT CONTRAINDICATION; TREATMENT RESPONSE;

ANIMALS; CARCINOMA, BASAL CELL; CLINICAL TRIALS, PHASE I AS TOPIC; HEDGEHOG PROTEINS; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SIGNAL TRANSDUCTION; SKIN NEOPLASMS;

EID: 84859376527     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2012.01.011     Document Type: Article

References (49)

1. K.K. Youssef, A. Van Keymeulen, G. Lapouge Identification of the cell lineage at the origin of basal cell carcinoma Nat Cell Biol 12 2010 299 305
2. D.L. Miller, M.A. Weinstock Nonmelanoma skin cancer in the United States: incidence J Am Acad Dermatol 30 1994 774 778
3. R.S. Stern Prevalence of a history of skin cancer in 2007: results of an incidence-based model Arch Dermatol 146 2010 279 282
4. T.S. Housman, S.R. Feldman, P.M. Williford Skin cancer is among the most costly of all cancers to treat for the Medicare population J Am Acad Dermatol 48 2003 425 429
5. V. Kiiski, E. de Vries, S.C. Flohil Risk factors for single and multiple basal cell carcinomas Arch Dermatol 146 2010 848 855
6. A.I. Rubin, E.H. Chen, D. Ratner Basal-cell carcinoma N Engl J Med 353 2005 2262 2269
7. L. Lum, P.A. Beachy The Hedgehog response network: sensors, switches, and routers Science 304 2004 1755 1759
8. R. Rohatgi, M.P. Scott Patching the gaps in Hedgehog signalling Nat Cell Biol 9 2007 1005 1009
9. M. Varjosalo, J. Taipale Hedgehog signaling J Cell Sci 120 2007 3 6
10. J.M. Bonifas, S. Pennypacker, P.T. Chuang Activation of expression of hedgehog target genes in basal cell carcinomas J Invest Dermatol 116 2001 739 742
11. N. Bodak, S. Queille, M.F. Avril High levels of patched gene mutations in basal-cell carcinomas from patients with xeroderma pigmentosum Proc Natl Acad Sci U S A 96 1999 5117 5122
12. S. Couve-Privat, B. Bouadjar, M.F. Avril, A. Sarasin, L. Daya-Grosjean Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients Cancer Res 62 2002 7186 7189
13. S. Han, H.T. Zhang, Z. Wang DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies Eur J Hum Genet 14 2006 1136 1144
14. J. Han, G.A. Colditz, L.D. Samson, D.J. Hunter Polymorphisms in DNA double-strand break repair genes and skin cancer risk Cancer Res 64 2004 3009 3013
15. N.R. Jacobsen, B.A. Nexo, A. Olsen No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer Cancer Epidemiol Biomarkers Prev 12 2003 584 585
16. M.R. Gailani, S.J. Bale, D.J. Leffell Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9 Cell 69 1992 111 117
17. H. Hahn, C. Wicking, P.G. Zaphiropoulous Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome Cell 85 1996 841 851
18. J. Xie, M. Murone, S.M. Luoh Activating Smoothened mutations in sporadic basal-cell carcinoma Nature 391 1998 90 92
19. E.H. Epstein Basal cell carcinomas: attack of the hedgehog Nat Rev Cancer 8 2008 743 754
20. M.E. Hutchin, M.S. Kariapper, M. Grachtchouk Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle Genes Dev 19 2005 214 223
21. R.L. Johnson, A.L. Rothman, J. Xie Human homolog of patched, a candidate gene for the basal cell nevus syndrome Science 272 1996 1668 1671
22. A.G. Knudson Jr Mutation and cancer: statistical study of retinoblastoma Proc Natl Acad Sci U S A 68 1971 820 823
23. S. Levanat, R.J. Gorlin, S. Fallet, D.R. Johnson, J.E. Fantasia, A.E. Bale A two-hit model for developmental defects in Gorlin syndrome Nat Genet 12 1996 85 87
24. S. Pan, Q. Dong, L.S. Sun, T.J. Li Mechanisms of inactivation of PTCH1 gene in nevoid basal cell carcinoma syndrome: modification of the two-hit hypothesis Clin Cancer Res 16 2010 442 450
