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Volumn 24, Issue 7, 2010, Pages 1283-1289

WHO-defined myelodysplastic syndrome with isolated del(5q) in 88 consecutive patients: Survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations

Author keywords

5q ; ferritin; iron; isocitrate dehydrogenase; prognosis

Indexed keywords

FERRITIN; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE ISOENZYME; JANUS KINASE 2; THROMBOPOIETIN RECEPTOR; UNCLASSIFIED DRUG; IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE 2, HUMAN; JAK2 PROTEIN, HUMAN; MPL PROTEIN, HUMAN;

EID: 77954658029     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.105     Document Type: Article
Times cited : (91)

References (37)
  • 3
    • 51449104487 scopus 로고    scopus 로고
    • Myelodysplastic syndromes associated with interstitial deletion of chromosome 5q: Clinicopathologic correlations and new insights from the pre-lenalidomide era
    • Holtan SG, Santana-Davila R, Dewald GW, Khetterling RP, Knudson RA, Hoyer JD et al. Myelodysplastic syndromes associated with interstitial deletion of chromosome 5q: clinicopathologic correlations and new insights from the pre-lenalidomide era. Am J Hematol 2008;83:708-713.
    • (2008) Am. J. Hematol , vol.83 , pp. 708-713
    • Holtan, S.G.1    Santana-Davila, R.2    Dewald, G.W.3    Khetterling, R.P.4    Knudson, R.A.5    Hoyer, J.D.6
  • 4
    • 10744229499 scopus 로고    scopus 로고
    • Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del (5q) including band q31
    • Giagounidis AA, Germing U, Haase S, Hildebrandt B, Schlegelberger B, Schoch C et al. Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del (5q) including band q31. Leukemia 2004;18:113-119.
    • (2004) Leukemia , vol.18 , pp. 113-119
    • Giagounidis, A.A.1    Germing, U.2    Haase, S.3    Hildebrandt, B.4    Schlegelberger, B.5    Schoch, C.6
  • 5
    • 70449378917 scopus 로고    scopus 로고
    • The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: How does it relate to the original lenalidomide experience in MDS?
    • Kantarjian H, O'Brien S, Ravandi F, Borthakur G, Faderl S, Bueso-Ramos C et al. The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS? Cancer 2009;115:5202-5209.
    • (2009) Cancer , vol.115 , pp. 5202-5209
    • Kantarjian, H.1    O'Brien, S.2    Ravandi, F.3    Borthakur, G.4    Faderl, S.5    Bueso-Ramos, C.6
  • 9
    • 39749117093 scopus 로고    scopus 로고
    • Chromosome 5q deletion: Specific diagnoses and cytogenetic details among 358 consecutive cases from a single institution
    • Santana-Davila R, Holtan SG, Dewald GW, Ketterling RP, Knudson RA, Hanson CA et al. Chromosome 5q deletion: specific diagnoses and cytogenetic details among 358 consecutive cases from a single institution. Leuk Res 2008;32:407-411.
    • (2008) Leuk Res. , vol.32 , pp. 407-411
    • Santana-Davila, R.1    Holtan, S.G.2    Dewald, G.W.3    Ketterling, R.P.4    Knudson, R.A.5    Hanson, C.A.6
  • 10
    • 51649121491 scopus 로고    scopus 로고
    • Primary myelofibrosis is the most frequent myeloproliferative neoplasm associated with del (5q): Clinicopathologic comparison of del (5q)-positive and-negative cases
    • Santana-Davila R, Tefferi A, Holtan SG, Ketterling RP, Dewald GW, Knudson RA et al. Primary myelofibrosis is the most frequent myeloproliferative neoplasm associated with del (5q): clinicopathologic comparison of del (5q)-positive and-negative cases. Leuk Res 2008;32:1927-1930.
    • (2008) Leuk Res. , vol.32 , pp. 1927-1930
    • Santana-Davila, R.1    Tefferi, A.2    Holtan, S.G.3    Ketterling, R.P.4    Dewald, G.W.5    Knudson, R.A.6
  • 11
    • 0022255053 scopus 로고
    • The efficacy of direct, 24-hour culture, and mitotic synchronization methods for cytogenetic analysis of bone marrow in neoplastic hematologic disorders
    • Dewald GW, Broderick DJ, Tom WW, Hagstrom JE, Pierre RV. The efficacy of direct, 24-hour culture, and mitotic synchronization methods for cytogenetic analysis of bone marrow in neoplastic hematologic disorders. Cancer Genet Cytogenet 1985;18:1-10.
