Update on molecular pathology in oral cancer and precancer

Anticancer Research

Volumn 28, Issue 2 B, 2008, Pages 1197-1205

  Campo Trapero, Julián ^a   Cano Sanchez J ^a   Palacios Sanchez B ^a   Sanchez Gutierrez Jj ^b   Gonzalez Moles M A ^c   Bascones Martinez A ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

Molecular markers; Molecular pathology; Oncogenes; Oral squamous carcinoma; Review; Tumour suppressor genes

Indexed keywords

AZACITIDINE; CANCER VACCINE; HISTONE DEACETYLASE INHIBITOR; MOLECULAR MARKER;

CANCER DIAGNOSIS; CANCER GROWTH; CANCER SURVIVAL; CARCINOGENESIS; CHROMOSOMAL INSTABILITY; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; EPIGENETICS; GENE AMPLIFICATION; GENE MUTATION; HISTOLOGY; HUMAN; METHYLATION; MOUTH CANCER; NONHUMAN; ONCOGENE; PATHOLOGY; POINT MUTATION; PRECANCER; PRIORITY JOURNAL; PROGNOSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVIEW; STROMA; SURVIVAL RATE; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; TUMOR VIRUS;

DISEASE PROGRESSION; HUMANS; MOUTH NEOPLASMS; PRECANCEROUS CONDITIONS;

EID: 42549154178     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (65)

