메뉴 건너뛰기




Volumn 17, Issue 5, 2012, Pages 1940-1947

Preclinical studies with synthetic peptides in systemic lupus erythematosus

Author keywords

Anti nucleosome peptide; Anti RNP peptide P140; Anti Sm peptide; HCDR1; PCons; Review; Synthetic peptides; Systemic lupus erythematosus

Indexed keywords

ANIMALIA; MURINAE;

EID: 84859256956     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4030     Document Type: Review
Times cited : (7)

References (60)
  • 3
    • 73349117550 scopus 로고    scopus 로고
    • Adverse events and efficacy of TNF-alpha blockade with infliximab in patients with systemic lupus erythematosus: Long-term follow-up of 13 patients
    • M Aringer, F Houssiau, C Gordon, WB Graninger, RE Voll, E Rath, G Steiner, JS Smolen: Adverse events and efficacy of TNF-alpha blockade with infliximab in patients with systemic lupus erythematosus: long-term follow-up of 13 patients. Rheumatology (Oxford) 48, 1451-1454 (2009).
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 1451-1454
    • Aringer, M.1    Houssiau, F.2    Gordon, C.3    Graninger, W.B.4    Voll, R.E.5    Rath, E.6    Steiner, G.7    Smolen, J.S.8
  • 4
    • 78649363138 scopus 로고    scopus 로고
    • Advances in drug therapy for systemic lupus erythematosus
    • DJ Wallace: Advances in drug therapy for systemic lupus erythematosus. BMC Med 8, 77 (2010).
    • (2010) BMC Med , vol.8 , Issue.77
    • Wallace, D.J.1
  • 7
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • A Iwasaki, R Medzhitov: Regulation of adaptive immunity by the innate immune system. Science 327, 291- 295 (2010).
    • (2010) Science , vol.327 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 8
    • 78650599246 scopus 로고    scopus 로고
    • Mechanisms for T cell receptor triggering
    • PA Van Der Merwe, O Dushek: Mechanisms for T cell receptor triggering. Nat Rev Immunol 11, 47-55 (2011).
    • (2011) Nat Rev Immunol , vol.11 , pp. 47-55
    • Merwe, P.A.V.D.1    Dushek, O.2
  • 9
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • CE Rudd, A Taylor, H Schneider: CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 229, 12-26 (2009).
    • (2009) Immunol Rev , vol.229 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 10
    • 8844250178 scopus 로고    scopus 로고
    • T cell tolerance and autoimmunity
    • DOI 10.1016/j.autrev.2004.07.004, PII S1568997204000989
    • AK Abbas, J Lohr, B Knoechel, V Nagabhushanam: T cell tolerance and autoimmunity. Autoimmun Rev 3, 471- 475 (2004). (Pubitemid 39531237)
    • (2004) Autoimmunity Reviews , vol.3 , Issue.7-8 SPEC. ISS. , pp. 471-475
    • Abbas, A.K.1    Lohr, J.2    Knoechel, B.3    Nagabhushanam, V.4
  • 11
    • 74049160009 scopus 로고    scopus 로고
    • Mechanisms maintaining peripheral tolerance
    • DL Mueller. Mechanisms maintaining peripheral tolerance. Nat Immunol 11, 21-27 (2010).
    • (2010) Nat Immunol , vol.11 , pp. 21-27
    • Mueller, D.L.1
  • 12
    • 0000017701 scopus 로고
    • Specific inhibition of antibody production, I. Protein-over loading paralysis
    • DW Dresser: Specific inhibition of antibody production. I. Protein-over loading paralysis. Immunology 5, 161-168 (1962).
    • (1962) Immunology , vol.5 , pp. 161-168
    • Dresser, D.W.1
  • 13
    • 0015546974 scopus 로고
    • Immunological unresponsiveness
    • WO Weigle: Immunological unresponsiveness. Adv Immunol 16, 61-122 (1973).
