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Volumn 1, Issue 3, 2011, Pages

Mutations with epigenetic effects in myeloproliferative neoplasms and recent progress in treatment: Proceedings from the 5th International Post-ASH Symposium

(17)  Tefferi, A a   Abdel Wahab, O b   Ervantes, F C c   Crispino, J D d   Finazzi, G e   Girodon, F f   Gisslinger, H g   Gotlib, J h   Kiladjian, J J i   Levine, R L b   Licht, J D d   Mullally, A j   Odenike, O k   Pardanani, A a   Silver, R T l   Solary, E m   Mughal, T n  


Author keywords

Mastocytosis; Myelofibrosis; Myeloproliferative; Polycythemia; Thrombocythemia

Indexed keywords

ADDITIONAL SEX COMB LIKE1 PROTEIN; ALPHA INTERFERON; BUSULFAN; CLADRIBINE; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; EVEROLIMUS; HYDROXYUREA; ISOCITRATE DEHYDROGENASE; MIDOSTAURIN; MOMELOTINIB; PIPOBROMAN; POMALIDOMIDE; PROTEIN; RUXOLITINIB; TET ONCOGENE FAMILY MEMBER 2 PROTEIN; UNCLASSIFIED DRUG;

EID: 84859306234     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2011.4     Document Type: Conference Paper
Times cited : (11)

References (146)
  • 2
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009; 114: 937-951.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3    Brunning, R.D.4    Borowitz, M.J.5    Porwit, A.6
  • 3
    • 38349060667 scopus 로고    scopus 로고
    • The history of myeloproliferative disorders: Before and after Dameshek
    • Tefferi A. The history of myeloproliferative disorders: before and after Dameshek. Leukemia 2008; 22: 3-13.
    • (2008) Leukemia , vol.22 , pp. 3-13
    • Tefferi, A.1
  • 6
    • 0017812507 scopus 로고
    • Agnogenic myeloid metaplasia: A clonal proliferation of hematopoietic stem cells with secondary myelofibrosis
    • Jacobson RJ, Salo A, Fialkow PJ. Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. Blood 1978; 51: 189-194. (Pubitemid 8284647)
    • (1978) Blood , vol.51 , Issue.2 , pp. 189-194
    • Jacobson, R.J.1    Salo, A.2    Fialkow, P.J.3
  • 7
    • 0019818299 scopus 로고
    • Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell
    • Fialkow PJ, Faguet GB, Jacobson RJ, Vaidya K, Murphy S. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood 1981; 58: 916-919. (Pubitemid 12227928)
    • (1981) Blood , vol.58 , Issue.5 , pp. 916-919
    • Fialkow, P.J.1    Faguet, G.B.2    Jacobson, R.J.3
  • 8
    • 0019307897 scopus 로고
    • Involvement of the B-lymphoid system in chronic myelogenous leukaemia
    • DOI 10.1038/287049a0
    • Martin PJ, Najfeld V, Hansen JA, Penfold GK, Jacobson RJ, Fialkow PJ. Involvement of the B-lymphoid system in chronic myelogenous leukaemia. Nature 1980; 287: 49-50. (Pubitemid 10018206)
    • (1980) Nature , vol.287 , Issue.5777 , pp. 49-50
    • Martin, P.J.1    Najfeld, V.2    Hansen, J.A.3
  • 9
    • 0021956939 scopus 로고
    • Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia
    • Raskind WH, Jacobson R, Murphy S, Adamson JW, Fialkow PJ. Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia. J Clin Invest 1985; 75: 1388-1390. (Pubitemid 15087170)
    • (1985) Journal of Clinical Investigation , vol.75 , Issue.4 , pp. 1388-1390
    • Raskind, W.H.1    Jacobson, R.2    Murphy, S.3
  • 10
    • 0037372287 scopus 로고    scopus 로고
    • Both B and T lymphocytes may be clonally involved in myelofibrosis with myeloid metaplasia
    • DOI 10.1182/blood-2002-07-2341
    • Reeder TL, Bailey RJ, Dewald GW, Tefferi A. Both B and T lymphocytes may be clonally involved in myelofibrosis with myeloid metaplasia. Blood 2003; 101: 1981-1983. (Pubitemid 36237603)
    • (2003) Blood , vol.101 , Issue.5 , pp. 1981-1983
    • Reeder, T.L.1    Bailey, R.J.2    Dewald, G.W.3    Tefferi, A.4
  • 12
    • 0023753816 scopus 로고
    • Evidence for pluripotent stem cell origin of idiopathic myelofibrosis: Clonal analysis of a case characterized by a N-ras gene mutation
    • Buschle M, Janssen JW, Drexler H, Lyons J, Anger B, Bartram CR. Evidence for pluripotent stem cell origin of idiopathic myelofibrosis: clonal analysis of a case characterized by a N-ras gene mutation. Leukemia 1988; 2: 658-660.
    • (1988) Leukemia , vol.2 , pp. 658-660
    • Buschle, M.1    Janssen, J.W.2    Drexler, H.3    Lyons, J.4    Anger, B.5    Bartram, C.R.6
  • 13
    • 70449497349 scopus 로고    scopus 로고
    • In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: A new disease paradigm
    • Lambert JR, Everington T, Linch DC, Gale RE. In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm. Blood 2009; 114: 3018-3023.
    • (2009) Blood , vol.114 , pp. 3018-3023
    • Lambert, J.R.1    Everington, T.2    Linch, D.C.3    Gale, R.E.4
  • 14
    • 54049129782 scopus 로고    scopus 로고
    • Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24, 577 first-degree relatives of 11, 039 patients with myeloproliferative neoplasms in Sweden
    • Landgren O, Goldin LR, Kristinsson SY, Helgadottir EA, Samuelsson J, Bjorkholm M. Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24, 577 first-degree relatives of 11, 039 patients with myeloproliferative neoplasms in Sweden. Blood 2008; 112: 2199-2204.
    • (2008) Blood , vol.112 , pp. 2199-2204
    • Landgren, O.1    Goldin, L.R.2    Kristinsson, S.Y.3    Helgadottir, E.A.4    Samuelsson, J.5    Bjorkholm, M.6
  • 15
    • 77955713863 scopus 로고    scopus 로고
    • Frequency and clinical correlates of JAK2 46/1 (GGCC) haplotype in primary myelofibrosis
    • Guglielmelli P, Biamonte F, Spolverini A, Pieri L, Isgro A, Antonioli E et al. Frequency and clinical correlates of JAK2 46/1 (GGCC) haplotype in primary myelofibrosis. Leukemia 2010; 24: 1533-1537.
    • (2010) Leukemia , vol.24 , pp. 1533-1537
    • Guglielmelli, P.1    Biamonte, F.2    Spolverini, A.3    Pieri, L.4    Isgro, A.5    Antonioli, E.6
  • 16
    • 77953925295 scopus 로고    scopus 로고
    • The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms
    • Jones AV, Campbell PJ, Beer PA, Schnittger S, Vannucchi AM, Zoi K et al. The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms. Blood 2010; 115: 4517-4523.
