메뉴 건너뛰기




Volumn 21, Issue 8, 2012, Pages 1693-1705

Silencing of multi-copy hpv16 by viral self-methylation and chromatin occlusion: A model for epigenetic virus-host interaction

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN E6; PROTEIN E7; VIRUS DNA;

EID: 84859219959     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr604     Document Type: Article
Times cited : (14)

References (70)
  • 1
    • 67651042998 scopus 로고    scopus 로고
    • HPV vaccine for all
    • Michels, K.B. and zur Hausen, H. (2009) HPV vaccine for all. Lancet, 374, 268-270.
    • (2009) Lancet , vol.374 , pp. 268-270
    • Michels, K.B.1    zur Hausen, H.2
  • 2
    • 59549085974 scopus 로고    scopus 로고
    • Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma
    • Thierry, F. (2009) Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma. Virology, 384, 375-379.
    • (2009) Virology , vol.384 , pp. 375-379
    • Thierry, F.1
  • 3
  • 4
    • 34547099574 scopus 로고    scopus 로고
    • Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?
    • Pett, M. and Coleman, N. (2007) Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis? J. Pathol., 212, 356-367.
    • (2007) J. Pathol. , vol.212 , pp. 356-367
    • Pett, M.1    Coleman, N.2
  • 5
    • 0024346218 scopus 로고
    • Chromatin structure and transcriptional regulation of human papillomavirus type 18 DNA in HeLa cells
    • Rosl, F., Westphal, E.M. and zur Hausen, H. (1989) Chromatin structure and transcriptional regulation of human papillomavirus type 18 DNA in HeLa cells. Mol. Carcinog., 2, 72-80.
    • (1989) Mol. Carcinog. , vol.2 , pp. 72-80
    • Rosl, F.1    Westphal, E.M.2    zur Hausen, H.3
  • 6
    • 0028900490 scopus 로고
    • Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis
    • Jeon, S. and Lambert, P.F. (1995) Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc. Natl Acad. Sci. USA, 92, 1654-1658.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 1654-1658
    • Jeon, S.1    Lambert, P.F.2
  • 7
    • 0029916755 scopus 로고    scopus 로고
    • Genomic cloning and characterization of the nonoccupied allele corresponding to the integration site of human papillomavirus type 16 DNA in the cervical cancer cell line SiHa
    • Bauer-Hofmann, R., Borghouts, C., Auvinen, E., Bourda, E., Rosl, F. and Alonso, A. (1996) Genomic cloning and characterization of the nonoccupied allele corresponding to the integration site of human papillomavirus type 16 DNA in the cervical cancer cell line SiHa. Virology, 217, 33-41.
    • (1996) Virology , vol.217 , pp. 33-41
    • Bauer-Hofmann, R.1    Borghouts, C.2    Auvinen, E.3    Bourda, E.4    Rosl, F.5    Alonso, A.6
  • 8
    • 0027243333 scopus 로고
    • The effect of DNA methylation on gene regulation of human papillomaviruses
    • Rosl, F., Arab, A., Klevenz, B. and zur Hausen, H. (1993) The effect of DNA methylation on gene regulation of human papillomaviruses. J. Gen. Virol., 74, 791-801.
    • (1993) J. Gen. Virol. , vol.74 , pp. 791-801
    • Rosl, F.1    Arab, A.2    Klevenz, B.3    zur Hausen, H.4
  • 9
    • 0038365277 scopus 로고    scopus 로고
    • CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression
    • Badal, V., Chuang, L.S., Tan, E.H., Badal, S., Villa, L.L., Wheeler, C.M., Li, B.F. and Bernard, H.U. (2003) CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression. J. Virol., 77, 6227-6234.
    • (2003) J. Virol. , vol.77 , pp. 6227-6234
    • Badal, V.1    Chuang, L.S.2    Tan, E.H.3    Badal, S.4    Villa, L.L.5    Wheeler, C.M.6    Li, B.F.7    Bernard, H.U.8
  • 10
    • 42649098924 scopus 로고    scopus 로고
    • Effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines
    • Kalantari, M., Lee, D., Calleja-Macias, I.E., Lambert, P.F. and Bernard, H.U. (2008) Effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines. Virology, 374, 292-303.
