Toxicokinetics of the flame retardant hexabromocyclododecane gamma: Effect of dose, timing, route, repeated exposure, and metabolism

Toxicological Sciences

Volumn 117, Issue 2, 2010, Pages 282-293

  Szabo, David T ^a,b   Diliberto, Janet J ^b   Hakk, Heldur ^c   Huwe, Janice K ^c   Birnbaum, Linda S ^d  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c U S DEPARTMENT OF AGRICULTURE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

ADME; Brominated flame retardant; Diastereomer; HBCD; Metabolism; Mouse; Persistent organic pollutant; Pharmacokinetics; Risk assessment; Stereoisomerization

Indexed keywords

DRUG METABOLITE; HEXABROMOCYCLODODECANE;

ABSORPTION; ADULT; ARTICLE; BILE; BLOOD; BODY FAT; BRAIN; DIASTEREOISOMER; DISTRIBUTION VOLUME; EXCRETION; FECES ANALYSIS; FEMALE; HALF LIFE TIME; HUMAN; KIDNEY; LIVER METABOLISM; LUNG; METABOLISM; MOUSE; MUSCLE; NONHUMAN; RISK ASSESSMENT; SKIN; STEREOISOMERISM; TISSUE DISTRIBUTION; TOXICOKINETICS; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLAME RETARDANTS; HALF-LIFE; HYDROCARBONS, BROMINATED; LIVER; MICE; MICE, INBRED C57BL; STEREOISOMERISM;

MUS;

EID: 77956922123     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq183     Document Type: Article

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