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Volumn 4, Issue 6, 2012, Pages 713-723

Pharmacokinetics, bioavailability and metabolism of rhaponticin in rat plasma by UHPLC-Q-TOF/MS and UHPLC-DAD-MS n

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; RESVERATROL; RHAPONTIGENIN; RHAPONTIN; UNCLASSIFIED DRUG;

EID: 84859123128     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.24     Document Type: Article
Times cited : (27)

References (45)
  • 1
    • 34250173427 scopus 로고    scopus 로고
    • Rhapontigenin from Rheum undulatum protects against oxidative-stress- induced cell damage through antioxidant activity
    • Zhang R, Kang KA, Piao MJ et al. Rhapontigenin from Rheum undulatum protects against oxidative-stress-induced cell damage through antioxidant activity. J. Toxicol. Environ. Health 70(13), 1155-1166 (2007).
    • (2007) J. Toxicol. Environ. Health , vol.70 , Issue.13 , pp. 1155-1166
    • Zhang, R.1    Kang, K.A.2    Piao, M.J.3
  • 2
    • 0035086905 scopus 로고    scopus 로고
    • Study on anti-Oketsu activity on rhubarb II. Antiallergic effects of stilbene components from Rhei undulati Rhizoma (dried rhizome of Rheum undulatum cultivated in Korea)
    • Matsuda H, Tomohiro N, Harima K et al. Study on anti-Oketsu activity on rhubarb II. Antiallergic effects of stilbene components from Rhei undulati Rhizoma (dried rhizome of Rheum undulatum cultivated in Korea). Biol. Pharm. Bull. 24(3), 264-267 (2001).
    • (2001) Biol. Pharm. Bull. , vol.24 , Issue.3 , pp. 264-267
    • Matsuda, H.1    Tomohiro, N.2    Harima, K.3
  • 3
    • 0033943744 scopus 로고    scopus 로고
    • Metabolism of rhaponticin and chrysophanol 8-O-glucopyranoside from the rhizome of Rheum undulatum by humam intestinal bacteria and their anti-allergic actions
    • Kim DH, Park EK, Bae EA, Han MJ. Metabolism of rhaponticin and chrysophanol 8-O-glucopyranoside from the rhizome of Rheum undulatum by humam intestinal bacteria and their anti-allergic actions. Biol. Pharm. Bull. 23(7), 830-833 (2000).
    • (2000) Biol. Pharm. Bull. , vol.23 , Issue.7 , pp. 830-833
    • Kim, D.H.1    Park, E.K.2    Bae, E.A.3    Han, M.J.4
  • 4
    • 0034696073 scopus 로고    scopus 로고
    • Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages
    • Matsuda H, Kageura T, Morikawa T, Toguchida I, Harima S, Yoshikawa M. Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages. Bioorg. Med. Chem. Lett. 10(4), 323-327 (2000).
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , Issue.4 , pp. 323-327
    • Matsuda, H.1    Kageura, T.2    Morikawa, T.3    Toguchida, I.4    Harima, S.5    Yoshikawa, M.6
  • 6
    • 33751234808 scopus 로고    scopus 로고
    • Protective effect of rhubarb derivatives on amyloid beta (1-42) peptide-induced apoptosis in IMR-32 cells: A case of nutrigenomic
    • Misiti F, Sampaolese B, Mezzogori D et al. Protective effect of rhubarb derivatives on amyloid beta (1-42) peptide-induced apoptosis in IMR-32 cells: a case of nutrigenomic. Brain Res. Bull. 71(1-3), 29-36 (2006).
    • (2006) Brain Res. Bull. , vol.71 , Issue.1-3 , pp. 29-36
    • Misiti, F.1    Sampaolese, B.2    Mezzogori, D.3
  • 7
    • 34548535042 scopus 로고    scopus 로고
    • Induction of apoptosis by rhapontcin having stilbene moiety, a component of rhubarb (Rheum officinale Baillon) in human stomach cancer KATO III cells
    • Hibasami H, Takagi K, Ishii T, Tsujikawa M, Imai N, Honad I. Induction of apoptosis by rhapontcin having stilbene moiety, a component of rhubarb (Rheum officinale Baillon) in human stomach cancer KATO III cells. Oncol. Rep. 18(2), 347-351 (2007).
