-
1
-
-
38549136843
-
Hepcidin: from discovery to differential diagnosis
-
Kemna EH, Tjalsma H, Willems HL, Swinkels DW, (2008) Hepcidin: from discovery to differential diagnosis. Haematologica 93: 90-97.
-
(2008)
Haematologica
, vol.93
, pp. 90-97
-
-
Kemna, E.H.1
Tjalsma, H.2
Willems, H.L.3
Swinkels, D.W.4
-
2
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093.
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.B.4
Donovan, A.5
-
3
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, et al. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819.
-
(2001)
J Biol Chem
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
Leroyer, P.4
Turlin, B.5
-
4
-
-
1642315903
-
Functional differences between hepcidin 1 and 2 in transgenic mice
-
Lou DQ, Nicolas G, Lesbordes JC, Viatte L, Grimber G, et al. (2004) Functional differences between hepcidin 1 and 2 in transgenic mice. Blood 103: 2816-2821.
-
(2004)
Blood
, vol.103
, pp. 2816-2821
-
-
Lou, D.Q.1
Nicolas, G.2
Lesbordes, J.C.3
Viatte, L.4
Grimber, G.5
-
5
-
-
0038025679
-
Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload
-
Ilyin G, Courselaud B, Troadec MB, Pigeon C, Alizadeh M, et al. (2003) Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload. FEBS Lett 542: 22-26.
-
(2003)
FEBS Lett
, vol.542
, pp. 22-26
-
-
Ilyin, G.1
Courselaud, B.2
Troadec, M.B.3
Pigeon, C.4
Alizadeh, M.5
-
6
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, et al. (2002) Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 99: 4596-4601.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4596-4601
-
-
Nicolas, G.1
Bennoun, M.2
Porteu, A.3
Mativet, S.4
Beaumont, C.5
-
7
-
-
2442681406
-
Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice
-
Krijt J, Cmejla R, Sykora V, Vokurka M, Vyoral D, et al. (2004) Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice. J Hepatol 40: 891-896.
-
(2004)
J Hepatol
, vol.40
, pp. 891-896
-
-
Krijt, J.1
Cmejla, R.2
Sykora, V.3
Vokurka, M.4
Vyoral, D.5
-
8
-
-
33745752870
-
Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis
-
Lesbordes-Brion JC, Viatte L, Bennoun M, Lou DQ, Ramey G, et al. (2006) Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood 108: 1402-1405.
-
(2006)
Blood
, vol.108
, pp. 1402-1405
-
-
Lesbordes-Brion, J.C.1
Viatte, L.2
Bennoun, M.3
Lou, D.Q.4
Ramey, G.5
-
9
-
-
70349261141
-
Urine proteome analysis in murine nephrotoxic serum nephritis
-
Wenderfer SE, Dubinsky WP, Hernandez-Sanabria M, Braun MC, (2009) Urine proteome analysis in murine nephrotoxic serum nephritis. Am J Nephrol 30: 450-458.
-
(2009)
Am J Nephrol
, vol.30
, pp. 450-458
-
-
Wenderfer, S.E.1
Dubinsky, W.P.2
Hernandez-Sanabria, M.3
Braun, M.C.4
-
10
-
-
33745041499
-
Defending the epithelium
-
Zasloff M, (2006) Defending the epithelium. Nat Med 12: 607-608.
-
(2006)
Nat Med
, vol.12
, pp. 607-608
-
-
Zasloff, M.1
-
11
-
-
69949128102
-
Hepcidin revisited, disulfide connectivity, dynamics, and structure
-
Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, et al. (2009) Hepcidin revisited, disulfide connectivity, dynamics, and structure. J Biol Chem 284: 24155-24167.
-
(2009)
J Biol Chem
, vol.284
, pp. 24155-24167
-
-
Jordan, J.B.1
Poppe, L.2
Haniu, M.3
Arvedson, T.4
Syed, R.5
-
12
-
-
34147197662
-
Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications
-
Kemna EH, Tjalsma H, Podust VN, Swinkels DW, (2007) Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 53: 620-628.
-
(2007)
Clin Chem
, vol.53
, pp. 620-628
-
-
Kemna, E.H.1
Tjalsma, H.2
Podust, V.N.3
Swinkels, D.W.4
-
13
-
-
50549094991
-
Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry
-
Swinkels DW, Girelli D, Laarakkers C, Kroot J, Campostrini N, et al. (2008) Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry. PLoS ONE 3: e2706.
