Role of zinc in bone formation and bone resorption

Journal of Trace Elements in Experimental Medicine

Volumn 11, Issue 2-3, 1998, Pages 119-135

  Yamaguchi, Masayoshi ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Bone formation; Bone resorption; Osteoporosis; Zinc

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; AMINO ACID TRANSFER RNA LIGASE; PROTEIN KINASE C; ZINC; ZINC SULFATE;

ARTICLE; BONE GROWTH; BONE MASS; BONE METABOLISM; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL PROLIFERATION; DETERIORATION; ENZYME ACTIVATION; HUMAN; ORAL DRUG ADMINISTRATION; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SENESCENCE; SIGNAL TRANSDUCTION; ZINC DEFICIENCY;

EID: 0031948054     PISSN: 0896548X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-670X(1998)11:2/3<119::AID-JTRA5>3.0.CO;2-3     Document Type: Article

References (72)

1. Prasad AS, Halsted JA, Nadimi M: Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Am J Med 31:532-546, 1961.
2. Burch RE, Hahn HK, Sullivan JF: Newer aspects of the roles of zinc, manganese, and copper in human nutrition. Clin Chem 21:501-520, 1975.
3. Parisi AF, Vallee BL: Zinc metalloenzyme: Characteristics and significance in biology and medicine. Am J Clin Nutr 22:1222-1230, 1969.
4. Hsieh HS, Navia JM: Zinc deficiency and bone formation in guinea pig alveolar implants. J Nutr 110:1581-1588, 1980.
5. Oner G, Bhaumick B, Bala RM: Effect of zinc deficiency on serum somatomedin levels and skeletal growth in young rats. Endocrinology 114:1860-1863, 1984.
6. Hurley LS: Tetratogenic aspects of manganese, zinc, and copper nutrition. Physiological Reviews 61:249-295, 1981.
7. da Cunha Ferreira RM, Marguiegui IM, Elizaga IV: Teratogenicity of zinc deficiency in the rat: Study of the fetal skeleton. Teratology 39:181-194, 1989.
8. Leek JC, Vogler JB, Gershwin ME, Golub MS, Hurley LS, Hendrickx AG: Studies of marginal zinc deprivation in rhesus monkeys. V. Fetal and infant skeletal defects. Am J Clin Nutr 40:1203-1212, 1984.
9. Ronaghy HA, Reinhold JG, Mahloudji M, Ghavami P, Spirey Fox MR, Halstead JA: Zinc supplementation of malnourished schoolboys in Iran: Increased growth and other effects. Am J Clin Nutr 27:112-121, 1974.
10. Herzberg M, Foldes J, Steinberg R, Menczel J: Zinc excretion in osteoporotic women. J Bone Mineral Res 5:251-257, 1990.
11. Haumont S: Distribution of zinc in bone tissue. J Histochem Cytochem 9:141, 1961.
12. Hurley LS, Shyy-Hwa T: Alleviation of tetratogenic effects of zinc deficiency by simultaneous lack of calcium. Am J Phys 222:322-325, 1972.
13. Masters DG, Keen CL, Lonnerdal B, Hurley LS: Release of zinc from maternal tissues during zinc deficiency or simultaneous zinc and calcium deficiency in the pregnant rat. J Nutr 116:2148-2154, 1986.
14. Murray EJ, Messer HH: Turnover of bone zinc during normal and accelerated bone loss in rats. J Nutr 111:1641-1647, 1981.
15. Sherman SS, Smith JC, Tobin JD, Soares JH: Ovariectomy, dietary zinc, and bone metabolism in retired breeder rats. Am J Clin Nutr 49:1184-1191, 1989.
16. Aitken JM: Factors affecting the distribution of zinc in the human skeleton. Calcif Tissue Res 20:23-30, 1976.
17. Sauer GR, Wuthier RE: Distribution of zinc in the avian growth plate. J Bone Mineral Res 5(Suppl. 2):S162, 1990.
18. Lappalainer R, Knuuttila M, Lammi S, Alhava EM: Fluoride content related to the elemental composition, mineral density and strength of bone in healthy and chronically diseased persons. J Chronic Disease 36:707-713, 1983.
19. Reginster JY, Strause LG, Saltman P, Franchimont P: Trace elements and postmenopausal osteoporosis: A preliminary study of decreased serum manganese. Med Sci Res 16:337-338, 1988.
20. Saltman P, Strause L: Trace elements in bone metabolism. J Inorg Biochem 43:284(abstract), 1991.
21. Baron R, Vignery A, Horowitz M: Lymphocytes, macrophages and the regulation of bone remodeling. Bone Miner Res 2:175-243, 1984.
22. Canalis E, McCarthy T, Centrella M: Growth factors and the regulation of bone remodeling. J Clin Invest 81:277-281, 1988.
23. Mohan S, Baylink DJ: Autocrine and paracrine aspects of bone metabolism. Growth-Genetics Hormones 6:1-6, 1990.