    • (2010) Blood , vol.115 , pp. 4517-4523
    • Jones, A.V.1    Campbell, P.J.2    Beer, P.A.3    Schnittger, S.4    Vannucchi, A.M.5    Zoi, K.6
  • 17
    • 77950921110 scopus 로고    scopus 로고
    • MPL mutation effect on JAK2 46/1 haplotype frequency in JAK2V617F-negative myeloproliferative neoplasms
    • Patnaik MM, Lasho TL, Finke CM, Gangat N, Caramazza D, Siragusa S et al. MPL mutation effect on JAK2 46/1 haplotype frequency in JAK2V617F-negative myeloproliferative neoplasms. Leukemia 2010; 24: 859-860.
    • (2010) Leukemia , vol.24 , pp. 859-860
    • Patnaik, M.M.1    Lasho, T.L.2    Finke, C.M.3    Gangat, N.4    Caramazza, D.5    Siragusa, S.6
  • 18
    • 74249123815 scopus 로고    scopus 로고
    • JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: Nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival
    • Tefferi A, Lasho TL, Patnaik MM, Finke CM, Hussein K, Hogan WJ et al. JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival. Leukemia 2010; 24: 105-109.
    • (2010) Leukemia , vol.24 , pp. 105-109
    • Tefferi, A.1    Lasho, T.L.2    Patnaik, M.M.3    Finke, C.M.4    Hussein, K.5    Hogan, W.J.6
  • 19
    • 74249121458 scopus 로고    scopus 로고
    • The JAK2 46/1 haplotype confers susceptibility to essential thrombocythemia regardless of JAK2V617F mutational status-clinical correlates in a study of 226 consecutive patients
    • Pardanani A, Lasho TL, Finke CM, Gangat N, Wolanskyj AP, Hanson CA et al. The JAK2 46/1 haplotype confers susceptibility to essential thrombocythemia regardless of JAK2V617F mutational status-clinical correlates in a study of 226 consecutive patients. Leukemia 2010; 24: 110-114.
    • (2010) Leukemia , vol.24 , pp. 110-114
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.M.3    Gangat, N.4    Wolanskyj, A.P.5    Hanson, C.A.6
  • 20
    • 84864036635 scopus 로고    scopus 로고
    • The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms
    • (in press)
    • Olcaydu D, Rumi E, Harutyunyan A, Passamonti F, Pietra D, Pascutto C et al. The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms. Haematologica 2010 (in press).
    • (2010) Haematologica
    • Olcaydu, D.1    Rumi, E.2    Harutyunyan, A.3    Passamonti, F.4    Pietra, D.5    Pascutto, C.6
  • 22
    • 54049110222 scopus 로고    scopus 로고
    • The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity
    • James C, Mazurier F, Dupont S, Chaligne R, Lamrissi-Garcia I, Tulliez M et al. The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity. Blood 2008; 112: 2429-2438.
    • (2008) Blood , vol.112 , pp. 2429-2438
    • James, C.1    Mazurier, F.2    Dupont, S.3    Chaligne, R.4    Lamrissi-Garcia, I.5    Tulliez, M.6
  • 23
    • 34748912399 scopus 로고    scopus 로고
    • Extending Jak2V617F and MplW515 mutation analysis to single hematopoietic colonies and B and T lymphocytes
    • DOI 10.1634/stemcells.2007-0175
    • Pardanani A, Lasho TL, Finke C, Mesa RA, Hogan WJ, Ketterling RP et al. Extending Jak2V617F and MplW515 mutation analysis to single hematopoietic colonies and B and T lymphocytes. Stem Cells 2007; 25: 2358-2362. (Pubitemid 47480495)
    • (2007) Stem Cells , vol.25 , Issue.9 , pp. 2358-2362
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.3    Mesa, R.A.4    Hogan, W.J.5    Ketterling, R.P.6    Gilliland, D.G.7    Tefferi, A.8
  • 24
    • 34548786770 scopus 로고    scopus 로고
    • Demonstration of MPLW515K, but not JAK2V617F, in in vitro expanded CD4+ T lymphocytes [9]
    • DOI 10.1038/sj.leu.2404749, PII 2404749
    • Pardanani A, Lasho TL, Finke C, Markovic SN, Tefferi A. Demonstration of MPLW515K, but not JAK2V617F, in in vitro expanded CD4+ T lymphocytes. Leukemia 2007; 21: 2206-2207. (Pubitemid 47430454)
    • (2007) Leukemia , vol.21 , Issue.10 , pp. 2206-2207
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.3    Markovic, S.N.4    Tefferi, A.5
  • 26
    • 66849124925 scopus 로고    scopus 로고
    • Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
    • Gelsi-Boyer V, Trouplin V, Adelaide J, Bonansea J, Cervera N, Carbuccia N et al. Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol 2009; 145: 788-800.
    • (2009) Br J Haematol , vol.145 , pp. 788-800
    • Gelsi-Boyer, V.1    Trouplin, V.2    Adelaide, J.3    Bonansea, J.4    Cervera, N.5    Carbuccia, N.6
  • 32
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 2006; 3: e270.
    • (2006) PLoS Med , vol.3
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3    McDowell, E.4    Ebert, B.L.5    Gozo, M.6
  • 33
    • 33750534561 scopus 로고    scopus 로고
    • MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
    • Pardanani AD, Levine RL, Lasho T, Pikman Y, Mesa RA, Wadleigh M et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 2006; 108: 3472-3476.
    • (2006) Blood , vol.108 , pp. 3472-3476
    • Pardanani, A.D.1    Levine, R.L.2    Lasho, T.3    Pikman, Y.4    Mesa, R.A.5    Wadleigh, M.6
  • 34
    • 67650401377 scopus 로고    scopus 로고
    • Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms
    • Grand FH, Hidalgo-Curtis CE, Ernst T, Zoi K, Zoi C, McGuire C et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood 2009; 113: 6182-6192.
    • (2009) Blood , vol.113 , pp. 6182-6192
    • Grand, F.H.1    Hidalgo-Curtis, C.E.2    Ernst, T.3    Zoi, K.4    Zoi, C.5    McGuire, C.6
  • 35
    • 77954658823 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic-or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
    • Tefferi A, Lasho TL, Abdel-Wahab O, Guglielmelli P, Patel J, Caramazza D et al. IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic-or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia 2010; 24: 1302-1309.
    • (2010) Leukemia , vol.24 , pp. 1302-1309
    • Tefferi, A.1    Lasho, T.L.2    Abdel-Wahab, O.3    Guglielmelli, P.4    Patel, J.5    Caramazza, D.6
  • 36
    • 77954573304 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation analysis in chronic-and blast-phase myeloproliferative neoplasms
    • Pardanani A, Lasho TL, Finke CM, Mai M, McClure RF, Tefferi A. IDH1 and IDH2 mutation analysis in chronic-and blast-phase myeloproliferative neoplasms. Leukemia 2010; 24: 1146-1151.
    • (2010) Leukemia , vol.24 , pp. 1146-1151
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.M.3    Mai, M.4    McClure, R.F.5    Tefferi, A.6
  • 37
    • 75449119103 scopus 로고    scopus 로고
    • Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms
    • Green A, Beer P. Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms. N Engl J Med 2010; 362: 369-370.
    • (2010) N Engl J Med , vol.362 , pp. 369-370
    • Green, A.1    Beer, P.2
  • 38
    • 76549109434 scopus 로고    scopus 로고
    • Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
    • Abdel-Wahab O, Manshouri T, Patel J, Harris K, Yao J, Hedvat C et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res 2010; 70: 447-452.