-
(2008)
PLoS ONE
, vol.3
-
-
Swinkels, D.W.1
Girelli, D.2
Laarakkers, C.3
Kroot, J.4
Campostrini, N.5
-
14
-
-
10744226568
-
Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice
-
Courselaud B, Troadec MB, Fruchon S, Ilyin G, Borot N, et al. (2004) Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis 32: 283-289.
-
(2004)
Blood Cells Mol Dis
, vol.32
, pp. 283-289
-
-
Courselaud, B.1
Troadec, M.B.2
Fruchon, S.3
Ilyin, G.4
Borot, N.5
-
15
-
-
23944502314
-
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
-
Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D, (2005) Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 106: 1864-6.
-
(2005)
Blood
, vol.106
, pp. 1864-1866
-
-
Kemna, E.1
Pickkers, P.2
Nemeth, E.3
van der Hoeven, H.4
Swinkels, D.5
-
16
-
-
14844291392
-
The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney
-
Kulaksiz H, Theilig F, Bachmann S, Gehrke SG, Rost D, et al. (2005) The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. J Endocrinol 184: 361-370.
-
(2005)
J Endocrinol
, vol.184
, pp. 361-370
-
-
Kulaksiz, H.1
Theilig, F.2
Bachmann, S.3
Gehrke, S.G.4
Rost, D.5
-
17
-
-
50849124744
-
Biomarkers of lupus nephritis determined by serial urine proteomics
-
Zhang X, Jin M, Wu H, Nadasdy T, Nadasdy G, et al. (2008) Biomarkers of lupus nephritis determined by serial urine proteomics. Kidney Int 74: 799-807.
-
(2008)
Kidney Int
, vol.74
, pp. 799-807
-
-
Zhang, X.1
Jin, M.2
Wu, H.3
Nadasdy, T.4
Nadasdy, G.5
-
18
-
-
51649096725
-
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
-
Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, et al. (2008) Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112: 1503-1509.
-
(2008)
Blood
, vol.112
, pp. 1503-1509
-
-
Kautz, L.1
Meynard, D.2
Monnier, A.3
Darnaud, V.4
Bouvet, R.5
-
19
-
-
63449122819
-
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
-
Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet 41: 478-481.
-
(2009)
Nat Genet
, vol.41
, pp. 478-481
-
-
Meynard, D.1
Kautz, L.2
Darnaud, V.3
Canonne-Hergaux, F.4
Coppin, H.5
-
20
-
-
63449103712
-
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
-
Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, et al. (2009) BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet 41: 482-487.
-
(2009)
Nat Genet
, vol.41
, pp. 482-487
-
-
Andriopoulos Jr., B.1
Corradini, E.2
Xia, Y.3
Faasse, S.A.4
Chen, S.5
-
21
-
-
34247366783
-
Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
-
Roy CN, Mak HH, Akpan I, Losyev G, Zurakowski D, et al. (2007) Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood 109: 4038-4044.
-
(2007)
Blood
, vol.109
, pp. 4038-4044
-
-
Roy, C.N.1
Mak, H.H.2
Akpan, I.3
Losyev, G.4
Zurakowski, D.5
-
22
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, et al. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 98: 8780-8785.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8780-8785
-
-
Nicolas, G.1
Bennoun, M.2
Devaux, I.3
Beaumont, C.4
Grandchamp, B.5
-
23
-
-
0038312385
-
Decreased liver hepcidin expression in the Hfe knockout mouse
-
Ahmad KA, Ahmann JR, Migas MC, Waheed A, Britton RS, et al. (2002) Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol Dis 29: 361-366.
-
(2002)
Blood Cells Mol Dis
, vol.29
, pp. 361-366
-
-
Ahmad, K.A.1
Ahmann, J.R.2
Migas, M.C.3
Waheed, A.4
Britton, R.S.5
-
24
-
-
0037460697
-
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
-
Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, et al. (2003) Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 361: 669-673.
-
(2003)
Lancet
, vol.361
, pp. 669-673
-
-
Bridle, K.R.1
Frazer, D.M.2
Wilkins, S.J.3
Dixon, J.L.4
Purdie, D.M.5
-
25
-
-
13544250486
-
Hepcidin is decreased in TFR2 hemochromatosis
-
Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C, (2005) Hepcidin is decreased in TFR2 hemochromatosis. Blood 105: 1803-1806.
-
(2005)
Blood
, vol.105
, pp. 1803-1806
-
-
Nemeth, E.1
Roetto, A.2
Garozzo, G.3
Ganz, T.4
Camaschella, C.5
-
26
-
-
50049109451
-
Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels
-
van Dijk BA, Laarakkers CM, Klaver SM, Jacobs EM, van Tits LJ, et al. (2008) Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels. Br J Haematol 142: 979-985.
