Critical roles for c-Myb in hematopoietic progenitor cells

Seminars in Immunology

Volumn 20, Issue 4, 2008, Pages 247-256

  Greig, Kylie T ^a,b   Carotta, Sebastian ^a   Nutt, Stephen L ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

c Myb; Differentiation; Hematopoiesis; p300; Transcription factor

Indexed keywords

B LYMPHOCYTE RECEPTOR; ERYTHROPOIETIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN C MYB; PROTEIN KINASE PIM 1; STEM CELL FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR PAX5; WNT PROTEIN;

B LYMPHOCYTE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL POPULATION; CELL PROLIFERATION; CELL TYPE; CONSENSUS SEQUENCE; DNA REPLICATION; ERYTHROID CELL; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GENOME; GRANULOCYTE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; LYMPHOPOIESIS; MACROPHAGE; MEGAKARYOCYTE; MULTIPOTENT STEM CELL; NONHUMAN; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SUMOYLATION; T LYMPHOCYTE; UBIQUITINATION;

ANIMALS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MODELS, BIOLOGICAL; PROTO-ONCOGENE PROTEINS C-MYB;

EID: 50849138482     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2008.05.003     Document Type: Review

References (108)

1. Wolff L. Myb-induced transformation. Crit Rev Oncog 7 (1996) 245-260
2. Oh I.H., and Reddy E.P. The myb gene family in cell growth, differentiation and apoptosis. Oncogene 18 (1999) 3017-3033
3. Mucenski M.L., McLain K., Kier A.B., Swerdlow S.H., Schreiner C.M., Miller T.A., et al. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65 (1991) 677-689
4. Ramsay R.G. c-Myb a stem-progenitor cell regulator in multiple tissue compartments. Growth Factors 23 (2005) 253-261
5. Weston K., and Bishop J.M. Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Cell 58 (1989) 85-93
6. Nomura T., Sakai N., Sarai A., Sudo T., Kanei-Ishii C., Ramsay R.G., et al. Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper. J Biol Chem 268 (1993) 21914-21923
7. Shen-Ong G.L. Alternative internal splicing in c-myb RNAs occurs commonly in normal and tumor cells. EMBO J 6 (1987) 4035-4039
8. Woo C.H., Sopchak L., and Lipsick J.S. Overexpression of an alternatively spliced form of c-Myb results in increases in transactivation and transforms avian myelomonoblasts. J Virol 72 (1998) 6813-6821
9. Weston K. Extension of the DNA binding consensus of the chicken c-Myb and v-Myb proteins. Nucleic Acids Res 20 (1992) 3043-3049
10. Dai P., Akimaru H., Tanaka Y., Hou D.X., Yasukawa T., Kanei-Ishii C., et al. CBP as a transcriptional coactivator of c-Myb. Genes Dev 10 (1996) 528-540
11. Oelgeschlager M., Janknecht R., Krieg J., Schreek S., and Luscher B. Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M. EMBO J 15 (1996) 2771-2780
12. Ogryzko V.V., Schiltz R.L., Russanova V., Howard B.H., and Nakatani Y. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87 (1996) 953-959
13. Mo X., Kowenz-Leutz E., Laumonnier Y., Xu H., and Leutz A. Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain. Genes Dev 19 (2005) 2447-2457
14. Tomita A., Towatari M., Tsuzuki S., Hayakawa F., Kosugi H., Tamai K., et al. c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300. Oncogene 19 (2000) 444-451
15. Sano Y., and Ishii S. Increased affinity of c-Myb for CREB-binding protein (CBP) after CBP-induced acetylation. J Biol Chem 276 (2001) 3674-3682
16. Nomura T., Tanikawa J., Akimaru H., Kanei-Ishii C., Ichikawa-Iwata E., Khan M.M., et al. Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski. J Biol Chem 279 (2004) 16715-16726
17. Gonda T.J., and Metcalf D. Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia. Nature 310 (1984) 249-251