    • (1973) Adv Immunol , vol.16 , pp. 61-122
    • Weigle, W.O.1
  • 14
    • 33748624618 scopus 로고    scopus 로고
    • Immunological tolerance using synthetic peptides - Basic mechanisms and clinical application
    • DOI 10.2174/156652406778194982
    • K Hochweller, CH Sweenie, SM Anderton. Immunological tolerance using synthetic peptides-basic mechanisms and clinical application. Curr Mol Med 6, 631- 643 (2006). (Pubitemid 44377762)
    • (2006) Current Molecular Medicine , vol.6 , Issue.6 , pp. 631-643
    • Hochweller, K.1    Sweenie, C.H.2    Anderton, S.M.3
  • 15
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • DOI 10.1038/nm1226
    • M Larché, DC Wraith: Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 11, S69-S76 (2005). (Pubitemid 40562306)
    • (2005) Nature Medicine , vol.11 , Issue.4 SUPPL.
    • Larche, M.1    Wraith, D.C.2
  • 16
    • 0013792105 scopus 로고
    • The natural history of the NZB/NZW F1 hybrid mouse: A laboratory model of systemic lupus erythematosus
    • FM Burnet, MC Holmes: The natural history of the NZB/NZW F1 hybrid mouse: a laboratory model of systemic lupus erythematosus. Australas Ann Med 14, 185- 191 (1965).
    • (1965) Australas Ann Med , vol.14 , pp. 185-191
    • Burnet, F.M.1    Holmes, M.C.2
  • 17
    • 0035092481 scopus 로고    scopus 로고
    • Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus
    • BH Hahn, RR Singh, WK Wong, BP Tsao, K Bulpitt, FM Ebling: Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus. Arthritis Rheum 44, 432-441 (2001).
    • (2001) Arthritis Rheum , vol.44 , pp. 432-441
    • Hahn, B.H.1    Singh, R.R.2    Wong, W.K.3    Tsao, B.P.4    Bulpitt, K.5    Ebling, F.M.6
  • 18
    • 4344634278 scopus 로고    scopus 로고
    • 1 mice suppress in vitro production of antibodies to DNA
    • A La Cava, FM Ebling, BH Hahn: Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA. J Immunol 173, 3542-3548 (2004). (Pubitemid 39142065)
    • (2004) Journal of Immunology , vol.173 , Issue.5 , pp. 3542-3548
    • La Cava, A.1    Ebling, F.M.2    Hahn, B.H.3
  • 19
    • 28244494166 scopus 로고    scopus 로고
    • + T cell suppressors
    • BH Hahn, RP Singh, A La Cava, FM Ebling: Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3- expressing, apoptosis-resistant, TGF-bsecreting CD8+ T cell suppressors. J Immunol 175, 7728- 7737 (2005). (Pubitemid 41713473)
    • (2005) Journal of Immunology , vol.175 , Issue.11 , pp. 7728-7737
    • Hahn, B.H.1    Singh, R.P.2    La Cava, A.3    Ebling, F.M.4
  • 20
    • 34250222393 scopus 로고    scopus 로고
    • + T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression
    • RP Singh, A La Cava, M Wong, FM Ebling, BH Hahn: CD8+ T cell- mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression. J Immunol 178, 7649-7657 (2007). (Pubitemid 46898035)
    • (2007) Journal of Immunology , vol.178 , Issue.12 , pp. 7649-7657
    • Singh, R.P.1    La Cava, A.2    Wong, M.3    Ebling, F.4    Hahn, B.H.5
  • 21
    • 42149151044 scopus 로고    scopus 로고
    • PConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating foxp3 and PD1 molecules
    • RP Singh, A La Cava A, BH Hahn: pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules. J Immunol 180, 2069-2080 (2008).
    • (2008) J Immunol , vol.180 , pp. 2069-2080
    • Singh, R.P.1    A, A.L.C.2    Hahn, B.H.3
  • 22
    • 77953121527 scopus 로고    scopus 로고
    • Distinct gene signature revealed in white blood cells, CD4(+) and CD8(+) T cells in (NZBx NZW) F1 lupus mice after tolerization with anti- DNA Ig peptide
    • RP Singh, R Dinesh, D Elashoff, S de Vos, RJ Rooney, D Patel, A La Cava, BH Hahn: Distinct gene signature revealed in white blood cells, CD4(+) and CD8(+) T cells in (NZBx NZW) F1 lupus mice after tolerization with anti- DNA Ig peptide. Genes Immun 11, 294-309 (2010).