24. Yamaguchi M, Takahashi K: Role of zinc as an activator of bone metabolism in weanling rats. Jpn J Bone Metab 2:186-191, 1984.
25. Yamaguchi M, Inamoto K, Suketa Y: Effect of essential trace metals on bone metabolism in weanling rats: Comparison with zinc and other metals' actions. Res Exp Med 186:337-342, 1986.
26. Yamaguchi M, Uchiyama M: Preventive effect of zinc for toxic actions of germanium and selenium on bone metabolism in weanling rats. Res Exp Med 187:395-400, 1987.
27. 3 effect on bone metabolism in weanling rats orally administered zinc sulphate. Acta Endocrinol 111:285-288, 1986.
28. Yamaguchi M, Yamaguchi R: Action of zinc on bone metabolism in rats. Increases in alkaline phosphatase activity and DNA content. Biochem Pharmacol 35:773-777, 1986.
29. Yamaguchi M, Inamoto K: Differential effects of calcium-regulating hormones on bone metabolism in weanling rats orally administered zinc sulfate. Metabolism 35:1044-1047, 1986.
30. McDonnell DP, Mongelsdorf DJ, Pike JW, Haussler MR, O'Malley BW: Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science 235:1214-1217, 1987.
31. Yamaguchi M, Oishi H, Suketa Y: Stimulatory effect of zinc on bone formation in tissue culture. Biochem Pharmacol 36:4007-4012, 1987.
32. Yamaguchi M, Oishi H, Suketa Y: Zinc stimulation of bone protein synthesis in tissue culture. Activation of aminoacyl-tRNA synthetase. Biochem Pharmacol 37:4075-4080, 1988.
33. Yamaguchi M, Matsui R: Effect of dipicolinate, a chelator of zinc, on bone protein synthesis in tissue culture. The essential role of zinc. Biochem Pharmacol 38:4485-4489, 1989.
34. Shimokawa N, Yamaguchi M: Characterization of bone protein components with polyacrylamide gel electrophoresis: Effects of zinc and hormones in tissue culture. Mol Cell Biochem 117:153-158, 1992.
35. 3 on bone metabolism in tissue culture. Enhancement of this steroid effect by zinc. Biochem Pharmacol 38:3453-3459, 1989.
36. Yamaguchi M, Kitajima T: Effect of estrogen on bone metabolism in tissue culture: Enhancement of the steroid effect by zinc. Res Exp Med 191:145-154, 1991.
37. Hashizume M, Yamaguchi M: Stimulatory effect of β-alanyl-histidinato zinc on cell proliferation is dependent on protein synthesis in osteoblastic MC3T3-E1 cells. Mol Cell Biochem 122:59-64, 1993.
38. Hashizume M, Yamaguchi M: Effect of β-alanyl-L-histidinato zinc on differentiation of osteoblastic MC3T3-E1 cells: Increases in alkaline phosphatase activity and protein concentration. Mol Cell Biochem 131:19-24, 1994.
39. Yamaguchi M, Hashizume M: Effect of β-alanyl-L-histidinato zinc on protein components in osteoblastic MC3T3-E1 cells: Increases in osteocalcin, insulin-like growth factor-I and transforming growth factor-β. Mol Cell Biochem 136:163-169, 1994.
40. Matsui T, Yamaguchi M: Zinc modulation of insulin-like growth factor's effect in osteoblastic MC3T3-E1 cells. Peptides 16:1063-1068, 1995.
41. Yamaguchi M, Kishi S, Hashizume M: Effect of zinc-chelating dipeptides on osteoblastic MC3T3-E1 cells: Activation of aminoacyl-tRNA synthetase. Peptides 15:1367-1371, 1994.
42. Yamaguchi M, Matsui T: Stimulatory effect of zinc-chelating dipeptide on deoxyribonucleic acid synthesis in osteoblastic MC3T3-E1 cells. Peptides 17:1207-1211, 1996.
43. Yamaguchi M, Segawa Y, Shimokawa N, Tsuzuike N, Tagashira E: Inhibitory effect of β-alanyl-L-histidinato zinc on bone resorption in tissue culture. Pharmacology 45:292-300, 1992.
44. Yamaguchi M, Hashizume M: Effect of parathyroid hormone and interleukin-1α in osteoblastic MC3T3-E1 cells: Interaction with β-alanyl-L-histidinato zinc. Peptides 15:633-636, 1994.
45. Kishi S, Yamaguchi M: Inhibitory effect of zinc compounds on osteoclast-like cell formation in mouse marrow cultures. Biochem Pharmacol 48:1225-1230, 1994.
46. Yamaguchi M, Kishi S: Zinc compounds inhibit osteoclast-like cell formation at the earlier stage of rat marrow culture but not osteoclast function. Mol Cell Biochem 158:171-177, 1996.
47. Yamaguchi M, Kishi S: Inhibitory effect of zinc-chelating dipeptide on parathyroid hormone-stimulated osteoclast-like cell formation in mouse marrow cultures: Involvement of calcium signaling. Peptides 16:629-633, 1995.
