Identification of a differentiation-inducible promoter in the E7 open reading frame of human papillomavirus type 16 (HPV-16) in raft cultures of a new cell line containing high copy numbers of episomal HPV-16 DNA

Journal of Virology

Volumn 70, Issue 4, 1996, Pages 2339-2349

  Grassmann, K ^a   Rapp, B ^a   Maschek, H ^b   Petry, K U ^b   Iftner, T ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER CELL CULTURE; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; VIRAL GENETICS; VIRUS EXPRESSION; VIRUS GENE; WART VIRUS;

3T3 CELLS; ANIMALS; CARCINOMA IN SITU; CELL DIFFERENTIATION; DNA, VIRAL; FEMALE; GENE EXPRESSION REGULATION, VIRAL; HUMANS; MICE; ONCOGENE PROTEINS, VIRAL; OPEN READING FRAMES; PAPILLOMAVIRIDAE; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; RNA SPLICING; RNA, VIRAL; TUMOR CELLS, CULTURED; VULVAR NEOPLASMS;

EID: 0029869006     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.4.2339-2349.1996     Document Type: Article

References (60)

1. Baker, C. C., and P. M. Howley. 1987 Differential promoter utilization by the bovine papillomavirus in transformed cells and productively infected wart tissues. EMBO J 6:1027-1035.
2. Baker, C. C., W. C. Phelps, V. Lindgren, M. J. Braun, M. A. Gonda, and P. M. Howley. 1987. Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J. Virol. 61: 962-971.
3. Bavin, P. J., P. G. Walker, and V. C. Emery. 1993. Sequence microheterogeneity in the long control region of clinical isolates of human papillomavirus type 16. J. Med. Virol. 39:267-272.
4. Bedell, M. A., J. B. Hudson, T. R. Golub, M. E. Turyk, M. Hosken, G. D. Wilbanks, and L. A. Laimins. 1991. Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation J. Virol. 65:2254-2260
5. Belyavsky, A., T. Vinogradova, and K. Rajewsky. 1989. PCR-based cDNA library construction: general cDNA libraries at the level of a few cells. Nucleic Acids Res. 17:2919-2932. (Erratum, 17:5883.)
6. Böhm, S., S. P. Wilczynski, H. Pfister, and T. Iftner. 1993. The predominant mRNA class in HPV-16-infected genital neoplasias does not encode the E6 or the E7 protein. Int. J. Cancer 55:791-798
7. Boshart, M., L. Gissmann, H. Ikenberg, A. Kleinhetnz, W. Scheurlen, and H. zur Hausen. 1984 A new type of papillomavirus DNA. its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J. 3:1151-1157.
8. Boukamp, P., R. T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham, and N. E. Fusenig. 1988. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line J. Cell Biol. 106:761-771.
9. Chan, S. Y., H. U. Bernard, C. K. Ong, S. P. Chan, B. Hofmann, and H. Delius. 1992. Phylogenetic analysis of 48 papillomavirus types and 28 subtypes and variants: a showcase for the molecular evolution of DNA viruses. J. Virol. 66:5714-5725.
10. Chan, W. K., G. Klock, and H. U. Bernard. 1989. Progesterone and glucocorticoid response elements occur in the long control regions of several human papillomaviruses involved in anogenital neoplasia. J. Virol. 63:3261-3269.
11. Chomczynski, P., and N. Sacchi. 1987 Single-step method of RNA isolation by acid guanidimum thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
12. Chong, T., D. Apt, B. Gloss, M. Isa, and H. U. Bernard. 1991. The enhancer of human papillomavirus type 16. binding sites for the ubiquitous trariscription factors oct-1, NFA. TEF-2, NF1. and AP-1 participate in epithelial cell-specific transcription J. Virol. 65:5933-5943.
13. Chong, T., W. K. Chan, and H. U. Bernard. 1990. Transcriptional activation of human papillomavirus 16 by nuclear factor I, AP1. steroid receptors and a possibly novel transcription factor, PVF: a model for the compusition of genital papillomavirus enhancers. Nucleic Acids Res 18:465-470
14. Chow, L. T., M. Nasseri, S. M. Wolinsky, and T. R. Broker. 1987 Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata. J. Virol. 61:2581-2588.
15. Crum, C. P., G. Nuovo, D. Friedman, and S. J. Silverstein. 1988 Accumulation of RNA homologous to human papillomavirus type 16 open reading frames in genital precancers. J. Virol. 62:84-90.
16. Dollard, S. C., J. L. Wilson, L. M. Demeter, W. Bonnez, R. C. Reichman, T. R. Broker, and L. T. Chow. 1992 Production of human papillomavirus and modulation of the infectious program in epithelial raft cultures. Genes Dev. 6:1131-1142
