Formulation and characterization of injectable poly(DL-lactide-co- glycolide) implants loaded with N-acetylcysteine, a MMP inhibitor

Pharmaceutical Research

Volumn 25, Issue 3, 2008, Pages 586-597

  Desai, Kashappa Goud H ^a   Mallery, Susan R ^b   Schwendeman, Steven P ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Burst effect; Controlled release; Drug induced plasticization; Drug induced PLGA degradation; Head and neck cancer; N Acetylcysteine; NAC salts; PLGA degradation; PLGA implants

Indexed keywords

ACETYLCYSTEINE; CALCIUM ION; MAGNESIUM ION; MATRIX METALLOPROTEINASE INHIBITOR; PLASTICIZER; POLYGLACTIN; POLYMER;

ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED DRUG RELEASE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; HEAD AND NECK CANCER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMPLANT; MICROENCAPSULATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM COMPOUNDS; CALORIMETRY, DIFFERENTIAL SCANNING; CATALYSIS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG IMPLANTS; DRUG STABILITY; HEAD AND NECK NEOPLASMS; HUMANS; INJECTIONS; KINETICS; LACTIC ACID; MAGNESIUM COMPOUNDS; MATRIX METALLOPROTEINASES; MICROSCOPY, ELECTRON, SCANNING; POLYGLYCOLIC ACID; POLYMERS; PROTEASE INHIBITORS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 40549146613     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9430-1     Document Type: Article

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