1. Williams HK: Molecular pathogenesis of oral squamous carcinoma. Mol Pathol 53: 165-172, 2000.
2. Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ and Thun MJ: Cancer statistics, 2004. CA Cancer J Clin 54: 8-29, 2004.
3. Pindborg JJ, Reichart PA, Smith CJ, Van der Waal I, and in collaboration with Sobin LH and pathologists in 9 countries: Histological-typing of Cancer and Precancer of the Oral Mucosa. New York, Springer Verlag, 1997.
4. Schantz SP and Yu GP: Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer. Arch Otolaryngol Head Neck Surg 128: 268-274, 2002.
5. Barnes L, Eveson JW, Reichart PA and Sidransky D: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Head and Neck. Lyon: IARC-press, 2005.
6. Kujan O, Oliver RJ, Khattab A, Roberts SA, Thakker N and Sloan P: Evaluation of a new binary system of grading oral epithelial dysplasia for prediction of malignant transformation. Oral Oncol 42: 987-993, 2006.
7. Warnakulasuriya KA, Tavassoli M and Johnson NW: Relationship of p53 overexpression to other cell cycle regulatory proteins in oral squamous cell carcinoma. J Oral Pathol Med 27: 376-381, 1998.
8. Joseph BK: Oral cancer: prevention and detection. Med Princ Pract 11(Suppl 1): 32-35, 2002.
9. Sidransky D: Molecular markers in cancer diagnosis. J Natl Cancer Inst Monogr 27-29, 1995.
10. Reshmi SC and Gollin SM: Chromosomal instability in oral cancer cells. J Dent Res 84: 107-117, 2005.
11. Califano J, van der RP, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W and Sidransky D: Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 56: 2488-2492, 1996.
12. Bockmuhl U, Wolf G, Schmidt S, Schwendel A, Jahnke V, Dietel M and Petersen I: Genomic alterations associated with malignancy in head and neck cancer. Head Neck 20: 145-151, 1998.
13. Kim MM and Califano JA: Molecular pathology of head-and-neck cancer. Int J Cancer 112: 545-553, 2004.
14. El Naggar AK, Hurr K, Batsakis JG, Luna MA, Goepfert H and Huff V: Sequential loss of heterozygosity at microsatellite motifs in preinvasive and invasive head and neck squamous carcinoma. Cancer Res 55: 2656-2659, 1995.
15. Braakhuis BJ, Leemans CR and Brakenhoff RH: A genetic progression model of oral cancer: current evidence and clinical implications. J Oral Pathol Med 33: 317-322, 2004.
16. Balz V, Scheckenbach K, Gotte K, Bockmuhl U, Petersen I and Bier H: Is the p53 inactivation frequency in squamous cell carcinomas of the head and neck underestimated? Analysis of p53 exons 2-11 and human papillomavirus 16/18 E6 transcripts in 123 unselected tumor specimens. Cancer Res 63: 1188-1191, 2003.
17. Mao L, Lee DJ, Tockman MS, Erozan YS, Askin F and Sidransky D: Microsatellite alterations as clonal markers for the detection of human cancer. Proc Natl Acad Sci USA 91: 9871-9875, 1994.
18. Rosin MP, Cheng X, Poh C, Lam WL, Huang Y, Lovas J, Berean K, Epstein JB, Priddy R, Le ND and Zhang L: Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res 6: 357-362, 2000.
19. Curfman GD, Morrissey S and Drazen JM: Retraction: Sudbo J et al: DNA content as a prognostic marker in patients with oral leukoplakia. N Engl J Med 344: 1270-1278, 2001
20. and Sudbo J et al: The influence of resection and aneuploidy on mortality in oral leukoplakia. N Engl J Med 350: 1405-13, 2004.
21. N Engl J Med 355: 1927, 2006.
22. Partridge M, Emilion G, Pateromichelakis S, A'Hern R, Lee G, Phillips E, and Langdon J: The prognostic significance of allelic imbalance at key chromosomal loci in oral cancer. Br J Cancer 79: 1821-1827, 1999.
23. Zhang L, Cheung KJ, Jr., Lam WL, Cheng X, Poh C, Priddy R, Epstein J, Le ND and Rosin MP: Increased genetic damage in oral leukoplakia from high risk sites: potential impact on staging and clinical management. Cancer 91: 2148-2155, 2001.
24. Shaw R: The epigenetics of oral cancer. Int J Oral Maxillofac Surg 35: 101-108, 2006.
25. Rosas SL, Koch W, Costa Carvalho MG, Wu L, Califano J, Westra W, Jen J and Sidransky D: Promoter hypermethylation patterns of p16, O6-methylguanine- DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res 61: 939-942, 2001.
26. Auerkari EI: Methylation of tumor suppressor genes p16(INK4a), p27(Kip1) and E-cadherin in carcinogenesis. Oral Oncol 42: 5-13, 2006.
27. Kulkarni V and Saranath D: Concurrent hypermethylation of multiple regulatory genes in chewing tobacco associated oral squamous cell carcinomas and adjacent normal tissues. Oral Oncol 40: 145-153, 2004.
28. Maruya S, Issa JP, Weber RS, Rosenthal DI, Haviland JC, Lotan R and El Naggar AK: Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications. Clin Cancer Res 10: 3825-3830, 2004.
29. Yeh KT, Shih MC, Lin TH, Chen JC, Chang JY, Kao CF, Lin KL and Chang JG: The correlation between CpG methylation on promoter and protein expression of E-cadherin in oral squamous cell carcinoma. Anticancer Res 22: 3971-3975, 2002.
30. Kresty LA, Mallery SR, Knobloch TJ, Song H, Lloyd M, Casto BC and Weghorst CM: Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia. Cancer Res 62: 5295-5300, 2002.
31. von Zeidler SV, Miracca EC, Nagai MA and Birman EG: Hypermethylation of the p16 gene in normal oral mucosa of smokers. Int J Mol Med 14: 807-811, 2004.
32. Ha PK and Califano JA: Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol 7: 77-82, 2006.
33. Ogi K, Toyota M, Ohe-Toyota M, Tanaka N, Noguchi M, Sonoda T, Kohama G and Tokino T: Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma. Clin Cancer Res 8: 3164-3171, 2002.
34. Viswanathan M, Tsuchida N and Shanmugam G: Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma. Int J Cancer 105: 41-46, 2003.
35. Sanchez-Cespedes M, Esteller M, Wu L, Nawroz-Danish H, Yoo GH, Koch WM, Jen J, Herman JG and Sidransky D: Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res 60: 892-895, 2000.