    • (2007) Oncol. Rep. , vol.18 , Issue.2 , pp. 347-351
    • Hibasami, H.1    Takagi, K.2    Ishii, T.3    Tsujikawa, M.4    Imai, N.5    Honad, I.6
  • 8
    • 0036690401 scopus 로고    scopus 로고
    • Antithrombotic and antiallergic activities of rhaponticin from Rhei Rhizoma are activated by human intestinal bacteria
    • Park EK, Choo MK, Yoon HK, Kim DH. Antithrombotic and antiallergic activities of rhaponticin from Rhei Rhizoma are activated by human intestinal bacteria. Arch. Pharm. Res. 25(4), 528-533 (2002).
    • (2002) Arch. Pharm. Res. , vol.25 , Issue.4 , pp. 528-533
    • Park, E.K.1    Choo, M.K.2    Yoon, H.K.3    Kim, D.H.4
  • 9
    • 43749106896 scopus 로고    scopus 로고
    • Lipoxygenase inhibitory constituents from rhubarb
    • Ngoc TM, Minh PTH, Hung TM et al. Lipoxygenase inhibitory constituents from rhubarb. Arch. Pharm. Res. 31(4), 598-605 (2008).
    • (2008) Arch. Pharm. Res. , vol.31 , Issue.4 , pp. 598-605
    • Ngoc, T.M.1    Minh, P.T.H.2    Hung, T.M.3
  • 10
    • 33846997210 scopus 로고    scopus 로고
    • Vasorelaxant effect of stilbenes from rhizome extract of rhubarb (Rheum undulatum) on the contractility of rat aorta
    • Yoo MY, Oh KS, Lee JW et al. Vasorelaxant effect of stilbenes from rhizome extract of rhubarb (Rheum undulatum) on the contractility of rat aorta. Phytother. Res. 21(2), 186-189 (2007).
    • (2007) Phytother. Res. , vol.21 , Issue.2 , pp. 186-189
    • Yoo, M.Y.1    Oh, K.S.2    Lee, J.W.3
  • 11
    • 30944468918 scopus 로고    scopus 로고
    • Insulin sensitizing and a-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma
    • Choi SB, Ko BS, Park SK, Jang JS, Park S. Insulin sensitizing and a-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma. Life Sci. 78(9), 934-942 (2006).
    • (2006) Life Sci. , vol.78 , Issue.9 , pp. 934-942
    • Choi, S.B.1    Ko, B.S.2    Park, S.K.3    Jang, J.S.4    Park, S.5
  • 12
    • 68949121366 scopus 로고    scopus 로고
    • Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice
    • Chen JL, Ma MM, Lu YW, Wang LS, Wu C. Duan HF. Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice. Planta Med. 75(5), 472-477 (2009).
    • (2009) Planta Med. , vol.75 , Issue.5 , pp. 472-477
    • Chen, J.L.1    Ma, M.M.2    Lu, Y.W.3    Wang, L.S.4    Wu, C.5    Duan, H.F.6
  • 13
    • 0028187419 scopus 로고
    • Quantitative determination of rhapontin in root of Rheum hotaoense by TLC-scanning
    • Wang LX, Zhang BC, Li LP, Zhou Z. Quantitative determination of rhapontin in root of Rheum hotaoense by TLC-scanning. China J. Chin. Mater. Med. 19(1), 37-62 (1994).
    • (1994) China J. Chin. Mater. Med. , vol.19 , Issue.1 , pp. 37-62
    • Wang, L.X.1    Zhang, B.C.2    Li, L.P.3    Zhou, Z.4
  • 14
    • 57749118601 scopus 로고    scopus 로고
    • Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography
    • Xu LN, Han X, Qi Y et al. Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. Anal. Chim. Acta 633(1), 136-148 (2009).
    • (2009) Anal. Chim. Acta , vol.633 , Issue.1 , pp. 136-148
    • Xu, L.N.1    Han, X.2    Qi, Y.3
  • 15
    • 70349753163 scopus 로고    scopus 로고
    • Analysis of stilbenes in wine by HPLC: Recent approaches
    • Gocan S. Analysis of stilbenes in wine by HPLC: recent approaches. J. Liq. Chromatogr. Related Technol. 32(11), 1598-1643 (2009).
    • (2009) J. Liq. Chromatogr. Related Technol. , vol.32 , Issue.11 , pp. 1598-1643
    • Gocan, S.1
  • 16
    • 34248403768 scopus 로고    scopus 로고
    • Identification and determination of the major constituents in traditional Chinese medicinal plant Polygonum multiflorum Thunb by HPLC coupled with PAD and ESI/MS
    • Yi T, Leung KSY, Lu GH, Zhang H, Chan K. Identification and determination of the major constituents in traditional Chinese medicinal plant Polygonum multiflorum Thunb by HPLC coupled with PAD and ESI/MS. Phytochem. Anal. 18(3), 181-187 (2007).