48. 3 in aged rats. J Pharmacobio-Dyn 12:67-73, 1989.
49. Yamaguchi M, Ozaki K: Aging affects cellular zinc and protein synthesis in the femoral diaphysis of rats. Res Exp Med 190:295-300, 1990.
50. Yamaguchi M, Ehara Y: Zinc decrease and bone metabolism in the femoral-metaphyseal tissues of rats with skeletal unloading. Calcif Tissue Int 57:218-223, 1995.
51. Yamaguchi M, Ehara Y: Effect of essential trace metal on bone metabolism in the femoral-metaphyseal tissues of rats with skeletal unloading: Comparison with zinc-chelating dipeptide. Calcif Tissue Int 59:27-32, 1996.
52. Yamaguchi M, Ozaki K: A new zinc compound, β-alanyl-L-histidinato zinc, stimulates bone growth in weanling rats. Res Exp Med 190:105-110, 1990.
53. Yamaguchi M, Miwa H: Stimulatory effect of beta-alanyl-L-histidinato zinc on bone formation in tissue culture. Pharmacology 42:230-240, 1991.
54. Samuchson J: Mechanism for the exchange of the calcium in bone mineral. Nature 216:193-194, 1967.
55. Yamaguchi M, Ohtaki J: Effect of beta-alanyl-L-histidinato zinc on osteoblastic MC3T3-E1 cells: Increases in alkaline phosphatase and proliferation. Pharmacology 43:225-232, 1991.
56. Yamaguchi M, Kishi S: Effect of zinc-chelating dipeptide on bone metabolism in weanling rats: Comparison with β-alanyl-L-histidinato zinc-related compounds. Peptides 15:671-673, 1994.
57. Yamaguchi M, Kishi S: Comparison of the effect of β-alanyl-L-histidinato zinc and its zinc-chelating ligand on bone metabolism in tissue culture. Biol Pharm Bull (Tokyo) 17:522-526, 1994.
58. Yamaguchi M, Ozaki K: Effect of the new zinc compound beta-alanyl-L-histidinato zinc on bone metabolism in elderly rats. Pharmacology 41:345-349, 1990.
59. Yamaguchi M, Ozaki K, Hoshi T: β-Alanyl-L-histidinato zinc prevents skeletal unloading-induced disorder of bone metabolism in rats. Res Exp Med 190:289-294, 1990.
60. Yamaguchi M, Ozaki K: Beta-alanyl-L-histidinato zinc prevents the toxic effect of aluminium on bone metabolism in weanling rats. Pharmacology 41:338-344, 1990.
61. Segawa Y, Tsuzuike N, Itokazu Y, Tagashira E, Yamaguchi M: β-Alanyl-L-histidinato zinc prevents hydrocortisone-induced disorder of bone metabolism in rats. Res Exp Med 192:317-322, 1992.
62. Segawa Y, Tsuzuike N, Tagashira E, Yamaguchi M: Preventive effect of β-alanyl-L-histidinato zinc on bone metabolism in rats fed on low-calcium and vitamin D-deficient diets. Res Exp Med 192: 213-219, 1992.
63. Segawa Y, Tsuzuike N, Itokazu Y, Tagashira E, Yamaguchi M: Effect of β-alanyl-L-histidinato zinc on bone metabolism in rats with adjuvant arthritis. Biol Pharm Bull (Tokyo) 16:656-659, 1993.
64. Segawa Y, Tsuzuike N, Tagashira E, Yamaguchi M: Preventive effect of β-alanyl-L-histidinato zinc on the deterioration of bone metabolism in ovariectomized rats. Biol Pharm Bull (Tokyo) 16:486-489, 1993.
65. Yamaguchi M, Kishi S: Prolonged administration of β-alanyl-L-histidinato zinc prevents bone loss in ovariectomized rats. Japan J Pharmacol 63:203-207, 1993.
66. Kishi S, Segawa Y, Yamaguchi M: Histomorphological confirmation of the preventive effect of β-alanyl-L-histidinato zinc on bone loss in ovariectomized rats. Biol Pharm Bull (Tokyo) 17:862-865, 1994.
67. Kishi S, Yamaguchi M: Stimulatory effect of β-alanyl-L-histidinato zinc on alkaline phosphatase activity in bone tissue from elderly rats: Comparison with zinc sulfate action. Biol Pharm Bull (Tokyo) 17:345-347, 1994.
68. Morey ER, Baylink DJ: Inhibition of bone formation during spaceflight. Science 201:1138-1141, 1978.
69. Maloney NA, Ott SM, Alfrey AC, Miller NL, Coburn JW, Sherrard DJ: Histological quantitation of aluminium in iliac from patients with renal failure. J Lab Clin Med 99:206-216, 1982.
70. Pock WA: The effects of glucocorticoids on bone cell metabolism and function. Adv Exp Med Biol 171:111-119, 1984.
71. Johnston CC Jr, Hui SL, Witt RM, Appledonn R, Baker RS, Longcope C: Early menopausal changes in bone mass and sex steroids. J Clin Endocrinol Metab 61:905-911, 1985.
72. Goulding A, Gold E: Effects of chronic prednisolone treatment on bone resorption and bone composition in intact and ovariectomized rats receiving β-estradiol. Endocrinology 122:482-487, 1987.