    • (2010) Cancer Res , vol.70 , pp. 447-452
    • Abdel-Wahab, O.1    Manshouri, T.2    Patel, J.3    Harris, K.4    Yao, J.5    Hedvat, C.6
  • 39
    • 79951865273 scopus 로고    scopus 로고
    • Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blastphase myeloproliferative neoplasms
    • Abdel-Wahab O, Pardanani A, Patel J, Lasho T, Heguy A, Levine R et al. Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blastphase myeloproliferative neoplasms. ASH Annu Meet Abstr 2010; 116: 3070.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 3070
    • Abdel-Wahab, O.1    Pardanani, A.2    Patel, J.3    Lasho, T.4    Heguy, A.5    Levine, R.6
  • 40
    • 77954661062 scopus 로고    scopus 로고
    • Deletions of the transcription factor Ikaros in myeloproliferative neoplasms
    • Jager R, Gisslinger H, Passamonti F, Rumi E, Berg T, Gisslinger B et al. Deletions of the transcription factor Ikaros in myeloproliferative neoplasms. Leukemia 2010; 24: 1290-1298.
    • (2010) Leukemia , vol.24 , pp. 1290-1298
    • Jager, R.1    Gisslinger, H.2    Passamonti, F.3    Rumi, E.4    Berg, T.5    Gisslinger, B.6
  • 41
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010; 42: 722-726.
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3    Hidalgo-Curtis, C.E.4    Bryant, C.5    Jones, A.V.6
  • 42
    • 77953485892 scopus 로고    scopus 로고
    • Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
    • Oh ST, Simonds EF, Jones C, Hale MB, Goltsev Y, Gibbs Jr KD et al. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood 2010; 116: 988-992.
    • (2010) Blood , vol.116 , pp. 988-992
    • Oh, S.T.1    Simonds, E.F.2    Jones, C.3    Hale, M.B.4    Goltsev, Y.5    Gibbs Jr., K.D.6
  • 44
    • 78650655384 scopus 로고    scopus 로고
    • Preferential nuclear accumulation of JAK2V617F in CD34+ but not in granulocytic, megakaryocytic, or erythroid cells of patients with Philadelphia-negative myeloproliferative neoplasia
    • Rinaldi CR, Rinaldi P, Alagia A, Gemei M, Esposito N, Formiggini F et al. Preferential nuclear accumulation of JAK2V617F in CD34+ but not in granulocytic, megakaryocytic, or erythroid cells of patients with Philadelphia-negative myeloproliferative neoplasia. Blood 2010; 116: 6023-6026.
    • (2010) Blood , vol.116 , pp. 6023-6026
    • Rinaldi, C.R.1    Rinaldi, P.2    Alagia, A.3    Gemei, M.4    Esposito, N.5    Formiggini, F.6
  • 46
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
    • Tefferi A, Pardanani A, Lim KH, Abdel-Wahab O, Lasho TL, Patel J et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia 2009; 23: 905-911.
    • (2009) Leukemia , vol.23 , pp. 905-911
    • Tefferi, A.1    Pardanani, A.2    Lim, K.H.3    Abdel-Wahab, O.4    Lasho, T.L.5    Patel, J.6
  • 47
    • 47649123488 scopus 로고    scopus 로고
    • Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: A critical reappraisal
    • Vannucchi AM, Antonioli E, Guglielmelli P, Pardanani A, Tefferi A. Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisal. Leukemia 2008; 22: 1299-1307.
    • (2008) Leukemia , vol.22 , pp. 1299-1307
    • Vannucchi, A.M.1    Antonioli, E.2    Guglielmelli, P.3    Pardanani, A.4    Tefferi, A.5
  • 49
    • 77957868375 scopus 로고    scopus 로고
    • Chromosomal abnormalities in transformed Phnegative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations
    • Nguyen-Khac F, Lesty C, Eclache V, Couronne L, Kosmider O, Andrieux J et al. Chromosomal abnormalities in transformed Phnegative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations. Genes Chromosomes Cancer 2010; 49: 919-927.
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 919-927
    • Nguyen-Khac, F.1    Lesty, C.2    Eclache, V.3    Couronne, L.4    Kosmider, O.5    Andrieux, J.6
  • 50
  • 51
    • 67650924270 scopus 로고    scopus 로고
    • Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/ MPN and AML
    • Tefferi A, Lim KH, Abdel-Wahab O, Lasho TL, Patel J, Patnaik MM et al. Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/ MPN and AML. Leukemia 2009; 23: 1343-1345.
    • (2009) Leukemia , vol.23 , pp. 1343-1345
    • Tefferi, A.1    Lim, K.H.2    Abdel-Wahab, O.3    Lasho, T.L.4    Patel, J.5    Patnaik, M.M.6
  • 52
    • 67349145955 scopus 로고    scopus 로고
    • Frequent TET2 mutations in systemic mastocytosis: Clinical, KITD816V and FIP1L1-PDGFRA correlates
    • Tefferi A, Levine RL, Lim KH, Abdel-Wahab O, Lasho TL, Patel J et al. Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates. Leukemia 2009; 23: 900-904.
    • (2009) Leukemia , vol.23 , pp. 900-904
    • Tefferi, A.1    Levine, R.L.2    Lim, K.H.3    Abdel-Wahab, O.4    Lasho, T.L.5    Patel, J.6
  • 53
    • 77950388949 scopus 로고    scopus 로고
    • Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms
    • Schaub FX, Looser R, Li S, Hao-Shen H, Lehmann T, Tichelli A et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood 2010; 115: 2003-2007.
    • (2010) Blood , vol.115 , pp. 2003-2007
    • Schaub, F.X.1    Looser, R.2    Li, S.3    Hao-Shen, H.4    Lehmann, T.5    Tichelli, A.6
  • 54
    • 77950977381 scopus 로고    scopus 로고
    • Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm
    • Beer PA, Delhommeau F, LeCouedic JP, Dawson MA, Chen E, Bareford D et al. Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood 2010; 115: 2891-2900.
    • (2010) Blood , vol.115 , pp. 2891-2900
    • Beer, P.A.1    Delhommeau, F.2    Lecouedic, J.P.3    Dawson, M.A.4    Chen, E.5    Bareford, D.6
  • 55
    • 77952426827 scopus 로고    scopus 로고
    • Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/ myeloproliferative neoplasms
    • Kosmider O, Gelsi-Boyer V, Slama L, Dreyfus F, Beyne-Rauzy O, Quesnel B et al. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/ myeloproliferative neoplasms. Leukemia 2010; 24: 1094-1096.
    • (2010) Leukemia , vol.24 , pp. 1094-1096
    • Kosmider, O.1    Gelsi-Boyer, V.2    Slama, L.3    Dreyfus, F.4    Beyne-Rauzy, O.5    Quesnel, B.6
  • 56
    • 77956237515 scopus 로고    scopus 로고
    • Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1
    • Kohlmann A, Grossmann V, Klein HU, Schindela S, Weiss T, Kazak B et al. Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1. J Clin Oncol 2010; 28: 3858-3865.