    • (2007) Phytochem. Anal. , vol.18 , Issue.3 , pp. 181-187
    • Yi, T.1    Leung, K.S.Y.2    Lu, G.H.3    Zhang, H.4    Chan, K.5
  • 17
    • 1942454713 scopus 로고    scopus 로고
    • Screening and identification of glycosides in biological samples using energy-gradient neutral loss scan and liquid chromatography tandem mass spectrometry
    • Qu J, Xiao SY, Wang YM, Luo GA. Screening and identification of glycosides in biological samples using energy-gradient neutral loss scan and liquid chromatography tandem mass spectrometry. Anal. Chem. 76(8), 2239-2247 (2004).
    • (2004) Anal. Chem. , vol.76 , Issue.8 , pp. 2239-2247
    • Qu, J.1    Xiao, S.Y.2    Wang, Y.M.3    Luo, G.A.4
  • 18
    • 0037041249 scopus 로고    scopus 로고
    • Determination of six components in rhubarb by cyclodextrin-modified micellar electrokinetic chromatography using a mixed micellar system of sodium cholate and sodium taurocholate
    • Shang XY, Yuan ZB. Determination of six components in rhubarb by cyclodextrin-modified micellar electrokinetic chromatography using a mixed micellar system of sodium cholate and sodium taurocholate. Anal. Chim. Acta 456(2), 183-188 (2002).
    • (2002) Anal. Chim. Acta , vol.456 , Issue.2 , pp. 183-188
    • Shang, X.Y.1    Yuan, Z.B.2
  • 19
    • 0036165405 scopus 로고    scopus 로고
    • Separation of effective constituents from rhubarb by micellar electrokinetic capillary chromatography
    • Shang XY, Yuan ZB. Separation of effective constituents from rhubarb by micellar electrokinetic capillary chromatography. Anal. Lett. 35(1), 195-202 (2002).
    • (2002) Anal. Lett. , vol.35 , Issue.1 , pp. 195-202
    • Shang, X.Y.1    Yuan, Z.B.2
  • 20
    • 0037293918 scopus 로고    scopus 로고
    • Determination of active components in rhubarb and study of their hydrophobicity by micellar electrokinetic chromatography
    • Shang XY, Yuan ZB. Determination of active components in rhubarb and study of their hydrophobicity by micellar electrokinetic chromatography. Bioorg Med. Chem. Lett. 13(4), 617-622 (2003).
    • (2003) Bioorg Med. Chem. Lett. , vol.13 , Issue.4 , pp. 617-622
    • Shang, X.Y.1    Yuan, Z.B.2
  • 21
    • 0037214824 scopus 로고    scopus 로고
    • Separation and determination of active components in rhubarb by cyclodextrin-modified micellar electrokinetic chromatography using a mixed micellar system
    • Shang XY, Yuan ZB. Separation and determination of active components in rhubarb by cyclodextrin-modified micellar electrokinetic chromatography using a mixed micellar system. Anal. Lett. 36(1), 203-214 (2003).
    • (2003) Anal. Lett. , vol.36 , Issue.1 , pp. 203-214
    • Shang, X.Y.1    Yuan, Z.B.2
  • 22
    • 0344128999 scopus 로고
    • A gas-liquid chromatographic examination of stilbene derivatives
    • Hemingway RW, Hillis WE, Bruerton K. A gas-liquid chromatographic examination of stilbene derivatives. J. Chromatogr. A 50(1), 391-399 (1970).
    • (1970) J. Chromatogr. A , vol.50 , Issue.1 , pp. 391-399
    • Hemingway, R.W.1    Hillis, W.E.2    Bruerton, K.3
  • 23
    • 79954443203 scopus 로고    scopus 로고
    • LC method for the determination of rhaponticin in rat plasma, faeces and urine for application to pharmacokinetic studies
    • First paper to report a LC method for quantification of rhaponticin in rat plasma, faeces and urine
    • Zhao YY, Wang LL, Miao H et al. LC method for the determination of rhaponticin in rat plasma, faeces and urine for application to pharmacokinetic studies. Chromatographia 73(5-6), 599-603 (2011). First paper to report a LC method for quantification of rhaponticin in rat plasma, faeces and urine.