18. Westin E.H., Gallo R.C., Arya S.K., Eva A., Souza L.M., Baluda M.A., et al. Differential expression of the amv gene in human hematopoietic cells. Proc Natl Acad Sci USA 79 (1982) 2194-2198
19. Yanagisawa H., Nagasawa T., Kuramochi S., Abe T., Ikawa Y., and Todokoro K. Constitutive expression of exogenous c-myb gene causes maturation block in monocyte-macrophage differentiation. Biochim Biophys Acta 1088 (1991) 380-384
20. Clarke M.F., Kukowska-Latallo J.F., Westin E., Smith M., and Prochownik E.V. Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol 8 (1988) 884-892
21. Golay J., Capucci A., Arsura M., Castellano M., Rizzo V., and Introna M. Expression of c-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells. Blood 77 (1991) 149-158
22. Toth C.R., Hostutler R.F., Baldwin Jr. A.S., and Bender T.P. Members of the nuclear factor kappa B family transactivate the murine c-myb gene. J Biol Chem 270 (1995) 7661-7671
23. McCann S., Sullivan J., Guerra J., Arcinas M., and Boxer L.M. Repression of the c-myb gene by WT1 protein in T and B cell lines. J Biol Chem 270 (1995) 23785-23789
24. Sullivan J., Feeley B., Guerra J., and Boxer L.M. Identification of the major positive regulators of c-myb expression in hematopoietic cells of different lineages. J Biol Chem 272 (1997) 1943-1949
25. Bender T.P., Thompson C.B., and Kuehl W.M. Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science 237 (1987) 1473-1476
26. Xiao C., Calado D.P., Galler G., Thai T.H., Patterson H.C., Wang J., et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 131 (2007) 146-159
27. Aziz N., Miglarese M.R., Hendrickson R.C., Shabanowitz J., Sturgill T.W., Hunt D.F., et al. Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain. Proc Natl Acad Sci USA 92 (1995) 6429-6433
28. Bies J., and Wolff L. Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway. Oncogene 14 (1997) 203-212
29. Bies J., Markus J., and Wolff L. Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity. J Biol Chem 277 (2002) 8999-9009
30. Sramko M., Markus J., Kabat J., Wolff L., and Bies J. Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins. J Biol Chem 281 (2006) 40065-40075
31. Luscher B., Christenson E., Litchfield D.W., Krebs E.G., and Eisenman R.N. Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation. Nature 344 (1990) 517-522
32. Kanei-Ishii C., Ninomiya-Tsuji J., Tanikawa J., Nomura T., Ishitani T., Kishida S., et al. Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev 18 (2004) 816-829
33. Leverson J.D., Koskinen P.J., Orrico F.C., Rainio E.M., Jalkanen K.J., Dash A.B., et al. Pim-1 kinase and p100 cooperate to enhance c-Myb activity. Mol Cell 2 (1998) 417-425
34. Winn L.M., Lei W., and Ness S.A. Pim-1 phosphorylates the DNA binding domain of c-Myb. Cell Cycle 2 (2003) 258-262
35. Ness S.A. Myb binding proteins: regulators and cohorts in transformation. Oncogene 18 (1999) 3039-3046
36. Luscher B., and Eisenman R.N. c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock. Mol Cell Biol 8 (1988) 2504-2512
37. Bender T.P., Kremer C.S., Kraus M., Buch T., and Rajewsky K. Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol 5 (2004) 721-729
38. Emambokus N., Vegiopoulos A., Harman B., Jenkinson E., Anderson G., and Frampton J. Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J 22 (2003) 4478-4488
39. Hooper J., Maurice D., Argent-Katwala M.J., and Weston K. Myb proteins regulate expression of histone variant H2A.Z during thymocyte development. Immunology (2007)
40. Lieu Y.K., Kumar A., Pajerowski A.G., Rogers T.J., and Reddy E.P. Requirement of c-myb in T cell development and in mature T cell function. Proc Natl Acad Sci USA 101 (2004) 14853-14858
41. Maurice D., Hooper J., Lang G., and Weston K. c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J 26 (2007) 3629-3640
