Genome-wide association study of intelligence: Additive effects of novel brain expressed genes

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 51, Issue 4, 2012, Pages

  Loo, Sandra K ^a   Shtir, Corina ^b   Doyle, Alysa E ^c   Mick, Eric ^d   McGough, James J ^a   McCracken, James ^a   Biederman, Joseph ^c   Smalley, Susan L ^a   Cantor, Rita M ^a   Faraone, Stephen V ^e   Nelson, Stanley F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

ADHD; cognitive ability; genetics; haplotype; SNPs

Indexed keywords

ARTICLE; ATTENTION DEFICIT DISORDER; COGNITION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; INTELLIGENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84859102967     PISSN: 08908567     EISSN: 15275418     Source Type: Journal    
DOI: 10.1016/j.jaac.2012.01.006     Document Type: Article

References (48)

1. G.D. Batty, M. Kivimaki, I.J. Deary Intelligence, education, and mortality BMJ 340 2010 c563
2. C.J. Edmonds, E.B. Isaacs, P.M. Visscher Inspection time and cognitive abilities in twins aged 7 to 17 years: age-related changes, heritability, and genetic covariance Intelligence 36 2008 210 225
3. N. Jacobs, J. van Os, C. Derom, E. Thiery Heritability of intelligence Twin Res Hum Genet 10 2007 11 14
4. L.M. Butcher, O.S. Davis, I.W. Craig, R. Plomin Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays Genes Brain Behav 7 2008 435 446 (Pubitemid 351590930)
5. I.J. Deary, L. Penke, W. Johnson The neuroscience of human intelligence differences Nat Rev Neurosci 11 2010 201 211
6. D. Ruano, G.R. Abecasis, B. Glaser Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability Am J Hum Genet 86 2010 113 125
7. D. Pinto, A.T. Pagnamenta, L. Klei Functional impact of global rare copy number variation in autism spectrum disorders Nature 466 2010 368 372
8. J. Elia, X. Gai, H.M. Xie Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes Mol Psychiatry 15 2010 637 646
9. J.T. Walters, A. Corvin, M.J. Owen Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia Arch Gen Psychiatry 67 2010 692 700
10. F.X. Castellanos, R. Tannock Neuroscience of attention-deficit/ hyperactivity disorder: the search for endophenotypes Nat Rev Neurosci 3 2002 617 628 (Pubitemid 135706670)
11. Y. Paloyelis, F. Rijsdijk, A.C. Wood, P. Asherson, J. Kuntsi The genetic association between ADHD symptoms and reading difficulties: the role of inattentiveness and IQ J Abnorm Child Psychol 38 2010 1083 1095
12. N.N. Rommelse, M.E. Altink, J. Oosterlaan, C.J. Buschgens, J. Buitelaar, J.A. Sergeant Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families Psychol Med 38 2008 1595 1606
13. A.C. Wood, F. Rijsdijk, K.A. Johnson The relationship between ADHD and key cognitive phenotypes is not mediated by shared familial effects with IQ Psychol Med 41 2011 861 871
14. D. Posthuma, M. Luciano, E.J. Geus A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p Am J Hum Genet 77 2005 318 326 (Pubitemid 41022713)
15. D.M. Dick, F. Aliev, L. Bierut Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample Behav Genet 36 2006 77 86
16. M. Luciano, M.J. Wright, D.L. Duffy Genome-wide scan of IQ finds significant linkage to a quantitative trait locus on 2q Behav Genet 36 2006 45 55
17. D.E. Comings, S. Wu, M. Rostamkhani Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition Mol Psychiatry 8 2003 10 11 (Pubitemid 36188566)
18. D.M. Dick, F. Aliev, J. Kramer Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence Behav Genet 37 2007 265 272 (Pubitemid 46425336)
19. M.F. Gosso, M. van Belzen, E.J. de Geus Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families Genes Brain Behav 5 2006 577 584 (Pubitemid 44665355)
20. T.S. Rizzi, A. Arias-Vasquez, N. Rommelse The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects Am J Med Genet B Neuropsychiatr Genet 156 2011 145 157
21. M.F. Egan, T.E. Goldberg Intermediate cognitive phenotypes associated with schizophrenia Methods Mol Med 77 2003 163 197