    • (1985) Cancer Genet. Cytogenet , vol.18 , pp. 1-10
    • Dewald, G.W.1    Broderick, D.J.2    Tom, W.W.3    Hagstrom, J.E.4    Pierre, R.V.5
  • 13
    • 33750534561 scopus 로고    scopus 로고
    • MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
    • Pardanani AD, Levine RL, Lasho T, Pikman Y, Mesa RA, Wadleigh M et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 2006;108:3472-3476.
    • (2006) Blood , vol.108 , pp. 3472-3476
    • Pardanani, A.D.1    Levine, R.L.2    Lasho, T.3    Pikman, Y.4    Mesa, R.A.5    Wadleigh, M.6
  • 14
    • 42449124578 scopus 로고    scopus 로고
    • Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival
    • Tefferi A, Lasho TL, Huang J, Finke C, Mesa RA, Li CY et al. Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival. Leukemia 2008;22:756-761.
    • (2008) Leukemia , vol.22 , pp. 756-761
    • Tefferi, A.1    Lasho, T.L.2    Huang, J.3    Finke, C.4    Mesa, R.A.5    Li, C.Y.6
  • 15
    • 65349150503 scopus 로고    scopus 로고
    • IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
    • Watanabe T, Nobusawa S, Kleihues P, Ohgaki H. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol 2009;174:1149-1153.
    • (2009) Am. J. Pathol. , vol.174 , pp. 1149-1153
    • Watanabe, T.1    Nobusawa, S.2    Kleihues, P.3    Ohgaki, H.4
  • 16
    • 70349653793 scopus 로고    scopus 로고
    • IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
    • Nobusawa S, Watanabe T, Kleihues P, Ohgaki H. IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin Cancer Res 2009;15:6002-6007.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6002-6007
    • Nobusawa, S.1    Watanabe, T.2    Kleihues, P.3    Ohgaki, H.4
  • 17
    • 64849091680 scopus 로고    scopus 로고
    • Dysgranulopoiesis is an independent adverse prognostic factor in chronic myeloid disorders with an isolated interstitial deletion of chromosome 5q
    • Chen D, Hoyer JD, Ketterling RP, Tefferi A, Steensma DP, Holtan SG et al. Dysgranulopoiesis is an independent adverse prognostic factor in chronic myeloid disorders with an isolated interstitial deletion of chromosome 5q. Leukemia 2009;23:796-800.
    • (2009) Leukemia , vol.23 , pp. 796-800
    • Chen, D.1    Hoyer, J.D.2    Ketterling, R.P.3    Tefferi, A.4    Steensma, D.P.5    Holtan, S.G.6
  • 18
    • 54149085320 scopus 로고    scopus 로고
    • JAK2 and MPL mutations in myeloproliferative neoplasms: Discovery and science
    • Kilpivaara O, Levine RL. JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science. Leukemia 2008;22:1813-1817.
    • (2008) Leukemia , vol.22 , pp. 1813-1817
    • Kilpivaara, O.1    Levine, R.L.2
  • 19
    • 39749198165 scopus 로고    scopus 로고
    • JAK and MPL mutations in myeloid malignancies
    • Tefferi A. JAK and MPL mutations in myeloid malignancies. Leuk Lymphoma 2008;49:388-397.
    • (2008) Leuk Lymphoma , vol.49 , pp. 388-397
    • Tefferi, A.1
  • 20
    • 33745213401 scopus 로고    scopus 로고
    • The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow
    • Ingram W, Lea NC, Cervera J, Germing U, Fenaux P, Cassinat B et al. The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow. Leukemia 2006;20:1319-1321.
    • (2006) Leukemia , vol.20 , pp. 1319-1321
    • Ingram, W.1    Lea, N.C.2    Cervera, J.3    Germing, U.4    Fenaux, P.5    Cassinat, B.6
  • 21
    • 47649123488 scopus 로고    scopus 로고
    • Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: A critical reappraisal
    • Vannucchi AM, Antonioli E, Guglielmelli P, Pardanani A, Tefferi A. Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisal. Leukemia 2008;22:1299-1307.
    • (2008) Leukemia , vol.22 , pp. 1299-1307
    • Vannucchi, A.M.1    Antonioli, E.2    Guglielmelli, P.3    Pardanani, A.4    Tefferi, A.5
  • 22
    • 77952097487 scopus 로고    scopus 로고
    • JAK2 (V617F) mutation in myelodysplastic syndrome (MDS) with del (5q) arises in genetically discordant clones