    • (2011) Chromatographia , vol.73 , Issue.5-6 , pp. 599-603
    • Zhao, Y.Y.1    Wang, L.L.2    Miao, H.3
  • 24
    • 79953236082 scopus 로고    scopus 로고
    • Ultra-performance hydrophilic interaction LC-MS-MS for the determination of metformin in mouse plasma
    • Hsieh Y, Gaviz G, Hwa J. Ultra-performance hydrophilic interaction LC-MS-MS for the determination of metformin in mouse plasma. Bioanalysis 1(6), 1073-1079 (2009).
    • (2009) Bioanalysis , vol.1 , Issue.6 , pp. 1073-1079
    • Hsieh, Y.1    Gaviz, G.2    Hwa, J.3
  • 25
    • 79953119928 scopus 로고    scopus 로고
    • Development of an ultra-performance liquid chromatography-tandem mass spectrometry micromethod for quantification of lamotrigine in human plasma and its use in a bioequivalence trial
    • Marcelín-Jiménez G, Moreno Alionka CPA, Mendoza-Morales L, Rivera-Espinosa L, Martínez MM. Development of an ultra-performance liquid chromatography-tandem mass spectrometry micromethod for quantification of lamotrigine in human plasma and its use in a bioequivalence trial. Bioanalysis 1(1), 47-55 (2009).
    • (2009) Bioanalysis , vol.1 , Issue.1 , pp. 47-55
    • Marcelín-Jiménez, G.1    Moreno Alionka, C.P.A.2    Mendoza-Morales, L.3    Rivera-Espinosa, L.4    Martínez, M.M.5
  • 26
    • 79952497246 scopus 로고    scopus 로고
    • Absolute quantification of a therapeutic domain antibody using ultra-performance liquid chromatography-mass spectrometry and immunoassay
    • Szapacs ME, Urbanski JJ, Kehler JR et al. Absolute quantification of a therapeutic domain antibody using ultra-performance liquid chromatography-mass spectrometry and immunoassay. Bioanalysis 2(1), 1597-1608 (2010).
    • (2010) Bioanalysis , vol.2 , Issue.1 , pp. 1597-1608
    • Szapacs, M.E.1    Urbanski, J.J.2    Kehler, J.R.3
  • 27
    • 77956184259 scopus 로고    scopus 로고
    • Rapid resolution liquid chromatography-mass spectrometry and high-performance liquid chromatography-fluorescence detection for metabolism and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one
    • Zhao YY, Qin XY, Cheng XL et al. Rapid resolution liquid chromatography-mass spectrometry and high-performance liquid chromatography-fluorescence detection for metabolism and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one. Anal. Chim. Acta 675(2), 199-206 (2010).
    • (2010) Anal. Chim. Acta , vol.675 , Issue.2 , pp. 199-206
    • Zhao, Y.Y.1    Qin, X.Y.2    Cheng, X.L.3
  • 28
    • 79959326346 scopus 로고    scopus 로고
    • Pharmacokinetics of ergosterol in rats using rapid resolution liquid chromatography-atmospheric pressure chemical ionization multi-stage tandem mass spectrometry and rapid resolution liquid chromatography/tandem mass spectrometry
    • Zhao YY, Cheng XL, Liu R et al. Pharmacokinetics of ergosterol in rats using rapid resolution liquid chromatography-atmospheric pressure chemical ionization multi-stage tandem mass spectrometry and rapid resolution liquid chromatography/tandem mass spectrometry. J. Chromatogr. B 879(21), 1945-1953 (2011).
    • (2011) J. Chromatogr. B , vol.879 , Issue.21 , pp. 1945-1953
    • Zhao, Y.Y.1    Cheng, X.L.2    Liu, R.3
  • 29
    • 79957933802 scopus 로고    scopus 로고
    • MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections
    • Li F, Hsieh Y, Kang L et al. MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections. Bioanalysis 1(2), 299-307 (2009).
    • (2009) Bioanalysis , vol.1 , Issue.2 , pp. 299-307
    • Li, F.1    Hsieh, Y.2    Kang, L.3
  • 30
    • 25144468977 scopus 로고    scopus 로고
    • 'All-in-One' analysis for metabolite identification using liquid chromatography/hybrid quadrupole TOF mass spectrometry with collision energy switching
    • Wrona M, Mauriala T, Bateman KP, Mortishire-Smith RJ, O'Connor D. 'All-in-One' analysis for metabolite identification using liquid chromatography/hybrid quadrupole TOF mass spectrometry with collision energy switching. Rapid Commun. Mass Spectrom. 19 (18), 2597-2602 (2005).
