High plasma uric acid concentration: Causes and consequences

Diabetology and Metabolic Syndrome

Volumn 4, Issue 1, 2012, Pages

  De Oliveira, Erick Prado ^a   Burini, Roberto Carlos ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Diet; Metabolic syndrome; Protection; Risk; Uric acid

Indexed keywords

FRUCTOSE; TRIACYLGLYCEROL; URIC ACID;

ALCOHOL CONSUMPTION; BODY COMPOSITION; BODY MASS; FOOD INTAKE; GOUT; HUMAN; HYPERURICEMIA; METABOLIC SYNDROME X; NEPHROLITHIASIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE;

EID: 84859206189     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-4-12     Document Type: Review

References (85)

1. Hyperuricemia and risk of stroke: a systematic review and meta-analysis. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA, Arthritis Rheum 2009 61 885 892 10.1002/art.24612 19565556
2. Richette P, Bardin T, Gout Lancet 2010 375 318 328
3. Epidemiology of gout. Roddy E, Doherty M, Arthritis Res Ther 2010 12 223 10.1186/ar3199 21205285
4. Uric acid and inflammatory markers. Ruggiero C, Cherubini A, Ble A, Bos AJ, Maggio M, Dixit VD, Lauretani F, Bandinelli S, Senin U, Ferrucci L, Eur Heart J 2006 27 1174 1181 16611671
5. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Chen JH, Chuang SY, Chen HJ, Yeh WT, Pan WH, Arthritis Rheum 2009 61 225 232 10.1002/art.24164 19177541
6. Hochberg MC, Smolen JS, Weinblatt ME, Rheumatology New York: Mosby 3 2003
7. Uric acid: A marker of increased cardiovascular risk. Gagliardi AC, Miname MH, Santos RD, Atherosclerosis 2009 202 11 17 10.1016/j.atherosclerosis. 2008.05.022 18585721
8. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M, Hypertension 2003 41 1183 1190 10.1161/01.HYP.0000069700.62727.C5 12707287 (Pubitemid 36706063)
9. Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nakagawa T, Tuttle KR, Short RA, Johnson RJ, Nat Clin Pract Nephrol 2005 1 80 86 16932373
10. Metabolic Syndrome and dietary components are associated with coronary artery disease risk score in free-living adults: a cross-sectional study. Takahashi MM, de Oliveira EP, de Carvalho AL, Dantas LA, Burini FH, Portero-McLellan KC, Burini RC, Diabetol Metab Syndr 2011 3 7 10.1186/1758-5996-3-7 21554698
11. Renal Transport of Urate in Humans. Roch-Ramel F, Guisan B, News Physiol Sci 1999 14 80 84 11390825
12. Uric acid and evolution. Alvarez-Lario B, Macarron-Vicente J, Rheumatology (Oxford) 2010 49 2010 2015 10.1093/rheumatology/keq204
13. Antioxidant status in patients with uncomplicated insulin-dependent and non-insulin-dependent diabetes mellitus. Maxwell SR, Thomason H, Sandler D, Leguen C, Baxter MA, Thorpe GH, Jones AF, Barnett AH, Eur J Clin Invest 1997 27 484 490 10.1046/j.1365-2362.1997.1390687.x 9229228 (Pubitemid 27288358)
14. Uric acid: the oxidant-antioxidant paradox. Sautin YY, Johnson RJ, Nucleosides Nucleotides Nucleic Acids 2008 27 608 619 10.1080/15257770802138558 18600514 (Pubitemid 351948591)
15. Uric acid nephrolithiasis. Liebman SE, Taylor JG, Bushinsky DA, Curr Rheumatol Rep 2007 9 251 257 10.1007/s11926-007-0040-z 17531180 (Pubitemid 46954785)
16. Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. Terkeltaub R, Bushinsky DA, Becker MA, Arthritis Res Ther 2006 8 Suppl 1 4 10.1186/ar1909 16899108
