Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Stacey, Kevin B ^a   Breen, Eamon ^a,b   Jefferies, Caroline A ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b CENTENARY INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; INTERFERON REGULATORY FACTOR 3; PHENYLALANINE; PROTEIN TRIM21; REGULATOR PROTEIN; SPROUTY PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TYROSINE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; RIBONUCLEOPROTEIN; SS A ANTIGEN; SS-A ANTIGEN; TLR3 PROTEIN, HUMAN; TLR3 PROTEIN, MOUSE; TLR4 PROTEIN, HUMAN; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; ANIMAL; BIOLOGICAL MODEL; CELL STRAIN HEK293; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MONONUCLEAR CELL; PHOSPHORYLATION; PLASMID; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; REPORTER GENE;

BACTERIA (MICROORGANISMS); MURINAE;

ANIMALS; GENE EXPRESSION REGULATION; GENES, REPORTER; HEK293 CELLS; HUMANS; INTERFERON REGULATORY FACTOR-3; LEUKOCYTES, MONONUCLEAR; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PLASMIDS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOPROTEINS; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TYROSINE;

EID: 84859152282     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034041     Document Type: Article

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