    • (2010) J Clin Oncol , vol.28 , pp. 3858-3865
    • Kohlmann, A.1    Grossmann, V.2    Klein, H.U.3    Schindela, S.4    Weiss, T.5    Kazak, B.6
  • 57
    • 77956513784 scopus 로고    scopus 로고
    • Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission
    • Nibourel O, Kosmider O, Cheok M, Boissel N, Renneville A, Philippe N et al. Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission. Blood 2010; 116: 1132-1135.
    • (2010) Blood , vol.116 , pp. 1132-1135
    • Nibourel, O.1    Kosmider, O.2    Cheok, M.3    Boissel, N.4    Renneville, A.5    Philippe, N.6
  • 59
    • 77949732119 scopus 로고    scopus 로고
    • Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis
    • Flach J, Dicker F, Schnittger S, Kohlmann A, Haferlach T, Haferlach C. Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis. Haematologica 2010; 95: 518-519.
    • (2010) Haematologica , vol.95 , pp. 518-519
    • Flach, J.1    Dicker, F.2    Schnittger, S.3    Kohlmann, A.4    Haferlach, T.5    Haferlach, C.6
  • 60
    • 77952299670 scopus 로고    scopus 로고
    • The idic(X)(q13) in myeloid malignancies: Breakpoint clustering in segmental duplications and association with TET2 mutations
    • Paulsson K, Haferlach C, Fonatsch C, Hagemeijer A, Andersen MK, Slovak ML et al. The idic(X)(q13) in myeloid malignancies: breakpoint clustering in segmental duplications and association with TET2 mutations. Hum Mol Genet 2010; 19: 1507-1514.
    • (2010) Hum Mol Genet , vol.19 , pp. 1507-1514
    • Paulsson, K.1    Haferlach, C.2    Fonatsch, C.3    Hagemeijer, A.4    Andersen, M.K.5    Slovak, M.L.6
  • 61
    • 78149454504 scopus 로고    scopus 로고
    • Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
    • Smith AE, Mohamedali AM, Kulasekararaj A, Lim Z, Gaken J, Lea NC et al. Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. Blood 2010; 116: 3923-3932.
    • (2010) Blood , vol.116 , pp. 3923-3932
    • Smith, A.E.1    Mohamedali, A.M.2    Kulasekararaj, A.3    Lim, Z.4    Gaken, J.5    Lea, N.C.6
  • 62
    • 70350438115 scopus 로고    scopus 로고
    • TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
    • Kosmider O, Gelsi-Boyer V, Cheok M, Grabar S, Della-Valle V, Picard F et al. TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood 2009; 114: 3285-3291.
    • (2009) Blood , vol.114 , pp. 3285-3291
    • Kosmider, O.1    Gelsi-Boyer, V.2    Cheok, M.3    Grabar, S.4    Della-Valle, V.5    Picard, F.6
  • 63
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 2009; 114: 144-147.
    • (2009) Blood , vol.114 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3    Garcia-Manero, G.4    Patel, J.5    Wadleigh, M.6
  • 64
    • 79958826405 scopus 로고    scopus 로고
    • TET2 mutations in acute myeloid leukemia (AML): Results on 783 patients treated within the AML HD98A Study of the AML Study Group (AMLSG)
    • Gaidzik VI, Schlenk RF, Paschka P, Kohne C-H, Held G, Habdank M et al. TET2 mutations in acute myeloid leukemia (AML): results on 783 patients treated within the AML HD98A Study of the AML Study Group (AMLSG). ASH Annu Meet Abstr 2010; 116: 97.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 97
    • Gaidzik, V.I.1    Schlenk, R.F.2    Paschka, P.3    Kohne, C.-H.4    Held, G.5    Habdank, M.6
  • 65
    • 84864063417 scopus 로고    scopus 로고
    • Mutations in the TET oncogene family member (TET2) gene refine the new european leukemia net risk classification of primary, cytogenetically normal acute myeloid leukemia (CN-AML) in adults: A cancer and leukemia group B (CALGB) study
    • Metzeler KH, Maharry K, Radmacher MD, Mrozek K, Margeson D, Becker H et al. Mutations in the TET oncogene family member (TET2) gene refine the new European leukemia net risk classification of primary, cytogenetically normal acute myeloid leukemia (CN-AML) in adults: a Cancer and Leukemia Group B (CALGB) Study. ASH Annu Meet Abstr 2010; 116: 98.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 98
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3    Mrozek, K.4    Margeson, D.5    Becker, H.6
  • 66
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009; 324: 930-935.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3    Pastor, W.A.4    Bandukwala, H.5    Brudno, Y.6
  • 67
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010; 468: 839-843.
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3    Pape, U.J.4    Tahiliani, M.5    Bandukwala, H.S.6
  • 68
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010; 18: 553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6
  • 69
    • 74949143986 scopus 로고    scopus 로고
    • Loss-of-function additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
    • Fisher CL, Pineault N, Brookes C, Helgason CD, Ohta H, Bodner C et al. Loss-of-function additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood 2010; 115: 38-46.
    • (2010) Blood , vol.115 , pp. 38-46
    • Fisher, C.L.1    Pineault, N.2    Brookes, C.3    Helgason, C.D.4    Ohta, H.5    Bodner, C.6
  • 70
    • 73649142039 scopus 로고    scopus 로고
    • ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1
    • Lee SW, Cho YS, Na JM, Park UH, Kang M, Kim EJ et al. ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1. J Biol Chem 2010; 285: 18-29.
    • (2010) J Biol Chem , vol.285 , pp. 18-29
    • Lee, S.W.1    Cho, Y.S.2    Na, J.M.3    Park, U.H.4    Kang, M.5    Kim, E.J.6
  • 71
    • 33745842538 scopus 로고    scopus 로고
    • Additional sex comblike (ASXL1) in cooperation with SRC-1, acts as a liganddependent coactivator for retinoic acid receptor
    • Cho YS, Kim EJ, Park UH, Sin HS, Um SJ. Additional sex comblike (ASXL1), in cooperation with SRC-1, acts as a liganddependent coactivator for retinoic acid receptor. J Biol Chem 2006; 281: 17588-17598.
    • (2006) J Biol Chem , vol.281 , pp. 17588-17598
    • Cho, Y.S.1    Kim, E.J.2    Park, U.H.3    Sin, H.S.4    Um, S.J.5
  • 74
    • 77952421834 scopus 로고    scopus 로고
    • Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
    • Boultwood J, Perry J, Pellagatti A, Fernandez-Mercado M, Fernandez-Santamaria C, Calasanz MJ et al. Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia 2010; 24: 1062-1065.
    • (2010) Leukemia , vol.24 , pp. 1062-1065
    • Boultwood, J.1    Perry, J.2    Pellagatti, A.3    Fernandez-Mercado, M.4    Fernandez-Santamaria, C.5    Calasanz, M.J.6
  • 75
    • 77954583280 scopus 로고    scopus 로고
    • High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression
    • Boultwood J, Perry J, Zaman R, Fernandez-Santamaria C, Littlewood T, Kusec R et al. High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression. Leukemia 2010; 24: 1139-1145.
    • (2010) Leukemia , vol.24 , pp. 1139-1145
    • Boultwood, J.1    Perry, J.2    Zaman, R.3    Fernandez-Santamaria, C.4    Littlewood, T.5    Kusec, R.6
  • 76
    • 78549279199 scopus 로고    scopus 로고
    • Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations
    • Chou WC, Huang HH, Hou HA, Chen CY, Tang JL, Yao M et al. Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations. Blood 2010; 116: 4086-4094.