17. Cardiovascular risk factors and obesity: are baseline levels of blood pressure, glucose, cholesterol and uric acid elevated prior to weight gain? Burack RC, Keller JB, Higgins MW, J Chronic Dis 1985 38 865 872 10.1016/0021-9681(85)90111-0 4044772 (Pubitemid 15241823)
18. Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies. Doehner W, Schoene N, Rauchhaus M, Leyva-Leon F, Pavitt DV, Reaveley DA, Schuler G, Coats AJ, Anker SD, Hambrecht R, Circulation 2002 105 2619 2624 10.1161/01.CIR.0000017502.58595. ED 12045167 (Pubitemid 34596038)
19. Alderman MH: Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. Fang J, Jama 2000 283 2404 2410 10.1001/jama.283.18.2404 10815083 (Pubitemid 30257539)
20. Allopurinol improves endothelial dysfunction in chronic heart failure. Farquharson CA, Butler R, Hill A, Belch JJ, Struthers AD, Circulation 2002 106 221 226 10.1161/01.CIR.0000022140.61460.1D 12105162 (Pubitemid 34761303)
21. Hyperuricemia in childhood primary hypertension. Feig DI, Johnson RJ, Hypertension 2003 42 247 252 10.1161/01.HYP.0000085858.66548.59 12900431 (Pubitemid 37093468)
22. Serum uric acid is a determinant of metabolic syndrome in a population-based study. Onat A, Uyarel H, Hergenc G, Karabulut A, Albayrak S, Sari I, Yazici M, Keles I, Am J Hypertens 2006 19 1055 1062 10.1016/j.amjhyper. 2006.02.014 17027827 (Pubitemid 44485960)
23. Relations of plasma high-sensitivity C-reactive protein to traditional cardiovascular risk factors. Saito M, Ishimitsu T, Minami J, Ono H, Ohrui M, Matsuoka H, Atherosclerosis 2003 167 73 79 10.1016/S0021-9150(02)00380-5 12618270 (Pubitemid 36255637)
24. Renal urate transport. Mount DB, Kwon CY, Zandi-Nejad K, Rheum Dis Clin North Am 2006 32 313 331 vi 10.1016/j.rdc.2006.02.006 16716882 (Pubitemid 43728821)
25. Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese. Shima Y, Teruya K, Ohta H, Life Sci 2006 79 2234 2237 10.1016/j.lfs.2006.07.030 16920156 (Pubitemid 44649204)
26. Could uric acid have a role in acute renal failure? Ejaz AA, Mu W, Kang DH, Roncal C, Sautin YY, Henderson G, Tabah-Fisch I, Keller B, Beaver TM, Nakagawa T, Johnson RJ, Clin J Am Soc Nephrol 2007 2 16 21 17699382
27. Towards the physiological function of uric acid. Becker BF, Free Radic Biol Med 1993 14 615 631 10.1016/0891-5849(93)90143-I 8325534 (Pubitemid 23172569)
28. Purine salvage pathways in myocardium. Manfredi JP, Holmes EW, Annu Rev Physiol 1985 47 691 705 10.1146/annurev.ph.47.030185.003355 2986542 (Pubitemid 15142406)
29. Uric acid production with particular reference to the role of xanthine oxidase and its inhibition. Watts RW, Proc R Soc Med 1966 59 287 292 5937675
30. Molecular physiology of urate transport. Hediger MA, Johnson RJ, Miyazaki H, Endou H, Physiology (Bethesda) 2005 20 125 133 10.1152/physiol.00039.2004 (Pubitemid 40627553)
31. Two independent mutational events in the loss of urate oxidase during hominoid evolution. Wu XW, Muzny DM, Lee CC, Caskey CT, J Mol Evol 1992 34 78 84 10.1007/BF00163854 1556746
32. Dietary factors associated with hyperuricemia in adults. Yu KH, See LC, Huang YC, Yang CH, Sun JH, Semin Arthritis Rheum 2008 37 243 250 10.1016/j.semarthrit.2007.04.007 17570471 (Pubitemid 351146592)
33. The management of gout. Emmerson BT, N Engl J Med 1996 334 445 451 10.1056/NEJM199602153340707 8552148 (Pubitemid 26055845)
34. Milestones in the treatment of gout. Yu T, Yu TF, Am J Med 1974 56 676 685 10.1016/0002-9343(74)90634-2 4604776