42. Thomas M.D., Kremer C.S., Ravichandran K.S., Rajewsky K., and Bender T.P. c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity 23 (2005) 275-286
43. Badiani P., Corbella P., Kioussis D., Marvel J., and Weston K. Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev 8 (1994) 770-782
44. Carpinelli M.R., Hilton D.J., Metcalf D., Antonchuk J.L., Hyland C.D., Mifsud S.L., et al. Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signalling. Proc Natl Acad Sci USA 101 (2004) 6553-6558
45. Sandberg M.L., Sutton S.E., Pletcher M.T., Wiltshire T., Tarantino L.M., Hogenesch J.B., et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell 8 (2005) 153-166
46. Kasper L.H., Boussouar F., Ney P.A., Jackson C.W., Rehg J., van Deursen J.M., et al. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419 (2002) 738-743
47. Sumner R., Crawford A., Mucenski M., and Frampton J. Initiation of adult myelopoiesis can occur in the absence of c-Myb whereas subsequent development is strictly dependent on the transcription factor. Oncogene 19 (2000) 3335-3342
48. Clarke D., Vegiopoulos A., Crawford A., Mucenski M., Bonifer C., and Frampton J. In vitro differentiation of c-myb(-/-) ES cells reveals that the colony forming capacity of unilineage macrophage precursors and myeloid progenitor commitment are c-Myb independent. Oncogene 19 (2000) 3343-3351
49. Allen III R.D., Bender T.P., and Siu G. c-Myb is essential for early T cell development. Genes Dev 13 (1999) 1073-1078
50. Vandenbark G.R., Chen Y., Friday E., Pavlik K., Anthony B., deCastro C., et al. Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements. Cell Growth Differ 7 (1996) 1383-1392
51. Metcalf D., Carpinelli M.R., Hyland C., Mifsud S., Dirago L., Nicola N.A., et al. Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Blood 105 (2005) 3480-3487
52. Sintes J., Vidal-Laliena M., Romero X., Tovar V., and Engel P. Characterization of mouse CD229 (Ly9), a leukocyte cell surface molecule of the CD150 (SLAM) family. Tissue Antigens 70 (2007) 355-362
53. Dakic A., Metcalf D., Di Rago L., Mifsud S., Wu L., and Nutt S.L. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med 201 (2005) 1487-1502
54. Houston I.B., Kamath M.B., Schweitzer B.L., Chlon T.M., and DeKoter R.P. Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality. Exp Hematol 35 (2007) 1056-1068
55. Ichikawa M., Asai T., Saito T., Seo S., Yamazaki I., Yamagata T., et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med 10 (2004) 299-304
56. Golay J., Broccoli V., Borleri G.M., Erba E., Faretta M., Basilico L., et al. Redundant functions of B-Myb and c-Myb in differentiating myeloid cells. Cell Growth Differ 8 (1997) 1305-1316
57. Akashi K., Traver D., Miyamoto T., and Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404 (2000) 193-197
58. Palis J., Robertson S., Kennedy M., Wall C., and Keller G. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development 126 (1999) 5073-5084
59. Sawada K., Krantz S.B., Dai C.H., Koury S.T., Horn S.T., Glick A.D., et al. Purification of human blood burst-forming units-erythroid and demonstration of the evolution of erythropoietin receptors. J Cell Physiol 142 (1990) 219-230
60. Bartunek P., Kralova J., Blendinger G., Dvorak M., and Zenke M. GATA-1 and c-myb crosstalk during red blood cell differentiation through GATA-1 binding sites in the c-myb promoter. Oncogene 22 (2003) 1927-1935
61. Kolbus A., Blazquez-Domingo M., Carotta S., Bakker W., Luedemann S., von Lindern M., et al. Cooperative signaling between cytokine receptors and the glucocorticoid receptor in the expansion of erythroid progenitors: molecular analysis by expression profiling. Blood 102 (2003) 3136-3146
