Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface

Journal of Biological Chemistry

Volumn 286, Issue 42, 2011, Pages 36478-36491

  Espinosa, Alexander ^a   Hennig, Janosch ^b   Ambrosi, Aurélie ^a   Anandapadmanaban, Madhanagopal ^b   Abelius, Martina Sandberg ^b   Sheng, Yi ^c,e   Nyberg, Filippa ^d   Arrowsmith, Cheryl H ^c   Sunnerhagen, Maria ^b   Wahren Herlenius, Marie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c UNIVERSITY OF TORONTO   (Canada)

^d DANDERYD HOSPITAL   (Sweden)

^e YORK UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODIES; AUTOIMMUNE DISEASE; E3 LIGASE; FUNCTIONAL INTERACTION; INTERFERON REGULATORY FACTORS; LIMITED PROTEOLYSIS; N-TERMINAL EXTENSION; PROINFLAMMATORY CYTOKINES; TRIPARTITE MOTIFS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION;

CATALYSTS; TRANSCRIPTION FACTORS;

ENZYMES;

AUTOANTIBODY; PROTEIN RO52; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIGEN BINDING; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RING FINGER MOTIF; SJOEGREN SYNDROME; UBIQUITINATION;

AUTOANTIBODIES; CELL LINE; HUMANS; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOPROTEINS; SJOGREN'S SYNDROME; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 80054680999     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.241786     Document Type: Article

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