25. G. Ling, A. Ahmadian, A. Persson PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer Oncogene 20 2001 7770 7778
26. A. Ouhtit, H. Nakazawa, B.K. Armstrong UV-radiation-specific p53 mutation frequency in normal skin as a predictor of risk of basal cell carcinoma J Natl Cancer Inst 90 1998 523 531
27. H. Hahn, L. Wojnowski, A.M. Zimmer, J. Hall, G. Miller, A. Zimmer Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome Nat Med 4 1998 619 622
28. R. Fodde, R. Smits Cancer biology A matter of dosage Science 298 2002 761 763
29. G.R. Hime, H. Lada, M.J. Fietz Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant-negative mechanism Dev Dyn 229 2004 780 790
30. R.L. Johnson, L. Zhou, E.C. Bailey Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs Dev Biol 242 2002 224 235
31. R.L. Johnson, L. Milenkovic, M.P. Scott In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration Mol Cell 6 2000 467 478
32. J.L. Rees The genetics of sun sensitivity in humans Am J Hum Genet 75 2004 739 751
33. J. Han, P. Kraft, G.A. Colditz, J. Wong, D.J. Hunter Melanocortin 1 receptor variants and skin cancer risk Int J Cancer 119 2006 1976 1984
34. D.F. Gudbjartsson, P. Sulem, S.N. Stacey ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma Nat Genet 40 2008 886 891
35. S.N. Stacey, P. Sulem, G. Masson New common variants affecting susceptibility to basal cell carcinoma Nat Genet 41 2009 909 914
36. N.F. Box, D.L. Duffy, R.E. Irving Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma J Invest Dermatol 116 2001 224 229
37. S.N. Stacey, D.F. Gudbjartsson, P. Sulem Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits Nat Genet 40 2008 1313 1318
38. T. Rafnar, P. Sulem, S.N. Stacey Sequence variants at the TERT-CLPTM1L locus associate with many cancer types Nat Genet 41 2009 221 227
39. J.M. McGregor, C.A. Harwood, L. Brooks Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer J Invest Dermatol 119 2002 84 90
40. S. Wilkening, K. Hemminki, P. Rudnai No association between MDM2 SNP309 promoter polymorphism and basal cell carcinoma of the skin Br J Dermatol 157 2007 375 377
41. J. Ahnert, J. Baselga, H. Tawbi A phase I dose-escalation study of LDE225, a smoothened (Smo) antagonist, in patients with advanced solid tumors al. E. J Clin Oncol 28 2010 abstract 2500
42. L. Siu, K. Papadopoulos, S. Alberts A first-in-human, phase I study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors al. E. J Clin Oncol 28 2010 abstract 2501
43. S.J. Scales, F.J. de Sauvage Mechanisms of Hedgehog pathway activation in cancer and implications for therapy Trends Pharmacol Sci 30 2009 303 312
44. J.K. Chen, J. Taipale, M.K. Cooper, P.A. Beachy Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened Genes Dev 16 2002 2743 2748
45. J. Taipale, J.K. Chen, M.K. Cooper Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine Nature 406 2000 1005 1009
46. R.L. Yauch, S.E. Gould, S.J. Scales A paracrine requirement for hedgehog signalling in cancer Nature 455 2008 406 410
47. D.D. Von Hoff, P.M. LoRusso, C.M. Rudin Inhibition of the hedgehog pathway in advanced basal-cell carcinoma N Engl J Med 361 2009 1164 1172
48. J.M. Hyman, A.J. Firestone, V.M. Heine Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade Proc Natl Acad Sci U S A 106 2009 14132 14137
49. J. Kim, J.Y. Tang, R. Gong Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth Cancer Cell 17 2010 388 399