Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: A 17-year follow-up from the Framingham Osteoporosis Study

Journal of Bone and Mineral Research

Volumn 24, Issue 6, 2009, Pages 1086-1094

  Sahni, Shivani ^a   Hannan, Marian T ^b   Blumberg, Jeffrey ^a   Cupples, L Adrienne ^c   Kiel, Douglas P ^b   Tucker, Katherine L ^a,d  

^a TUFTS UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^d TUFTS UNIVERSITY   (United States)

Author keywords

Aging; Bone; Nutrition; Osteoporosis; Population studies

Indexed keywords

ALPHA CAROTENE; BETA CAROTENE; BETA CRYPTOXANTHIN; CALCIUM; ESTROGEN; LYCOPENE; VITAMIN D; XANTHOPHYLL; ZEAXANTHIN;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOLLOW UP; FOOD FREQUENCY QUESTIONNAIRE; FRAGILITY FRACTURE; GROUPS BY AGE; HEIGHT; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PHYSICAL ACTIVITY; RISK FACTOR; SEX DIFFERENCE; SMOKING HABIT; VITAMIN INTAKE;

ADULT; AGED; CAROTENOIDS; CONFOUNDING FACTORS (EPIDEMIOLOGY); FEMALE; FOLLOW-UP STUDIES; HIP FRACTURES; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; QUESTIONNAIRES;

EID: 66349125617     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.090102     Document Type: Article

References (67)