    • (2008) Virology , vol.374 , pp. 292-303
    • Kalantari, M.1    Lee, D.2    Calleja-Macias, I.E.3    Lambert, P.F.4    Bernard, H.U.5
  • 13
    • 0242661842 scopus 로고    scopus 로고
    • Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection
    • Kim, K., Garner-Hamrick, P.A., Fisher, C., Lee, D. and Lambert, P.F. (2003) Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection. J. Virol., 77, 12450-12459.
    • (2003) J. Virol. , vol.77 , pp. 12450-12459
    • Kim, K.1    Garner-Hamrick, P.A.2    Fisher, C.3    Lee, D.4    Lambert, P.F.5
  • 15
    • 74549136674 scopus 로고    scopus 로고
    • Recombination of human papillomavirus-16 and host DNA in exfoliated cervical cells: a pilot study of L1 gene methylation and chromosomal integration as biomarkers of carcinogenic progression
    • Kalantari, M., Chase, D.M., Tewari, K.S. and Bernard, H.U. (2010) Recombination of human papillomavirus-16 and host DNA in exfoliated cervical cells: a pilot study of L1 gene methylation and chromosomal integration as biomarkers of carcinogenic progression. J. Med. Virol., 82, 311-320.
    • (2010) J. Med. Virol. , vol.82 , pp. 311-320
    • Kalantari, M.1    Chase, D.M.2    Tewari, K.S.3    Bernard, H.U.4
  • 16
    • 33644870575 scopus 로고    scopus 로고
    • Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response
    • Pett, M.R., Herdman, M.T., Palmer, R.D., Yeo, G.S., Shivji, M.K., Stanley, M.A. and Coleman, N. (2006) Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response. Proc. Natl Acad. Sci. USA, 103, 3822-3827.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 3822-3827
    • Pett, M.R.1    Herdman, M.T.2    Palmer, R.D.3    Yeo, G.S.4    Shivji, M.K.5    Stanley, M.A.6    Coleman, N.7
  • 17
    • 77952821748 scopus 로고    scopus 로고
    • In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis
    • Gray, E., Pett, M.R., Ward, D., Winder, D.M., Stanley, M.A., Roberts, I., Scarpini, C.G. and Coleman, N. (2010) In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis. Cancer Res., 70, 4081-4091.
    • (2010) Cancer Res. , vol.70 , pp. 4081-4091
    • Gray, E.1    Pett, M.R.2    Ward, D.3    Winder, D.M.4    Stanley, M.A.5    Roberts, I.6    Scarpini, C.G.7    Coleman, N.8
  • 20
    • 0023629534 scopus 로고
    • Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in situ hybridization
    • Mincheva, A., Gissmann, L. and zur Hausen, H. (1987) Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in situ hybridization. Med. Microbiol. Immunol., 176, 245-256.
    • (1987) Med. Microbiol. Immunol. , vol.176 , pp. 245-256
    • Mincheva, A.1    Gissmann, L.2    zur Hausen, H.3
  • 21
    • 0035232519 scopus 로고    scopus 로고
    • In situ analysis of the transcriptional activity of integrated viral DNA using tyramide-FISH
    • Van Tine, B.A., Knops, J., Broker, T.R., Chow, L.T. and Moen, P.T. Jr (2001) In situ analysis of the transcriptional activity of integrated viral DNA using tyramide-FISH. Dev. Biol. (Basel), 106, 381-385.
    • (2001) Dev. Biol. (Basel) , vol.106 , pp. 381-385
    • Van Tine, B.A.1    Knops, J.2    Broker, T.R.3    Chow, L.T.4    Moen Jr., P.T.5
  • 22
    • 0023144684 scopus 로고
    • Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
    • Baker, C.C., Phelps, W.C., Lindgren, V., Braun, M.J., Gonda, M.A. and Howley, P.M. (1987) Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J. Virol., 61, 962-971.
