Mucoadhesive fenretinide patches for site-specific chemoprevention of oral cancer: Enhancement of oral mucosal permeation of fenretinide by coincorporation of propylene glycol and menthol

Molecular Pharmaceutics

Volumn 9, Issue 4, 2012, Pages 937-945

  Wu, Xiao ^a   Desai, Kashappa Goud H ^a   Mallery, Susan R ^b   Holpuch, Andrew S ^b   Phelps, Maynard P ^b   Schwendeman, Steven P ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

fenretinide; local drug delivery; menthol; mucoadhesive patch; oral mucosa; permeation enhancement; propylene glycol

Indexed keywords

EUDRAGIT; FENRETINIDE; MENTHOL; PROPYLENE GLYCOL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CELL DIFFERENTIATION; CELL SWELLING; CHEEK MUCOSA; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG TISSUE LEVEL; EPITHELIUM CELL; EX VIVO STUDY; EXPERIMENTAL RABBIT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; HYDROPHOBICITY; IN VIVO STUDY; MEMBRANE PERMEABILITY; MORPHOLOGY; MOUTH CANCER; MOUTH MUCOSA; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SWINE; TRANSDERMAL PATCH;

ANIMALS; CHEMOPREVENTION; FENRETINIDE; MENTHOL; MOUTH MUCOSA; MOUTH NEOPLASMS; PROPYLENE GLYCOL; RABBITS; SOLUBILITY; SWINE;

EID: 84859333475     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200655k     Document Type: Article

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