The role of dendritic cells in the mechanism of action of a peptide that ameliorates lupus in murine models

Immunology

Volumn 128, Issue 1 PART 2, 2009, Pages

  Sela, Uri ^a,b   Sharabi, Amir ^a   Dayan, Molly ^a   Hershkoviz, Rami ^b   Mozes, Edna ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cytokines; Dendritic cells; Murine lupus; T cell functions; Tolerogenic peptide

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; COMPLEMENTARITY DETERMINING REGION 1; DNA ANTIBODY; GAMMA INTERFERON; HCDR1 PEPTIDE; INTERLEUKIN 12; MESSENGER RNA; PEPTIDE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; ANTIGENS, CD80; ANTIGENS, CD86; AUTOANTIGENS; DENDRITIC CELLS; DOWN-REGULATION; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-12; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED BALB C; NERVE TISSUE PROTEINS; PEPTIDES; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 68249153387     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2008.02988.x     Document Type: Article

References (46)

1. Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 2004 202 : 96 105.
2. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 52.
3. Tan JK, O'Neill HC. Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity. J Leukoc Biol 2005 78 : 319 24.
4. Cella M, Engering A, Pinet V, Pieters J, Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 1997 388 : 782 7.
5. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001 106 : 255 8.
6. De Heusch M, Oldenhove G, Urbain J, Thielemans K, Maliszewski C, Leo O, Moser M. Depending on their maturation state, splenic dendritic cells induce the differentiation of CD4(+) T lymphocytes into memory and/or effector cells in vivo. Eur J Immunol 2004 34 : 1861 9.
7. Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol 2002 23 : 445 9.
8. Heufler C, Koch F, Stanzl U et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol 1996 26 : 659 68.
9. Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 2006 311 : 17 58.
10. Lang TJ, Nguyen P, Papadimitriou JC, Via CS. Increased severity of murine lupus in female mice is due to enhanced expansion of pathogenic T cells. J Immunol 2003 171 : 5795 801.
11. Sherer Y, Gorstein A, Fritzler MJ, Shoenfeld Y. Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients. Semin Arthritis Rheum 2004 34 : 501 37.
12. Zhou G, Fujio K, Sadakata A, Okamoto A, Yu R, Yamamoto K. Identification of systemically expanded activated T cell clones in MRL/lpr and NZB/W F1 lupus model mice. Clin Exp Immunol 2004 136 : 448 55.
13. Ding D, Mehta H, McCune WJ, Kaplan MJ. Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus. J Immunol 2006 177 : 5878 89.
14. Decker P, Kötter I, Klein R, Berner B, Rammensee HG. Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus. Rheumatology 2006 45 : 1087 95.
15. Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, Wakeland EK, Mohan C. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J Clin Inves 2005 115 : 1869 78.
16. Mendlovic S, Brocke S, Shoenfeld Y, Ben-Bassat M, Meshorer A, Bakimer R, Mozes E. Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype. Proc Natl Acad Sci USA 1988 85 : 2260 4.
17. Waisman A, Mendlovic S, Ruiz PJ, Zinger H, Meshorer A, Mozes E. The role of the 16/6 idiotype network in the induction and manifestations of systemic lupus erythematosus. Int Immunol 1993 5 : 1293 300.
18. Waisman A, Ruiz PJ, Israeli E, Eilat E, Konen-Waisman S, Zinger H, Dayan M, Mozes E. Modulation of murine systemic lupus erythematosus with peptides based on complementarity determining regions of a pathogenic anti-DNA monoclonal antibody. Proc Natl Acad Sci USA 1997 94 : 4620 5.
19. 1 mice via active suppression. Int Immunol 2003 15 : 205 14.
20. Eilat E, Dayan M, Zinger H, Mozes E. The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus. Proc Natl Acad Sci USA 2001 98 : 1148 53.
21. 1 mice by treating with CDR1- and CDR3-based peptides of a pathogenic autoantibody. J Clin Immunol 2000 20 : 268 78.
22. Luger D, Dayan M, Zinger H, Liu JP, Mozes E. A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation. J Clin Immunol 2004 24 : 579 90.