    • (2010) Blood , vol.116 , pp. 4086-4094
    • Chou, W.C.1    Huang, H.H.2    Hou, H.A.3    Chen, C.Y.4    Tang, J.L.5    Yao, M.6
  • 77
    • 77958591628 scopus 로고    scopus 로고
    • ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia
    • Gelsi-Boyer V, Trouplin V, Roquain J, Adelaide J, Carbuccia N, Esterni B et al. ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia. Br J Haematol 2010; 151: 365-375.
    • (2010) Br J Haematol , vol.151 , pp. 365-375
    • Gelsi-Boyer, V.1    Trouplin, V.2    Roquain, J.3    Adelaide, J.4    Carbuccia, N.5    Esterni, B.6
  • 78
    • 77956440933 scopus 로고    scopus 로고
    • The most commonly reported variant in ASXL1 (c.1934dupG;p.- Gly646TrpfsX12) is not a somatic alteration
    • Abdel-Wahab O, Kilpivaara O, Patel J, Busque L, Levine RL. The most commonly reported variant in ASXL1 (c.1934dupG;p.-Gly646TrpfsX12) is not a somatic alteration. Leukemia 2010; 24: 1656-1657.
    • (2010) Leukemia , vol.24 , pp. 1656-1657
    • Abdel-Wahab, O.1    Kilpivaara, O.2    Patel, J.3    Busque, L.4    Levine, R.L.5
  • 80
    • 84864059178 scopus 로고    scopus 로고
    • Frequent mutation of the polycomb-associated gene ASXL1 in acute myeloid leukemia secondary to myelodysplastic syndrome or chronic myelomonocytic leukemia
    • Fernandez-Mercado M, Pellagatti A, Perry J, Fernandez-Santamaria C, Calasanz MJ, Larrayoz MJ et al. Frequent mutation of the polycomb-associated gene ASXL1 in acute myeloid leukemia secondary to myelodysplastic syndrome or chronic myelomonocytic leukemia. ASH Annu Meet Abstr 116: 2940.
    • ASH Annu Meet Abstr , vol.116 , pp. 2940
    • Fernandez-Mercado, M.1    Pellagatti, A.2    Perry, J.3    Fernandez-Santamaria, C.4    Calasanz, M.J.5    Larrayoz, M.J.6
  • 81
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010; 17: 225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6
  • 85
    • 79751530369 scopus 로고    scopus 로고
    • The prognostic impact and stability of isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia
    • Chou WC, Lei WC, Ko BS, Hou HA, Chen CY, Tang JL et al. The prognostic impact and stability of isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia. Leukemia 2011; 25: 246-253.
    • (2011) Leukemia , vol.25 , pp. 246-253
    • Chou, W.C.1    Lei, W.C.2    Ko, B.S.3    Hou, H.A.4    Chen, C.Y.5    Tang, J.L.6
  • 86
    • 78650306174 scopus 로고    scopus 로고
    • IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia
    • Caramazza D, Lasho TL, Finke CM, Gangat N, Dingli D, Knudson RA et al. IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 2010; 24: 2120-2122.
    • (2010) Leukemia , vol.24 , pp. 2120-2122
    • Caramazza, D.1    Lasho, T.L.2    Finke, C.M.3    Gangat, N.4    Dingli, D.5    Knudson, R.A.6
  • 88
    • 77957759961 scopus 로고    scopus 로고
    • The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
    • Green CL, Evans CM, Hills RK, Burnett AK, Linch DC, Gale RE. The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status. Blood 2010; 116: 2779-2782.
    • (2010) Blood , vol.116 , pp. 2779-2782
    • Green, C.L.1    Evans, C.M.2    Hills, R.K.3    Burnett, A.K.4    Linch, D.C.5    Gale, R.E.6
  • 89
    • 77957286222 scopus 로고    scopus 로고
    • Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: A study by the Acute Leukemia French Association group
    • Boissel N, Nibourel O, Renneville A, Gardin C, Reman O, Contentin N et al. Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group. J Clin Oncol 2010; 28: 3717-3723.
    • (2010) J Clin Oncol , vol.28 , pp. 3717-3723
    • Boissel, N.1    Nibourel, O.2    Renneville, A.3    Gardin, C.4    Reman, O.5    Contentin, N.6
  • 90
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Kronke J, Bullinger L et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010; 28: 3636-3643.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3    Habdank, M.4    Kronke, J.5    Bullinger, L.6
  • 91
    • 77954660316 scopus 로고    scopus 로고
    • Recurrent IDH mutations in high-risk myelodysplastic syndrome or acute myeloid leukemia with isolated del(5q)
    • Pardanani A, Patnaik MM, Lasho TL, Mai M, Knudson RA, Finke C et al. Recurrent IDH mutations in high-risk myelodysplastic syndrome or acute myeloid leukemia with isolated del(5q). Leukemia 2010; 24: 1370-1372.
    • (2010) Leukemia , vol.24 , pp. 1370-1372
    • Pardanani, A.1    Patnaik, M.M.2    Lasho, T.L.3    Mai, M.4    Knudson, R.A.5    Finke, C.6
  • 92
    • 77954658029 scopus 로고    scopus 로고
    • WHO-defined 'myelodysplastic syndrome with isolated del(5q)' in 88 consecutive patients: Survival data leukemic transformation rates and prevalence of JAK2 MPL and IDH mutations
    • Patnaik MM, Lasho TL, Finke CM, Gangat N, Caramazza D, Holtan SG et al. WHO-defined 'myelodysplastic syndrome with isolated del(5q)' in 88 consecutive patients: survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations. Leukemia 2010; 24: 1283-1289.
    • (2010) Leukemia , vol.24 , pp. 1283-1289
    • Patnaik, M.M.1    Lasho, T.L.2    Finke, C.M.3    Gangat, N.4    Caramazza, D.5    Holtan, S.G.6
  • 93
    • 75749093015 scopus 로고    scopus 로고
    • Deregulation of H3K27 methylation in cancer
    • Martinez-Garcia E, Licht JD. Deregulation of H3K27 methylation in cancer. Nat Genet 2010; 42: 100-101.
    • (2010) Nat Genet , vol.42 , pp. 100-101
    • Martinez-Garcia, E.1    Licht, J.D.2
  • 94
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010; 42: 181-185.
    • (2010) Nat Genet , vol.42 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3    Mungall, A.J.4    An, J.5    Goya, R.6
  • 95
    • 79952167230 scopus 로고    scopus 로고
    • Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
    • blood-2010-2011-321208 (in press)
    • Yap DB, Chu J, Berg T, Schapira M, Cheng SWG, Moradian A et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 2011 blood-2010-2011-321208 (in press).
    • (2011) Blood
    • Yap, D.B.1    Chu, J.2    Berg, T.3    Schapira, M.4    Cheng, S.W.G.5    Moradian, A.6
  • 96
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • Sneeringer CJ, Scott MP, Kuntz KW, Knutson SK, Pollock RM, Richon VM et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci USA 107, 20980-20985.
