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Volumn 2, Issue 8, 2011, Pages 805-817

Identification of c-Myb Target Genes in K562 Cells Reveals a Role for c-Myb as a Master Regulator

Author keywords

3C; c Myb; chromosome conformation capture; GATA2; hematopoiesis; IKZF1; LMO2; MYADM; STAT5A; transcription factors

Indexed keywords

SMALL INTERFERING RNA;

EID: 84859146886     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601911428224     Document Type: Article
Times cited : (31)

References (53)
  • 1
    • 31144458874 scopus 로고    scopus 로고
    • c-Myb a stem-progenitor cell regulator in multiple tissue compartments
    • Ramsay RG.c-Myb a stem-progenitor cell regulator in multiple tissue compartments.Growth Factors. 2005;23:253-61.
    • (2005) Growth Factors , vol.23 , pp. 253-261
    • Ramsay, R.G.1
  • 2
    • 45849137069 scopus 로고    scopus 로고
    • MYB function in normal and cancer cells
    • Ramsay RG,Gonda TJ.MYB function in normal and cancer cells.Nat Rev Cancer. 2008;8:523-34.
    • (2008) Nat Rev Cancer , vol.8 , pp. 523-534
    • Ramsay, R.G.1    Gonda, T.J.2
  • 3
    • 50849138482 scopus 로고    scopus 로고
    • Critical roles for c-Myb in hematopoietic progenitor cells
    • Greig KT,Carotta S,Nutt SL.Critical roles for c-Myb in hematopoietic progenitor cells.Semin Immunol. 2008;20:247-56.
    • (2008) Semin Immunol , vol.20 , pp. 247-256
    • Greig, K.T.1    Carotta, S.2    Nutt, S.L.3
  • 4
    • 0025821494 scopus 로고
    • A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
    • Mucenski ML,McLain K,Kier AB, et al.A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis.Cell. 1991;65:677-89.
    • (1991) Cell , vol.65 , pp. 677-689
    • Mucenski, M.L.1    McLain, K.2    Kier, A.B.3
  • 5
    • 0034644259 scopus 로고    scopus 로고
    • Initiation of adult myelopoiesis can occur in the absence of c-Myb whereas subsequent development is strictly dependent on the transcription factor
    • Sumner R,Crawford A,Mucenski M,Frampton J.Initiation of adult myelopoiesis can occur in the absence of c-Myb whereas subsequent development is strictly dependent on the transcription factor.Oncogene. 2000;19:3335-42.
    • (2000) Oncogene , vol.19 , pp. 3335-3342
    • Sumner, R.1    Crawford, A.2    Mucenski, M.3    Frampton, J.4
  • 6
    • 0043239343 scopus 로고    scopus 로고
    • Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb
    • Emambokus N,Vegiopoulos A,Harman B,Jenkinson E,Anderson G,Frampton J.Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.EMBO J. 2003;22:4478-88.
    • (2003) EMBO J , vol.22 , pp. 4478-4488
    • Emambokus, N.1    Vegiopoulos, A.2    Harman, B.3    Jenkinson, E.4    Anderson, G.5    Frampton, J.6
  • 7
    • 33745061675 scopus 로고    scopus 로고
    • Coordination of erythropoiesis by the transcription factor c-Myb
    • Vegiopoulos A,Garcia P,Emambokus N,Frampton J.Coordination of erythropoiesis by the transcription factor c-Myb.Blood. 2006;107:4703-10.
    • (2006) Blood , vol.107 , pp. 4703-4710
    • Vegiopoulos, A.1    Garcia, P.2    Emambokus, N.3    Frampton, J.4
  • 10
    • 3242784226 scopus 로고    scopus 로고
    • Critical functions for c-Myb at three checkpoints during thymocyte development
    • Bender TP,Kremer CS,Kraus M,Buch T,Rajewsky K.Critical functions for c-Myb at three checkpoints during thymocyte development.Nat Immunol. 2004;5:721-9.