1. U.S. Department of Health and Human Services 2004 Bone Health and Osteoporosis: A Report of the Surgeon General. U.S. Department of Health and Human Services, Office of the Surgeon General, Rockville, MD, USA.
2. Riggs BL, Melton LJ III 1995 The worldwide problem of osteoporosis: Insights afforded by epidemiology. Bone 17(Suppl):505S-511S.
3. Chrischilles EA, Butler CD, Davis CS, Wallace RB 1991 A model of lifetime osteoporosis impact. Arch Intern Med 151:2026-2032.
4. Cummings SR, Melton LJ 2002 Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761-1767.
5. WHO Scientific Group 2003 Prevention and management of osteoporosis. World Health Organ Tech Rep Ser 921:1-9.
6. Tucker KL, Hannan MT, Kiel DP 2001 The acid-base hypothesis: Diet and bone in the Framingham Osteoporosis Study. Eur J Nutr 40:231-237. (Pubitemid 34093229)
7. Prynne CJ, Mishra GD, O'Connell MA, Muniz G, Laskey MA, Yan L, Prentice A, Ginty F 2006 Fruit and vegetable intakes and bone mineral status: A cross sectional study in 5 age and sex cohorts. Am J Clin Nutr 83:1420-1428. (Pubitemid 44713075)
8. Tucker KL, Chen H, Hannan MT, Cupples LA, Wilson PW, Felson D, Kiel DP 2002 Bone mineral density and dietary patterns in older adults: The Framingham Osteoporosis Study. Am J Clin Nutr 76:245-252. (Pubitemid 34686574)
9. Macdonald HM, New SA, Golden MH, Campbell MK, Reid DM 2004 Nutritional associations with bone loss during the menopausal transition: Evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr 79:155-165. (Pubitemid 41132077)
10. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP 1999 Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69:727-736. (Pubitemid 29193397)
11. New SA, Bolton-Smith C, Grubb DA, Reid DM 1997 Nutritional influences on bone mineral density: A cross-sectional study in premenopausal women. Am J Clin Nutr 65:1831-1839. (Pubitemid 27240701)
12. Chen Y, Ho S, Lee R, Lam S, Woo J 2001 Fruit intake is associated with better bone mass among Hong Kong Chinese early postmenopausal women. J Bone Miner Res 16:S1;S386.
13. Macdonald H, Downie F, More F, New S, Grubb D, Reid D 2001 Higher intakes of fruit and vegetables are associated with higher bone mass in perimenopausal Scottish women. Proc Nutr Soc 60:202A.
14. New SA, Robins SP, Campbell MK, Martin JC, Garton MJ, Bolton-Smith C, Grubb DA, Lee SJ, Reid DM 2000 Dietary influences on bone mass and bone metabolism: Further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 71:142-151. (Pubitemid 30033597)
15. Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR 1990 Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85:632-639. (Pubitemid 20087462)
16. Key LL Jr, Ries WL, Taylor RG, Hays BD, Pitzer BL 1990 Oxygen derived free radicals in osteoclasts: The specificity and location of the nitroblue tetrazolium reaction. Bone 11:115-119. (Pubitemid 20226570)
17. Ries WL, Key LL Jr, Rodriguiz RM 1992 Nitroblue tetrazolium reduction and bone resorption by osteoclasts in vitro inhibited by a manganese-based superoxide dismutase mimic. J Bone Miner Res 7:931-939.
18. Basu S, Michaelsson K, Olofsson H, Johansson S, Melhus H 2001 Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 288:275-279. (Pubitemid 32999758)
19. Astley SB, Hughes DA, Wright AJ, Elliott RM, Southon S 2004 DNA damage and susceptibility to oxidative damage in lymphocytes: Effects of carotenoids in vitro and in vivo. Br J Nutr 91:53-61. (Pubitemid 38100559)
20. Kiokias S, Gordon MH 2003 Dietary supplementation with a natural carotenoid mixture decreases oxidative stress. Eur J Clin Nutr 57:1135-1140. (Pubitemid 37121011)
21. Rao LG, Mackinnon ES, Josse RG, Murray TM, Strauss A, Rao AV 2007 Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women. Osteoporos Int 18:109-115. (Pubitemid 44885502)
22. Conner EM, Grisham MB 1996 Inflammation, free radicals, and antioxidants. Nutrition 12:274-277. (Pubitemid 26286465)
23. Yamaguchi M, Uchiyama S 2004 beta-Cryptoxanthin stimulates bone formation and inhibits bone resorption in tissue culture in vitro. Mol Cell Biochem 258:137-144. (Pubitemid 38268208)
