Does hepatic hepcidin play an important role in exercise-associated anemia in rats?

International Journal of Sport Nutrition and Exercise Metabolism

Volumn 21, Issue 1, 2011, Pages 19-26

  Liu, Yu Qian ^a   Chang, Yan Zhong ^a   Zhao, Bin ^a   Wang, Hai Tao ^a   Duan, Xiang Lin ^a  

^a HEBEI NORMAL UNIVERSITY   (China)

Author keywords

Duodenum; Inflammation; Iron absorption; Skeletal muscle

Indexed keywords

FERRITIN; FERROPORTIN 1; HEMOJUVELIN; HEMOPROTEIN; HEPCIDIN; INTERLEUKIN 6; IRON; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PROTON COUPLED FOLATE TRANSPORTER; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DUODENUM; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE; EXERCISE ASSOCIATED ANEMIA; FERRITIN BLOOD LEVEL; GASTROCNEMIUS MUSCLE; HEMATOCRIT; INTESTINE EPITHELIUM; IRON ABSORPTION; IRON BLOOD LEVEL; LEUKOCYTE; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; TREADMILL EXERCISE; WESTERN BLOTTING;

RATTUS; RATTUS NORVEGICUS;

EID: 79952836201     PISSN: 1526484X     EISSN: 15432742     Source Type: Journal    
DOI: 10.1123/ijsnem.21.1.19     Document Type: Article

References (39)

