Serum paraoxonase phenotype distribution in exudative age-related macular degeneration and its relationship to homocysteine and oxidized low-density lipoprotein

Retina

Volumn 32, Issue 4, 2012, Pages 658-666

  Javadzadeh, Alireza ^a   Ghorbanihaghjo, Amir ^a   Bahreini, Elham ^a   Rashtchizadeh, Nadereh ^b   Argani, Hassan ^b   Alizadeh, Samira ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

exudative age related macular degeneration; homocysteine; oxidized LDL; paraoxonase

Indexed keywords

ARYLDIALKYLPHOSPHATASE; BIOLOGICAL MARKER; HOMOCYSTEINE; OXIDIZED LOW DENSITY LIPOPROTEIN; PARAOXON; PHENYLACETIC ACID;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXUDATIVE MACULAR DEGENERATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PHENOTYPE; RETINA MACULA AGE RELATED DEGENERATION; STATISTICAL SIGNIFICANCE;

AGED; AGED, 80 AND OVER; ARYLDIALKYLPHOSPHATASE; FEMALE; HOMOCYSTEINE; HUMANS; LIPOPROTEINS, LDL; MACULAR DEGENERATION; MALE; MIDDLE AGED; OXIDATIVE STRESS; PHENOTYPE;

EID: 84859103862     PISSN: 0275004X     EISSN: 15392864     Source Type: Journal    
DOI: 10.1097/IAE.0b013e31822529b1     Document Type: Article

References (64)

