Role of carotenoid β-cryptoxanthin in bone homeostasis

Journal of Biomedical Science

Volumn 19, Issue 1, 2012, Pages

  Yamaguchi, Masayoshi ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

cryptoxanthin; Carotenoid; Osteoblastic bone formation; Osteoclastic bone resorption; Osteoporosis

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; ALKALINE PHOSPHATASE; ASCORBIC ACID; ASTAXANTHIN; BETA CRYPTOXANTHIN; CANTHAXANTHIN; CAROTENE; CAROTENOID; FUCOXANTHIN; GENISTEIN; HESPERIDIN; ISORHAMNETIN; KAEMPFEROL; LYCOPENE; MYRICETIN; OSTEOCLAST DIFFERENTIATION FACTOR; PLATELET DERIVED GROWTH FACTOR; PROSTAGLANDIN E2; PROTEIN BCL 2; RETINOL; TRANSCRIPTION FACTOR RUNX2; VIOLAXANTHIN; XANTHOPHYLL; ZINC; ANTINEOPLASTIC AGENT; CRYPTOXANTHIN;

AGAR GEL ELECTROPHORESIS; AGING; BONE DENSITY; BONE GROWTH; BONE HOMEOSTASIS; BONE METABOLISM; CELL PROLIFERATION; CROSS-SECTIONAL STUDY; DIETARY INTAKE; DUAL ENERGY X RAY ABSORPTIOMETRY; FRACTURE; GENE EXPRESSION; GROWTH RETARDATION; HIP FRACTURE; HOMEOSTASIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KNEE OSTEOARTHRITIS; MESENCHYMAL STEM CELL; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; REVIEW; SATSUMA; STREPTOZOCIN DIABETES; VITAMIN INTAKE; ANIMAL; BONE DEVELOPMENT; CELL LINE; CHEMISTRY; CITRUS; DRUG EFFECT; FEMALE; METABOLISM; MOUSE; OSTEOBLAST; OSTEOCLAST; PATHOLOGY;

ANIMALIA; CITRUS RETICULATA; CITRUS UNSHIU;

ANIMALS; ANTICARCINOGENIC AGENTS; BONE RESORPTION; CELL LINE; CITRUS; FEMALE; HUMANS; MICE; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; XANTHOPHYLLS;

EID: 84859136421     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-19-36     Document Type: Review

References (76)