35. Cuppari L, Guia de nutrição: nutrição clínica no adulto Barueri: Manole 2 2005 474
36. Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey. Choi HK, Liu S, Curhan G, Arthritis Rheum 2005 52 283 289 10.1002/art.20761 15641075 (Pubitemid 40129260)
37. Champe PC, Harvey RA, Biochemistry Philadelphia: J.B. Lippincott: Lippincotts' illustrated reviews 2 1994 253 255
38. Free sugars and sorbitol in fruits-a complication from the literature. Wrolstad RE, Shallenberger RS, J Assoc Off Anal Chem 1981 64 91 103 7204315
39. Depletion of liver adenosine phosphates and metabolic effects of intravenous infusion of fructose or sorbitol in man and in the rat. Bode JC, Zelder O, Rumpelt HJ, Wittkamp U, Eur J Clin Invest 1973 3 436 441 10.1111/j.1365-2362.1973.tb02211.x 4772339
40. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Lotito SB, Frei B, Free Radic Biol Med 2006 41 1727 1746 10.1016/j.freeradbiomed.2006.04.033 17157175 (Pubitemid 44839139)
41. Metabolic effects of dietary fructose. Hallfrisch J, Faseb J 1990 4 2652 2660 2189777
42. Intermediary metabolism of fructose. Mayes PA, Am J Clin Nutr 1993 58 754S 765S 8213607 (Pubitemid 23319973)
43. A causal role for uric acid in fructose-induced metabolic syndrome. Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, Ouyang X, Feig DI, Block ER, Herrera-Acosta J, et al. Am J Physiol Renal Physiol 2006 290 625 F631 16234313
44. Vitamin C intake and the risk of gout in men: a prospective study. Choi HK, Gao X, Curhan G, Arch Intern Med 2009 169 502 507 10.1001/archinternmed. 2008.606 19273781
45. The effect of ascorbic acid on uric acid excretion with a commentary on the renal handling of ascorbic acid. Berger L, Gerson CD, Yu TF, Am J Med 1977 62 71 76 10.1016/0002-9343(77)90351-5 835593 (Pubitemid 8025540)
46. Ascorbic acid-induced uricosuria. A consequency of megavitamin therapy. Stein HB, Hasan A, Fox IH, Ann Intern Med 1976 84 385 388 1259282
47. Beer drinking and its effect on uric acid. Gibson T, Rodgers AV, Simmonds HA, Toseland P, Br J Rheumatol 1984 23 203 209 10.1093/rheumatology/23.3.203 6743968 (Pubitemid 14089882)
48. Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey. Choi HK, Curhan G, Arthritis Rheum 2007 57 816 821 10.1002/art.22762 17530681 (Pubitemid 46932088)
49. Elevation of serum uric acid as a clue to alcohol abuse. Drum DE, Goldman PA, Jankowski CB, Arch Intern Med 1981 141 477 479 10.1001/archinte.1981. 00340040073020 7212890 (Pubitemid 11155835)
50. The effects of alcoholic beverages on urate metabolism in gout sufferers. Eastmond CJ, Garton M, Robins S, Riddoch S, Br J Rheumatol 1995 34 756 759 10.1093/rheumatology/34.8.756 7551661
51. Ethanol-induced hyperuricemia: evidence for increased urate production by activation of adenine nucleotide turnover. Faller J, Fox IH, N Engl J Med 1982 307 1598 1602 10.1056/NEJM198212233072602 7144847 (Pubitemid 13250418)
52. Purine-rich foods, dairy and protein intake, and the risk of gout in men. Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G, N Engl J Med 2004 350 1093 1103 10.1056/NEJMoa035700 15014182 (Pubitemid 38298989)
53. The influence of dairy products on plasma uric acid in women. Ghadirian P, Shatenstein B, Verdy M, Hamet P, Eur J Epidemiol 1995 11 275 281 10.1007/BF01719431 7493659
54. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arion WJ, Canfield WK, Ramos FC, Schindler PW, Burger HJ, Hemmerle H, Schubert G, Below P, Herling AW, Arch Biochem Biophys 1997 339 315 322 10.1006/abbi.1996.9874 9056264 (Pubitemid 27199976)
55. Fructose, glycemic load, and quantity and quality of carbohydrate in relation to plasma C-peptide concentrations in US women. Wu T, Giovannucci E, Pischon T, Hankinson SE, Ma J, Rifai N, Rimm EB, Am J Clin Nutr 2004 80 1043 1049 15447918
56. Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. Tsunoda S, Kamide K, Minami J, Kawano Y, Am J Hypertens 2002 15 697 701 10.1016/S0895-7061(02)02953-9 12160192 (Pubitemid 34804275)
57. Uric acid and the kidney: urate transport, stone disease and progressive renal failure. Capasso G, Jaeger P, Robertson WG, Unwin RJ, Curr Pharm Des 2005 11 4153 4159 10.2174/138161205774913219 16375737 (Pubitemid 41672465)
58. Relationship between hyperuricemia and metabolic syndrome. Chen LY, Zhu WH, Chen ZW, Dai HL, Ren JJ, Chen JH, Chen LQ, Fang LZ, J Zhejiang Univ Sci B 2007 8 593 598 17657863
59. Uric acid and the development of metabolic syndrome in women and men. Sui X, Church TS, Meriwether RA, Lobelo F, Blair SN, Metabolism 2008 57 845 852 10.1016/j.metabol.2008.01.030 18502269 (Pubitemid 351697915)
60. Analysis of the Relationship of Leptin, High-Sensitivity C-Reactive Protein, Adiponectin, Insulin, and Uric Acid to Metabolic Syndrome in Lean, Overweight, and Obese Young Females. Abdullah AR, Hasan HA, Raigangar VL, Metab Syndr Relat Disord 2009 7 17 22 10.1089/met.2008.0045 19025443
61. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. Facchini F, Chen YD, Hollenbeck CB, Reaven GM, Jama 1991 266 3008 3011 10.1001/jama.1991. 03470210076036 1820474
62. Analysis of the relationship between fasting serum uric acid and the insulin sensitivity index in a population-based sample of 380 young healthy Caucasians. Clausen JO, Borch-Johnsen K, Ibsen H, Pedersen O, Eur J Endocrinol 1998 138 63 69 10.1530/eje.0.1380063 9461318 (Pubitemid 28078811)
63. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. Conen D, Wietlisbach V, Bovet P, Shamlaye C, Riesen W, Paccaud F, Burnier M, BMC Public Health 2004 4 9 10.1186/1471-2458-4-9 15043756
64. Uric acid and hypertension. Schachter M, Curr Pharm Des 2005 11 4139 4143 10.2174/138161205774913246 16375735 (Pubitemid 41672463)
65. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Matsuura F, Yamashita S, Nakamura T, Nishida M, Nozaki S, Funahashi T, Matsuzawa Y, Metabolism 1998 47 929 933 10.1016/S0026-0495(98)90346-8 9711987 (Pubitemid 28364609)
66. Clustering of dyslipidemia, hyperuricemia, diabetes, and hypertension and its association with fasting insulin and central and overall obesity in a general population. Atherosclerosis Risk in Communities Study Investigators. Schmidt MI, Watson RL, Duncan BB, Metcalf P, Brancati FL, Sharrett AR, Davis CE, Heiss G, Metabolism 1996 45 699 706 10.1016/S0026-0495(96)90134-1 8637443 (Pubitemid 26176111)
67. Dietary, anthropometric, and biochemical determinants of plasma high-density lipoprotein-cholesterol in free-living adults. de Oliveira EP, Manda RM, Torezan GA, Corrente JE, Burini RC, Cholesterol 2011 2011 851750 21490775
68. Leptin might be a regulator of serum uric acid concentrations in humans. Bedir A, Topbas M, Tanyeri F, Alvur M, Arik N, Jpn Heart J 2003 44 527 536 10.1536/jhj.44.527 12906034 (Pubitemid 41518990)