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , Issue.18 , pp. 2597-2602
    • Wrona, M.1    Mauriala, T.2    Bateman, Kp.3    Mortishire-Smith, R.J.4    O'Connor, D.5
  • 31
    • 84863012683 scopus 로고    scopus 로고
    • Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole TOF mass spectrometry
    • doi:10.3109/1354750X.637180 Epub ahead of print
    • Zhao YY, Cheng XL, Wei F et al. Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole TOF mass spectrometry. Biomarkers doi:10.3109/1354750X.637180 (2012) (Epub ahead of print).
    • (2012) Biomarkers
    • Zhao, Y.Y.1    Cheng, X.L.2    Wei, F.3
  • 32
    • 84862777866 scopus 로고    scopus 로고
    • Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS
    • Zhao YY, Liu J, Cheng XL, Bai X, Lin RC. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS. Clin. Chim. Acta 413(5-6), 642-649 (2012).
    • (2012) Clin. Chim. Acta , vol.413 , Issue.5-6 , pp. 642-649
    • Zhao, Y.Y.1    Liu, J.2    Cheng, X.L.3    Bai, X.4    Lin, R.C.5
  • 33
    • 79952196139 scopus 로고    scopus 로고
    • Crystal and molecular structure of rhaponticin from Rheum hotaoense
    • Zhao YY, Qin XY, Chen SP et al. Crystal and molecular structure of rhaponticin from Rheum hotaoense. J. Chem. Crystallogr. 41(3), 409-414 (2011).
    • (2011) J. Chem. Crystallogr. , vol.41 , Issue.3 , pp. 409-414
    • Zhao, Y.Y.1    Qin, X.Y.2    Chen, S.P.3
  • 34
    • 0003484310 scopus 로고    scopus 로고
    • U.S. Department of Health and Human Services, Food and Drug administration, Centre for Drug Evaluation and Research (CDER), Centre for Veterinary Centre (CVM)
    • U.S. Department of Health and Human Services, Food and Drug administration, Centre for Drug Evaluation and Research (CDER), Centre for Veterinary Centre (CVM). Guidance for industry: bioanalytical method validation (2001).
    • (2001) Guidance for Industry: Bioanalytical Method Validation
  • 35
    • 71149118225 scopus 로고    scopus 로고
    • A fast and sensitive HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of ergone in rats
    • Zhao YY, Cheng XL, Zhang YM et al. A fast and sensitive HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of ergone in rats. J. Chromatogr. B 878(1), 29-33 (2010).
    • (2010) J. Chromatogr. B , vol.878 , Issue.1 , pp. 29-33
    • Zhao, Y.Y.1    Cheng, X.L.2    Zhang, Y.M.3
  • 36
    • 77957302285 scopus 로고    scopus 로고
    • Quantitative HPLC method and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one, a natural product with diuretic activity from Polyporus umbellatus
    • Zhao YY, Qin XY, Zhang YM et al. Quantitative HPLC method and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one, a natural product with diuretic activity from Polyporus umbellatus. Biomed. Chromatogr. 24(10), 1120-1124 (2010).
    • (2010) Biomed. Chromatogr. , vol.24 , Issue.10 , pp. 1120-1124
    • Zhao, Y.Y.1    Qin, X.Y.2    Zhang, Y.M.3
  • 37
    • 27444439740 scopus 로고    scopus 로고
    • Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: Applications to metabolism, pharmacokinetics and anti-cancer studies
    • A simple HPLC method was developed for the determination of rhapontigenin. The assay was successfully applied to both the in vitro and in vivo metabolic kinetic study of rhapontigenin
    • Roupe KA, Helms GL, Halls SC, Yáñez JA, Davies NM. Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. J. Pharm. Pharmaceut. Sci. 8(3), 374-386 (2005). A simple HPLC method was developed for the determination of rhapontigenin. The assay was successfully applied to both the in vitro and in vivo metabolic kinetic study of rhapontigenin.