36. Lopez M, Aguirre JM, Cuevas N, Anzola M, Videgain J, Aguirregaviria J and Martinez DP: Gene promoter hypermethylation in oral rinses of leukoplakia patients - a diagnostic and/or prognostic tool? Eur J Cancer 39: 2306-2309, 2003.
37. Goldenberg D, Harden S, Masayesva BG, Ha P, Benoit N, Westra WH, Koch WM, Sidransky D and Califano JA: Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg 130: 39-44, 2004.
38. Soni S, Mathur M, Shukla NK, Deo SV and Ralhan R: Stromelysin-3 expression is an early event in human oral tumorigenesis. Int J Cancer 107: 309-316, 2003.
39. Chow V, Yuen AP, Lam KY, Tsao GS, Ho WK and Wei WI: A comparative study of the clinicopathological significance of E-cadherin and catenins (alpha, beta, gamma) expression in the surgical management of oral tongue carcinoma. J Cancer Res Clin Oncol 127: 59-63, 2001.
40. Santos-Garcia A, Abad-Hernandez MM, Fonseca-Sanchez E, Julian-Gonzalez R, Galindo-Villardon P, Cruz-Hernandez JJ and Bullon-Sopelana A: E-cadherin, laminin and collagen IV expression in the evolution from dysplasia to oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal 11: E100-E105, 2006.
41. Swan EA, Jasser SA, Holsinger FC, Doan D, Bucana C and Myers JN: Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer. Oral Oncol 39: 648-655, 2003.
42. Kupferman ME, Patel V, Sriuranpong V, Amornphimoltham P, Jasser SA, Mandai M, Zhou G, Wang J, Coombes K, Multani A, Pathak S, Silvio GJ and Myers JN: Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma. Oral Oncol 43: 440-54, 2007.
43. Grandis JR and Tweardy DJ: Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 53: 3579-3584, 1993.
44. Scully C: Oncogenes, tumor suppressors and viruses in oral squamous carcinoma. J Oral Pathol Med 22: 337-347, 1993.
45. Altuna MX, Algaba GJ, Wang RJ, Weisman R and Ongkeko W: Immunohistochemistry study of EGFR expression in head and neck squamous cell carcinoma. Acta Otorrinolaringol Esp 56: 143-146, 2005 (In Spanish).
46. Ralhan R, Chakravarti N, Kaur J, Sharma C, Kumar A, Mathur M, Bahadur S, Shukla NK and Deo SV: Clinical significance of altered expression of retinoid receptors in oral precancerous and cancerous lesions: relationship with cell cycle regulators. Int J Cancer 118: 1077-1089, 2006.
47. Milasin J, Pujic N, Dedovic N, Nikolic Z, Petrovic V and Dimitrijevic B: High incidence of H-ras oncogene mutations in squamous cell carcinoma of lip vermilion. J Oral Pathol Med 23: 298-301, 1994.
48. Kuo MY, Jeng JH, Chiang CP and Hahn LJ: Mutations of Ki-ras oncogene codon 12 in betel quid chewing-related human oral squamous cell carcinoma in Taiwan. J Oral Pathol Med 23: 70-74, 1994.
49. Freier K, Joos S, Flechtenmacher C, Devens F, Benner A, Bosch FX, Lichter P and Hofele C: Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma. Cancer Res 63: 1179-1182, 2003.
50. Kuo WP, Whipple ME, Sonis ST, Ohno-Machado L and Jenssen TK: Gene expression profiling by DNA microarrays and its application to dental research. Oral Oncol 38: 650-656, 2002.
51. Mendez E, Cheng C, Farwell DG, Ricks S, Agoff SN, Futran ND, Weymuller EA Jr, Maronian NC, Zhao LP and Chen C: Transcriptional expression profiles of oral squamous cell carcinomas. Cancer 95: 1482-1494, 2002.
52. Otero-Rey E, Garcia-Garcia A, Barros-Angueira F, Torres-Espanol M, Gandara-Rey JM and Somoza-Martin M: DNA microarrays in oral cancer. Med Oral 9: 288-292, 2004.
53. Bascones-Ilundain C, Gonzalez-Moles M, Campo-Trapero J, Gil-Montoya J, Esparza-Gomez G, Cano-Sanchez J and Bascones-Martinez A: No differences in caspase-3 and Bax expression in atrophic-erosive vs. reticular oral lichen planus. J Eur Acad Dermatol Venereol 22: 204-212, 2008.
54. Reibel J: Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med 14: 47-62, 2003.
55. Cruz IB, Snijders PJ, Meijer CJ, Braakhuis BJ, Snow GB, Walboomers JM and van Der Waal I: p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma. J Pathol 184: 360-368, 1998.
56. Lee JJ, Hong WK, Hittelman WN, Mao L, Lotan R, Shin DM, Benner SE, Xu XC, Lee JS, Papadimitrakopoulou VM, Geyer C, Perez C, Martin JW, El Naggar AK and Lippman SM: Predicting cancer development in oral leukoplakia: ten years of translational research. Clin Cancer Res 6: 1702-1710, 2000.
57. Partridge M, Kiguwa S, Emilion G, Pateromichelakis S, A'Hern R and Langdon JD: New insights into p53 protein stabilisation in oral squamous cell carcinoma. Oral Oncol 35: 45-55, 1999.
58. INK4a and CD44s in tongue cancer. Oncol Rep 18: 389-396, 2007.
59. INK4A adenovirus-mediated gene therapy for human head and neck squamous cell cancer. Clin Cancer Res 4: 1697-1704, 1998.
60. Pande P, Mathur M, Shukla NK and Ralhan R: pRb and p16 protein alterations in human oral tumorigenesis. Oral Oncol 34: 396-403, 1998.
61. Soni S, Kaur J, Kumar A, Chakravarti N, Mathur M, Bahadur S, Shukla NK, Deo SV and Ralhan R: Alterations of rb pathway components are frequent events in patients with oral epithelial dysplasia and predict clinical outcome in patients with squamous cell carcinoma. Oncology 68: 314-325, 2005.
62. Miller CS and Johnstone BM: Human papillomavirus as a risk factor for oral squamous cell carcinoma: a meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91: 622-635, 2001.
63. Kreimer AR, Clifford GM, Boyle P and Franceschi S: Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 14: 467-475, 2005.
64. Mishra A, Bharti AC, Varghese P, Saluja D and Das BC: Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection. Int J Cancer 119: 2840-2850, 2006.
65. Maeda H, Kubo K, Sugita Y, Miyamoto Y, Komatsu S, Takeuchi S, Umebayashi T, Morikawa S, Kawanishi K and Kameyama Y: DNA vaccine against hamster oral papillomavirus-associated oral cancer. J Int Med Res 33: 647-653, 2005.