    • (2010) Genes Immun , vol.11 , pp. 294-309
    • Singh, R.P.1    Dinesh, R.2    Elashoff, D.3    De Vos, S.4    Rooney, R.J.5    Patel, D.6    Cava, A.L.7    Hahn, B.H.8
  • 23
    • 78650656619 scopus 로고    scopus 로고
    • Blockade of programmed death-1 in young (new zealand black x new zealand white)F1 mice promotes the activity of suppressive CD8+ T cells that protect from lupus-like disease
    • M Wong, A La Cava, RP Singh, BH Hahn: Blockade of programmed death-1 in young (New Zealand black x New Zealand white)F1 mice promotes the activity of suppressive CD8+ T cells that protect from lupus-like disease. J Immunol 185, 6563-6571 (2010).
    • (2010) J Immunol , vol.185 , pp. 6563-6571
    • Wong, M.1    Cava, A.L.2    Singh, R.P.3    Hahn, B.H.4
  • 24
    • 49449104712 scopus 로고    scopus 로고
    • Anti-DNA Ig peptides promote regulatory T cell activity in systemic lupus erythematosus patients
    • B Hahn, M Anderson, E Le, A La Cava: Anti-DNA Ig peptides promote regulatory T cell activity in systemic lupus erythematosus patients. Arthritis Rheum 58, 2488- 2497 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 2488-2497
    • Hahn, B.1    Anderson, M.2    Le, E.3    Cava, A.L.4
  • 25
    • 0033916136 scopus 로고    scopus 로고
    • Immune response of SLE patients to peptides based on the complementarity determining regions of a pathogenic anti-dna monoclonal antibody
    • DOI 10.1023/A:1006685413157
    • M Dayan, R Segal, Z Sthoeger, A Waisman, N Brosh, O Elkayam, E Eilat, M Fridkin, E Mozes: Immune response of SLE patients to peptides based on the complementarity determining regions of a pathogenic anti-DNA monoclonal antibody. J Clin Immunol 20, 187-194 (2000). (Pubitemid 30485879)
    • (2000) Journal of Clinical Immunology , vol.20 , Issue.3 , pp. 187-194
    • Dayan, M.1    Segal, R.2    Sthoeger, Z.3    Waisman, A.4    Brosh, N.5    Elkayam, O.6    Eilat, E.7    Fridkin, M.8    Mozes, E.9
  • 27
    • 21644484449 scopus 로고    scopus 로고
    • A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation
    • DOI 10.1007/s10875-004-6245-2
    • D Luger, M Dayan, H Zinger, JP Liu, E Mozes: A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody amelioratesspontaneous and induced lupus manifestations in correlation with cytokine immunomodulation. J Clin Immunol 24, 579- 590 (2004). (Pubitemid 40933109)
    • (2004) Journal of Clinical Immunology , vol.24 , Issue.6 , pp. 579-590
    • Luger, D.1    Dayan, M.2    Zinger, H.3    Liu, J.-P.4    Mozes, E.5
  • 28
    • 51549118939 scopus 로고    scopus 로고
    • The suppression of murine lupus by a tolerogenic peptide involves foxp3-expressing CD8 cells that are required for the optimal induction and function of foxp3-expressing CD4 cells
    • A Sharabi, E Mozes: The suppression of murine lupus by a tolerogenic peptide involves foxp3-expressing CD8 cells that are required for the optimal induction and function of foxp3-expressing CD4 cells. J Immunol 181, 3243-3251 (2008).