1. Estrogen deficiency and bone loss: an inflammatory tale. Weitzmann MN, Pacifici R, J Clin Invest 2006 116 1186 1194 10.1172/JCI28550 16670759
2. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Johnell O, Kanis JA, Osteoporos Int 2006 17 1726 1733 10.1007/s00198-006-0172-4 16983459 (Pubitemid 44607392)
3. Nutritional aspects of hip fracture. Bonjour J-P, Schurch M-A, Rizzori R, Bone 1996 18 1395 1445
4. Isoflavone and bone metabolism: its cellular mechanism and preventive role in bone loss. Yamaguchi M, J Health Sci 2002 48 209 222 10.1248/jhs.48.209 (Pubitemid 41295320)
5. Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis. Yamaguchi M, Yakugaku Zasshi 2006 126 1117 1137 10.1248/yakushi.126.1117 17077614 (Pubitemid 44715696)
6. Role of nutritional zinc in the prevention of osteoporosis. Yamaguchi M, Mol Cell Biochem 2010 338 241 254 10.1007/s11010-009-0358-0 20035439
7. Effects of flavonoid on calcium content in femoral tissue culture and parathyroid hormone-stimulated osteoclastogenesis in bone marrow culture in vitro. Yamaguchi M, Hamamoto R, Uchiyama S, Ishiyama K, Mol Cell Biochem 2008 303 83 88 (Pubitemid 47261304)
8. Effect of marine algae extract on bone calcification in the femoral-metaphyseal tissues of rats: Anabolic effect of Sargassum horneri. Yamaguchi M, Hachiya S, Hiratsuka S, Suzuki T, J Health Sci 2001 47 533 538 10.1248/jhs.47.533 (Pubitemid 33126610)
9. Anabolic effect of marine alga Sargassum horneri extract on bone components in the femoral-diaphyseal and -metaphyseal tissues of young and aged rats in vivo. Uchiyama S, Yamaguchi M, J Health Sci 2002 48 325 330 10.1248/jhs.48.325 (Pubitemid 41301518)
10. Anabolic effects of bee pollen Cistus ladaniferus extract on bone components in the femoral-diaphyseal and -metaphyseal tissues of rats in vitro and in vivo. Yamaguchi M, Hamamoto R, Uchiyama S, Ishiyama K, Hashimoto K, J Health Sci 2006 52 43 49 10.1248/jhs.52.43 (Pubitemid 43212173)
11. Preventive effects of bee pollen Cistus ladaniferus extract on bone loss in ovariectomiaed rats in vivo. Yamaguchi M, Uchiyama S, Nakagawa T, J Health Sci 2007 53 571 575 10.1248/jhs.53.571 (Pubitemid 47535664)
12. Anabolic effect of wasabi leafstalk (Wasabia Japonica MATSUM.) extract on bone components in the femoral-diaphyseal and -metaphyseal tissues of aged female rats in vitro and in vivo. Yamaguchi M, Ma ZJ, Suzuki T, J Health Sci 2003 49 123 128 10.1248/jhs.49.123 (Pubitemid 41301479)
13. Purification of active component in wasabi leafstalk (Wasabia japonica MATSUM.) extract in stimulating bone calcification in vitro. Suzuki T, Yamaguchi M, J Health Sci 2004 50 483 490 10.1248/jhs.50.483 (Pubitemid 41295292)
14. Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Williams JA, Kondo N, Okabe T, Takeshita N, Pilchak DM, Koyama E, Ochiai T, Jensen D, Chu M-L, Kane MA, Napoli JL, Enomoto-Iwamoto M, Ghyselinck N, Chambon P, Pacifici M, Iwamoto M, Dev Biol 2009 328 315 327 10.1016/j.ydbio.2009.01.031 19389355
15. Vitamin A and carotenoids stimulate differentiation of mouse osteoblastic cells. Park CK, Ishimi Y, Ohmura M, Yamaguchi M, Ikegami S, J Nutr Sci Vitaminol (Tokyo) 1997 43 281 296 10.3177/jnsv.43.281 (Pubitemid 27321853)
16. Retinoids inhibit differentiation of hematopoetic osteoclast progenitors. Conaway HH, Persson E, Halén M, Granholm S, Svensson O, Pettersson U, Lie A, Lerner UH, FASEB J 2009 23 3526 3538 10.1096/fj.09-132548 19546303
17. Vitamin A and retinol intakes and the risk of fractures among participants of the Women's Health Initiative Observational Study. Caire-Juvera G, Ritenbaugh C, Wactawski-Wende J, Snetselaar LG, Chen Z, Am J Clin Nutr 2009 89 323 330 19056568
18. Vitamin D deficiency and high serum levels of vitamin A increase the risk of osteoporosis evaluated by Quantitative Ultrasound Measurements (QUS) in postmenopausal Spanish women. Mata-Granados JM, Cuenca-Acevedo R, Luque de Castro MD, Sosa M, Quesada-Gámez JM, Clin Biochem 2010 43 1064 1068 10.1016/j.clinbiochem.2010.06.001 20599880
19. Retinol intake and bone mineral density in the elderly: the rancho brenardo study. Promislow JHE, Goodman-Gruen D, Slymen DJ, Barret-Connor E, J Bone Miner Res 2002 17 1349 1358 10.1359/jbmr.2002.17.8.1349 12162487 (Pubitemid 34803818)