    • Proc Natl Acad Sci USA , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1    Scott, M.P.2    Kuntz, K.W.3    Knutson, S.K.4    Pollock, R.M.5    Richon, V.M.6
  • 99
    • 84856286617 scopus 로고    scopus 로고
    • Mutations of EZH2 in myeloproliferative neoplasms with myelofibrosis: Correlation with molecular and clinical data
    • Stegelmann F, Schlenk RF, Griesshammer M, Paschka P, Blersch C, Kuhn S et al. Mutations of EZH2 In myeloproliferative neoplasms with myelofibrosis: correlation with molecular and clinical data. ASH Annu Meet Abstr 116: 4111.
    • ASH Annu Meet Abstr , vol.116 , pp. 4111
    • Stegelmann, F.1    Schlenk, R.F.2    Griesshammer, M.3    Paschka, P.4    Blersch, C.5    Kuhn, S.6
  • 103
    • 84864059180 scopus 로고    scopus 로고
    • Mutational spectrum in chronic myelomonocytic leukemia includes genes associated with epigenetic regulation such as UTX and EZH2
    • Jankowska A, Makishima H, Tiu RV, Szpurka H, Huang Y, Sugimoto Y et al. Mutational spectrum in chronic myelomonocytic leukemia includes genes associated with epigenetic regulation such as UTX and EZH2. ASH Annu Meet Abstr 116, 611.
    • ASH Annu Meet Abstr , vol.116 , pp. 611
    • Jankowska, A.1    Makishima, H.2    Tiu, R.V.3    Szpurka, H.4    Huang, Y.5    Sugimoto, Y.6
  • 104
    • 74049112732 scopus 로고    scopus 로고
    • Prodromal myeloproliferative neoplasms: The 2008 WHO classification
    • Kvasnicka HM, Thiele J. Prodromal myeloproliferative neoplasms: the 2008 WHO classification. Am J Hematol 2010; 85: 62-69.
    • (2010) Am J Hematol , vol.85 , pp. 62-69
    • Kvasnicka, H.M.1    Thiele, J.2
  • 105
    • 33745079673 scopus 로고    scopus 로고
    • Bone marrow histopathology in the diagnosis of chronic myeloproliferative disorders: A forgotten pearl
    • DOI 10.1016/j.beha.2005.07.015, PII S1521692605001027
    • Thiele J, Kvasnicka HM, Vardiman J. Bone marrow histopathology in the diagnosis of chronic myeloproliferative disorders: a forgotten pearl. Best Pract Res Clin Haematol 2006; 19: 413-437. (Pubitemid 43884244)
    • (2006) Best Practice and Research: Clinical Haematology , vol.19 , Issue.3 , pp. 413-437
    • Thiele, J.1    Kvasnicka, H.M.2    Vardiman, J.3
  • 107
    • 79953701749 scopus 로고    scopus 로고
    • Survival and risk of leukemic transformation in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: An international study on 1, 104 patients
    • Barbui T, Thiele J, Passamonti F, Rumi E, Boveri E, Ruggeri M et al. Survival and risk of leukemic transformation in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study on 1, 104 patients. ASH Annu Meet Abstr 2010; 116: 457.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 457
    • Barbui, T.1    Thiele, J.2    Passamonti, F.3    Rumi, E.4    Boveri, E.5    Ruggeri, M.6
  • 108
    • 38349101871 scopus 로고    scopus 로고
    • Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms
    • Tefferi A, Vardiman JW. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia 2008; 22: 14-22.
    • (2008) Leukemia , vol.22 , pp. 14-22
    • Tefferi, A.1    Vardiman, J.W.2
  • 109
    • 63849328927 scopus 로고    scopus 로고
    • New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
    • Cervantes F, Dupriez B, Pereira A, Passamonti F, Reilly JT, Morra E et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood 2009; 113: 2895-2901.
    • (2009) Blood , vol.113 , pp. 2895-2901
    • Cervantes, F.1    Dupriez, B.2    Pereira, A.3    Passamonti, F.4    Reilly, J.T.5    Morra, E.6
  • 110
    • 77950352432 scopus 로고    scopus 로고
    • A dynamic prognostic model to predict survival in primary myelofibrosis: A study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)
    • Passamonti F, Cervantes F, Vannucchi AM, Morra E, Rumi E, Pereira A et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood 2010; 115: 1703-1708.
    • (2010) Blood , vol.115 , pp. 1703-1708
    • Passamonti, F.1    Cervantes, F.2    Vannucchi, A.M.3    Morra, E.4    Rumi, E.5    Pereira, A.6
  • 111
    • 79952087335 scopus 로고    scopus 로고
    • DIPSS-Plus: A Refined Dynamic International Prognostic Scoring System (DIPSS) for Primary Myelofibrosis that Incorporates Prognostic Information from Karyotype, Platelet Count and Transfusion Status
    • Gangat N, Caramazza D, Vaidya R, George G, Begna KH, Schwager SM et al. DIPSS-Plus: A Refined Dynamic International Prognostic Scoring System (DIPSS) for Primary Myelofibrosis that Incorporates Prognostic Information from Karyotype, Platelet Count and Transfusion Status. J Clin Oncol 2011; 29: 392-397.
    • (2011) J Clin Oncol , vol.29 , pp. 392-397
    • Gangat, N.1    Caramazza, D.2    Vaidya, R.3    George, G.4    Begna, K.H.5    Schwager, S.M.6
  • 112
    • 78651344350 scopus 로고    scopus 로고
    • Refined cytogenetic risk categorization for overall and leukemia-free survival in primary myelofibrosis: A single center study of 433 patients
    • Caramazza D, Begna KH, Gangat N, Vaidya R, Siragusa S, Van Dyke DLet al. Refined cytogenetic risk categorization for overall and leukemia-free survival in primary myelofibrosis: a single center study of 433 patients. Leukemia 2011; 25: 82-88.
    • (2011) Leukemia , vol.25 , pp. 82-88
    • Caramazza, D.1    Begna, K.H.2    Gangat, N.3    Vaidya, R.4    Siragusa, S.5    Van Dyke, D.L.6
  • 113
    • 65649110882 scopus 로고    scopus 로고
    • Red blood cell transfusion need at diagnosis adversely affects survival in primary myelofibrosis-increased serum ferritin or transfusion load does not
    • Tefferi A, Mesa RA, Pardanani A, Hussein K, Schwager S, Hanson CA et al. Red blood cell transfusion need at diagnosis adversely affects survival in primary myelofibrosis-increased serum ferritin or transfusion load does not. Am J Hematol 2009; 84: 265-267.
    • (2009) Am J Hematol , vol.84 , pp. 265-267
    • Tefferi, A.1    Mesa, R.A.2    Pardanani, A.3    Hussein, K.4    Schwager, S.5    Hanson, C.A.6
  • 114
    • 74049158614 scopus 로고    scopus 로고
    • Transfusion-dependency at presentation and its acquisition in the first year of diagnosis are both equally detrimental for survival in primary myelofibrosis-prognostic relevance is independent of IPSS or karyotype
    • Tefferi A, Siragusa S, Hussein K, Schwager SM, Hanson CA, Pardanani A et al. Transfusion-dependency at presentation and its acquisition in the first year of diagnosis are both equally detrimental for survival in primary myelofibrosis-prognostic relevance is independent of IPSS or karyotype. Am J Hematol 2009; 85: 14-17.