62. Zsebo K.M., Williams D.A., Geissler E.N., Broudy V.C., Martin F.H., Atkins H.L., et al. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63 (1990) 213-224
63. Ratajczak M.Z., Perrotti D., Melotti P., Powzaniuk M., Calabretta B., Onodera K., et al. Myb and ets proteins are candidate regulators of c-kit expression in human hematopoietic cells. Blood 91 (1998) 1934-1946
64. Vegiopoulos A., Garcia P., Emambokus N., and Frampton J. Coordination of erythropoiesis by the transcription factor c-Myb. Blood 107 (2006) 4703-4710
65. Deutsch V.R., and Tomer A. Megakaryocyte development and platelet production. Br J Haematol 134 (2006) 453-466
66. Mukai H.Y., Motohashi H., Ohneda O., Suzuki N., Nagano M., and Yamamoto M. Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation. Mol Cell Biol 26 (2006) 7953-7965
67. Wu L. T lineage progenitors: the earliest steps en route to T lymphocytes. Curr Opin Immunol 18 (2006) 121-126
68. Lahortiga I., De Keersmaecker K., Van Vlierberghe P., Graux C., Cauwelier B., Lambert F., et al. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nat Genet 39 (2007) 593-595
69. Reizis B., and Leder P. The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes. J Exp Med 194 (2001) 979-990
70. Pearson R., and Weston K. c-Myb regulates the proliferation of immature thymocytes following beta-selection. EMBO J 19 (2000) 6112-6120
71. Schmidt T., Karsunky H., Rodel B., Zevnik B., Elsasser H.P., and Moroy T. Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection. EMBO J 17 (1998) 5349-5359
72. Taylor D., Badiani P., and Weston K. A dominant interfering Myb mutant causes apoptosis in T cells. Genes Dev 10 (1996) 2732-2744
73. Hsiang Y.H., Goldman J.P., and Raulet D.H. The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer. J Immunol 154 (1995) 5195-5204
74. Hernandez-Munain C., Lauzurica P., and Krangel M.S. Regulation of T cell receptor delta gene rearrangement by c-Myb. J Exp Med 183 (1996) 289-293
75. Siu G. Linking CD4 gene expression and T cell development. Curr Mol Med 1 (2001) 523-532
76. Hernandez-Hoyos G., Anderson M.K., Wang C., Rothenberg E.V., and Alberola-Ila J. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 19 (2003) 83-94
77. Hardy R.R., Kincade P.W., and Dorshkind K. The protean nature of cells in the B lymphocyte lineage. Immunity 26 (2007) 703-714
78. Nutt S.L., and Kee B.L. The transcriptional regulation of B cell lineage commitment. Immunity 26 (2007) 715-725
79. Jin Z.X., Kishi H., Wei X.C., Matsuda T., Saito S., and Muraguchi A. Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells. J Immunol 169 (2002) 3783-3792
80. Carvalho T.L., Mota-Santos T., Cumano A., Demengeot J., and Vieira P. Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/-) mice. J Exp Med 194 (2001) 1141-1150
81. von Freeden-Jeffry U., Vieira P., Lucian L.A., McNeil T., Burdach S.E., and Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181 (1995) 1519-1526
82. Goetz C.A., Harmon I.R., O'Neil J.J., Burchill M.A., and Farrar M.A. STAT5 activation underlies IL7 receptor-dependent B cell development. J Immunol 172 (2004) 4770-4778
83. Domen J., van der Lugt N.M., Acton D., Laird P.W., Linders K., and Berns A. Pim-1 levels determine the size of early B lymphoid compartments in bone marrow. J Exp Med 178 (1993) 1665-1673
84. Berge T., Matre V., Brendeford E.M., Saether T., Luscher B., and Gabrielsen O.S. Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitation and c-Myb knockdown. Blood Cells Mol Dis 39 (2007) 278-286
85. Lang G., White J.R., Argent-Katwala M.J., Allinson C.G., and Weston K. Myb proteins regulate the expression of diverse target genes. Oncogene 24 (2005) 1375-1384