17. Dong, X. P., F. Stubenrauch, E. Beyer Finkler, and H. Pfister. 1994 Prevalence of deletions of YY1-binding sites in episomal HPV 16 DNA from cervical cancers Int. J. Cancer 58:803-808.
18. Doorbar, J., A. Parton, K. Hartley, L. Banks, T. Crook, M. Stanley, and L. Crawford. 1990. Detection of novel splicing patterns in a HPV16-containing keratinocyte cell line. Virology 178:254-262.
19. Dürst, M., D. Glitz, A. Schneider, and H. zur Hausen. 1992 Human papillomavirus type 16 (HPV 16) gene expression and DNA replication in cervical neoplasia: analysis by in situ hybridization. Virology 189:132-140.
20. Friedman, A. D., W. H. Landschulz, and S. L. McKnight. 1989. CCAAT/ enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells Genes Dev. 3:1314-1322.
21. Frohman, M. A., M. K. Dush, and G. R. Martin. 1988. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci USA 85:8998-9002.
22. Fuchs, P. G., T. Iftner, J. Weninger, and H. Pfister. 1986. Epidermodysplasia verruciformis-associated human papillomavirus 8: genomic sequence and comparative analysis. J. Virol. 58:626-634.
23. Higgins, G. D., D. M. Uzelin, G. E. Phillips, P. McEvoy, R. Marin, and C. J. Burrell. 1992. Transcription patterns of human papillomavirus type 16 in genital intraepithelial neoplasia. evidence for promoter usage within the E7 open reading frame during epithelial differentiation. J. Gen. Virol. 73:2047-2057.
24. Hummel, M., J. B. Hudson, and L. A. Laimins. 1992 Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes. J Virol. 66:6070-6080
25. Hummel, M., H. B. Lim, and L. A. Laimins. 1995 Human papillomavirus type 31b late gene expression is regulated through protein kinase C-mediated changes in RNA processing J. Virol. 69:3381-3388.
26. Iftner, T., M. Oft, S. Bohm, S. P. Wilczynski, and H. Pfister. 1992 Transcription of the E6 and E7 genes of human papillomavirus type 6 in anogenital condylomata is restricted to undifferentiated cell layers of the epithelium. J Virol. 66:4639-4646.
27. Iftner, T., G. Sagner, H. Pfister, and F. O. Wettstein. 1990 The E7 protein of human papillomavirus 8 is a nonphosphorylated protein of 17 LDa and can be generated by two different mechanisms. Virology 179:428-436.
28. Johnson, P. F., and S. L. McKnight. 1989. Eukaryotic transcriptional regulatory proteins. Annu Rev Biochem. 58:799-839.
29. Kopan, R., G. Traska, and E. Fuchs. 1987. Refinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. J. Cell Biol. 105:427-440
30. Kozak, M. 1987 Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes. Mol. Cell. Biol. 7:3438-3445
31. Krajinovic, M., and A. Savic. 1991. Sequencing data on the long control region of human papillomavirus type 16. J. Gen. Virol. 72:2573-2576
32. Maxam, A. M., and W. Gilbert. 1977. A new method for sequencing DNA. Proc. Natl. Acad Sci USA 74:560-564.
33. May, M., X. P. Dong, E. Beyer Finkler, F. Stubenrauch, P. G. Fuchs, and H. Pfister. 1994. The E6/E7 promoter of extrachromosomal HPV16 DNA in cervical cancers escapes from cellular repression by mutation of target sequences for YY1. EMBO J. 13:1460-1466.
34. McCance, D. J., R. Kopan, E. Fuchs, and L. A. Laimins. 1988 Human papillomavirus type 16 alters human epithelial cell differentiation in vitro Proc. Natl. Acad. Sci. USA 85:7169-7173.
35. Meyers, C., M. G. Frattini, J. B. Hudson, and L. A. Laimins. 1992 Biosynthesis of human papillomavirus from a continuous cell line upon epsthelial differentiation. Science 257:971-973.
36. Nasseri, M., F. O. Wettstein, and J. G. Stevens. 1982. Two colinear and spliced viral transcripts are present in non-virus-producing benign and malignant neoplasms induced by the Shope (rabbit) papilloma virus J Virol. 44:263-268.
37. Philippe, J. M., F. Renaud, S. Desset, M. Laurent, J. Mallet, V. Courtois, and J. B. Edwards. 1992. Cloning of two different 5′-untranslated exons of bovine acidic fibroblast growth factor by the single strand ligation to single-stranded cDNA methodology. Biochem Biophys. Res Commun 188:843-850.