    • (2009) Am J Hematol , vol.85 , pp. 14-17
    • Tefferi, A.1    Siragusa, S.2    Hussein, K.3    Schwager, S.M.4    Hanson, C.A.5    Pardanani, A.6
  • 115
    • 74049116496 scopus 로고    scopus 로고
    • Age and platelet count are IPSS-independent prognostic factors in young patients with primary myelofibrosis and complement IPSS in predicting very long or very short survival
    • Patnaik MM, Caramazza D, Gangat N, Hanson CA, Pardanani A, Tefferi A. Age and platelet count are IPSS-independent prognostic factors in young patients with primary myelofibrosis and complement IPSS in predicting very long or very short survival. Eur J Haematol 2010; 84: 105-108.
    • (2010) Eur J Haematol , vol.84 , pp. 105-108
    • Patnaik, M.M.1    Caramazza, D.2    Gangat, N.3    Hanson, C.A.4    Pardanani, A.5    Tefferi, A.6
  • 116
    • 42449124578 scopus 로고    scopus 로고
    • Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival
    • DOI 10.1038/sj.leu.2405097, PII 2405097
    • Tefferi A, Lasho TL, Huang J, Finke C, Mesa RA, Li CY et al. Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival. Leukemia 2008; 22: 756-761. (Pubitemid 351559282)
    • (2008) Leukemia , vol.22 , Issue.4 , pp. 756-761
    • Tefferi, A.1    Lasho, T.L.2    Huang, J.3    Finke, C.4    Mesa, R.A.5    Li, C.Y.6    Wu, W.7    Hanson, C.A.8    Pardanani, A.9
  • 117
    • 70349580685 scopus 로고    scopus 로고
    • Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele
    • Guglielmelli P, Barosi G, Specchia G, Rambaldi A, Lo Coco F, Antonioli E et al. Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele. Blood 2009; 114: 1477-1483.
    • (2009) Blood , vol.114 , pp. 1477-1483
    • Guglielmelli, P.1    Barosi, G.2    Specchia, G.3    Rambaldi, A.4    Lo Coco, F.5    Antonioli, E.6
  • 118
    • 79953178917 scopus 로고    scopus 로고
    • Circulating IL-2R, IL-8, IL-15 and CXCL10 levels are independently prognostic in primary myelofibrosis: A comprehensive cytokine profiling study
    • Vaidya R, Caramazza D, Finke C, Lasho T, Pardanani A, Tefferi A. Circulating IL-2R, IL-8, IL-15 and CXCL10 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study. ASH Annu Meet Abstr 2010; 116: 3068.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 3068
    • Vaidya, R.1    Caramazza, D.2    Finke, C.3    Lasho, T.4    Pardanani, A.5    Tefferi, A.6
  • 119
    • 79551585770 scopus 로고    scopus 로고
    • A phase I/II study of CYT387, an oral JAK-1/2 inhibitor, in myelofibrosis: Significant response rates in anemia, splenomegaly, and constitutional symptoms
    • Pardanani A, George G, Lasho T, Hogan WJ, Litzow MR, Begna K et al. A phase I/II study of CYT387, an oral JAK-1/2 inhibitor, in myelofibrosis: significant response rates in anemia, splenomegaly, and constitutional symptoms. ASH Annu Meet Abst 2010; 116: 460
    • (2010) ASH Annu Meet Abst , vol.116 , pp. 460
    • Pardanani, A.1    George, G.2    Lasho, T.3    Hogan, W.J.4    Litzow, M.R.5    Begna, K.6
  • 120
    • 79959605267 scopus 로고    scopus 로고
    • Durable responses with the JAK1/JAK2 inhibitor, INCB018424, in patients with polycythemia vera (PV) and essential thrombocythemia (ET) refractory or intolerant to hydroxyurea (HU)
    • Verstovsek S, Passamonti F, Rambaldi A, Barosi G, Rosen PJ, Levy R et al. Durable responses with the JAK1/JAK2 inhibitor, INCB018424, in patients with polycythemia vera (PV) and essential thrombocythemia (ET) refractory or intolerant to hydroxyurea (HU). ASH Annu Meet Abst 2010; 116: 313.
    • (2010) ASH Annu Meet Abst , vol.116 , pp. 313
    • Verstovsek, S.1    Passamonti, F.2    Rambaldi, A.3    Barosi, G.4    Rosen, P.J.5    Levy, R.6
  • 124
    • 73949090770 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera
    • Quintas-Cardama A, Kantarjian H, Manshouri T, Luthra R, Estrov Z, Pierce S et al. Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera. J Clin Oncol 2009; 27: 5418-5424.
    • (2009) J Clin Oncol , vol.27 , pp. 5418-5424
    • Quintas-Cardama, A.1    Kantarjian, H.2    Manshouri, T.3    Luthra, R.4    Estrov, Z.5    Pierce, S.6
  • 125
    • 54049141336 scopus 로고    scopus 로고
    • Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera
    • Kiladjian JJ, Cassinat B, Chevret S, Turlure P, Cambier N, Roussel M et al. Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera. Blood 2008; 112: 3065-3072.
    • (2008) Blood , vol.112 , pp. 3065-3072
    • Kiladjian, J.J.1    Cassinat, B.2    Chevret, S.3    Turlure, P.4    Cambier, N.5    Roussel, M.6
  • 126
    • 34548125318 scopus 로고    scopus 로고
    • Busulphan is safe and efficient treatment in elderly patients with essential thrombocythemia [15]
    • DOI 10.1038/sj.leu.2404743, PII 2404743
    • Shvidel L, Sigler E, Haran M, Klepfish A, Duek A, Berrebi A et al. Busulphan is safe and efficient treatment in elderly patients with essential thrombocythemia. Leukemia 2007; 21: 2071-2072. (Pubitemid 47299992)
    • (2007) Leukemia , vol.21 , Issue.9 , pp. 2071-2072
    • Shvidel, L.1    Sigler, E.2    Haran, M.3    Klepfish, A.4    Duek, A.5    Berrebi, A.6    Shtalrid, M.7
  • 127
    • 0019488158 scopus 로고
    • Treatment of polycythaemia vera by radiophosphorus or busulphan: A randomized trial. Leukemia and Hematosarcoma' Cooperative Group, European Organization for Research on Treatment of Cancer (E.O.R.T.C.)
    • Treatment of polycythaemia vera by radiophosphorus or busulphan: a randomized trial. Leukemia and Hematosarcoma' Cooperative Group, European Organization for Research on Treatment of Cancer (E.O.R.T.C.). Br J Cancer 1981 44:75-80.
    • (1981) Br J Cancer , vol.44 , pp. 75-80
  • 128
    • 0033757965 scopus 로고    scopus 로고
    • Efficacy of pipobroman in the treatment of polycythemia vera: Long-term results in 163 patients
    • Passamonti F, Brusamolino E, Lazzarino M, Barate C, Klersy C, Orlandi E et al. Efficacy of pipobroman in the treatment of polycythemia vera: long-term results in 163 patients. Haematologica 2000; 85: 1011-1018.