    • (1987) J. Virol. , vol.61 , pp. 962-971
    • Baker, C.C.1    Phelps, W.C.2    Lindgren, V.3    Braun, M.J.4    Gonda, M.A.5    Howley, P.M.6
  • 23
    • 39849091786 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells
    • You, J.S., Kang, J.K., Lee, E.K., Lee, J.C., Lee, S.H., Jeon, Y.J., Koh, D.H., Ahn, S.H., Seo, D.W., Lee, H.Y. et al. (2008) Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells. Oncogene, 27, 1376-1386.
    • (2008) Oncogene , vol.27 , pp. 1376-1386
    • You, J.S.1    Kang, J.K.2    Lee, E.K.3    Lee, J.C.4    Lee, S.H.5    Jeon, Y.J.6    Koh, D.H.7    Ahn, S.H.8    Seo, D.W.9    Lee, H.Y.10
  • 24
    • 34250369627 scopus 로고    scopus 로고
    • FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin
    • Giresi, P.G., Kim, J., McDaniell, R.M., Iyer, V.R. and Lieb, J.D. (2007) FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Res., 17, 877-885.
    • (2007) Genome Res. , vol.17 , pp. 877-885
    • Giresi, P.G.1    Kim, J.2    McDaniell, R.M.3    Iyer, V.R.4    Lieb, J.D.5
  • 26
    • 35348979623 scopus 로고    scopus 로고
    • Retinoic acid receptor beta silences human papillomavirus-18 oncogene expression by induction of de novo methylation and heterochromatinization of the viral control region
    • De-Castro Arce, J., Gockel-Krzikalla, E. and Rosl, F. (2007) Retinoic acid receptor beta silences human papillomavirus-18 oncogene expression by induction of de novo methylation and heterochromatinization of the viral control region. J. Biol. Chem., 282, 28520-28529.
    • (2007) J. Biol. Chem. , vol.282 , pp. 28520-28529
    • De-Castro Arce, J.1    Gockel-Krzikalla, E.2    Rosl, F.3
  • 31
    • 34548433964 scopus 로고    scopus 로고
    • Marking histone H3 variants: how, when and why?
    • Loyola, A. and Almouzni, G. (2007) Marking histone H3 variants: how, when and why? Trends Biochem. Sci., 32, 425-433.
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 425-433
    • Loyola, A.1    Almouzni, G.2
  • 32
    • 34250745886 scopus 로고    scopus 로고
    • Nucleosome stability mediated by histone variants H3.3 and H2A.Z
    • Jin, C. and Felsenfeld, G. (2007) Nucleosome stability mediated by histone variants H3.3 and H2A.Z. Genes Dev., 21, 1519-1529.
    • (2007) Genes Dev. , vol.21 , pp. 1519-1529
    • Jin, C.1    Felsenfeld, G.2
  • 33
    • 0026566674 scopus 로고
    • RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon
    • Nagpal, S., Zelent, A. and Chambon, P. (1992) RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon. Proc. Natl Acad. Sci. USA, 89, 2718-2722.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 2718-2722
    • Nagpal, S.1    Zelent, A.2    Chambon, P.3
  • 34
    • 3142594438 scopus 로고    scopus 로고
    • Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer
    • Youssef, E.M., Estecio, M.R. and Issa, J.P. (2004) Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer. Cancer Biol. Ther., 3, 82-86.
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 82-86
    • Youssef, E.M.1    Estecio, M.R.2    Issa, J.P.3
  • 36
    • 0035038209 scopus 로고    scopus 로고
    • Protein binding protects sites on stable episomes and in the chromosome from de novo methylation
    • Han, L., Lin, I.G. and Hsieh, C.L. (2001) Protein binding protects sites on stable episomes and in the chromosome from de novo methylation. Mol. Cell. Biol., 21, 3416-3424.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3416-3424
    • Han, L.1    Lin, I.G.2    Hsieh, C.L.3
  • 37
    • 0028824891 scopus 로고
    • Suppression of cellular proliferation by the papillomavirus E2 protein
    • Dowhanick, J.J., McBride, A.A. and Howley, P.M. (1995) Suppression of cellular proliferation by the papillomavirus E2 protein. J. Virol., 69, 7791-7799.
