Recurrent IDH mutations in high-risk myelodysplastic syndrome or acute myeloid leukemia with isolated del(5q)

Leukemia

Volumn 24, Issue 7, 2010, Pages 1370-1372

  Pardanani, A ^a   Patnaik, M M ^a   Lasho, T L ^a   Mai, M ^a   Knudson, R A ^a   Finke, C ^a   Ketterling, R P ^a   McClure, R F ^a   Tefferi, A ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE ISOENZYME; UNCLASSIFIED DRUG; IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE 2, HUMAN;

ACUTE GRANULOCYTIC LEUKEMIA; CANCER GROWTH; CANCER RECURRENCE; CANCER RISK; CYTOGENETICS; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HUMAN; LETTER; MYELODYSPLASTIC SYNDROME; POLYCYTHEMIA VERA; PRIORITY JOURNAL; THROMBOCYTHEMIA; AGED; CHROMOSOME 5; CHROMOSOME DELETION; FEMALE; GENETICS; KARYOTYPING; MALE; MIDDLE AGED; MUTATION; PATHOLOGY; POLYMERASE CHAIN REACTION; RISK FACTOR; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 5; FEMALE; HUMANS; ISOCITRATE DEHYDROGENASE; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MUTATION; MYELODYSPLASTIC SYNDROMES; POLYMERASE CHAIN REACTION; RISK FACTORS;

EID: 77954660316     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.98     Document Type: Letter

References (7)

1. Pardanani A, Lasho TL, Finke C, Mai M, McClure RF, Tefferi A. IDH1 and IDH2 mutation analysis in chronic and blast phase myeloproliferative neoplasms. Leukemia 2010, e-pub ahead of print 22 April 2010.
2. Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009;361:1058-1066.
3. Patnaik MM, Lasho TL, Finke C, Gangat N, Caramazza D, Holtan SG et al. WHO-defined 'myelodysplastic syndrome with isolated del (5q)'in 88 consecutive patients: survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations. Leukemia 2010, e-pub ahead of print 20 May 2010.
4. Tefferi A, Vardiman JW. Myelodysplastic syndromes. N Engl J Med 2009;361:1872-1885.
5. Watanabe T, Nobusawa S, Kleihues P, Ohgaki H. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol 2009;174:1149-1153.
6. Nobusawa S, Watanabe T, Kleihues P, Ohgaki H. IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin Cancer Res 2009;15:6002-6007.
7. Tefferi A, Lasho TL, Patnaik MM, Finke CM, Hussein K, Hogan WJ et al. JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival. Leukemia 2010;24:105-109.