24. Kim L, Rao AV, Rao LG 2003 Lycopene II-effect on osteoblasts: The carotenoid lycopene stimulates cell proliferation and alkaline phosphatase activity of SaOS-2 cells. J Med Food 6:79-86. (Pubitemid 37128467)
25. Rao LG, Krishnadev N, Banasikowska K, Rao AV 2003 Lycopene I - effect on osteoclasts: Lycopene inhibits basal and parathyroid hormone-stimulated osteoclast formation and mineral resorption mediated by reactive oxygen species in rat bone marrow cultures. J Med Food 6:69-78. (Pubitemid 37128466)
26. Yamaguchi M, Uchiyama S 2003 Effect of carotenoid on calcium content and alkaline phosphatase activity in rat femoral tissues in vitro: The unique anabolic effect of b-cryptoxanthin. Biol Pharm Bull 26:1188-1191. (Pubitemid 40012589)
27. Uchiyama S, Sumida T, Yamaguchi M 2004 Oral administration of beta-cryptoxanthin induces anabolic effects on bone components in the femoral tissues of rats in vivo. Biol Pharm Bull 27:232-235. (Pubitemid 41694706)
28. Yamaguchi M, Igarashi A, Uchiyama S, Morita S, Sugawara K, Sumida T 2004 Prolonged intake of juice (Citrus Unshiu) reinforced with β-cryptoxanthin has an effect on circulating bone biochemical markers in normal individuals. J Home Sci. 50:619-624. (Pubitemid 41295274)
29. Barker ME, McCloskey E, Saha S, Gossiel F, Charlesworth D, Powers HJ, Blumsohn A 2005 Serum retinoids and beta-carotene as predictors of hip and other fractures in elderly women. J Bone Miner Res 20:913-920. (Pubitemid 40712814)
30. Sahni S, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL 2009 Inverse association of carotenoid intakes with 4-yr change in BMD in elderly men and women: the Framingham Osteoporosis Study. Am J Clin Nutr 89:416-424.
31. Dawber TR, Meadors GF, Moore FE Jr 1951 Epidemiological approaches to heart disease: The Framingham Study. Am J Public Health 41:279-281.
32. Rimm EB, Giovannucci EL, Stampfer MJ, Colditz GA, Litin LB, Willett WC 1992 Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol 135:1114-1126.
33. Willett W, Stampfer MJ 1986 Total energy intake: Implications for epidemiologic analyses. Am J Epidemiol 124:17-27. (Pubitemid 16095831)
34. Tucker KL, Chen H, Vogel S, Wilson PW, Schaefer EJ, Lammi-Keefe CJ 1999 Carotenoid intakes, assessed by dietary questionnaire, are associated with plasma carotenoid concentrations in an elderly population. J Nutr 129:438-445. (Pubitemid 29072133)
35. U.S. Department of Agriculture, Agricultural Research Service 2007 USDA National Nutrient Database for Standard Reference, Release 20. Available online at http://www.ars.usda.gov/ba/bhnrc/ndl. Accessed January 16, 2008.
36. Kiel DP, Felson DT, Anderson JJ, Wilson PW, Moskowitz MA 1987 Hip fracture and the use of estrogens in postmenopausal women. The Framingham Study. N Engl J Med 317:1169-1174. (Pubitemid 17150327)
37. Nevitt MC, Cummings SR, Browner WS, Seeley DG, Cauley JA, Vogt TM, Black DM 1992 The accuracy of self-report of fractures in elderly women: Evidence from a prospective study. Am J Epidemiol 135:490-499.
38. Hannan MT, Felson DT, Dawson-Hughes B, Tucker KL, Cupples LA, Wilson PW, Kiel DP 2000 Risk factors for longitudinal bone loss in elderly men and women: The Framingham Osteoporosis Study. J Bone Miner Res 15:710-720. (Pubitemid 30174025)
39. Asomaning K, Bertone-Johnson ER, Nasca PC, Hooven F, Pekow PS 2006 The association between body mass index and osteoporosis in patients referred for a bone mineral density examination. J Womens Health (Larchmt) 15:1028-1034. (Pubitemid 46381777)
40. Kiel DP, Zhang Y, Hannan MT, Anderson JJ, Baron JA, Felson DT 1996 The effect of smoking at different life stages on bone mineral density in elderly men and women. Osteoporos Int 6:240-248. (Pubitemid 26171278)
41. Kiel DP, Felson DT, Hannan MT, Anderson JJ, Wilson PW 1990 Caffeine and the risk of hip fracture: The Framingham Study. Am J Epidemiol 132:675-684. (Pubitemid 20344535)
42. Felson DT, Zhang Y, Hannan MT, Kannel WB, Kiel DP 1995 Alcohol intake and bone mineral density in elderly men and women. The Framingham Study. Am J Epidemiol 142:485-492.
43. Cauley JA, Seeley DG, Ensrud K, Ettinger B, Black D, Cummings SR 1995 Estrogen replacement therapy and fractures in older women. Study of Osteoporotic Fractures Research Group. Ann Intern Med 122:9-16.