    • (1995) J. Virol. , vol.69 , pp. 7791-7799
    • Dowhanick, J.J.1    McBride, A.A.2    Howley, P.M.3
  • 38
    • 0028071697 scopus 로고
    • Transcription-modulatory activity of full-length E6 and E6*I proteins of human papillomavirus type 16
    • Shirasawa, H., Jin, M.H., Shimizu, K., Akutsu, N., Shino, Y. and Simizu, B. (1994) Transcription-modulatory activity of full-length E6 and E6*I proteins of human papillomavirus type 16. Virology, 203, 36-42.
    • (1994) Virology , vol.203 , pp. 36-42
    • Shirasawa, H.1    Jin, M.H.2    Shimizu, K.3    Akutsu, N.4    Shino, Y.5    Simizu, B.6
  • 39
    • 0026564760 scopus 로고
    • Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16
    • Desaintes, C., Hallez, S., Van Alphen, P. and Burny, A. (1992) Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16. J. Virol., 66, 325-333.
    • (1992) J. Virol. , vol.66 , pp. 325-333
    • Desaintes, C.1    Hallez, S.2    Van Alphen, P.3    Burny, A.4
  • 41
    • 78650647794 scopus 로고    scopus 로고
    • Rolling circle replication of human papillomavirus type 16 DNA in epithelial cell extracts
    • Kusumoto-Matsuo, R., Kanda, T. and Kukimoto, I. (2011) Rolling circle replication of human papillomavirus type 16 DNA in epithelial cell extracts. Genes Cells, 16, 23-33.
    • (2011) Genes Cells , vol.16 , pp. 23-33
    • Kusumoto-Matsuo, R.1    Kanda, T.2    Kukimoto, I.3
  • 42
    • 49249128140 scopus 로고    scopus 로고
    • In pursuit of the first recognized epigenetic signal-DNA methylation: a 1976 to 2008 synopsis
    • Doerfler, W. (2008) In pursuit of the first recognized epigenetic signal-DNA methylation: a 1976 to 2008 synopsis. Epigenetics, 3, 125-133.
    • (2008) Epigenetics , vol.3 , pp. 125-133
    • Doerfler, W.1
  • 44
    • 78650748371 scopus 로고    scopus 로고
    • Persistence of human papillomavirus infection: keys to malignant progression
    • Bodily, J. and Laimins, L.A. (2011) Persistence of human papillomavirus infection: keys to malignant progression. Trends Microbiol., 19, 33-39.
    • (2011) Trends Microbiol. , vol.19 , pp. 33-39
    • Bodily, J.1    Laimins, L.A.2
  • 45
    • 78651526843 scopus 로고    scopus 로고
    • When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases
    • Navratil, V., de Chassey, B., Combe, C.R. and Lotteau, V. (2011) When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases. BMC Syst. Biol., 5, 13.
    • (2011) BMC Syst. Biol. , vol.5 , pp. 13
    • Navratil, V.1    de Chassey, B.2    Combe, C.R.3    Lotteau, V.4
  • 46
    • 78649396546 scopus 로고    scopus 로고
    • HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53
    • Au Yeung, C.L., Tsang, W.P., Tsang, T.Y., Co, N.N., Yau, P.L. and Kwok, T.T. (2010) HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53. Oncol. Rep., 24, 1599-1604.
    • (2010) Oncol. Rep. , vol.24 , pp. 1599-1604
    • Au Yeung, C.L.1    Tsang, W.P.2    Tsang, T.Y.3    Co, N.N.4    Yau, P.L.5    Kwok, T.T.6
  • 47
    • 1842614369 scopus 로고    scopus 로고
    • The binding of histone deacetylases and the integrity of zinc finger-like motifs of the E7 protein are essential for the life cycle of human papillomavirus type 31
    • Longworth, M.S. and Laimins, L.A. (2004) The binding of histone deacetylases and the integrity of zinc finger-like motifs of the E7 protein are essential for the life cycle of human papillomavirus type 31. J. Virol., 78, 3533-3541.
    • (2004) J. Virol. , vol.78 , pp. 3533-3541
    • Longworth, M.S.1    Laimins, L.A.2
  • 48
    • 12344295621 scopus 로고    scopus 로고
    • E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation
    • Thomas, M.C. and Chiang, C.M. (2005) E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation. Mol. Cell, 17, 251-264.
