Editorials and perspectives regulation of lmo2 mrna and protein expression in erythroid differentiation

Haematologica

Volumn 94, Issue 4, 2009, Pages 447-448

  Brandt, Stephen J ^a,b,c   Koury, Mark J ^a,b,c  

^a Medical Center   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIM DOMAIN ONLY PROTEIN 2; LIM PROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; LMO2 PROTEIN, HUMAN; METALLOPROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME TRANSLOCATION; DOWN REGULATION; EDITORIAL; ERYTHROCYTE; ERYTHROID CELL; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE TARGETING; KNOCKOUT GENE; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; CYTOLOGY; GENETICS; HUMAN; NOTE; PHYSIOLOGY;

CELL DIFFERENTIATION; DNA-BINDING PROTEINS; ERYTHROCYTES; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; HUMANS; METALLOPROTEINS; RNA, MESSENGER;

EID: 66349084170     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2008.005140     Document Type: Editorial

References (16)

1. von Lindern M, Schmidt U, Beug H. Control of erythro- poiesis by erythropoietin and stem cell factor: A novel role for Bruton's tyrosine kinase. Cell Cycle 2004;3:876-9.
2. Koury MJ. Erythropoietin: The story of hypoxia and a fine- ly regulated hematopoietic hormone. Exp Hematol 2005; 33:1263-70.
3. Rhodes MM, Kopsombut P, Bondurant MC, Price JO, Koury MJ. Adherence to macrophages in erythroblastic islands enhances erythroblast proliferation and increases erythro- cyte production by a different mechanism than erythropoi- etin. Blood 2008;111:1700-8.
4. Chen JJ. Regulation of protein synthesis by the heme-regu- lated eIF2alpha kinase: Relevance to anemias. Blood 2007; 109:2693-9.
5. Weiss MJ, Zhou S, Feng L, Gell DA, Mackay JP, Shi Y, et al. Role of alpha-hemoglobin-stabilizing protein in normal ery- thropoiesis and beta-thalassemia. Ann NY Acad Sci 2005; 1054:103-17.
6. Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH. The oncogenic cysteine-rich LIM domain pro- tein rbtn2 is essential for erythroid development. Cell 1994;78:45-57.
7. Nam CH, Lobato MN, Appert A, Drynan LF, Tanaka T, Rabbitts TH. An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions. Oncogene 2008;27:4962-8.
8. Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci USA 1997;94:13707-12.
9. Terano T, Zhong Y, Toyokuni S, Hiai H, Yamada Y. Trans- criptional control of fetal liver hematopoiesis: Dominant negative effect of the overexpression of the LIM domain mutants of LMO2. Exp Hematol 2005;33:641-51.
10. Felli N, Pedini F, Romania P, Biffoni M, Morsilli O, Castelli G, et al. MicroRNA 223 dependent expression of LMO2 regulates normal erythropoiesis. Haematologica 2009;94: 479-486.
11. Malumbres R, Sarosiek KA, Cubedo E, Ruiz JW, Jiang X, Gascoyne RD, et al. Differentiation-stage-specific expres- sion of microRNAs in B-lymphocytes and diffuse large B- cell lymphomas. Blood 2008. Epub ahead of print as doi:10.1182/blood2008-10-184077.
12. Yuan JY, Wang F, Yu J, Yang GH, Liu XL, Zhang JW. MicroRNA-223 reversibly regulates erythroid and mega- karyocytic differentiation of K562 cells. J Cell Mol Med 2008. Epub as doi:10.1111/j.1582-4934.2008.00585.
13. Wadman IA, Osada H, Grütz GG, Agulnick AD, Westphal H, Forster A, et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI pro- teins. EMBO J 1997;16:3145-57.
14. Xu Z, Meng X, Cai Y, Liang H, Nagarajan L, Brandt SJ. Single-stranded DNA-binding proteins regulate the abun- dance of LIM domain and LIM domain-binding proteins. Genes Dev 2007;21:942-55.
15. Song SH, Hou C, Dean A. A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell 2007;28:810-22.
16. Yuan W, Sun W, Yang S, Du J, Zhai CL, Wang ZQ, et al. Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors. Leukemia 2008;22:1067-71.