    • (2004) Nat Immunol , vol.5 , pp. 721-729
    • Bender, T.P.1    Kremer, C.S.2    Kraus, M.3    Buch, T.4    Rajewsky, K.5
  • 11
    • 0033135877 scopus 로고    scopus 로고
    • c-Myb is essential for early T cell development
    • Allen RD,Bender TP,Siu G.c-Myb is essential for early T cell development.Genes Dev. 1999;13:1073-8.
    • (1999) Genes Dev , vol.13 , pp. 1073-1078
    • Allen, R.D.1    Bender, T.P.2    Siu, G.3
  • 12
    • 0033551375 scopus 로고    scopus 로고
    • Myb binding proteins: regulators and cohorts in transformation
    • Ness SA.Myb binding proteins: regulators and cohorts in transformation.Oncogene. 1999;18:3039-46.
    • (1999) Oncogene , vol.18 , pp. 3039-3046
    • Ness, S.A.1
  • 13
    • 49149102326 scopus 로고    scopus 로고
    • FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci
    • Alm-Kristiansen AH,Saether T,Matre V,Gilfillan S,Dahle O,Gabrielsen OS.FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci.Oncogene. 2008;27:4644-56.
    • (2008) Oncogene , vol.27 , pp. 4644-4656
    • Alm-Kristiansen, A.H.1    Saether, T.2    Matre, V.3    Gilfillan, S.4    Dahle, O.5    Gabrielsen, O.S.6
  • 15
    • 34347233098 scopus 로고    scopus 로고
    • The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb
    • Saether T,Berge T,Ledsaak M, et al.The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb.J Biol Chem. 2007;282:13994-4005.
    • (2007) J Biol Chem , vol.282 , pp. 13994-14005
    • Saether, T.1    Berge, T.2    Ledsaak, M.3
  • 16
    • 79951696298 scopus 로고    scopus 로고
    • PIAS1 interacts with FLASH and enhances its co-activation of c-Myb
    • Alm-Kristiansen AH,Lorenzo PI,Molvaersmyr AK, et al.PIAS1 interacts with FLASH and enhances its co-activation of c-Myb.Mol Cancer. 2011;10:21.
    • (2011) Mol Cancer , vol.10 , pp. 21
    • Alm-Kristiansen, A.H.1    Lorenzo, P.I.2    Molvaersmyr, A.K.3
  • 18
    • 77956117262 scopus 로고    scopus 로고
    • A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment
    • Molvaersmyr AK,Saether T,Gilfillan S, et al.A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment.Nucleic Acids Res. 2010;38:4970-84.
    • (2010) Nucleic Acids Res , vol.38 , pp. 4970-4984
    • Molvaersmyr, A.K.1    Saether, T.2    Gilfillan, S.3
  • 19
    • 0037423368 scopus 로고    scopus 로고
    • Phosphorylation-dependent down-regulation of c-Myb DNA binding is abrogated by a point mutation in the v-myb oncogene
    • Andersson KB,Kowenz-Leutz E,Brendeford EM,Tygsett AH,Leutz A,Gabrielsen OS.Phosphorylation-dependent down-regulation of c-Myb DNA binding is abrogated by a point mutation in the v-myb oncogene.J Biol Chem. 2003;278:3816-24.
    • (2003) J Biol Chem , vol.278 , pp. 3816-3824
    • Andersson, K.B.1    Kowenz-Leutz, E.2    Brendeford, E.M.3    Tygsett, A.H.4    Leutz, A.5    Gabrielsen, O.S.6
  • 20
    • 0037351924 scopus 로고    scopus 로고
    • Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner
    • Dahle O,Andersen TO,Nordgard O,Matre V,Del Sal G,Gabrielsen OS.Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.Eur J Biochem. 2003;270:1338-48.
    • (2003) Eur J Biochem , vol.270 , pp. 1338-1348
    • Dahle, O.1    Andersen, T.O.2    Nordgard, O.3    Matre, V.4    Del Sal, G.5    Gabrielsen, O.S.6
  • 21
    • 34547941361 scopus 로고    scopus 로고
    • MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    • Xiao C,Calado DP,Galler G, et al.MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb.Cell. 2007;131:146-59.