    • (2005) Mol. Cell , vol.17 , pp. 251-264
    • Thomas, M.C.1    Chiang, C.M.2
  • 50
    • 0029869006 scopus 로고    scopus 로고
    • Identification of a differentiation-inducible promoter in the E7 open reading frame of human papillomavirus type 16 (HPV-16) in raft cultures of a new cell line containing high copy numbers of episomal HPV-16 DNA
    • Grassmann, K., Rapp, B., Maschek, H., Petry, K.U. and Iftner, T. (1996) Identification of a differentiation-inducible promoter in the E7 open reading frame of human papillomavirus type 16 (HPV-16) in raft cultures of a new cell line containing high copy numbers of episomal HPV-16 DNA. J. Virol., 70, 2339-2349.
    • (1996) J. Virol. , vol.70 , pp. 2339-2349
    • Grassmann, K.1    Rapp, B.2    Maschek, H.3    Petry, K.U.4    Iftner, T.5
  • 52
    • 0035407651 scopus 로고    scopus 로고
    • Bisulfite genomic sequencing: systematic investigation of critical experimental parameters
    • Grunau, C., Clark, S.J. and Rosenthal, A. (2001) Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res., 29, E65-E65.
    • (2001) Nucleic Acids Res. , vol.29
    • Grunau, C.1    Clark, S.J.2    Rosenthal, A.3
  • 53
    • 33746407333 scopus 로고    scopus 로고
    • The emerging science of epigenomics
    • Callinan, P.A. and Feinberg, A.P. (2006) The emerging science of epigenomics. Hum. Mol. Genet., 15(Spec no. 1), R95-R101.
    • (2006) Hum. Mol. Genet. , vol.15 , Issue.SPEC. NO. 1
    • Callinan, P.A.1    Feinberg, A.P.2
  • 55
    • 0000700054 scopus 로고    scopus 로고
    • Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase
    • Chen, W.Y., Bailey, E.C., McCune, S.L., Dong, J.Y. and Townes, T.M. (1997) Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. Proc. Natl Acad. Sci. USA, 94, 5798-5803.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 5798-5803
    • Chen, W.Y.1    Bailey, E.C.2    McCune, S.L.3    Dong, J.Y.4    Townes, T.M.5
  • 56
    • 24344466882 scopus 로고    scopus 로고
    • DNA methylation and histone modifications: teaming up to silence genes
    • Fuks, F. (2005) DNA methylation and histone modifications: teaming up to silence genes. Curr. Opin. Genet. Dev., 15, 490-495.
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 490-495
    • Fuks, F.1
  • 57
    • 77956288615 scopus 로고    scopus 로고
    • Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation
    • Si, J., Boumber, Y.A., Shu, J., Qin, T., Ahmed, S., He, R., Jelinek, J. and Issa, J.P. (2010) Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation. Cancer Res., 70, 6968-6977.
    • (2010) Cancer Res. , vol.70 , pp. 6968-6977
    • Si, J.1    Boumber, Y.A.2    Shu, J.3    Qin, T.4    Ahmed, S.5    He, R.6    Jelinek, J.7    Issa, J.P.8
  • 59
    • 31444437043 scopus 로고    scopus 로고
    • Distribution of histone H3.3 in hematopoietic cell lineages
    • Jin, C. and Felsenfeld, G. (2006) Distribution of histone H3.3 in hematopoietic cell lineages. Proc. Natl Acad. Sci. USA, 103, 574-579.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 574-579
    • Jin, C.1    Felsenfeld, G.2
  • 60
    • 0029815037 scopus 로고    scopus 로고
    • CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences
    • Thain, A., Jenkins, O., Clarke, A.R. and Gaston, K. (1996) CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences. J. Virol., 70, 7233-7235.
    • (1996) J. Virol. , vol.70 , pp. 7233-7235
    • Thain, A.1    Jenkins, O.2    Clarke, A.R.3    Gaston, K.4
  • 61
    • 0037068351 scopus 로고    scopus 로고
    • Gene silencing in mammalian cells and the spread of DNA methylation
    • Turker, M.S. (2002) Gene silencing in mammalian cells and the spread of DNA methylation. Oncogene, 21, 5388-5393.