1. de Jong PT. Age-related macular degeneration. N Engl J Med 2006;355:1474-1485.
2. Bourla DH, Young TA. Age-related macular degeneration: apractical approach to a challenging disease. JAm Geriatr Soc 2006;54:1130-1135. (Pubitemid 43992553)
3. Resnikoff S, Pascolini D, Etya'ale D, et al. Global data onvisual impairment in the year 2002. Bull World Health Organ 2004;82:844-851. (Pubitemid 39573742)
4. DeAngelis MM, Ji F, Kim IK, et al. Cigarette smoking, CFH, APOE, ELOVL4, and risk of neovascular age-related macular degeneration. Arch Ophthalmol 2007;125:49-54. (Pubitemid 46072375)
5. Mousa SA, Lorelli W, Campochiaro PA. Role of hypoxia and extracellular matrix-integrin binding in the modulation of angiogenic growth factors secretion by retinal pigmented epithelial cells. J Cell Biochem 1999;74:135-143. (Pubitemid 29270036)
6. Chaine G, Hullo A, Sahel J, et al. Case-control study of the risk factors for age related macular degeneration. France-DMLA Study Group. Br J Ophthalmol 1998;82:996-1002. (Pubitemid 28451268)
7. Seddon JM, Cote J, Page WF, et al. The UStwin study of age-related macular degeneration: relative roles of genetic and environmental influences. Arch Ophthalmol 2005;123:321-327. (Pubitemid 41007575)
8. Smith W, Mitchell P, Leeder SR, Wang JJ. Plasma fibrinogen levels, other cardiovascular risk factors, and age-related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol 1998;116:583-587. (Pubitemid 28414571)
9. Beatty S, Koh H, Phil M, et al. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000;45:115-134.
10. Winkler BS, Boulton ME, Gottsch JD, Sternberg P. Oxidative damage and age-related macular degeneration. Mol Vis 1999; 5:32.
11. Wiegand RD, Giusto NM, Rapp LM, Anderson RE. Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina. Invest Ophthalmol Vis Sci 1983; 24:1433-1435. (Pubitemid 13015840)
12. Gerster H. Review: antioxidant protection of the ageing macula. Age Ageing 1991;20:60-69.
13. Hoppe G, Marmorstein AD, Pennock EA, Hoff HF. Oxidized low density lipoprotein-induced inhibition of processing of photoreceptor outer segments by RPE. Invest Ophthalmol Vis Sci 2001;42:2714-2720. (Pubitemid 32954884)
14. Wassell J, Boulton M. A role for vitamin A in the formation of ocular lipofuscin. Br J Ophthalmol 1997;81:911-918. (Pubitemid 27469978)
15. Bok D. The retinal pigment epithelium: a versatile partner in vision. J Cell Sci Suppl 1993;17:189-195. (Pubitemid 24041298)
16. Bostom AG, Rosenberg IH, Silbershatz H, et al. Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: the Framingham Study. Ann Intern Med 1999; 131:352-355. (Pubitemid 29424629)
17. Rees MM, Rodgers GM. Homocysteinemia: association of ametabolic disorder with vascular disease and thrombosis. Thromb Res 1993;71:337-359. (Pubitemid 23244324)
18. den HT, Vermeer SE, Clarke R, et al. Homocysteine and brain atrophy on MRI of non-demented elderly. Brain 2003;126: 170-175.
19. Seddon JM, Gensler G, Klein ML, et al. Evaluation of plasma homocysteine and risk of age-related macular degeneration. Am J Ophthalmol 2006;141:201-203. (Pubitemid 43016200)
20. Christen WG, Glynn RJ, Chew EY, et al. Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study. Arch Intern Med 2009;169:335-341.
21. Bleich S, Roedl J, Von AN, et al. Elevated homocysteine levels inaqueous humor of patients with pseudoexfoliation glaucoma. Am J Ophthalmol 2004;138:162-164. (Pubitemid 38850275)
22. Stein JH, McBride PE. Hyperhomocysteinemia and atherosclerotic vascular disease: pathophysiology, screening, and treatment. off. Arch Intern Med 1998;158:1301-1306. (Pubitemid 28287522)
23. Ciaccio M, Bivona G, Bellia C. Therapeutical approach toplasma homocysteine and cardiovascular risk reduction. Ther Clin Risk Manag 2008;4:219-224. (Pubitemid 351460946)
24. Heuberger RA, Fisher AI, Jacques PF, et al. Relation of blood homocysteine and its nutritional determinants to age-related maculopathy in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2002;76:897-902.
25. Mackness MI, Arrol S, Abbott C, Durrington PN. Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis 1993;104:129-135. (Pubitemid 24035640)
26. Aviram M, Hardak E, Vaya J, et al. Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities. Circulation 2000;101:2510-2517. (Pubitemid 30366256)
27. Jakubowski H. Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J 1999;13:2277-2283.
28. Ates O, Azizi S, Alp HH, et al. Decreased serum paraoxonase 1activity and increased serum homocysteine and malondialdehyde levels in age-related macular degeneration. Tohoku J Exp Med 2009;217:17-22.
29. Eckerson HW, Romson J,Wyte C, La Du BN. The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts. Am J Hum Genet 1983;35:214-227. (Pubitemid 13111118)
30. Nevin DN, Zambon A, Furlong CE, et al. Paraoxonase genotypes, lipoprotein lipase activity, and HDL. Arterioscler Thromb Vasc Biol 1996;16:1243-1249. (Pubitemid 26339711)
31. Vendrov AE, Hakim ZS, Madamanchi NR, et al. Atherosclerosis isattenuated by limiting superoxide generation in both macrophages and vessel wall cells. Arterioscler Thromb Vasc Biol 2007;27:2714-2721. (Pubitemid 350158927)
32. Inoue M, Itoh H, Tanaka T, et al. Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator-activated receptor-gamma. Arterioscler Thromb Vasc Biol 2001;21:560-566. (Pubitemid 32323389)