    • (2007) Cell , vol.131 , pp. 146-159
    • Xiao, C.1    Calado, D.P.2    Galler, G.3
  • 22
    • 60249101120 scopus 로고    scopus 로고
    • The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells
    • Zhao H,Kalota A,Jin S,Gewirtz AM.The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells.Blood. 2009;113:505-16.
    • (2009) Blood , vol.113 , pp. 505-516
    • Zhao, H.1    Kalota, A.2    Jin, S.3    Gewirtz, A.M.4
  • 23
    • 65149083962 scopus 로고    scopus 로고
    • The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
    • Suzuki H,Forrest AR,van Nimwegen E, et al.The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.Nat Genet. 2009;41:553-62.
    • (2009) Nat Genet , vol.41 , pp. 553-562
    • Suzuki, H.1    Forrest, A.R.2    van Nimwegen, E.3
  • 24
    • 78649452404 scopus 로고    scopus 로고
    • c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression
    • Bianchi E,Zini R,Salati S, et al.c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression.Blood. 2010;116:e99-110.
    • (2010) Blood , vol.116 , pp. 99-110
    • Bianchi, E.1    Zini, R.2    Salati, S.3
  • 25
    • 78751646290 scopus 로고    scopus 로고
    • Identification and regulation of c-Myb target genes in MCF-7 cells
    • Quintana AM,Liu F,O'Rourke JP,Ness SA.Identification and regulation of c-Myb target genes in MCF-7 cells.BMC Cancer. 2011;11:30.
    • (2011) BMC Cancer , vol.11 , pp. 30
    • Quintana, A.M.1    Liu, F.2    O'Rourke, J.P.3    Ness, S.A.4
  • 26
    • 79959473094 scopus 로고    scopus 로고
    • Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb
    • Zhao L,Glazov EA,Pattabiraman DR, et al.Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb.Nucleic Acids Res. 2011;39:4664-79.
    • (2011) Nucleic Acids Res , vol.39 , pp. 4664-4679
    • Zhao, L.1    Glazov, E.A.2    Pattabiraman, D.R.3
  • 27
    • 0344255770 scopus 로고    scopus 로고
    • Mechanisms involved in the induced differentiation of leukemia cells
    • Tsiftsoglou AS,Pappas IS,Vizirianakis IS.Mechanisms involved in the induced differentiation of leukemia cells.Pharmacol Ther. 2003;100:257-90.
    • (2003) Pharmacol Ther , vol.100 , pp. 257-290
    • Tsiftsoglou, A.S.1    Pappas, I.S.2    Vizirianakis, I.S.3
  • 28
    • 33646137140 scopus 로고    scopus 로고
    • cAMP differentially regulates gamma-globin gene expression in erythroleukemic cells and primary erythroblasts through c-Myb expression
    • Kuroyanagi Y,Kaneko Y,Muta K, et al.cAMP differentially regulates gamma-globin gene expression in erythroleukemic cells and primary erythroblasts through c-Myb expression.Biochem Biophys Res Commun. 2006;344:1038-47.
    • (2006) Biochem Biophys Res Commun , vol.344 , pp. 1038-1047
    • Kuroyanagi, Y.1    Kaneko, Y.2    Muta, K.3
  • 29
    • 58149521944 scopus 로고    scopus 로고
    • Highly parallel identification of essential genes in cancer cells
    • Luo B,Cheung HW,Subramanian A, et al.Highly parallel identification of essential genes in cancer cells.Proc Natl Acad Sci U S A. 2008;105:20380-5.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 20380-20385
    • Luo, B.1    Cheung, H.W.2    Subramanian, A.3
  • 30
    • 0037685280 scopus 로고    scopus 로고
    • Expression profiling reveals off-target gene regulation by RNAi
    • Jackson AL,Bartz SR,Schelter J, et al.Expression profiling reveals off-target gene regulation by RNAi.Nat Biotechnol. 2003;21:635-7.
    • (2003) Nat Biotechnol , vol.21 , pp. 635-637
    • Jackson, A.L.1    Bartz, S.R.2    Schelter, J.3
  • 31
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
    • Jackson AL,Burchard J,Schelter J, et al.Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.RNA. 2006;12:1179-87.