20. Vitamin A: is it a risk factor for osteoporosis and bone fracture? Ribaya-Mercado JD, Blumberg JB, Nutr Rev 2007 65 425 438 10.1111/j.1753-4887. 2007.tb00268.x 17972437 (Pubitemid 351804344)
21. Effect of carotenoid on calcium content and alkaline phosphatase activity in rat femoral tissues in vitro: the unique anabolic effect of β-cryptoxanthin. Yamaguchi M, Uchiyama S, Biol Pharm Bull 2003 26 1188 1191 10.1248/bpb.26.1188 12913275 (Pubitemid 40012589)
22. -Cryptoxanthin stimulates bone formation and inhibits bone resorption in tissue culture in vitro. Yamaguchi M, Uchiyama S, Mol Cell Biochem 2004 258 137 144 15030178 (Pubitemid 38268208)
23. Bone-forming cells in clinical conditions. Parfitt AM, The Osteoblast and Osteocyte. Bone Boca Raton, FL: Telford Press and CRC Press, Hall BK, 1990 1 351 429
24. Cellular and molecular mechanisms of bone remodeling. Raggatt LJ, Partridge C, J Biol Chem 2010 285 25103 25108 10.1074/jbc.R109.041087 20501658
25. Growth factors and the regulation of bone remodeling. Canalis E, McCarthy T, Centrella M, J Clin Invest 1988 81 277 281 10.1172/JCI113318 3276726 (Pubitemid 18075217)
26. Low levels of carotenoids and retinol in involutional osteoporosis. Maggio D, Polidori MC, Barabani M, Tufi A, Ruggiero C, Cecchetti R, Aisa MC, Stahl W, Cherubini A, Bone 2006 38 244 248 10.1016/j.bone.2005.08.003 16188508 (Pubitemid 43168318)
27. Lycopene effects on osteoclasts: lycopene inhibits basal and parathyroid hormone-stimulated osteoclast formation and mineral resorption mediated by reactive oxygen species in rat bone marrow cultures. Rao LG, Krishnadev N, Banasikowska K, Rao AV, J Med Food 2003 6 69 78 10.1089/109662003322233459 12935316 (Pubitemid 37128466)
28. Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women. Rao LG, Mackinnon ES, Josse RG, Murray TM, Strauss A, Rao AV, Osteoporos Int 2007 18 109 115 10.1007/s00198-006-0205-z 16941193 (Pubitemid 44885502)
29. Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women. Mackinnon ES, Rao AV, Josse RG, Rao LG, Osteoporos Int 2011 22 1091 1101 10.1007/s00198-010-1308-0 20552330
30. Comparison of the effects of synthetic human parathyroid hormone (PTH)-(1-34)-related peptide of malignancy and bovine PTH-(1-34) on bone formation and resorption in organ culture. Klein-Nulend J, Fall PM, Raisz LG, Endocrinology 1990 126 223 227 2293986 (Pubitemid 20037146)
31. Comparison of bone and parathyroid hormone as stimulators of osteoclast development and activity in calvarial cell cultures from normal and osteopetrotic (mi/mi) mice. Graves L III, Jilka RL, J Cell Physiol 1990 145 102 109 10.1002/jcp.1041450115 2211836
32. Stimulation of bone resorption in tissue culture. Klein DC, Raisz LG, Endocrinology 1970 86 1436 1440 10.1210/endo-86-6-1436 4315103
33. Comparison of serum carotenoid responses between women consuming vegetable juice and women consuming raw or cooked vegetable. McEligot AJ, Rock CL, Shanks TG, Flatt SW, Newman V, Farber S, Pierce JP, Cancer Epideminol Biomarkers Prev 1999 8 227 231 (Pubitemid 29114200)
34. β- Cryptoxanthin stimulates cell proliferation and transcriptional activity in osteoblastic MC3T3-E1cells. Uchiyama S, Yamaguchi M, Int J Mol Med 2005 15 675 681 15754031
35. - Cryptoxanthin stimulates cell differentiation and mineralization in osteoblastic MC3T3-E1 cells. Uchiyama S, Yamaguchi M, J Cell Biochem 2005 95 1224 1234 10.1002/jcb.20496 15962303 (Pubitemid 41420129)
36. Receptors for insulin-like growth factor-I and -II in osteoblast-enriched cultures from fetal rat bone. Centrella M, McCarthy TL, Canalis E, Endocrinology 1990 126 39 44 10.1210/endo-126-1-39 2152868 (Pubitemid 20037122)
37. Role of activator protein 1 transcriptional activity in the regulation of gene expression by transforming growth factor 1 and bone morphogenic protein 2 in ROS 17/2.8 osteoblast-like cells. Palcy S, Bolivar I, Goltzman D, J Bone Miner Res 2000 15 2352 2361 10.1359/jbmr.2000.15.12.2352 11127200
38. Transforming growth factor-1 to the bone. Janssens K, Dijke PT, Janssens S, Hul WV, Endocrine Rev 2005 26 743 774 10.1210/er.2004-0001 (Pubitemid 41428537)
39. Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic SMAD activation, through NF-kappaB. Li Y, Li A, Strait K, Zhang H, Nanes MS, Weitzmann MN, J Bone Miner Res 2007 22 646 655 10.1359/jbmr.070121 17266397 (Pubitemid 351339092)
40. The bone anabolic carotenoids p-hydroxycinnamic acid and β-cryptoxanthin antagonize NF-B activation in MC3T3 preosteoblasts. Yamaguchi M, Weitzmann MN, Mol Med Rep 2009 2 641 644
41. The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-1-induced SMAD activation in MC3T3 preosteoblasts. Yamaguchi M, Weitzmann MN, Int J Mol Med 2009 24 671 675 19787201
42. Targeted disruption of Cbfa1 results in a comple lack of bone formation owing to maturational arrest of osteoblasts. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T, Cell 1997 89 755 764 10.1016/S0092-8674(00)80258-5 9182763 (Pubitemid 27516178)
43. Bone formation: Osteoblast lineage cells, growth factors, matrix proteins, and the mineralization process. Lian JB, Stein GS, Canalis E, Roby PG, Boskey AL, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism New York: Lippincott Williams & Wilkins Press, Favus MJ, 4 1999 14 29
44. Role of serum in the developmental expression of alkaline phosphatase in MC3T3-E1 osteoblasts. Yohay DA, Zhang J, Thrailkill KM, Arthur JM, Quarles LD, J Cell Physiol 1994 158 467 475 10.1002/jcp.1041580311 8126070 (Pubitemid 24094428)
45. Osteoclastogenesis, bone resorption, and osteoblast-based therapeutics. Zaidi M, Blair HC, Moonga BS, Abe E, Huang CL-H, J Bone Miner Res 2003 18 599 609 10.1359/jbmr.2003.18.4.599 12674320 (Pubitemid 36899309)
46. How are osteoclasts induced to resorb bone? Chambers TJ, Fuller K, Ann N Y Acad Sci 2011 1240 1 6 10.1111/j.1749-6632.2011.06249.x 22172032
47. Inhibitory effect of β-cryptoxanthin on osteoclast-like cell formation in mouse marrow cultures. Uchiyama S, Yamaguchi M, Biochem Pharmacol 2004 67 1297 1305 10.1016/j.bcp.2003.11.011 15013845 (Pubitemid 38315095)
48. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Gailibert L, Nature 1997 390 175 195 10.1038/36593 9367155 (Pubitemid 27507987)
49. Activation of c-Jun N-terminal kinase and activator protein 1 by receptor activator of NF-B. Lee ZH, Kwack K, Kim KK, Lee SH, Kim H-H, Mol Pharmacol 2000 58 1536 1545 11093794
50. -Cryptoxanthin stimulates apoptotic cell death and suppresses cell function in osteoclastic cells: Change in their related gene expression. Uchiyama S, Yamaguchi M, J Cell Biochem 2006 98 1185 1195 10.1002/jcb.20824 16514646 (Pubitemid 44128358)
51. Stimulatory effect of zinc on bone formation in tissue culture. Yamaguchi M, Oishi H, Suketa Y, Biochem Pharmacol 1987 36 4007 4012 10.1016/0006-2952(87) 90471-0 3689432
52. Inhibitory effect of zinc compounds on osteoclast-like cell formation in mouse marrow culture. Kishi S, Yamaguchi M, Biochem Pharmacol 1994 48 1225 1230 10.1016/0006-2952(94)90160-0 7945416 (Pubitemid 24298374)
53. Role of zinc in bone formation and bone resorption. Yamaguchi M, J Trace Elem Exp Med 1998 11 119 135 10.1002/(SICI)1520-670X(1998)11:2/3<119::AID- JTRA5>3.0.CO;2-3 (Pubitemid 28344704)
54. - Alanyl-L-histidinato zinc: a potent activator in bone formation. Yamaguchi M, Curr Med Chem 1995 1 356 365
55. Nutritional factors and bone homeostasis: Synergistic effect of zinc and genistein in osteogenesis. Yamaguchi M, Mol Cell Biochem 2012
56. Synergistic effect of β-cryptoxanthin and zinc sulfate on the bone component in rat femoral tissues in vitro: the unique anabolic effect with zinc. Uchiyama S, Ishiyama K, Hashimoto K, Yamaguchi M, Biol Pharm Bull 2005 28 2142 2145 10.1248/bpb.28.2142 16272706 (Pubitemid 41634268)
57. Anabolic effect of β-cryptoxanthin in osteoblastic MC3T3-E1 cells is enhanced with 17 -estradiol, genistein, or zinc sulfate in vitro: the unique effect with zinc on Runx2 and 1(I) collagen mRNA espression. Uchiyama S, Yamaguchi M, Mol Cell Biochem 2008 307 209 219 17899321 (Pubitemid 350238663)
58. Combination of β-cryptoxanthin and zinc has potent effects on apoptotic cell death and suppression of bone resorption-related gene expression in osteoclastic cells. Yamaguchi M, Uchiyama S, Int J Mol Med 2008 22 221 228 18636177