    • Sokol L, Caceres G, Rocha K, Stockero KJ, Dewald DW, List AF. JAK2 (V617F) mutation in myelodysplastic syndrome (MDS) with del (5q) arises in genetically discordant clones. Leuk Res 2010;34:821-823.
    • (2010) Leuk Res. , vol.34 , pp. 821-823
    • Sokol, L.1    Caceres, G.2    Rocha, K.3    Stockero, K.J.4    Dewald, D.W.5    List, A.F.6
  • 23
    • 75449119103 scopus 로고    scopus 로고
    • Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms
    • Green A, Beer P. Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms. N Engl J Med 2010;362:369-370.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 369-370
    • Green, A.1    Beer, P.2
  • 25
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 2006;3: e270.
    • (2006) PLoS Med. , vol.3
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3    McDowell, E.4    Ebert, B.L.5    Gozo, M.6
  • 26
    • 39749178544 scopus 로고    scopus 로고
    • Detection of three different MPLW515 mutations in 10.1% of all JAK2 V617 unmutated ET and 9.3% of all JAK2 V617F unmutated OMF: A study of 387 patients
    • Schnittger S, Haferlach C, Beelen DW, Bojko P, Dengler R, Diestelrath A et al. Detection of three different MPLW515 mutations in 10.1% of all JAK2 V617 unmutated ET and 9.3% of all JAK2 V617F unmutated OMF: a study of 387 patients. ASH Annu Meet Abstr 2007;110:2546.
    • (2007) ASH Annu. Meet Abstr , vol.110 , pp. 2546
    • Schnittger, S.1    Haferlach, C.2    Beelen, D.W.3    Bojko, P.4    Dengler, R.5    Diestelrath, A.6
  • 29
  • 30
    • 50949127379 scopus 로고    scopus 로고
    • Characteristics and clinical correlates of MPL 515W4L/K mutation in essential thrombocythemia
    • Vannucchi AM, Antonioli E, Guglielmelli P, Pancrazzi A, Guerini V, Barosi G et al. Characteristics and clinical correlates of MPL 515W4L/K mutation in essential thrombocythemia. Blood 2008;112:844-847.
    • (2008) Blood , vol.112 , pp. 844-847
    • Vannucchi, A.M.1    Antonioli, E.2    Guglielmelli, P.3    Pancrazzi, A.4    Guerini, V.5    Barosi, G.6
  • 32
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010;17:225-234.
    • (2010) Cancer Cell. , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6
  • 33
    • 77149134353 scopus 로고    scopus 로고
    • Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
    • Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med 2010;207:339-344.
    • (2010) J. Exp. Med. , vol.207 , pp. 339-344
    • Gross, S.1    Cairns, R.A.2    Minden, M.D.3    Driggers, E.M.4    Bittinger, M.A.5    Jang, H.G.6
  • 34
    • 76549109434 scopus 로고    scopus 로고
    • Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
    • Abdel-Wahab O, Manshouri T, Patel J, Harris K, Yao J, Hedvat C et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res 2010;70:447-452.
    • (2010) Cancer Res. , vol.70 , pp. 447-452
    • Abdel-Wahab, O.1    Manshouri, T.2    Patel, J.3    Harris, K.4    Yao, J.5    Hedvat, C.6
  • 35
    • 77954573304 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation analysis in chronic and blast phase myeloproliferative neoplasms
    • press
    • Pardanani A, Lasho T, Finke C, Mai M, McClure R, Tefferi A. IDH1 and IDH2 mutation analysis in chronic and blast phase myeloproliferative neoplasms. Leukemia 2010 (in press).
    • (2010) Leukemia
    • Pardanani, A.1    Lasho, T.2    Finke, C.3    Mai, M.4    McClure, R.5    Tefferi, A.6
  • 37
    • 77649303359 scopus 로고    scopus 로고
    • Patients with del (5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression
    • Gohring G, Giagounidis A, Busche G, Kreipe HH, Zimmermann M, Hellstrom-Lindberg E et al. Patients with del (5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression. Ann Hematol 2010;89:365-374.
    • (2010) Ann. Hematol , vol.89 , pp. 365-374
    • Gohring, G.1    Giagounidis, A.2    Busche, G.3    Kreipe, H.H.4    Zimmermann, M.5    Hellstrom-Lindberg, E.6


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