    • (2008) J Immunol , vol.181 , pp. 3243-3251
    • Sharabi, A.1    Mozes, E.2
  • 30
    • 29344448889 scopus 로고    scopus 로고
    • Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase
    • DOI 10.1016/j.clim.2005.09.003, PII S1521661605003232
    • MJ Rapoport, A Sharabi, D Aharoni, O Bloch, H Zinger, M Dayan, E Mozes: Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a downregulation of apoptosis and of the pro-apoptotic factor JNK kinase. Clin Immunol 117, 262-270 (2005). (Pubitemid 43005212)
    • (2005) Clinical Immunology , vol.117 , Issue.3 , pp. 262-270
    • Rapoport, M.J.1    Sharabi, A.2    Aharoni, D.3    Bloch, O.4    Zinger, H.5    Dayan, M.6    Mozes, E.7
  • 31
    • 38449119975 scopus 로고    scopus 로고
    • The role of apoptosis in the ameliorating effects of a CDR1-based peptide on lupus manifestations in a mouse model
    • A Sharabi, D Luger, H Ben-David, M Dayan, H Zinger, E Mozes: The role of apoptosis in the ameliorating effects of a CDR1-based peptide on lupus manifestations in a mouse model. J Immunol; 179, 4979-4987 (2007).
    • (2007) J Immunol , vol.179 , pp. 4979-4987
    • Sharabi, A.1    Luger, D.2    Ben-David, H.3    Dayan, M.4    Zinger, H.5    Mozes, E.6
  • 32
    • 33645980321 scopus 로고    scopus 로고
    • Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: Different effects on cytokines and apoptosis
    • A Sharabi, A Haviv, H Zinger, M Dayan, E Mozes: Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: different effects on cytokines and apoptosis. Clin Immunol 119, 146-155 (2006).
    • (2006) Clin Immunol , vol.119 , pp. 146-155
    • Sharabi, A.1    Haviv, A.2    Zinger, H.3    Dayan, M.4    Mozes, E.5
  • 33
    • 75349098582 scopus 로고    scopus 로고
    • Bcl-xL is required for the development of functional regulatory CD4 cells in lupusafflicted mice following treatment with a tolerogenic peptide
    • A Sharabi, Lapter S, Mozes E: Bcl-xL is required for the development of functional regulatory CD4 cells in lupusafflicted mice following treatment with a tolerogenic peptide. J Autoimmun 34, 87-95 (2010).
    • (2010) J Autoimmun , vol.34 , pp. 87-95
    • Sharabi, A.1    Lapter, S.2    Mozes, E.3
  • 34
    • 63749129584 scopus 로고    scopus 로고
    • B-cell activating factor (BAFF) plays a role in the mechanism of action of a tolerogenic peptide that ameliorates lupus
    • R Parameswaran, H Ben David, A Sharabi, H Zinger, E Mozes: B-cell activating factor (BAFF) plays a role in the mechanism of action of a tolerogenic peptide that ameliorates lupus. Clin Immunol 131, 223-232 (2009).
    • (2009) Clin Immunol , vol.131 , pp. 223-232
    • Parameswaran, R.1    David, H.B.2    Sharabi, A.3    Zinger, H.4    Mozes, E.5
  • 35
    • 77953182426 scopus 로고    scopus 로고
    • B cells as therapeutic targets in SLE
    • I Sanz, FE Lee: B cells as therapeutic targets in SLE. Nat Rev Rheumatol 6, 326-337 (2010).
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 326-337
    • Sanz, I.1    Lee, F.E.2
  • 36
    • 68249153387 scopus 로고    scopus 로고
    • The role of dendritic cells in the mechanism of action of a peptide that ameliorates lupus in murine models
    • U Sela, A Sharabi, M Dayan, R Hershkoviz, E Mozes: The role of dendritic cells in the mechanism of action of a peptide that ameliorates lupus in murine models. Immunology 128, e395-e405 (2009).
    • (2009) Immunology , vol.128
    • Sela, U.1    Sharabi, A.2    Dayan, M.3    Hershkoviz, R.4    Mozes, E.5
  • 37
    • 77249141746 scopus 로고    scopus 로고
    • A new model of induced experimental systemic lupus erythematosus (SLE) in pigs and its amelioration by treatment with a tolerogenic peptide
    • A Sharabi, M Dayan, H Zinger, E Mozes: A new model of induced experimental systemic lupus erythematosus (SLE) in pigs and its amelioration by treatment with a tolerogenic peptide. J Clin Immunol 30, 34-44 (2010).