59. Oral administration in combination with zinc enhances β-cryptoxanthin-induced anabolic effects on bone components in the femoral tissues of rats in vivo. Yamaguchi M, Uchiyama S, Ishiyama K, Hashimoto K, Biol Pharm Bull 2006 29 371 374 10.1248/bpb.29.371 16462048 (Pubitemid 43200913)
60. Oral administration of β-cryptoxanthin induces anabolic effects on bone components in the femoral tissues of rats in vivo. Uchiyama S, Sumida T, Yamaguchi M, Biol Pharm Bull 2004 27 232 235 10.1248/bpb.27.232 14758041 (Pubitemid 41694706)
61. Anabolic effect of β-cryptoxanthin on bone components in the femoral tissues of aged rats in vivo and in vitro. Uchiyama S, Sumida T, Yamaguchi M, J Health Sci 2004 50 491 496 10.1248/jhs.50.491 (Pubitemid 41295293)
62. Oral administration of β-cryptoxanthin prevents bone loss in streptozotocin-diabetic rats in vivo. Uchiyama S, Yamaguchi M, Biol Pharm Bull 2005 28 1766 1769 10.1248/bpb.28.1766 16141556 (Pubitemid 41324149)
63. Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats. Uchiyama S, Yamaguchi M, Int J Mol Med 2006 17 15 20 16328006
64. Vitamin K-dependent formation of bone gla protein (osteocalcin) and its function. Price PA, Vitam Horm 1985 42 65 108 3006348
65. Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells. Levy JR, Murray E, Manolagass S, Olefsky JM, Endocrinology 1986 119 1786 1792 10.1210/endo-119-4-1786 3530724 (Pubitemid 17170552)
66. Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption. Hallen JM, Alatalo SL, Suminen H, Cheng S, Janekila A, Vaananen HK, J Bone Miner Res 2000 15 1337 1345 10.1359/jbmr.2000.15.7.1337 10893682 (Pubitemid 30413866)
67. Evidence that serum NTx (collagen-type I N-telopeptides) can act as an immunochemical marker of bone resorption. Clements JD, Herrick MV, Singer FR, Eyre DR, Clin Chem 1997 43 2058 2063 9365389 (Pubitemid 27497803)
68. Prolonged intake of jucice (Citrus unshiu) reinforced with β-cryptoxanthin has an effect on circulating bone biochemical markers in normal individuals. Yamaguchi M, Igarashi A, Uchiyama S, Morita S, Sugawara K, Sumida K, J Health Sci 2004 50 619 624 10.1248/jhs.50.619 (Pubitemid 41295274)
69. Relationship between serum β-cryptoxanthin and circulating bone metabolic markers in healthy individuals with the intake of juice (Citrus unshiu) containing β-cryptoxanthin. Yamaguchi M, Igarashi A, Morita S, Sumida T, Sugawara K, J Health Sci 2005 51 738 743 10.1248/jhs.51.738 (Pubitemid 41739075)
70. Effect of β-cryptoxanthin on circulating bone metabolic markers: Intake of juice (Citrus unshiu) supplemented with β-cryptoxanthin has an effect in menopausal women. Yamaguchi M, Igarashi A, Uchiyama S, Sugawara K, Sumida T, Morita S, Ogawa H, Nishitani M, Kajimoto Y, J Health Sci 2006 52 758 768 10.1248/jhs.52.758 (Pubitemid 44903946)
71. Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study. Wang Y, Hodge AM, Wluka AE, English DR, Giles GG, O'Sullivan R, Forbes A, Cicuttini FM, Arthritis Res Ther 2007 9 66 10.1186/ar2225 17617909 (Pubitemid 47249054)
72. Bone mineral density in post-menopausal female subjects is associated with serum antioxidant carotenoids. Sugiura M, Nakamura M, Ogawa K, Ikoma Y, Ando F, Yano M, Osteoporos Int 2008 19 211 219 10.1007/s00198-007-0457-2 17846860
73. 3in women with osteoporosis. Granado-Lorencio F, Olmedilla-Alonso B, Herrero-Barbudo C, Blanco-Navarro I, Perez-Sacristan B, Osteoporos Int 2008 19 717 720 10.1007/s00198-007-0470-5 17882465 (Pubitemid 351642169)
74. Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham osteoporosis study. Sahni S, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL, J Bone Miner Res 2009 24 1086 1094 10.1359/jbmr.090102 19138129
75. Serum carotenoid concentrations in postmenopausal women from the United States with and without osteoporosis. Yang Z, Zhang Z, Penniston KL, Binkley N, Tanumihardjo SA, Int J Vitm Nutr Res 2008 78 105 110 10.1024/0300-9831.78.3.105
76. Dietary patterns of antioxidant vitamin and carotenoid intake associated with bone mineral density: findings from post-menopausal Japanese female subjects. Sugiura M, Nakamura M, Ogawa K, Ikoma Y, Ando F, Shimokata H, Yano M, Osteoporos Int 2010 36 2293 2298