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3
  • 32
    • 33646188259 scopus 로고    scopus 로고
    • 3' UTR seed matches, but not overall identity, are associated with RNAi off-targets
    • Birmingham A,Anderson EM,Reynolds A, et al.3' UTR seed matches, but not overall identity, are associated with RNAi off-targets.Nat Methods. 2006;3:199-204.
    • (2006) Nat Methods , vol.3 , pp. 199-204
    • Birmingham, A.1    Anderson, E.M.2    Reynolds, A.3
  • 33
    • 33745608078 scopus 로고    scopus 로고
    • Off-target effects by siRNA can induce toxic phenotype
    • Fedorov Y,Anderson EM,Birmingham A, et al.Off-target effects by siRNA can induce toxic phenotype.RNA. 2006;12:1188-96.
    • (2006) RNA , vol.12 , pp. 1188-1196
    • Fedorov, Y.1    Anderson, E.M.2    Birmingham, A.3
  • 34
    • 66349084170 scopus 로고    scopus 로고
    • Regulation of LMO2 mRNA and protein expression in erythroid differentiation
    • Brandt SJ,Koury MJ.Regulation of LMO2 mRNA and protein expression in erythroid differentiation.Haematologica. 2009;94:447-8.
    • (2009) Haematologica , vol.94 , pp. 447-448
    • Brandt, S.J.1    Koury, M.J.2
  • 35
    • 33845735501 scopus 로고    scopus 로고
    • Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells
    • Wang Q,Li N,Wang X, et al.Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells.Life Sci. 2007;80:420-9.
    • (2007) Life Sci , vol.80 , pp. 420-429
    • Wang, Q.1    Li, N.2    Wang, X.3
  • 36
    • 19944367565 scopus 로고    scopus 로고
    • An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division
    • Kittler R,Putz G,Pelletier L, et al.An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division.Nature. 2004;432:1036-40.
    • (2004) Nature , vol.432 , pp. 1036-1040
    • Kittler, R.1    Putz, G.2    Pelletier, L.3
  • 38
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • Birney E,Stamatoyannopoulos JA,Dutta A, et al.Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.Nature. 2007;447:799-816.
    • (2007) Nature , vol.447 , pp. 799-816
    • Birney, E.1    Stamatoyannopoulos, J.A.2    Dutta, A.3
  • 39
    • 73349090560 scopus 로고    scopus 로고
    • Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
    • Schoenfelder S,Sexton T,Chakalova L, et al.Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells.Nat Genet. 2010;42:53-61.
    • (2010) Nat Genet , vol.42 , pp. 53-61
    • Schoenfelder, S.1    Sexton, T.2    Chakalova, L.3
  • 40
    • 1342289322 scopus 로고    scopus 로고
    • Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency
    • McCormack MP,Rabbitts TH.Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency.N Engl J Med. 2004;350:913-22.
    • (2004) N Engl J Med , vol.350 , pp. 913-922
    • McCormack, M.P.1    Rabbitts, T.H.2
  • 41
    • 76749097260 scopus 로고    scopus 로고
    • The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal
    • McCormack MP,Young LF,Vasudevan S, et al.The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.Science. 2010;327:879-83.
    • (2010) Science , vol.327 , pp. 879-883
    • McCormack, M.P.1    Young, L.F.2    Vasudevan, S.3
  • 42
    • 0033812432 scopus 로고    scopus 로고
    • Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation
    • Pettersson M,Dannaeus K,Nilsson K,Jonsson JI.Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation.J Leukoc Biol. 2000;67:423-31.
    • (2000) J Leukoc Biol , vol.67 , pp. 423-431
    • Pettersson, M.1    Dannaeus, K.2    Nilsson, K.3    Jonsson, J.I.4
  • 43
    • 0036095183 scopus 로고    scopus 로고
    • Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid
    • Cui W,Yu L,He H, et al.Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid.Mol Biol Rep. 2002;28:123-38.