38. Rohlfs, M., S. Winkenbach, S. Meyer, T. Rupp, and M. Durst. 1991 Viral transcription in human keratinocyte cell lines immortalized by human papillomavirus type-16. Virology 183:331-342.
39. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989 Molecular cloning, a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
40. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad. Sci USA 74:5463-5467.
41. Schmitt, A., J. B. Harry, B. Rapp, F. O. Wettstein, and T. Iftner. 1994. Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1. J. Virol. 68:7051-7059.
42. Schneider Maunoury, S., G. Pehau Arnandet, F. Breitburd, and G. Orth. 1990 Expression of the human papillomavirus type 16 genome in SK-v cells, a line derived from a vulvar intraepithelial neoplasia. J. Gen. Virol. 71:809-817.
43. Schwarz, E., U. K. Freese, L. Gissmann, W. Majer, B. Roggenbuck, A. Stremlau, and H. zur Hausen. 1985. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature (London) 314: 111-114
44. Seedorf, K., G. Krammer, M. Durst, S. Suhai, and W. G. Rowekamp. 1985 Human papillomavirus type 16 DNA sequence. Virology 145:181-185.
45. Sherman, L., and N. Alloul. 1992. Human papillomavirus type 16 expresses a variety of alternatively spliced mRNAs putatively encoding the E2 protein. Virology 191:953-959.
46. Sherman, L., N. Alloul, I. Golan, M. Durst, and A. Baram. 1992. Expression and splicing patterns of human papillomavirus type-16 mRNAs in pre-cancerous lesions and carcinomas of the cervix, in human keratinocytes immortalized by HPV 16, and in cell lines established from cervical cancers. Int. J. Cancer 50:356-364.
47. Shirasawa, H., Y. Tomita, S. Sekiya, H. Takamizawa, and B. Simizu. 1987. Integration and transcription of human papillomavirus type 16 and 18 sequences in cell lines derived from cervical carcinomas. J. Gen Virol. 68:583-591.
48. Smotkin, D., H. Prokoph, and F. O. Wettstein. 1989. Oncogenic and non oncogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms. J. Virol. 63:1441-1447.
49. Smotkin, D., and F. O. Wettstein. 1986 Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc. Natl. Acad. Sci. USA 83:4680-4684.
50. Smotkin, D., and F. O. Wettstein. 1987. The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein J. Virol. 61: 1686-1689.
51. Stanley, M. A. 1994. Virus-keratinocyte interactions in the infectious cycle, p. 116-128. In P. L. Stern and M. A. Stanley (ed.), Human papillomaviruses and cervical cancer, biology and immunology. Oxford University Press, Oxford.
52. Stoler, M. H., and T. R. Broker. 1986. In situ hybridization detection of human papillomavirus DNAs and messenger RNAs in genital eondylomas and a cervical carcinoma. Hum Pathol. 17:1250-1258.
53. Stoler, M. H., C. R. Rhodes, A. Whitbeck, S. M. Wolinsky, L. T. Chow, and T. R. Broker. 1992. Human papillomavirus type 16 and 18 gene expression in cervical neoplasias. Hum. Pathol. 23:117-128.
54. Umek, R. M., A. D. Friedman, and S. L. McKnight. 1991. CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251:288-292.
55. von Knebel Doeberitz, M., C. Rittmuller, H. zur Hausen, and M. Dürst. 1992. Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6-E7 anti-sense RNA. Int J. Cancer 51:831-834. (Letter.)
56. Walboomers, J. M., A.-M. De Roda Husman, A. J. Van Den Brule, P. J. Snijders, and C. J. Meijer. 1994. Detection of genital human papillomavirus infections' critical review of methods and prevalence studies in relation to cervical cancer, p. 41-69. In P. L. Stern and M. A. Stanley (ed.), Human papillomaviruses and cervical cancer, biology and immunology. Oxford University Press, Oxford.
57. Wettstein, F. O., and J. G. Stevens. 1982. Variable-sized free episomes of Shope papilloma virus DNA are present in all non-virus-producing neoplasms and integrated episomes are detected in some Proc. Natl. Acad. Sci. USA 79:790-794.
58. Yee, C., I. Krishnan Hewlett, C. C. Baker, R. Schlegel, and P. M. Howley. 1985. Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am. J. Pathol 119:361-366.
59. zur Hausen, H. 1991. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13
60. zur Hausen, H. 1994. Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types, p. 131-156. In H. zur Hausen (ed.), Human pathogenic papillomaviruses. Springer-Verlag, Berlin