33. Johnston N, Jernberg T, Lagerqvist B, et al. Improved identification of patients with coronary artery disease by the use of new lipid and lipoprotein biomarkers. Am J Cardiol 2006;97:640-645. (Pubitemid 43255031)
34. Wong TY, Klein R, Sun C, Mitchell P, et al. Age-related macular degeneration and risk for stroke. Ann Intern Med 2006;145:98-106. (Pubitemid 46780583)
35. Fujimoto WY. Friedewald's LDL-cholesterol estimation formula in a Japanese American population. Jpn Circ J 1988;52:604-606.
36. Paolisso G, Tagliamonte MR, Rizzo MR, et al. Oxidative stress and advancing age: results in healthy centenarians. J Am Geriatr Soc 1998;46:833-838. (Pubitemid 28328497)
37. Bartlett H, Eperjesi F. A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology [ISRCTN78467674]. Nutr J 2003;2:12.
38. Sprecher H, Chen Q. Polyunsaturated fatty acid biosynthesis: a microsomal-peroxisomal process. Prostaglandins Leukot Essent Fatty Acids 1999;60:317-321. (Pubitemid 29401786)
39. Ferrari CK. Functional foods and physical activities in health promotion of aging people. Maturitas 2007;58:327-339. (Pubitemid 350167511)
40. Adkins S, Gan KN, Mody M, La Du BN. Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes. Am J Hum Genet 1993;52:598-608. (Pubitemid 23311330)
41. Humbert R, Adler DA, Disteche CM, et al. The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet 1993;3:73-76. (Pubitemid 23063292)
42. Tribble DL. Lipoprotein oxidation indyslipidemia: insights into general mechanisms affecting lipoprotein oxidative behavior. Curr Opin Lipidol 1995;6:196-208.
43. Richter RJ, Furlong CE. Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics 1999;9:745-753. (Pubitemid 30011938)
44. Lynch SM, Campione AL, Moore MK. Plasma thiols inhibit hemin-dependent oxidation of human low-density lipoprotein. Biochim Biophys Acta 2000;1485:11-22. (Pubitemid 30259191)
45. Bolann BJ, Solli JD, Schneede J, et al. Evaluation of indicators of cobalamin deficiency defined as cobalamin-induced reduction in increased serum methylmalonic acid. Clin Chem 2000;46:1744-50.
46. Kazemi MB, Eshraghian K, Omrani GR, et al. Homocysteine level inCAD patients of Iranian population. Angiology 2006; 57:9-14.
47. Axer-Siegel R, Bourla D, Ehrlich R, et al. Association of neovascular age-related macular degeneration and hyperhomocysteinemia. Am J Ophthalmol 2004;137:84-89. (Pubitemid 38045191)
48. Rochtchina E, Wang JJ, Flood VM, et al. Elevated serum homocysteine, low serum vitamin B12, folate, and age-related macular degeneration: the Blue Mountains Eye Study. Am J Ophthalmol 2007;143:344-346. (Pubitemid 46136142)
49. Ferdinandusse S, Denis S, Mooijer PA, et al. Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. J Lipid Res 2001;42: 1987-1995. (Pubitemid 34001047)
50. Drobek-Slowik M, Karczewicz D, Safranow K. [The potential role of oxidative stress in the pathogenesis of the age-related macular degeneration (AMD)]. Postepy Hig Med Dosw (Online) 2007;61:28-37.
51. Johnston N, Jernberg T, Lagerqvist B, et al. Improved identification of patients with coronary artery disease by the use of new lipid and lipoprotein biomarkers. Am J Cardiol 2006;97:640-645. (Pubitemid 43255031)
52. Heuberger RA, Fisher AI, Jacques PF, et al. Relation of blood homocysteine and its nutritional determinants to age-related maculopathy in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2002;76:897-902.
53. Ciaccio M, Bivona G, Bellia C. Therapeutical approach toplasma homocysteine and cardiovascular risk reduction. Ther Clin Risk Manag 2008;4:219-224. (Pubitemid 351460946)
54. Vignini A, Nanetti L, Bacchetti T, et al. Modification induced byhomocysteine and low-density lipoprotein on human aortic endothelial cells: an in vitro study. J Clin Endocrinol Metab 2004;89:4558-4561. (Pubitemid 39244469)
55. Chwatko G, Jakubowski H. The determination of homocysteinethiolactone in human plasma. Anal Biochem 2005;337:271-277.
56. Ferretti G, Bacchetti T, Moroni C, et al. Effect of homocysteinylation of low density lipoproteins on lipid peroxidation of human endothelial cells. J Cell Biochem 2004;92:351-360.
57. Jakubowski H. Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation. J Biol Chem 2000;275: 3957-3962. (Pubitemid 30094622)
58. Jakubowski H, Ambrosius WT, Pratt JH. Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis. FEBS Lett 2001;491:35-39.
59. Abbott CA, Mackness MI, Kumar S, et al. Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipids and lipoproteins. Arterioscler Thromb Vasc Biol 1995;15:1812-1818.
60. Selhub J, Jacques PF, Bostom AG, et al. Association between plasma homocysteine concentrations and extracranial carotidartery stenosis. N Engl J Med 1995;332:286-291.
61. Baskol G, Karakucuk S, Oner AO, et al. Serum paraoxonase 1activity and lipid peroxidation levels in patients with age-related macular degeneration. Ophthalmologica 2006;220:12-16. (Pubitemid 41832689)
62. Clemons TE, Milton RC, Klein R, et al. Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19. Ophthalmology 2005;112:533-539. (Pubitemid 41108849)
63. Robertson KS, Hawe E, Miller GJ, et al. Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II. Biochim Biophys Acta 2003;1639:203-212. (Pubitemid 37421428)
64. Smith W, Assink J, Klein R, et al. Risk factors for age-related macular degeneration: pooled findings from three continents. Ophthalmology 2001;108:697-704. (Pubitemid 32238465)