    • (2010) J Clin Immunol , vol.30 , pp. 34-44
    • Sharabi, A.1    Dayan, M.2    Zinger, H.3    Mozes, E.4
  • 38
    • 61349192167 scopus 로고    scopus 로고
    • The tolerogenic peptide hCDR1 downregulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T cells in peripheral blood mononuclear cells of lupus patients
    • ZM Sthoeger, A Sharabi, M Dayan, H Zinger, I Asher, U Sela, E Mozes: The tolerogenic peptide hCDR1 downregulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T cells in peripheral blood mononuclear cells of lupus patients. Hum Immunol 70, 139-145 (2009).
    • (2009) Hum Immunol , vol.70 , pp. 139-145
    • Sthoeger, Z.M.1    Sharabi, A.2    Dayan, M.3    Zinger, H.4    Asher, I.5    Sela, U.6    Mozes, E.7
  • 39
    • 67349261724 scopus 로고    scopus 로고
    • Treatment of lupus patients with a tolerogenic peptide, hCDR1 (Edratide): Immunomodulation of gene expression
    • ZM Sthoeger, A Sharabi, Y Molad, I Asher, H Zinger, M Dayan, E Mozes: Treatment of lupus patients with a tolerogenic peptide, hCDR1 (Edratide): immunomodulation of gene expression. J Autoimmun 33, 77-82 (2009).
    • (2009) J Autoimmun , vol.33 , pp. 77-82
    • Sthoeger, Z.M.1    Sharabi, A.2    Molad, Y.3    Asher, I.4    Zinger, H.5    Dayan, M.6    Mozes, E.7
  • 40
    • 84870517922 scopus 로고    scopus 로고
    • www.tevapharm.com.
  • 41
    • 77956221530 scopus 로고    scopus 로고
    • Autoantibodies in autoimmune diseases
    • M Eggert, UK Zettl, G Neeck: Autoantibodies in autoimmune diseases. Curr Pharm Des 16, 1634-1643 (2010).
    • (2010) Curr Pharm des , vol.16 , pp. 1634-1643
    • Eggert, M.1    Zettl, U.K.2    Neeck, G.3
  • 42
    • 44849110309 scopus 로고    scopus 로고
    • Pathogenic anti-nucleosome antibodies
    • DOI 10.1177/0961203308090030, Proceedings of the 7th european Lupus Meeting
    • S Muller, J Dieker, A Tincani, PL Meroni: Pathogenic anti-nucleosome antibodies. Lupus 17, 431-436 (2008). (Pubitemid 351798722)
    • (2008) Lupus , vol.17 , Issue.5 SPEC. ISS. , pp. 431-436
    • Muller, S.1    Dieker, J.2    Tincani, A.3    Meroni, P.L.4
  • 43
    • 0037903481 scopus 로고    scopus 로고
    • Major peptide autoepitopes for nucleosome-centered T and B cell interaction in human and murine lupus
    • SK Datta: Major peptide autoepitopes for nucleosomecentered Tm and B cell interaction in human and murine lupus. Ann NY Acad Sci 987, 79-90 (2003). (Pubitemid 36584009)
    • (2003) Annals of the New York Academy of Sciences , vol.987 , pp. 79-90
    • Datta, S.K.1
  • 44
    • 0033562983 scopus 로고    scopus 로고
    • Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: Tolerance spreading impairs pathogenic function of autoimmune T and B cells
    • A Kaliyaperumal, MA Michaels, SK Datta: Antigenspecific therapy of murine lupus nephritis using nucleosomal peptides: tolerance spreading impairs pathogenic function of autoimmune T and B cells. J Immunol 162, 5775-5783 (1999). (Pubitemid 29314928)
    • (1999) Journal of Immunology , vol.162 , Issue.10 , pp. 5775-5783
    • Kaliyaperumal, A.1    Michaels, M.A.2    Datta, S.K.3
  • 45
    • 14844346513 scopus 로고    scopus 로고
    • Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets
    • HK Kang, MA Michaels, BR Berner, SK Datta: Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets. J Immunol 174, 3247-3255 (2005). (Pubitemid 40354027)
    • (2005) Journal of Immunology , vol.174 , Issue.6 , pp. 3247-3255
    • Kang, H.-K.1    Michaels, M.A.2    Berner, B.R.3    Datta, S.K.4
  • 46