-
(2008)
Br J Haematol
, vol.142
, pp. 979-985
-
-
van Dijk, B.A.1
Laarakkers, C.M.2
Klaver, S.M.3
Jacobs, E.M.4
van Tits, L.J.5
-
27
-
-
73149083742
-
Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
-
Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, et al. (2009) Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology 50: 1992-2000.
-
(2009)
Hepatology
, vol.50
, pp. 1992-2000
-
-
Wallace, D.F.1
Summerville, L.2
Crampton, E.M.3
Frazer, D.M.4
Anderson, G.J.5
-
28
-
-
33646899011
-
Hereditary hemochromatosis: genetic complexity and new diagnostic approaches
-
Swinkels DW, Janssen MC, Bergmans J, Marx JJ, (2006) Hereditary hemochromatosis: genetic complexity and new diagnostic approaches. Clin Chem 52: 950-968.
-
(2006)
Clin Chem
, vol.52
, pp. 950-968
-
-
Swinkels, D.W.1
Janssen, M.C.2
Bergmans, J.3
Marx, J.J.4
-
29
-
-
2542560427
-
Hereditary hemochromatosis-a new look at an old disease
-
Pietrangelo A, (2004) Hereditary hemochromatosis-a new look at an old disease. N Engl J Med 350: 2383-2397.
-
(2004)
N Engl J Med
, vol.350
, pp. 2383-2397
-
-
Pietrangelo, A.1
-
30
-
-
14944345916
-
Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes
-
Pietrangelo A, Caleffi A, Henrion J, Ferrara F, Corradini E, et al. (2005) Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes. Gastroenterology 128: 470-479.
-
(2005)
Gastroenterology
, vol.128
, pp. 470-479
-
-
Pietrangelo, A.1
Caleffi, A.2
Henrion, J.3
Ferrara, F.4
Corradini, E.5
-
31
-
-
48149090865
-
The hepcidin-binding site on ferroportin is evolutionarily conserved
-
De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, et al. (2008) The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab 8: 146-156.
-
(2008)
Cell Metab
, vol.8
, pp. 146-156
-
-
de Domenico, I.1
Nemeth, E.2
Nelson, J.M.3
Phillips, J.D.4
Ajioka, R.S.5
-
32
-
-
74049162507
-
Hepcidin is elevated in mice injected with Mycoplasma arthritidis
-
Koening CL, Mu HH, Van SA, Lo E, Ward DM, et al. (2009) Hepcidin is elevated in mice injected with Mycoplasma arthritidis. J Inflamm 6: 33.
-
(2009)
J Inflamm
, vol.6
, pp. 33
-
-
Koening, C.L.1
Mu, H.H.2
Van, S.A.3
Lo, E.4
Ward, D.M.5
-
33
-
-
0029353515
-
Dissociation between tissue iron concentrations and transferrin saturation among inbred mouse strains
-
LeBoeuf RC, Tolson D, Heinecke JW, (1995) Dissociation between tissue iron concentrations and transferrin saturation among inbred mouse strains. J Lab Clin Med 126: 128-136.
-
(1995)
J Lab Clin Med
, vol.126
, pp. 128-136
-
-
LeBoeuf, R.C.1
Tolson, D.2
Heinecke, J.W.3
-
34
-
-
0036581160
-
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
-
Pfaffl MW, Horgan GW, Dempfle L, (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36.
-
(2002)
Nucleic Acids Res
, vol.30
-
-
Pfaffl, M.W.1
Horgan, G.W.2
Dempfle, L.3
-
35
-
-
0036678091
-
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
-
Fleming RE, Ahmann JR, Migas MC, Waheed A, Koeffler HP, et al. (2002) Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci USA 99: 10653-10658.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10653-10658
-
-
Fleming, R.E.1
Ahmann, J.R.2
Migas, M.C.3
Waheed, A.4
Koeffler, H.P.5
-
36
-
-
41349106987
-
Autocrine formation of hepcidin induces iron retention in human monocytes
-
Theurl I, Theurl M, Seifert M, Mair S, Nairz M, et al. (2008) Autocrine formation of hepcidin induces iron retention in human monocytes. Blood 111: 2392-2399.
-
(2008)
Blood
, vol.111
, pp. 2392-2399
-
-
Theurl, I.1
Theurl, M.2
Seifert, M.3
Mair, S.4
Nairz, M.5
|