1. Christiansen, H., Sheikh, N., Saile, B., Reuter, F., Rave-Fränk, M., Hermann, R.M., . . . Ramadori, G. (2007). x-Irradiation in rat liver: Consequent upregulation of hepcidin and downregulation of hemojuvelin and ferroportin-1 gene expression. Radiology, 242(1), 189-197. (Pubitemid 44956024)
2. Collins, J.F., Wessling-Resnick, M., & Knutson, M.D. (2008). Hepcidin regulation of iron transport. The Journal of Nutrition, 138(11), 2284-2288.
3. Darshan, D., & Anderson, G.J. (2009). Interacting signals in the control of hepcidin expression. Biometals, 22(1), 77-87.
4. Davis, M.C., Zautra, A.J., Younger, J., Motivala, S.J., Attrep, J., & Irwin, M.R. (2008). Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: Implications for fatigue. Brain, Behavior, and Immunity, 22(1), 24-32.
5. de Mast, Q., van Dongen-Lases, E.C., Swinkels, D.W., Nieman, A.E., Roestenberg, M., Druilhe, P., . . . van der Ven, A.J. (2009). Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection. British Journal of Haematology, 145(5), 657-664.
6. Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S.J., Moynihan, J., . . . Zon, L.I. (2000). Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter. Nature, 403(6771), 776-781. (Pubitemid 30111839)
7. Fleming, R.E. (2008). Iron and inflammation: Cross-talk between pathways regulating hepcidin. Journal of Molecular Medicine (Berlin, Germany), 86(5), 491-494.
8. Ganz, T. (2003). Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood, 102(3), 783-788.
9. Gardenghi, S., Marongiu, M.F., Ramos, P., Guy, E., Breda, L., Chadburn, A., . . . Rivella, S. (2007). Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood, 109(11), 5027-5035. (Pubitemid 46827803)
10. Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin, Y., Romero, M.F., Boron, W.F., . . . Hediger, M.A. (1997). Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature, 388(6641), 482-488. (Pubitemid 27328927)
11. Harris, M.B., Mitchell, B.M., Sood, S.G., Webb, R.C., & Venema, R.C. (2008). Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise. European Journal of Applied Physiology, 104(5), 795-802.
12. Hoppe, M., Lönnerdal, B., Hossain, B., Olsson, S., Nilsson, F., Lundberg, P.A., . . . Hulthén, L. (2009). Hepcidin, interleukin-6 and hematological iron markers in males before and after heart surgery. The Journal of Nutritional Biochemistry, 20(1), 11-16.
13. Hubert, N., & Hentze, M.W. (2002). Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function. Proceedings of the National Academy of Sciences of the United States of America, 99(19), 12345-12350.
14. Hunter, G.A., Sampson, M.P., & Ferreira, G.C. (2008). Metal ion substrate inhibition of ferrochelatase. The Journal of Biological Chemistry, 283(35), 23685-23691.
15. Beard, J., & Tobin, B. (2000). Iron status and exercise. American Journal of Clinical Nutrition, 72(2 Suppl.), 594S-597S.
16. Kemna, E., Pickkers, P., Nemeth, E., van der Hoeven, H., & Swinkels, D. (2005). Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood, 106(5), 1864-1866. (Pubitemid 41208606)
17. Kong, W.N., Zhao, S.E., Duan, X.L., Yang, Z., Qian, Z.M., & Chang, Y.Z. (2008). Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats. Journal of Cellular Biochemistry, 104(2), 629-641. (Pubitemid 351671650)
18. Krause, A., Neitz, S., Magert, H.J., Schulz, A., Forssmann, W.G., Schulz-Knappe, P., & Adermann, K. (2000). LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Letters, 480(2-3), 147-150.
19. Liew, Y.F., & Shaw, N.S. (2005). Mitochondrial cysteine desulfurase iron-sulfur cluster S and aconitase are posttranscriptionally regulated by dietary iron in skeletal muscle of rats. The Journal of Nutrition, 135(9), 2151-2158.
20. Lin, L., Goldberg, Y.P., & Ganz, T. (2005). Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood, 106(8), 2884-2889. (Pubitemid 41510769)
21. Liu, Y.Q., Duan, X.L., Chang, Y.Z., Wang, H.T., & Qian, Z.M. (2006). Molecular analysis of increased iron status in moderately exercised rats. Molecular and Cellular Biochemistry, 282(1-2), 117-123. (Pubitemid 43019470)
22. Lukaski, H.C. (2004). Vitamin and mineral status: Effects on physical performance. Nutrition (Burbank, Los Angeles County, Calif.), 20(7-8), 632-644.
23. Malyszko, J., & Mysliwiec, M. (2007). Hepcidin in anemia and inflammation in chronic kidney disease. Kidney & Blood Pressure Research, 30(1), 15-30.
24. Nemeth, E., Tuttle, M.S., Powelson, J., Vaughn, M.B., Donovan, A., Ward, D.M., . . . Kaplan, J. (2004). Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306(5704), 2090-2093. (Pubitemid 40007660)
25. Peeling, P., Dawson, B., Goodman, C., Landers, G., & Trinder, D. (2008). Athletic induced iron deficiency: New insights into the role of inflammation, cytokines and hormones. European Journal of Applied Physiology, 103(4), 381-391.
26. Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., &Trinder, D. (2009a). Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity. European Journal of Applied Physiology, 106(1), 51-59.
27. Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., &Trinder, D. (2009b). Training surface and intensity: Inflammation, hemolysis and hepcidin expression. Medicine and Science in Sports and Exercise, 41(5), 1138-1145.
28. Qian, Z.M. (2002). Nitric oxide and changes of iron metabolism in exercise. Biological Reviews of the Cambridge Philosophical Society, 77(4), 529-536.
29. Roecker, L., Meier-Buttermilch, R., Brechtel, L., Nemeth, E., & Ganz, T. (2005). Iron regulatory protein hepcidin is increased in female athletes after a marathon. European Journal of Applied Physiology, 95(5-6), 569-571. (Pubitemid 41762564)
30. Shayeghi, M., Latunde-Dada, G.O., Oakhill, J.S., Laftah, A.H., Takeuchi, K., Halliday, N., . . . McKie, A.T. (2005). Identification of an intestinal heme transporter. Cell, 122(5), 789-801. (Pubitemid 41242642)
31. Silvestri, L., Pagani, A., & Camaschella, C. (2008). Fur-inmediated release of soluble hemojuvelin: A new link between hypoxia and iron homeostasis. Blood, 111(2), 924-931.
32. Theurl, M., Theurl, I., Hochegger, K., Obrist, P., Subramaniam, N., van Rooijen, N., . . . Weiss, G. (2008). Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression. Journal of Molecular Medicine (Berlin, Germany), 86(7), 825-835.
33. Troadec, M.B., Lainé, F., Daniel, V., Rochcongar, P., Ropert, M., Cabillic, F., . . . Brissot, P. (2009). Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. European Journal of Applied Physiology, 106(3), 435-443.
34. Williams, M.H. (2005). Dietary supplements and sports performance: Minerals. Journal of the International Society of Sports Nutrition, 2(1), 43-49.
35. Wrighting, D.M., & Andrews, N.C. (2006). Interleukin-6 induces hepcidin expression through STAT3. Blood, 108(9), 3204-3209.
36. Yamamoto, M., Otani, M., & Otsuki, M. (2006). A new model of chronic pancreatitis in rats. American Journal of Physiology. Gastrointestinal and Liver Physiology, 291(4), G700-G708. (Pubitemid 44511687)
37. Young, M.F., Glahn, R.P., Ariza-Nieto, M., Inglis, J., Olbina, G., Westerman, M., &O'Brien, K.O. (2009). Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women. The American Journal of Clinical Nutrition, 89(2), 533-538.
38. Zhang, A.S., Anderson, S.A., Meyers, K.R., Hernandez, C., Eisenstein, R.S., & Enns, C.A. (2007). Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin. The Journal of Biological Chemistry, 282(17), 12547-12556. (Pubitemid 47100643)
39. Zoller, H., & Vogel, W. (2004). Iron supplementation in athletes - First do no harm. Nutrition (Burbank, Los Angeles County, Calif.), 20(7), 615-619. (Pubitemid 38798078)