Association of neovascular age-related macular degeneration and hyperhomocysteinemia

American Journal of Ophthalmology

Volumn 137, Issue 1, 2004, Pages 84-89

  Axer Siegel, Ruth ^a,c   Bourla, Dan ^a,c   Ehrlich, Rita ^a,c   Dotan, Gad ^a,c   Benjamini, Yoav ^c   Gavendo, Slava ^b   Weinberger, Dov ^a,c   Sela, Ben Ami ^b,c  

^a RABIN MEDICAL CENTER   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE;

AGED; ANAMNESIS; ARTICLE; BLOOD SAMPLING; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETINA MACULA DEGENERATION;

EID: 0346099260     PISSN: 00029394     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9394(03)00864-X     Document Type: Article

References (36)

1. Report of the retinal diseases panel: vision research: a national plan, 1994-1998. 1993;United States Department of Health and Human Services, Bethesda, MD. Publication NIH93-3186.
2. Klein R., Wang Q., Klein B.E.K., et al. The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci. 36:1995;183-191.
3. Attebo K., Mitchell P., Smith W. Visual acuity and the causes of visual loss in Australia the Blue Mountain Eye Study . Ophthalmology. 103:1996;357-364.
4. Klaver C.C., Wolfs R.C., Vingerling J.R., et al. Age-specific prevalence and causes of blindness and visual impairment in an older population the Rotterdam Study . Arch Opthalmol. 116:1998;653-658.
5. Smith W., Assink J., Klein R., et al. Risk factors for age-related macular degeneration. Pooled findings from three continents. Ophthalmology. 108:2001;697-704.
6. Hammond C.J., Webster A.R., Snieder H. Genetic influence on early age-related maculopathy. Ophthalmology. 109:2002;730-736.
7. Risk factors for neovascular age-related macular degeneration. Arch Ophthalmol. 110:1992;1701-1708.
8. Vingerling K.R., Klaver C.C., Hofman A., De Jong P.T. Epidemiology of age-related maculopathy. Epidemiol Rev. 17:1995;347-360.
9. Archer D.B., Gardiner T.A. Electron microscopic features of experimental choroidal neovascularization. Am J Ophthalmol. 91:1981;433-457.
10. Peck-Lin L., Blann A.D., Hop-Ross M. Age-related macular degeneration is associated with increased vascular endothelial growth factor, hemorrheology and endothelial dysfunction. Ophthalmology. 108:2001;705-710.
11. Vingerling J.R., Dielemans I., Bots M.L., et al. Age-related macular degeneration is associated with atherosclerosis. The Rotterdam Study. Am J Epidemiol. 142:1995;404-409.
12. Clarke R., Daly L., Robinson K., et al. Hyperhomocysteinemia an independent risk factor for vascular disease . N Engl J Med. 324:1991;1149-1155.
13. Eikelbloom J.W., Hankey G.J., Anand S.S., et al. Association between high homocysteine and ischemic stroke due to large and small artery disease but not other etiologic subtypes of ischemic stroke. Stroke. 31:2000;1069-1075.
14. Rosenberg I.H., Silbershatz H., Jacques P.F., et al. Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons the Framingham Study . Ann Intern Med. 131:1999;352-355.
15. McCully K.S. Vascular pathology of homocysteinemia. Am J Pathol. 56:1969;111-128.
16. Upchurch G.R. Jr, Welch G.N., Fabian A.J., et al. Homocysteine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 272:1997;17012-17017.
17. Stamler J.S., Osborne J.A., Jaraki O., et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 91:1993;308-318.
18. Jakubowski H. Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels. J Biol Chem. 272:1997;1935-1942.
19. Pianka P., Almog Y., Man O., et al. Hyperhomocysteinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. Ophthalmology. 107:2000;1588-1592.
20. Jacobsen D.W., Gatautis V.J., Green R., et al. Determination of plasma homocysteine by high-performance liquid chromatography with fluorescence detection. Anal Biochem. 178:1989;208-214.
21. Hyman L.G., Lilienfeld A.M., Ferris F.L. III, Fine S.L. Senile macular degeneration a case control study . Am J Epidemiol. 118:1983;213-227.
22. Goldberg J., Flowerdew G., Smith E., et al. Factors associated with age-related macular degeneration an analysis of data from the first National Health and Nutrition Examination Survey . Am J Epidemiol. 128:1988;700-710.
23. Klein R., Klein B.E.K., Jensen S.C. The relation of cardiovascular disease and its risk factors to the 5-year incidence of age-related maculopathy. Ophthalmology. 104:1997;1804-1812.
24. Friedman E. The role of the atherosclerotic process in the pathogenesis of age-related macular degeneration. Am J Ophthalmol. 130:2000;658-663.
25. Ramrattan R.S., van der Schaft T.L., Mooy C.M., et al. Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging. Invest Ophthalmol Vis Sci. 35:1994;2857-2864.
26. Chen J.C., Fitzke F.W., Payuleikhoff D., Bird A.C. Poor choroidal perfusion is a cause of visual impairment in age-related macular degeneration. Invest Ophthalmol Vis Sci. 30:(Suppl):1989;153.
27. Yoneya S., Saito T., Komatsu Y., et al. The improved image of indocyanine green angiography in young healthy volunteers. Retina. 18:1998;30-36.
28. Yoneya S., Saito T., Komtsu Y., et al. Binding properties of indocyanine green in human blood. Invest Ophthalmol Vis Sci. 39:1998;1286-1290.
29. Ross R.D., Barofsky J.M., Cohen G., et al. Presumed macular choroidal watershed vascular filling, choroidal neovascularization, and systemic vascular disease in patients with age-related macular degeneration. Am J Ophthalmol. 125:1998;71-80.
30. Du Vigneaud V. A trial of research in sulfur chemistry and metabolism and related fields. 1952;Cornell University Press, Ithaca, NY. 213.
31. Stabler S.P., Marcell P.D., Podell E.T., et al. Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem. 162:1987;185-196.
32. Ueland P.M., Refsum H., Stabler S.P., et al. Total homocysteine in plasma or serum methods and clinical applications . Clin Chem. 39:1993;1764-1779.
33. Clarke R., Smith A.D., Jobst K.A., et al. Folate, vitamin B(12), and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 55:1998;1449-1455.
34. Kluijtmans L.A.J., Young I.S., Boreham C.A., et al. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood. 101:2003;2483-2488.
35. Seddon J.M., Ajani U.A., Sperduto R.D., et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA. 272:1994;1413-1421.
36. Heuberger R.A., Fisher A.I., Jacques P.F., et al. Relation of blood homocysteine and its nutritional determinants to age-related maculopathy in the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 76:2002;897-902.