    • (2000) Haematologica , vol.85 , pp. 1011-1018
    • Passamonti, F.1    Brusamolino, E.2    Lazzarino, M.3    Barate, C.4    Klersy, C.5    Orlandi, E.6
  • 129
    • 0031804798 scopus 로고    scopus 로고
    • Polycythemia vera treated with pipobroman as single agent: Low incidence of secondary leukemia in a cohort of patients observed during 20 years (1971-1991)
    • Petti MC, Spadea A, Avvisati G, Spadea T, Latagliata R, Montefusco E et al. Polycythemia vera treated with pipobroman as single agent: low incidence of secondary leukemia in a cohort of patients observed during 20 years (1971-1991). Leukemia 1998; 12: 869-874. (Pubitemid 28287208)
    • (1998) Leukemia , vol.12 , Issue.6 , pp. 869-874
    • Petti, M.C.1    Spadea, A.2    Avvisati, G.3    Spadea, T.4    Latagliata, R.5    Montefusco, E.6    Cosenza, M.7    Malagnino, F.8
  • 132
    • 33846540216 scopus 로고    scopus 로고
    • Risk stratification for survival and leukemic transformation in essential thrombocythemia: A single institutional study of 605 patients
    • DOI 10.1038/sj.leu.2404500, PII 2404500
    • Gangat N, Wolanskyj AP, McClure RF, Li CY, Schwager S, WuW et al. Risk stratification for survival and leukemic transformation in essential thrombocythemia: a single institutional study of 605 patients. Leukemia 2007; 21: 270-276. (Pubitemid 46158119)
    • (2007) Leukemia , vol.21 , Issue.2 , pp. 270-276
    • Gangat, N.1    Wolanskyj, A.P.2    McClure, R.F.3    Li, C.-Y.4    Schwager, S.5    Wu, W.6    Tefferi, A.7
  • 133
    • 34447132275 scopus 로고    scopus 로고
    • Leucocytosis in polycythaemia vera predicts both inferior survival and leukaemic transformation
    • DOI 10.1111/j.1365-2141.2007.06674.x
    • Gangat N, Strand J, Li CY, Wu W, Pardanani A, Tefferi A. Leucocytosis in polycythaemia vera predicts both inferior survival and leukaemic transformation. Br J Haematol 2007; 138: 354-358. (Pubitemid 47035399)
    • (2007) British Journal of Haematology , vol.138 , Issue.3 , pp. 354-358
    • Gangat, N.1    Strand, J.2    Li, C.-Y.3    Wu, W.4    Pardanani, A.5    Tefferi, A.6
  • 135
    • 0022400901 scopus 로고
    • Treatment of primary proliferative polycythaemia by venesection and low dose busulphan: Retrospective study from one centre
    • Messinezy M, Pearson TC, Prochazka A, Wetherley-Mein G. Treatment of primary proliferative polycythaemia by venesection and low dose busulphan: retrospective study from one centre. Br J Haematol 1985; 61: 657-666. (Pubitemid 16231518)
    • (1985) British Journal of Haematology , vol.61 , Issue.4 , pp. 657-666
    • Messinezy, M.1    Pearson, T.C.2    Prochazka, A.3    Wetherley-Mein, G.4
  • 138
    • 84864036647 scopus 로고    scopus 로고
    • Synergistic activity of combinations of JAK2 kinase inhibitor with PI3K/mTOR, MEK or PIM kinase inhibitor against human myeloproliferative neoplasm
    • Fiskus W, Manepalli RR, Balusu R, Bhalla KN. Synergistic activity of combinations of JAK2 kinase inhibitor with PI3K/mTOR, MEK or PIM kinase inhibitor against human myeloproliferative neoplasm cells expressing JAK2V617F. ASH Annu Meet Abstr 2010; 116: 798.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 798
    • Fiskus, W.1    Manepalli, R.R.2    Balusu, R.3    Bhalla, K.N.4
  • 140
    • 79960404044 scopus 로고    scopus 로고
    • KIT inhibitor midostaurin exhibits a high rate of clinically meaningful and durable responses in advanced systemic mastocytosis: Report of a fully accrued phase II trial
    • Gotlib J, DeAngelo DJ, George TI, Corless CL, Linder A, Langford C et al. KIT inhibitor midostaurin exhibits a high rate of clinically meaningful and durable responses in advanced systemic mastocytosis: report of a fully accrued phase II trial. ASH Annu Meet Abstr 2010; 116: 316.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 316
    • Gotlib, J.1    Deangelo, D.J.2    George, T.I.3    Corless, C.L.4    Linder, A.5    Langford, C.6
  • 141
    • 84858268181 scopus 로고    scopus 로고
    • Long term efficacy and safety of cladribine in adult systemic mastocytosis: A French Multicenter STUDY of 44 patients
    • Hermine O, Hirsh I, Damaj G, Granpeix C, Barete S, Suarez F et al. long term efficacy and safety of cladribine in adult systemic mastocytosis: a French Multicenter STUDY of 44 patients. ASH Annu Meet Abstr 2010; 116: 1982.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 1982
    • Hermine, O.1    Hirsh, I.2    Damaj, G.3    Granpeix, C.4    Barete, S.5    Suarez, F.6
  • 143
    • 73349111582 scopus 로고    scopus 로고
    • Cytoreductive therapy in 108 adults with systemic mastocytosis: Outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosine
    • Lim KH, Pardanani A, Butterfield JH, Li CY, Tefferi A. Cytoreductive therapy in 108 adults with systemic mastocytosis: outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosine. Am J Hematol 2009; 84: 790-794.
    • (2009) Am J Hematol , vol.84 , pp. 790-794
    • Lim, K.H.1    Pardanani, A.2    Butterfield, J.H.3    Li, C.Y.4    Tefferi, A.5
  • 144
    • 27644454273 scopus 로고    scopus 로고
    • Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia [3]
    • DOI 10.1007/s00277-005-1057-x
    • Penack O, Sotlar K, Noack F, Horny HP, Thiel E, Notter M. Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia. Ann Hematol 2005; 84: 692-693. (Pubitemid 41554248)
    • (2005) Annals of Hematology , vol.84 , Issue.10 , pp. 692-693
    • Penack, O.1    Sotlar, K.2    Noack, F.3    Horny, H.-P.4    Thiel, E.5    Notter, M.6
  • 145
    • 79959616533 scopus 로고    scopus 로고
    • High rates of molecular response after long-term follow-up of patients with advanced essential thrombocythemia (ET) or polycythemia vera (PV) treated with pegylated interferon-ALFA-2A (PEG-IFN-{alpha}-2A; PEGASYS)
    • Quintas-Cardama A, Levine R, Manshouri T, Kilpivaara O, Kantarjian HM, Verstovsek S. High rates of molecular response after long-term follow-up of patients with advanced essential thrombocythemia (ET) or polycythemia vera (PV) treated with pegylated interferon-ALFA-2A (PEG-IFN-{alpha}-2A; PEGASYS). ASH Annu Meet Abstr 2010; 116: 461.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 461
    • Quintas-Cardama, A.1    Levine, R.2    Manshouri, T.3    Kilpivaara, O.4    Kantarjian, H.M.5    Verstovsek, S.6
  • 146
    • 77954581139 scopus 로고    scopus 로고
    • Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
    • Tefferi A. Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia 2010; 24: 1128-1138.
    • (2010) Leukemia , vol.24 , pp. 1128-1138
    • Tefferi, A.1


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