69. Serum leptin is associated with serum uric acid concentrations in humans. Fruehwald-Schultes B, Peters A, Kern W, Beyer J, Pfutzner A, Metabolism 1999 48 677 680 10.1016/S0026-0495(99)90163-4 10381138 (Pubitemid 29277635)
70. Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease. Baldus S, Koster R, Chumley P, Heitzer T, Rudolph V, Ostad MA, Warnholtz A, Staude HJ, Thuneke F, Koss K, et al. Free Radic Biol Med 2005 39 1184 1190 10.1016/j.freeradbiomed.2005.06.004 16214034 (Pubitemid 41407712)
71. Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Messerli FH, Frohlich ED, Dreslinski GR, Suarez DH, Aristimuno GG, Ann Intern Med 1980 93 817 821 7447188 (Pubitemid 11197783)
72. Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: Findings from NHANES III. Beavers KM, Beavers DP, Serra MC, Bowden RG, Wilson RL, Journal of Nutrition, Health and Aging 2009 13 177 182 10.1007/s12603-009-0054-5
73. Sarcopenia: alteraçes metabálicas e consequências no envelhecimento. Pierine DT, Nicola M, de Oliveira EP, R bras Ci e Mov 2009 17 96 103
74. Mechanisms of disuse muscle atrophy: role of oxidative stress. Powers SK, Kavazis AN, DeRuisseau KC, Am J Physiol Regul Integr Comp Physiol 2005 288 337 R344 15637170
75. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Kanellis J, Kang DH, Semin Nephrol 2005 25 39 42 10.1016/j.semnephrol.2004.09.007 15660333 (Pubitemid 40128147)
76. Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude. Baillie JK, Bates MG, Thompson AA, Waring WS, Partridge RW, Schnopp MF, Simpson A, Gulliver-Sloan F, Maxwell SR, Webb DJ, Chest 2007 131 1473 1478 10.1378/chest.06-2235 17494796 (Pubitemid 46762355)
77. Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo. Yu ZF, Bruce-Keller AJ, Goodman Y, Mattson MP, J Neurosci Res 1998 53 613 625 10.1002/(SICI)1097-4547(19980901)53:5<613::AID-JNR11>3.0.CO;2-1 9726432 (Pubitemid 28380802)
78. Uric acid and oxidative stress. Glantzounis GK, Tsimoyiannis EC, Kappas AM, Galaris DA, Curr Pharm Des 2005 11 4145 4151 10.2174/138161205774913255 16375736 (Pubitemid 41672464)
79. The effects of vitamin C and urate on the oxidation kinetics of human low-density lipoprotein. Ma YS, Stone WL, LeClair IO, Proc Soc Exp Biol Med 1994 206 53 59 8183962 (Pubitemid 24157468)
80. Antioxidant defenses and lipid peroxidation in human blood plasma. Frei B, Stocker R, Ames BN, Proc Natl Acad Sci USA 1988 85 9748 9752 10.1073/pnas.85.24.9748 3200852 (Pubitemid 19027202)
81. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Hooper DC, Spitsin S, Kean RB, Champion JM, Dickson GM, Chaudhry I, Koprowski H, Proc Natl Acad Sci USA 1998 95 675 680 10.1073/pnas.95.2.675 9435251 (Pubitemid 28083802)
82. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Wayner DD, Burton GW, Ingold KU, Barclay LR, Locke SJ, Biochim Biophys Acta 1987 924 408 419 10.1016/0304-4165(87)90155-3 3593759
83. Altered uric acid levels and disease states. Kutzing MK, Firestein BL, J Pharmacol Exp Ther 2008 324 1 7 17890445 (Pubitemid 350294141)
84. The role of uric acid in protection against peroxynitrite-mediated pathology. Scott GS, Hooper DC, Med Hypotheses 2001 56 95 100 10.1054/mehy.2000.1118 11133262 (Pubitemid 32052828)
85. Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis. Cipriani S, Chen X, Schwarzschild MA, Biomark Med 2010 4 701 712 10.2217/bmm.10.94 20945982