86. Frazer K.A., Pachter L., Poliakov A., Rubin E.M., and Dubchak I. VISTA: computational tools for comparative genomics. Nucleic Acids Res 32 (2004) W273-W279
87. Ess K.C., Whitaker T.L., Cost G.J., Witte D.P., Hutton J.J., and Aronow B.J. A central role for a single c-Myb binding site in a thymic locus control region. Mol Cell Biol 15 (1995) 5707-5715
88. Frampton J., Ramqvist T., and Graf T. v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells. Genes Dev 10 (1996) 2720-2731
89. Peng S., Lalani S., Leavenworth J.W., Ho I.C., and Pauza M.E. c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells. Eur J Immunol 37 (2007) 2868-2880
90. Salomoni P., Perrotti D., Martinez R., Franceschi C., and Calabretta B. Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of bcl-2 promoter activity. Proc Natl Acad Sci USA 94 (1997) 3296-3301
91. Schmidt M., Nazarov V., Stevens L., Watson R., and Wolff L. Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis. Mol Cell Biol 20 (2000) 1970-1981
92. Chen J., Kremer C.S., and Bender T.P. The carbonic anhydrase I locus contains a c-Myb target promoter and modulates differentiation of murine erythroleukemia cells. Oncogene 25 (2006) 2758-2772
93. Hogg A., Schirm S., Nakagoshi H., Bartley P., Ishii S., Bishop J.M., et al. Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2. Oncogene 15 (1997) 2885-2898
94. Cogswell J.P., Cogswell P.C., Kuehl W.M., Cuddihy A.M., Bender T.M., Engelke U., et al. Mechanism of c-myc regulation by c-Myb in different cell lineages. Mol Cell Biol 13 (1993) 2858-2869
95. Nakagoshi H., Kanei-Ishii C., Sawazaki T., Mizuguchi G., and Ishii S. Transcriptional activation of the c-myc gene by the c-myb and B-myb gene products. Oncogene 7 (1992) 1233-1240
96. Zobel A., Kalkbrenner F., Guehmann S., Nawrath M., Vorbrueggen G., and Moelling K. Interaction of the v-and c-Myb proteins with regulatory sequences of the human c-myc gene. Oncogene 6 (1991) 1397-1407
97. Allen III R.D., Kim H.K., Sarafova S.D., and Siu G. Negative regulation of CD4 gene expression by a HES-1-c-Myb complex. Mol Cell Biol 21 (2001) 3071-3082
98. Nakata Y., Shetzline S., Sakashita C., Kalota A., Rallapalli R., Rudnick S.I., et al. c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression. Mol Cell Biol 27 (2007) 2048-2058
99. Lausen J., Liu S., Fliegauf M., Lubbert M., and Werner M.H. ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO. Oncogene 25 (2006) 1349-1357
100. Oelgeschlager M., Nuchprayoon I., Luscher B., and Friedman A.D. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol Cell Biol 16 (1996) 4717-4725
101. Yang H., Huang Z.Z., Wang J., and Lu S.C. The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma. FASEB J 15 (2001) 1507-1516
102. Zeng Z., Yang H., Huang Z.Z., Chen C., Wang J., and Lu S.C. The role of c-Myb in the up-regulation of methionine adenosyltransferase 2A expression in activated Jurkat cells. Biochem J 353 (2001) 163-168
103. Dudek H., Tantravahi R.V., Rao V.N., Reddy E.S., and Reddy E.P. Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter. Proc Natl Acad Sci USA 89 (1992) 1291-1295
104. Ness S.A., Kowenz-Leutz E., Casini T., Graf T., and Leutz A. Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev 7 (1993) 749-759
105. Kishi H., Jin Z.X., Wei X.C., Nagata T., Matsuda T., Saito S., et al. Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells. Blood 99 (2002) 576-583
106. Wang Q.F., Lauring J., and Schlissel M.S. c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells. Mol Cell Biol 20 (2000) 9203-9211
107. Carabana J., Ortigoza E., and Krangel M.S. Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb. J Immunol 174 (2005) 4144-4152
108. Hernandez-Munain C., and Krangel M.S. Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors. Mol Cell Biol 14 (1994) 473-483