Some commonly used brominated flame retardants cause ca 2+-atpase inhibition, beta-amyloid peptide release and apoptosis in sh-sy5y neuronal cells

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Al Mousa, Fawaz ^a   Michelangeli, Francesco ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); AMYLOID BETA PROTEIN[1-42]; CALCIUM ION; CASPASE; CYTOCHROME C; DECABROMODIPHENYL ETHER; FLAME RETARDANT; HEXABROMOCYCLODODECANE; REACTIVE OXYGEN METABOLITE; TETRABROMOBISPHENOL A; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); BROMINATED HYDROCARBON; CALCIUM; PEPTIDE FRAGMENT; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DISRUPTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LC 50; MICROSOME; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROTOXICITY; PROTEIN SECRETION; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MITOCHONDRION; NERVE CELL; PHYSIOLOGY; RISK FACTOR; SECRETION; TUMOR CELL LINE;

ANIMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; APOPTOSIS; CALCIUM; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; FLAME RETARDANTS; HUMANS; HYDROCARBONS, BROMINATED; MITOCHONDRIA; NEURONS; PEPTIDE FRAGMENTS; REACTIVE OXYGEN SPECIES; RISK FACTORS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 84859242331     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033059     Document Type: Article

References (46)

1. De Wit CA, (2002) An overview of brominated Flame retardants in the environment. Chemosphere 46: 583-624.
2. Alaee M, Wenning R, (2002) The significance of brominated flame retardants in the environment: current understanding, issues and challenges. Chemosphere 46: 579-582.
3. Szabo DT, Diliberto JJ, Hakk H, Huwe JK, Birnbaum LS, (2010) Toxicokinetics of the flame retardant hexabromocyclododecane gamma: effect of dose, timing, route, repeated exposure, and metabolism. Toxicol Sci. 117: 282-293.
4. Viberg H, Johansson N, Fredriksson A, Eriksson J, Marsh G, et al. (2006) Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nona-bromodiphenyl ethers, impairs spontaneous behaviour and learning and memory functions of adult mice. Toxicol. Sci. 92: 211-218.
5. Viberg H, Fredriksson A, Eriksson P, (2003) Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice. Toxicol. App. Pharmacol. 192: 95-106.
6. Eriksson P, Viberg H, Jakobsson E, Orn U, Fredriksson A, (2002) A brominated fl{ligature}ame retardant, 2,2',4,4',5-pentabromodiphenyl ether: Uptake, retention, and induction of neurobehavioral alterations in mice during a critical phase of neonatal brain development. Toxicol. Sci. 67: 98-103.
7. Darneraud PO, (2003) Brominated flame retardants in man and in wildlife. Environ. Intl. 29: 841-853.
8. Bi X, Thomas GO, Jones KC, Qu W, Sheng G, et al. (2007) Exposure of electronics dismantling workers to polybrominated diphenyl ethers, polychlorinated biphenyls, and organochlorine pesticides in South China. Environ. Sci Technol. 41: 5647-53.
9. Thomsen C, Molander P, Daae HL, Janák K, Froshaug M, et al. (2007) Occupational exposure to hexabromocyclododecane at an industrial plant. Environ Sci Technol. 41: 5210-5216.
10. Ogunbayo OA, Jensen KT, Michelangeli F, (2007) The interaction of the brominated flame retardant: tetrabromobisphenol A, with phospholipid membranes. Biochim. Biophys. Acta 1768: 1559-1566.
11. McStay GP, Salvesen GS, Green DR, (2008) Overlapping cleavage motif selectivity of caspasases: implications for analysis of apoptotic pathways. Cell death and Differentiation 15: 322-331.
12. Berger AB, Sexton KB, Bogyo M, (2006) Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity. Cell research 2006 1-3 pp. 1-3.
13. Michelangeli F, Ogunbayo OA, Wootton LL, Lai PF, Al-Mousa F, et al. (2008) Endocrine disrupting alkylphenols: structural requirements for their adverse effects on Ca2+ pumps, Ca2+ homeostasis & Sertoli TM4 cell viability. Chem Biol Interact. 176: 220-226.
14. Ogunbayo OA, Lai PF, Connolly TJ, Michelangeli F, (2008) Tetrabromobisphenol A (TBBPA), induces cell death in TM4 Sertoli cells by modulating Ca2+ transport proteins and causing dysregulation of Ca2+ homeostasis. Toxicol In Vitro. 22: 943-952.
15. Hayden RE, Pratt G, Drayson MT, Bunce CM, (2010) Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance. Haematologica. 95: 1889-1896.
16. Lai, P, Michelangeli F, (2009) Changes in expression and activity of the secretory pathway Ca2+ ATPase 1 (SPCA1) in A7r5 vascular smooth muscle cells cultured at different glucose concentrations. Biosci. Rep. 29: 397-404.
17. Reistad T, Fonnum F, Mariussen E, (2006) Neurotoxicity of the pentabrominated diphenyl ether mixture, DE-71, and hexabromocyclododecane (HBCD) in rat cerebellar granule cells in vitro. Arch Toxicol. 80: 785-796.
