Endothelial RIG-I activation impairs endothelial function

Biochemical and Biophysical Research Communications

Volumn 420, Issue 1, 2012, Pages 66-71

  Asdonk, Tobias ^a   Motz, Inga ^a   Werner, Nikos ^a   Coch, Christoph ^a   Barchet, Winfried ^a   Hartmann, Gunther ^a   Nickenig, Georg ^a   Zimmer, Sebastian ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Atherosclerosis; Endothelial biology; Inflammation; Innate immune system; RIG I

Indexed keywords

REACTIVE OXYGEN METABOLITE; RETINOIC ACID INDUCIBLE PROTEIN I; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ENDOTHELIUM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL MICROPARTICLE; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RECEPTOR UPREGULATION; VASCULAR ENDOTHELIUM; VASODILATATION; WILD TYPE;

ANIMALS; ATHEROSCLEROSIS; DEAD-BOX RNA HELICASES; ENDOTHELIUM, VASCULAR; HUMANS; MICE; REACTIVE OXYGEN SPECIES;

MUS;

EID: 84859110348     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.02.116     Document Type: Article

References (31)

1. Ross R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 1999, 340:115-126.
2. Murray C.J., Lopez A.D. Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study. Lancet 1997, 349:1498-1504.
3. Hansson G.K., Libby P., Schonbeck U., Yan Z.Q. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ. Res. 2002, 91:281-291.
4. Lee M.S., Kim Y.J. Pattern-recognition receptor signaling initiated from extracellular, membrane, and cytoplasmic space. Mol. Cells 2007, 23:1-10.
5. Shi Y., Evans J.E., Rock K.L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 2003, 425:516-521.
6. Liu L., Botos I., Wang Y., Leonard J.N., Shiloach J., Segal D.M., Davies D.R. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science 2008, 320:379-381.
7. Pichlmair A., Schulz O., Tan C.P., Rehwinkel J., Kato H., Takeuchi O., Akira S., Way M., Schiavo G., Reis e Sousa C. Activation of MDA5 requires higher-order RNA structures generated during virus infection. J. Virol. 2009, 83:10761-10769.
8. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 2000, 408:740-745.
9. Takaoka A., Wang Z., Choi M.K., Yanai H., Negishi H., Ban T., Lu Y., Miyagishi M., Kodama T., Honda K., Ohba Y., Taniguchi T. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007, 448:501-505.
10. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., Bauer S. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004, 303:1526-1529.
11. Hornung V., Ellegast J., Kim S., Brzozka K., Jung A., Kato H., Poeck H., Akira S., Conzelmann K.K., Schlee M., Endres S., Hartmann G. 5'-Triphosphate RNA is the ligand for RIG-I. Science 2006, 314:994-997.
12. Schlee M., Roth A., Hornung V., Hagmann C.A., Wimmenauer V., Barchet W., Coch C., Janke M., Mihailovic A., Wardle G., Juranek S., Kato H., Kawai T., Poeck H., Fitzgerald K.A., Takeuchi O., Akira S., Tuschl T., Latz E., Ludwig J., Hartmann G. Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity 2009, 31:25-34.
13. Lee M.S., Kim Y.J. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu. Rev. Biochem. 2007, 76:447-480.
14. F. Liu, J. Gu, Retinoic acid inducible gene-I more than a virus sensor, Protein Cell 2 351-357.
15. Schachinger V., Britten M.B., Zeiher A.M. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000, 101:1899-1906.
16. Wassmann S., Werner N., Czech T., Nickenig G. Improvement of endothelial function by systemic transfusion of vascular progenitor cells. Circ. Res. 2006, 99:e74-83.
17. Sieveking D.P., Buckle A., Celermajer D.S., Ng M.K. Strikingly different angiogenic properties of endothelial progenitor cell subpopulations: insights from a novel human angiogenesis assay. J. Am. Coll. Cardiol. 2008, 51:660-668.
18. Walenta K., Friedrich E.B., Sehnert F., Werner N., Nickenig G. In vitro differentiation characteristics of cultured human mononuclear cells-implications for endothelial progenitor cell biology. Biochem. Biophys. Res. Commun. 2005, 333:476-482.
19. Wassmann S., Stumpf M., Strehlow K., Schmid A., Schieffer B., Bohm M., Nickenig G. Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ. Res. 2004, 94:534-541.
20. Werner N., Priller J., Laufs U., Endres M., Bohm M., Dirnagl U., Nickenig G. Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition. Arterioscler. Thromb. Vasc. Biol. 2002, 22:1567-1572.
21. Custodis F., Baumhakel M., Schlimmer N., List F., Gensch C., Bohm M., Laufs U. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation 2008, 117:2377-2387.
22. S. Zimmer, M. Steinmetz, T. Asdonk, I. Motz, C. Coch, E. Hartmann, W. Barchet, S. Wassmann, G. Hartmann, and G. Nickenig, Activation of endothelial toll-like receptor 3 impairs endothelial function. Circ. Res. 108 1358-1366.
23. Imaizumi T., Yagihashi N., Kubota K., Yoshida H., Sakaki H., Yagihashi S., Kimura H., Satoh K. Expression of retinoic acid-inducible gene-I (RIG-I) in macrophages: possible involvement of RIG-I in atherosclerosis. J. Atheroscler. Thromb. 2007, 14:51-55.
24. Hendrix M.G., Salimans M.M., van Boven C.P., Bruggeman C.A. High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis. Am. J. Pathol. 1990, 136:23-28.
25. Peng S., Geng J., Sun R., Tian Z., Wei H. Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors. Cancer Sci. 2009, 100:529-536.
26. Pan M., Geng S., Xiao S., Ren J., Liu Y., Li X., Li Z., Peng Z. Apoptosis induced by synthetic retinoic acid CD437 on human melanoma A375 cells involves RIG-I pathway. Arch. Dermatol. Res. 2009, 301:15-20.
27. Imaizumi T., Hatakeyama M., Yamashita K., Yoshida H., Ishikawa A., Taima K., Satoh K., Mori F., Wakabayashi K. Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells. Endothelium 2004, 11:169-173.
28. Luster A.D., Unkeless J.C., Ravetch J.V. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 1985, 315:672-676.
29. Heller E.A., Liu E., Tager A.M., Yuan Q., Lin A.Y., Ahluwalia N., Jones K., Koehn S.L., Lok V.M., Aikawa E., Moore K.J., Luster A.D., Gerszten R.E. Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation 2006, 113:2301-2312.
30. Schuett H., Luchtefeld M., Grothusen C., Grote K., Schieffer B. How much is too much? Interleukin-6 and its signalling in atherosclerosis. Thromb. Haemost. 2009, 102:215-222.
31. F. Liu, S. Wu, H. Ren, J. Gu, Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat. Cell. Biol. 13 254-262.