    • 34250162775 scopus 로고    scopus 로고
    • Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells
    • HK Kang, M Liu, SK Datta: Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J Immunol 178, 7849-7858 (2007). (Pubitemid 46898057)
    • (2007) Journal of Immunology , vol.178 , Issue.12 , pp. 7849-7858
    • Kang, H.-K.1    Liu, M.2    Datta, S.K.3
  • 47
    • 17144365819 scopus 로고    scopus 로고
    • Anti-Sm and anti-RNP antibodies
    • DOI 10.1080/08916930400022715
    • P Migliorini, C Baldini, V Rocchi, S Bombardieri: Anti- Sm and anti-RNP antibodies. Autoimmunity 38, 47-54 (2005). (Pubitemid 40515003)
    • (2005) Autoimmunity , vol.38 , Issue.1 , pp. 47-54
    • Migliorini, P.1    Baldini, C.2    Rocchi, V.3    Bombardieri, S.4
  • 48
    • 0033838117 scopus 로고    scopus 로고
    • + T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein
    • DOI 10.1002/1521-4141(2000)30:8<2191::AID-IMMU2191>3.0.CO;2-R
    • F Monneaux, JP Briand, S Muller: B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein. Eur J Immunol 30, 2191-2200 (2000). (Pubitemid 30655758)
    • (2000) European Journal of Immunology , vol.30 , Issue.8 , pp. 2191-2200
    • Monneaux, F.1    Briand, J.-P.2    Muller, S.3
  • 49
    • 0034812564 scopus 로고    scopus 로고
    • 1 lupus mice
    • F Monneaux, H Dumortier, G Steiner, JP Briand, S Muller: Murine models of systemic lupus erythematosus: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Fas(lpr) and (NZB x NZW)F(1) lupus mice. Int Immunol 13, 1155-1163 (2001). (Pubitemid 32899158)
    • (2001) International Immunology , vol.13 , Issue.9 , pp. 1155-1163
    • Monneaux, F.1    Dumortier, H.2    Steiner, G.3    Briand, J.-P.4    Muller, S.5
  • 50
    • 0345701527 scopus 로고    scopus 로고
    • T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MRL/lpr mice
    • DOI 10.1002/immu.200310002
    • F Monneaux, JM Lozano, ME Patarroyo, JP Briand, S Muller: T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice. Eur J Immunol 33, 287-296 (2003). (Pubitemid 36267592)
    • (2003) European Journal of Immunology , vol.33 , Issue.2 , pp. 287-296
    • Monneaux, F.1    Lozano, J.M.2    Patarroyo, M.E.3    Briand, J.-P.4    Muller, S.5
  • 52
    • 5644227423 scopus 로고    scopus 로고
    • Intramolecular T cell spreading in unprimed MRL/lpr mice: Importance of the U1-70K protein sequence 131-151
    • DOI 10.1002/art.20510
    • F Monneaux, V Parietti, JP Briand, S Muller: Intramolecular T cell spreading in unprimed MRL/lpr mice: importance of the U1-70k protein sequence 131-151. Arthritis Rheum 50, 3232-3238 (2004). (Pubitemid 39372000)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.10 , pp. 3232-3238
    • Monneaux, F.1    Parietti, V.2    Briand, J.-P.3    Muller, S.4
  • 53
  • 54
    • 74549208358 scopus 로고    scopus 로고
    • Molecular therapies for systemic lupus erythematosus: Clinical trials and future prospects
    • F Monneaux, S Muller: Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects. Arthritis Res Ther 11, 234 (2009).
    • (2009) Arthritis Res Ther , vol.11 , Issue.234
    • Monneaux, F.1    Muller, S.2
  • 55
    • 84870573354 scopus 로고    scopus 로고
    • http://www.immupharma.com.
  • 56
    • 0013886630 scopus 로고
    • Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus
    • EM Tan, HG Kunkel: Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol 96, 464-471 (1966).
    • (1966) J Immunol , vol.96 , pp. 464-471
    • Tan, E.M.1    Kunkel, H.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.