    • (2005) J. Pharm. Pharmaceut. Sci. , vol.8 , Issue.3 , pp. 374-386
    • Roupe, K.A.1    Helms, G.L.2    Halls, S.C.3    Yáñez, J.A.4    Davies, N.M.5
  • 38
    • 0034932102 scopus 로고    scopus 로고
    • Inhibitors from rhubarb on lipopolysaccharide-induced nitric oxide production in macrophages: Structural requirements of stilbenes for the activity
    • Kageura T, Matsuda H, Morikawa T et al. Inhibitors from rhubarb on lipopolysaccharide-induced nitric oxide production in macrophages: structural requirements of stilbenes for the activity. Bioorg. Med. Chem. 9(7), 1887-1893 (2001).
    • (2001) Bioorg. Med. Chem. , vol.9 , Issue.7 , pp. 1887-1893
    • Kageura, T.1    Matsuda, H.2    Morikawa, T.3
  • 39
    • 0032971740 scopus 로고    scopus 로고
    • Anti-allergic action of resveratrol and related hydroxystilbenes
    • Cheong H, Ryu SY, Kim KM. Anti-allergic action of resveratrol and related hydroxystilbenes. Planta Med. 65(3), 266-268 (1999).
    • (1999) Planta Med. , vol.65 , Issue.3 , pp. 266-268
    • Cheong, H.1    Ryu, S.Y.2    Kim, K.M.3
  • 40
    • 0034727718 scopus 로고    scopus 로고
    • Anti-platelet stilbenes from the aerial parts of Rheum palaestinum
    • Aburjai TA. Anti-platelet stilbenes from the aerial parts of Rheum palaestinum. Phytochemistry 55(5), 407-410 (2000).
    • (2000) Phytochemistry , vol.55 , Issue.5 , pp. 407-410
    • Aburjai, T.A.1
  • 41
    • 0035064593 scopus 로고    scopus 로고
    • Mechanism-based inhibition of human Cytochrome P450 1A1 by rhapontigenin
    • Rhapontigenin is a potent mechanism-based inactivator of human P450 1A1 and may be considered as a good candidate for a cancer chemopreventive agent in humans
    • Chun YJ, Ryu SY, Jeong TC, Kim MY. Mechanism-based inhibition of human Cytochrome P450 1A1 by rhapontigenin. Drug Met. Disp. 29(4), 389-393 (2001). Rhapontigenin is a potent mechanism-based inactivator of human P450 1A1 and may be considered as a good candidate for a cancer chemopreventive agent in humans.
    • (2001) Drug Met. Disp. , vol.29 , Issue.4 , pp. 389-393
    • Chun, Y.J.1    Ryu, S.Y.2    Jeong, T.C.3    Kim, M.Y.4
  • 42
    • 0037292971 scopus 로고    scopus 로고
    • Cytochrome P450 1B1: A target for inhibition in anticarcinogenesis strategies
    • Guengerich FP, Chun Y, Kim D, Gilliam EMJ, Shimada T. Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies. Mut. Res. 523-524(1-2),173-182 (2003).
    • (2003) Mut. Res. , vol.523-524 , Issue.1-2 , pp. 173-182
    • Guengerich, F.P.1    Chun, Y.2    Kim, D.3    Gilliam, E.M.J.4    Shimada, T.5
  • 43
    • 33751232933 scopus 로고    scopus 로고
    • Pharmacokinetics of selected stilbenes: Rhapontigenin, piceatannol and pinosylvin in rats
    • Rhapontigenin was highly distributed into tissues and were highly extracted by the liver. The estimates of oral bioavailability characterize rhapontigenin as poorly bioavailable compounds
    • Roupe KA, Yáñez JA, Teng XW, Davies NM. Pharmacokinetics of selected stilbenes: rhapontigenin, piceatannol and pinosylvin in rats. J. Pharm. Pharmacol. 58(11), 1443-1450 (2006). Rhapontigenin was highly distributed into tissues and were highly extracted by the liver. The estimates of oral bioavailability characterize rhapontigenin as poorly bioavailable compounds.
    • (2006) J. Pharm. Pharmacol. , vol.58 , Issue.11 , pp. 1443-1450
    • Roupe, K.A.1    Yáñez, J.A.2    Teng, X.W.3    Davies, N.M.4
  • 44
    • 10744229260 scopus 로고    scopus 로고
    • Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene
    • Sale S, Verschoyle RD, Boocock D et al. Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene. Brit. J. Cancer 90(3), 736-744 (2004).
    • (2004) Brit. J. Cancer , vol.90 , Issue.3 , pp. 736-744
    • Sale, S.1    Verschoyle, R.D.2    Boocock, D.3


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