Conjugates of plumbagin and phenyl-2-amino-1-thioglucoside inhibit MshB, a deacetylase involved in the biosynthesis of mycothiol

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2501-2514

  Gammon, David W ^a   Steenkamp, Daniel J ^b   Mavumengwana, Vuyo ^b   Marakalala, Mohlopheni J ^b   Mudzunga, Theophilus T ^a   Hunter, Roger ^a   Munyololo, Muganza ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Enzyme inhibitors; Glucosamine derivatives; Mycothiol; Thioglucosides

Indexed keywords

ACYLTRANSFERASE; AMIDASE; AMIDE; BENZENE DERIVATIVE; CARBENE; INOSITOL; INOSITOL DERIVATIVE; MYCOTHIOL; N ACETYLGLUCOSAMINYLINOSITOL; NATURAL PRODUCT; PHENYL 2 AMINO 1 THIOGLUCOSIDE; PLUMBAGIN; PROTEIN MSHB; THIOGLYCOSIDE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ACTINOBACTERIA; ARTICLE; DETOXIFICATION; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; MYCOBACTERIUM; REACTION ANALYSIS;

ACETYLCYSTEINE; AMIDOHYDROLASES; BACTERIAL PROTEINS; CELL SURVIVAL; CYSTEINE; ENZYME INHIBITORS; GLYCOPEPTIDES; INDICATORS AND REAGENTS; INOSITOL; MYCOBACTERIUM TUBERCULOSIS; NADH, NADPH OXIDOREDUCTASES; NAPHTHOQUINONES; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIOGLUCOSIDES;

ACTINOBACTERIA (CLASS); CORYNEBACTERINEAE;

EID: 77950041558     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.049     Document Type: Article

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