23. Sela U, Hershkoviz R, Cahalon L, Lider O, Mozes E. Down-regulation of stromal cell-derived factor-1alpha-induced T cell chemotaxis by a peptide based on the complementarity-determining region 1 of an anti-DNA autoantibody via up-regulation of TGF-beta secretion. J Immunol 2005 174 : 302 9.
24. Sela U, Mauermann N, Hershkoviz R et al. The inhibition of autoreactive T cell functions by a peptide based on the CDR1 of an anti-DNA autoantibody is via TGF-beta-mediated suppression of LFA-1 and CD44 expression and function. J Immunol 2005 175 : 7255 63.
25. Sela U, Dayan M, Hershkoviz R, Cahalon L, Lider O, Mozes E. The negative regulators Foxj1 and Foxo3a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses. Eur J Immunol 2006 36 : 2971 80.
26. Waisman A, Shoenfeld Y, Blank M, Ruiz PJ, Mozes E. The pathogenic human monoclonal anti-DNA that induces experimental systemic lupus erythematosus in mice is encoded by a VH4 gene segment. Int Immunol 1995 7 : 689 96.
27. + cells and TGF- β. Proc Natl Acad Sci USA 2006 103 : 8810 15.
28. Sharabi A, Mozes E. The suppression of murine lupus by a tolerogenic peptide involves foxp3-expressing CD8 cells that are required for the optimal induction and function of foxp3-expressing CD4 cells. J Immunol 2008 181 : 3243 51.
29. Sharabi A, Azulai H, Shtoeger ZM, Mozes E. Clinical amelioration of murine lupus by a peptide based on the complementarity determining region-1 of an autoantibody and by cyclophosphamide: similarities and differences in the mechanisms of action. Immunology 2007 121 : 248 57.
30. 1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase. Clin Immunol 2005 117 : 262 70.
31. Sharabi A, Haviv A, Zinger H, Dayan M, Mozes E. Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: different effects on cytokines and apoptosis. Clin Immunol 2006 119 : 146 55.
32. Sharabi A, Luger D, Ben-David H, Dayan M, Zinger H, Mozes E. The role of apoptosis in the ameliorating effects of a CDR1-based peptide on lupus manifestations in a mouse model. J Immunol 2007 179 : 4979 87.
33. Sthoeger ZM, Dayan M, Tcherniack A, Green L, Toledo S, Segal R, Elkayam O, Mozes E. Modulation of autoreactive responses of peripheral blood lymphocytes of patients with systemic lupus erythematosus by peptides based on human and murine anti-DNA autoantibodies. Clin Exp Immunol 2003 131 : 385 92.
34. Mueller DL. T cells: a proliferation of costimulatory molecules. Curr Biol 2000 10 : R227 30.
35. Capper ER, Maskill JK, Gordon C, Blakemore AI. Interleukin (IL)-10, IL-1ra and IL-12 profiles in active and quiescent systemic lupus erythematosus: could longitudinal studies reveal patient subgroups of differing pathology? Clin Exp Immunol 2004 138 : 348 56.
36. Dai J, Liu B, Cua DJ, Li Z. Essential roles of IL-12 and dendritic cells but not IL-23 and macrophages in lupus-like diseases initiated by cell surface HSP gp96. Eur J Immunol 2007 37 : 706 15.
37. Maruo S, Toyo-oka K, Oh-hora M et al. IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones. J Immunol 1996 156 : 1748 55.
38. Ahn HJ, Tomura M, Yu WG, Iwasaki M, Park WR, Hamaoka T, Fujiwara H. Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation. J Immunol 1998 161 : 5893 900.
39. Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998 16 : 137 61.
40. Dean GS, Tyrrell-Price J, Crawley E, Isenberg DA. Cytokines and systemic lupus erythematosus. Ann Rheum Dis 2000 59 : 243 51.
41. Ohtsuka K, Gray JD, Stimmler MM, Toro B, Horwitz DA. Decreased production of TGF-beta by lymphocytes from patients with systemic lupus erythematosus. J Immunol 1998 160 : 2539 45.
42. Raz E, Dudler J, Lotz M, Baird SM, Berry CC, Eisenberg RA, Carson DA. Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus 1995 4 : 286 92.
43. 1 induced by Plasmodium chabaudi and their implications in the reversal of clinical symptoms. Clin Exp Immunol 2000 119 : 333 9.
44. + dendritic cells. J Immunol 2005 174 : 2061 70.
45. Geissmann F, Revy P, Regnault A et al. TGF-beta 1 prevents the noncognate maturation of human dendritic langerhans cells. J Immunol 1999 163 : 1737 41.
46. Strobl H, Knapp W. TGF-beta1 regulation of dendritic cells. Microbes Infect 1999 1 : 1283 90.