44. Bakhireva LN, Barrett-Connor E, Kritz-Silverstein D, Morton DJ 2004 Modifiable predictors of bone loss in older men: A prospective study. Am J Prev Med 26:436-442. (Pubitemid 38698265)
45. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE, Falconer G, Green CL 1995 Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. Am J Clin Nutr 61:1140-1145.
46. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE 1997 Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337:670-676. (Pubitemid 27375473)
47. Kannel WB, Sorlie P 1979 Some health benefits of physical activity. The Framingham Study. Arch Intern Med 139:857-861.
48. Zhang J, Munger RG, West NA, Cutler DR, Wengreen HJ, Corcoran CD 2006 Antioxidant intake and risk of osteoporotic hip fracture in Utah: An effect modified by smoking status. Am J Epidemiol 163:9-17. (Pubitemid 43007110)
49. Marangon K, Herbeth B, Lecomte E, Paul-Dauphin A, Grolier P, Chancerelle Y, Artur Y, Siest G 1998 Diet, antioxidant status, and smoking habits in French men. Am J Clin Nutr 67:231-239. (Pubitemid 28076714)
50. Pasco JA, Henry MJ, Wilkinson LK, Nicholson GC, Schneider HG, Kotowicz MA 2006 Antioxidant vitamin supplements and markers of bone turnover in a community sample of non-smoking women. J Womens Health (Larchmt) 15:295-300. (Pubitemid 43891182)
51. Melhus H, Michaelsson K, Holmberg L, Wolk A, Ljunghall S 1999 Smoking, antioxidant vitamins, and the risk of hip fracture. J Bone Miner Res 14:129-135. (Pubitemid 29021613)
52. Stahl W, Sies H 1996 Lycopene: A biologically important carotenoid for humans? Arch Biochem Biophys 336:1-9.
53. Huang JP, Zhang M, Holman CD, Xie X 2007 Dietary carotenoids and risk of breast cancer in Chinese women. Asia Pac J Clin Nutr 16(Suppl 1)::437-442. (Pubitemid 46524641)
54. Uchiyamam S, Sumida T, Yamaguchi M 2004 Anabolic effect of β-cryptoxanthin on bone components in the femoral tissue of aged rats in vivo and in vitro. J Health Sci 50:491-496. (Pubitemid 41295293)
55. Lanham-New SA 2008 The balance of bone health: Tipping the scales in favor of potassium-rich, bicarbonate-rich foods. J Nutr 138:172S-177S.
56. lotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R 1997 Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 3:1285-1289. (Pubitemid 27508833)
57. Schreck R, Rieber P, Baeuerle PA 1991 Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 10:2247-2258. (Pubitemid 21905698)
58. Schreck R, Albermann K, Baeuerle PA 1992 Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 17:221-237. (Pubitemid 23207431)
59. Sen CK, Packer L 1996 Antioxidant and redox regulation of gene transcription. FASEB J 10:709-720. (Pubitemid 26172817)
60. Stahl W, Ale-Agha N, Polidori MC 2002 Non-antioxidant properties of carotenoids. Biol Chem 383:553-558. (Pubitemid 34506291)
61. Mehta PP, Hotz-Wagenblatt A, Rose B, Shalloway D, Loewenstein WR 1991 Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth. J Membr Biol 124:207-225.
62. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y 1999 Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Nutr Cancer 33:105-112. (Pubitemid 29196131)
63. Kim Y, Lian F, Yeum KJ, Chongviriyaphan N, Choi SW, Russell RM, Wang XD 2007 The effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer. Int J Cancer 120:1847-1854. (Pubitemid 46418359)
64. Landi F, Capoluongo E, Russo A, Onder G, Cesari M, Lulli P, Minucci A, Pahor M, Zuppi C, Bernabei R 2007 Free insulin-like growth factor-I and cognitive function in older persons living in community. Growth Horm IGF Res 17:58-66. (Pubitemid 46299993)
65. Tinetti ME, Speechley M, Ginter SF 1988 Risk factors for falls among elderly persons living in the communitv. N Engl J Med 319:1701-1707. (Pubitemid 19019577)
66. Kostic D, White WS, Olson JA 1995 Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses. Am J Clin Nutr 62:604-610.
67. Lindqvist A, Sharvill J, Sharvill DE, Andersson S 2007 Loss-of-function mutation in carotenoid 15,15′-monooxygenase identified in a patient with hypercarotenemia and hypovitaminosis A. J Nutr 137:2346-2350. (Pubitemid 350058699)