Interleukin-6 contributes to hepcidin mRNA increase in response to exercise

Cytokine

Volumn 58, Issue 2, 2012, Pages 158-161

  Banzet, Sébastien ^a   Sanchez, Hervé ^a   Chapot, Rachel ^a   Bigard, Xavier ^a   Vaulont, Sophie ^b,c,d   Koulmann, Nathalie ^a,e  

^a INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^b INSTITUT COCHIN   (France)

^c CNRS   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e Hôpital Inter Armées du Val de Grâce   (France)

Author keywords

Hepcidin; Il 6; Strenuous exercise

Indexed keywords

CYCLOSPORIN A; HEPCIDIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; MESSENGER RNA; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; EXERCISE INTENSITY; GENE; GENE EXPRESSION; IL 6 RECEPTOR ALPHA GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RUNNING; SOCS3 GENE;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BASE SEQUENCE; CYCLOSPORINE; DNA PRIMERS; INTERLEUKIN-6; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

ANIMALIA; RATTUS; RODENTIA;

EID: 84859218438     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.01.006     Document Type: Article

References (22)

1. Peeling P., Dawson B., Goodman C., Landers G., Trinder D. Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones. Eur J Appl Physiol 2008, 103:381-391.
2. Ganz T. Hepcidin and iron regulation, 10 years later. Blood 2011, 117:4425-4433.
3. Nemeth E., Rivera S., Gabayan V., Keller C., Taudorf S., Pedersen B.K., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004, 113:1271-1276.
4. Peeling P., Dawson B., Goodman C., Landers G., Wiegerinck E.T., Swinkels D.W., et al. Effects of exercise on hepcidin response and iron metabolism during recovery. Int J Sport Nutr Exerc Metab 2009, 19:583-597.
5. Peeling P., Dawson B., Goodman C., Landers G., Wiegerinck E.T., Swinkels D.W., et al. Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity. Eur J Appl Physiol 2009, 106:51-59.
6. Robson-Ansley P., Walshe I., Ward D. The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise. Cytokine 2011, 53:196-200.
7. Roecker L., Meier-Buttermilch R., Brechtel L., Nemeth E., Ganz T. Iron-regulatory protein hepcidin is increased in female athletes after a marathon. Eur J Appl Physiol 2005, 95:569-571.
8. Sim M, Dawson B, Landers G, Wiegerinck ET, Swinkels DW, Townsend MA, et al. The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levels. Eur J Appl Physiol; in press.
9. Liu Y.Q., Chang Y.Z., Zhao B., Wang H.T., Duan X.L. Does hepatic hepcidin play an important role in exercise-associated anemia in rats?. Int J Sport Nutr Exerc Metab 2011, 21:19-26.
10. Pedersen B.K., Febbraio M.A. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 2008, 88:1379-1406.
11. Højbjerre L., Rosenzweig M., Dela F., Bruun J.M., Stallknecht B. Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects. Eur J Endocrinol 2007, 157:613-623.
12. Rosa Neto J.C., Lira F.S., Oyama L.M., Zanchi N.E., Yamashita A.S., Batista M.L.J., et al. Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats. Eur J Appl Physiol 2009, 106:697-704.
13. Banzet S., Koulmann N., Simler N., Sanchez H., Chapot R., Serrurier B., et al. Control of gluconeogenic genes during intense/prolonged exercise: hormone-independent effect of muscle-derived IL-6 on hepatic tissue and PEPCK mRNA. J Appl Physiol 2009, 107:1830-1839.
14. Banzet S., Koulmann N., Sanchez H., Serrurier B., Peinnequin A., Alonso A., et al. Contraction-induced interleukin-6 transcription in rat slow-type muscle is partly dependent on calcineurin activation. J Cell Physiol 2007, 210:596-601.
15. Tjalsma H., Laarakkers C.M., van Swelm R.P., Theurl M., Theurl I., Kemna E.H., et al. Mass spectrometry analysis of hepcidin peptides in experimental mouse models. PLoS One 2011, 6:e16762.
16. Fritsche L., Hoene M., Lehmann R., Ellingsgaard H., Hennige A.M., Pohl A.K., et al. IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise. Diabetologia 2010, 53:1732-1742.
17. Erdem S.R., Emre-Aydi{dotless}ngöz S., Atilla P., Cakar A.N., Dalkara T., Bolay H., et al. Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow. Life Sci 2011, 88:753-760.
18. Naesens M., Kuypers D.R., Sarwal M. Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol 2009, 4:481-508.
19. Hashizume M., Uchiyama Y., Horai N., Tomosugi N., Mihara M. Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production. Rheumatol Int 2010, 30:917-923.
20. Verga Falzacappa M.V., Vujic Spasic M., Kessler R., Stolte J., Hentze M.W., Muckenthaler M.U. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 2007, 109:353-358.
21. Wrighting D.M., Andrews N.C. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006, 108:3204-3209.
22. Troadec M.B., Laine F., Daniel V., Rochcongar P., Ropert M., Cabillic F., et al. Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. Eur J Appl Physiol 2009, 106:435-443.