22. S.E. Harris, H. Fox, A.F. Wright The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills Mol Psychiatry 11 2006 505 513
23. A. Payton The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009 Neuropsychol Rev 19 2009 451 477
24. American Psychiatric Association Diagnostic and Statistical Manual of Mental DisordersTR 4th ed. 2000 American Psychiatric Association Washington, DC
25. J. Kaufman, B. Birmaher, D. Brent Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data J Am Acad Child Adolesc Psychiatry 36 1997 980 988 (Pubitemid 27272932)
26. E. Mick, A. Todorov, S. Smalley Family-based genome-wide association scan of attention-deficit/hyperactivity disorder J Am Acad Child Adolesc Psychiatry 49 2010 898 905
27. D. Wechsler Examiner's Manual: Wechsler Intelligence Scale for Children 3rd Edition 1991 Psychological Corporation New York
28. D. Wechsler WIAS-III: Administration and Scoring Manual 1997 Psychological Corporation San Antonio, TX
29. C. Tian, P.K. Gregersen, M.F. Seldin Accounting for ancestry: population substructure and genome-wide association studies Hum Mol Genet 17 2008 R143 R150
30. A.P. Dempster, N.M. Laird, D. Rubin Maximum likelihood from incomplete dta via the EM algorithm J R Stat Soc B 39 1977 1 38
31. L. Excoffier, M. Slatkin Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population Mol Biol Evolut 12 1995 921 927
32. F. Dudbridge, A. Gusnanto Estimation of significance thresholds for genomewide association scans Genet Epidemiol 32 2008 227 234 (Pubitemid 351550369)
33. I. Pe'er, R. Yelensky, D. Altshuler, M.J. Daly Estimation of the multiple testing burden for genomewide association studies of nearly all common variants Genet Epidemiol 32 2008 381 385 (Pubitemid 351656309)
34. R. Plomin, D.M. Turic, L. Hill A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability Mol Psychiatry 9 2004 582 586 (Pubitemid 38850437)
35. G. Davies, A. Tenesa, A. Payton Genome-wide association studies establish that human intelligence is highly heritable and polygenic Mol Psychiatry 16 2011 996 1005
36. A.C. Need, D.K. Attix, J.M. McEvoy A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB Hum Mol Genet 18 2009 4650 4661
37. O.S. Davis, L.M. Butcher, S.J. Docherty A three-stage genome-wide association study of general cognitive ability: hunting the small effects Behav Genet 40 2010 759 767
38. A.B. Goodman Three independent lines of evidence suggest retinoids as causal to schizophrenia Proc Natl Acad Sci U S A 95 1998 7240 7244 (Pubitemid 28293235)
39. C.H. Lee, C.M. Liu, C.C. Wen, S.M. Chang, H.G. Hwu Genetic copy number variants in sib pairs both affected with schizophrenia J Biomed Sci 17 2010 2
40. W. Krezel, N. Ghyselinck, T.A. Samad Impaired locomotion and dopamine signaling in retinoid receptor mutant mice Science 279 1998 863 867 (Pubitemid 28106280)
41. A. Wallen-Mackenzie, A. Mata de Urquiza, S. Petersson Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells Genes Dev 17 2003 3036 3047 (Pubitemid 38040768)
42. N. Hirokawa, S. Niwa, Y. Tanaka Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease Neuron 68 2010 610 638
43. H.H. Simon, L. Bhatt, D. Gherbassi, P. Sgado, L. Alberi Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors Ann N Y Acad Sci 991 2003 36 47 (Pubitemid 36793799)
44. T. Dijkhuizen, T. van Essen, P. van der Vlies FISH and array-CGH analysis of a complex chromosome 3 aberration suggests that loss of CNTN4 and CRBN contributes to mental retardation in 3pter deletions Am J Med Genet A 140 2006 2482 2487 (Pubitemid 44684945)
45. J.L. Stein, X. Hua, S. Lee Voxelwise genome-wide association study (vGWAS) Neuroimage 53 2010 1160 1174
46. K.P. Lesch, N. Timmesfeld, T.J. Renner Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies J Neural Transm 115 2008 1573 1585
47. C.M. Haworth, M.J. Wright, M. Luciano The heritability of general cognitive ability increases linearly from childhood to young adulthood Mol Psychiatry 15 2010 1112 1120
48. J. Flynn What Is Intelligence? 2007 Cambridge University Press Cambridge, UK