    • (2002) Mol Biol Rep , vol.28 , pp. 123-138
    • Cui, W.1    Yu, L.2    He, H.3
  • 44
    • 0034644130 scopus 로고    scopus 로고
    • In vitro differentiation of c-myb(-/-) ES cells reveals that the colony forming capacity of unilineage macrophage precursors and myeloid progenitor commitment are c-Myb independent
    • Clarke D,Vegiopoulos A,Crawford A,Mucenski M,Bonifer C,Frampton J.In vitro differentiation of c-myb(-/-) ES cells reveals that the colony forming capacity of unilineage macrophage precursors and myeloid progenitor commitment are c-Myb independent.Oncogene. 2000;19:3343-51.
    • (2000) Oncogene , vol.19 , pp. 3343-3351
    • Clarke, D.1    Vegiopoulos, A.2    Crawford, A.3    Mucenski, M.4    Bonifer, C.5    Frampton, J.6
  • 45
    • 58149399353 scopus 로고    scopus 로고
    • GATA-2 regulates granulocyte-macrophage progenitor cell function
    • Rodrigues NP,Boyd AS,Fugazza C, et al.GATA-2 regulates granulocyte-macrophage progenitor cell function.Blood. 2008;112:4862-73.
    • (2008) Blood , vol.112 , pp. 4862-4873
    • Rodrigues, N.P.1    Boyd, A.S.2    Fugazza, C.3
  • 46
    • 54049102271 scopus 로고    scopus 로고
    • Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34+ cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis
    • Olthof SG,Fatrai S,Drayer AL,Tyl MR,Vellenga E,Schuringa JJ.Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34+ cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis.Stem Cells. 2008;26:1732-42.
    • (2008) Stem Cells , vol.26 , pp. 1732-1742
    • Olthof, S.G.1    Fatrai, S.2    Drayer, A.L.3    Tyl, M.R.4    Vellenga, E.5    Schuringa, J.J.6
  • 48
    • 77953255983 scopus 로고    scopus 로고
    • A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
    • Lefebvre C,Rajbhandari P,Alvarez MJ, et al.A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers.Mol Syst Biol. 2010;6:377.
    • (2010) Mol Syst Biol , vol.6 , pp. 377
    • Lefebvre, C.1    Rajbhandari, P.2    Alvarez, M.J.3
  • 49
    • 13444269762 scopus 로고    scopus 로고
    • An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas
    • Roepman P,Wessels LF,Kettelarij N, et al.An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas.Nat Genet. 2005;37:182-6.
    • (2005) Nat Genet , vol.37 , pp. 182-186
    • Roepman, P.1    Wessels, L.F.2    Kettelarij, N.3
  • 50
    • 23744490065 scopus 로고    scopus 로고
    • Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets
    • van de,Peppel J,Kettelarij N,van Bakel H,Kockelkorn TT,van Leenen D,Holstege FC.Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.Mol Cell. 2005;19:511-22.
    • (2005) Mol Cell , vol.19 , pp. 511-522
    • van de Peppel, J.1    Kettelarij, N.2    van Bakel, H.3    Kockelkorn, T.T.4    van Leenen, D.5    Holstege, F.C.6
  • 52
    • 0036376993 scopus 로고    scopus 로고
    • Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments
    • Dudoit S,Yang YH,Callow MJ,Speed TP.Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments.Stat Sin. 2002;12:111-39.
    • (2002) Stat Sin , vol.12 , pp. 111-139
    • Dudoit, S.1    Yang, Y.H.2    Callow, M.J.3    Speed, T.P.4
  • 53
    • 0029781614 scopus 로고    scopus 로고
    • Flexibility in the second half-site sequence recognised by the c-Myb R2 domain: in vitro and in vivo analysis
    • Ording E,Bergholtz S,Brendeford EM,Jamin N,Gabrielsen OS.Flexibility in the second half-site sequence recognised by the c-Myb R2 domain: in vitro and in vivo analysis.Oncogene. 1996;13:1043-51.
    • (1996) Oncogene , vol.13 , pp. 1043-1051
    • Ording, E.1    Bergholtz, S.2    Brendeford, E.M.3    Jamin, N.4    Gabrielsen, O.S.5


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