18. He P, Wang AG, Xia T, Gao P, Niu Q, et al. (2009) Mechanism of the neurotoxic effect of PBDE-47 and interaction of PBDE-47 and PCB-153 in enhancing toxicity in SH-SY5Y cells. Neurotoxicol. 30: 10-15.
19. Nuñez G, Benedict MA, Hu Y, Inohara N, (1998) Caspases: the proteases of the apoptotic pathway. Oncogene 17: 3237-45.
20. Ogunbayo OA, Michelangeli F, (2007) The widely utilized brominated flame retardant tetrabromobisphenol A (TBBPA) is a potent inhibitor of the SERCA Ca2+ pump. Biochem J. 408: 407-415.
21. Bezprozvanny I, Mattson MP, (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci. 31: 454-463.
22. Stutzmann GE, (2007) The pathogenesis of Alzheimers disease is it a lifelong "calciumopathy"? Neuroscientist 13: 546-559.
23. Walsh DM, Minogue AM, Sala-Frigerio C, Fadeeva JV, Wasco W, et al. (2007) The APP family of proteins: similarities and differences. Biochem. Soc. Trans. 35: 416-420.
24. De Strooper B, Annaert W, (2000) Proteolytic processing and cell biological functions of the Amyloid precursor protein. J. Cell Sci. 113: 1857-1870.
25. Viswanath V, Wu Y, Boonplueang R, Chen S, Stevenson FF, et al. (2001) Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. J. Neurosci. 21: 9519-9528.
26. Fonnum F, Mariussen E, Reistad T, (2006) Molecular mechanisms involved in the toxic effects of polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs). J Toxicol Environ Health A. 69: 21-35.
27. Franklin JL, (2011) Redox regulation of the intrinsic pathway in neuronal apoptosis. Antioxid Redox Signal. 14: 1437-1448.
28. Mattson MP, Chan SL, (2003) Neuronal and glial calcium signalling in Alzheimer's disease. Cell Calcium 34: 385-397.
29. Stutzmann GE, Caccamo A, LaFerla FM, Parker I, (2004) Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J. Neurosci. 24: 508-513.
30. Mattson MP, (2004) Pathways towards and away from Alzheimer's disease. Nature 430: 631-639.
31. Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, et al. (2000) Presenilin-mediated modulation of capacitative calcium entry. Neuron. 27: 561-572.
32. Stutzmann GE, Smith I, Caccamo A, Oddo S, LaFerla FM, et al. (2006) Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J. Neurosci. 26: 5180-5189.
33. Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, et al. (2006) PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release. FASEB J. 20: 151-153.
34. Leissring MA, Parker I, LaFerla FM, (1999) Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals. J. Biol. Chem. 274: 32535-32538.
35. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, et al. (2008) SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J. Cell Biol. 181: 1107-1116.
36. Demuro A, Parker I, Stutzmann GE, (2010) Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem. 285: 12463-12468.
37. Lai P, Yip NCMichelangeliF, (2011) Regucalcin (RGN/SMP30) alters agonist- and thapsigargin-induced cytosolic [Ca2+] transients in cells by increasing SERCA Ca2+-ATPase levels. FEBS Letts. 585: 2291-2294.
38. Michelangeli F, East JM, (2011) A diversity of SERCA Ca2+ pump inhibitors. Biochem. Soc Trans. 39: 789-797.
39. Toescu EC, Verkhratsky A, (2007) The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging. Aging Cell. 6: 267-73.
40. He P, Wang AG, Xiam T, Gao P, Niu Q, et al. (2009) Mechanism of the neurotoxic effect of PBDE-47 and interaction of PBDE-47 and PCB153 in enhancing toxicity in SH-SY5Y cells. Neurotoxicology 30: 10-15.
41. Camandola S, Mattson MP, (2011) Aberrant subcellular neuronal calcium regulation in aging and alzheimer's disease. Biochimica et Biophysica Acta 1813 965-973 pp. 965-973.
42. Koyama Y, Matsuzaki S, Gomi F, Yamada T, Sato K,et al. (2008) Induction of Amyloid beta accumulation by ER calcium disruption and upregulation of angiogenic factors in ARPE19 cells. Invest Ophthalmol. Vis Sci. 49: 2376-2383.
43. Querfurth HW, Jiang J, Geiger JD, Selkoe DJ, (1997) Caffeine stimulates amyloid β-peptide release from β-amyloid precursor protein-transfected HEK293 cells. J. Neurochem. 69: 1580-1591.
44. Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG, (2010) Calpain activation promotes BACE1 expression, amyloid precursor processing and amyloid plaque formation in transgenic mouse model of Alzheimer's disease. J. Biol. Chem. 285: 27737-27744.
45. Tesco G, Koh YH, Kang EL, Cameron AN, Das S, et al. (2007) Depletion of GAA3 stabilizes BACE and enhances beta-secretase activity. Neuron 54: 721-737.
46. Demuro A, Mina E, Kayed R, Milton SC, Parker I, et al. (2005) Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J. Biol Chem. 280: 17294-17300.