Examination of mechanism of N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy- α-D-glucopyranoside deacetylase (MshB) reveals unexpected role for dynamic tyrosine

Journal of Biological Chemistry

Volumn 287, Issue 13, 2012, Pages 10424-10434

  Huang, Xinyi ^a   Hernick, Marcy ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID BASE; ACID CATALYST; CATALYTIC MECHANISMS; CHEMICAL MECHANISM; DEACETYLASE; DRUG DEVELOPMENT; GENERAL BASE; GLUTATHIONES; GRAM-POSITIVE BACTERIUM; MUTAGENESIS EXPERIMENT; MYCOBACTERIAL; MYCOBACTERIUM TUBERCULOSIS; OXYANIONS; PRODUCT RELEASE; REACTIVE NUCLEOPHILES; SIDE-CHAINS; SMALL MOLECULES; SUBSTRATE BINDING;

AMINO ACIDS; BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; DETOXIFICATION; QUANTUM CHEMISTRY;

DYNAMICS;

ASPARTIC ACID; COBALT; HISTIDINE; HYDROLASE; IRON; MANGANESE; N ACETYL 1 DEXTRO MYOINOSITYL 2 AMINO 2 DEOXY ALPHA DEXTRO GLUCOPYRANOSIDE DEACETYLASE; NICKEL; NUCLEOPHILE; TYROSINE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BACTERIAL GENE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME SUBSTRATE COMPLEX; ENZYME SYNTHESIS; GENE MUTATION; INTERMETHOD COMPARISON; IONIZATION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTAGENESIS; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOPHILICITY; OUTCOME ASSESSMENT; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REFERENCE VALUE; RESIDUE ANALYSIS; STEADY STATE;

AMIDOHYDROLASES; BACTERIAL PROTEINS; CARIOSTATIC AGENTS; ENZYME INHIBITORS; HYDROLYSIS; MODELS, CHEMICAL; MYCOBACTERIUM TUBERCULOSIS; SODIUM FLUORIDE; TYROSINE; XENOBIOTICS;

ACTINOBACTERIA (CLASS); MYCOBACTERIUM TUBERCULOSIS; POSIBACTERIA;

EID: 84858972822     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.320184     Document Type: Article

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