DNA damage in nijmegen breakage syndrome cells leads to PARP hyperactivation and increased oxidative stress

PLoS Genetics

Volumn 8, Issue 3, 2012, Pages

  Krenzlin, Harald ^a   Demuth, Ilja ^a   Salewsky, Bastian ^a   Wessendorf, Petra ^a   Weidele, Kathrin ^b   Bürkle, Alexander ^b   Digweed, Martin ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MUTAGENIC AGENT; NIBRIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; BLEOMYCIN; CELL CYCLE PROTEIN; NIJMEGEN BREAKAGE SYNDROME 1 PROTEIN, MOUSE; NUCLEAR PROTEIN; PARP1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NIJMEGEN BREAKAGE SYNDROME; NONHUMAN; OXIDATIVE STRESS; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; MOUSE MUTANT; TRANSCRIPTION INITIATION;

MUS;

ANIMALS; BLEOMYCIN; CELL CYCLE PROTEINS; CELLS, CULTURED; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; MICE, MUTANT STRAINS; NAD; NIJMEGEN BREAKAGE SYNDROME; NUCLEAR PROTEINS; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; TRANSCRIPTIONAL ACTIVATION;

EID: 84859248021     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002557     Document Type: Article

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