    • (2002) Oncogene , vol.21 , pp. 5388-5393
    • Turker, M.S.1
  • 62
    • 78650010371 scopus 로고    scopus 로고
    • The occlusis model of cell fate restriction
    • Lahn, B.T. (2010) The occlusis model of cell fate restriction. Bioessays, 33, 13-20.
    • (2010) Bioessays , vol.33 , pp. 13-20
    • Lahn, B.T.1
  • 63
    • 0025339154 scopus 로고
    • Growth-regulating functions of human papillomavirus early gene products in cervical cancer cells acting dominant over enhanced epidermal growth factor receptor expression
    • von Knebel Doeberitz, M., Gissmann, L. and zur Hausen, H. (1990) Growth-regulating functions of human papillomavirus early gene products in cervical cancer cells acting dominant over enhanced epidermal growth factor receptor expression. Cancer Res., 50, 3730-3736.
    • (1990) Cancer Res. , vol.50 , pp. 3730-3736
    • von Knebel Doeberitz, M.1    Gissmann, L.2    zur Hausen, H.3
  • 64
    • 0023809597 scopus 로고
    • Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells
    • von Knebel Doeberitz, M., Oltersdorf, T., Schwarz, E. and Gissmann, L. (1988) Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells. Cancer Res., 48, 3780-3786.
    • (1988) Cancer Res. , vol.48 , pp. 3780-3786
    • von Knebel Doeberitz, M.1    Oltersdorf, T.2    Schwarz, E.3    Gissmann, L.4
  • 65
  • 66
    • 77954365636 scopus 로고    scopus 로고
    • HPV16 E2 is an immediate early marker of viral infection, preceding E7 expression in precursor structures of cervical carcinoma
    • Xue, Y., Bellanger, S., Zhang, W., Lim, D., Low, J., Lunny, D. and Thierry, F. (2010) HPV16 E2 is an immediate early marker of viral infection, preceding E7 expression in precursor structures of cervical carcinoma. Cancer Res., 70, 5316-5325.
    • (2010) Cancer Res. , vol.70 , pp. 5316-5325
    • Xue, Y.1    Bellanger, S.2    Zhang, W.3    Lim, D.4    Low, J.5    Lunny, D.6    Thierry, F.7
  • 67
    • 80052531865 scopus 로고    scopus 로고
    • Differential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation
    • Vinokurova, S. and von Knebel Doeberitz, M. (2011) Differential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation. PLoS One, 6, e24451.
    • (2011) PLoS One , vol.6
    • Vinokurova, S.1    von Knebel Doeberitz, M.2
  • 68
    • 8544257379 scopus 로고    scopus 로고
    • Ectopic expression of nonliganded retinoic acid receptor beta abrogates AP-1 activity by selective degradation of c-Jun in cervical carcinoma cells
    • De-Castro Arce, J., Soto, U., van Riggelen, J., Schwarz, E., Hausen, H.Z. and Rosl, F. (2004) Ectopic expression of nonliganded retinoic acid receptor beta abrogates AP-1 activity by selective degradation of c-Jun in cervical carcinoma cells. J. Biol. Chem., 279, 45408-45416.
    • (2004) J. Biol. Chem. , vol.279 , pp. 45408-45416
    • De-Castro Arce, J.1    Soto, U.2    van Riggelen, J.3    Schwarz, E.4    Hausen, H.Z.5    Rosl, F.6
  • 69
    • 67649524640 scopus 로고    scopus 로고
    • Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements)
    • Giresi, P.G. and Lieb, J.D. (2009) Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements). Methods, 48, 233-239.
    • (2009) Methods , vol.48 , pp. 233-239
    • Giresi, P.G.1    Lieb, J.D.2
  • 70
    • 33748052706 scopus 로고    scopus 로고
    • IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression
    • Schneider, G., Saur, D., Siveke, J.T., Fritsch, R., Greten, F.R. and Schmid, R.M. (2006) IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. EMBO J., 25, 3801-3812.
    • (2006) EMBO J. , vol.25 , pp. 3801-3812
    • Schneider, G.1    Saur, D.2    Siveke, J.T.3    Fritsch, R.4    Greten, F.R.5    Schmid, R.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.