The Crystal Structure of 1-D-myo-Inosityl 2-Acetamido-2-deoxy-α -D-glucopyranoside Deacetylase (MshB) from Mycobacterium tuberculosis Reveals a Zinc Hydrolase with a Lactate Dehydrogenase Fold

Journal of Biological Chemistry

Volumn 278, Issue 47, 2003, Pages 47166-47170

  Maynes, Jason T ^a   Garen, Craig ^a   Cherney, Maia M ^a   Newton, Gerald ^b   Arad, Dorit ^c   Av Gay, Yossef ^c   Fahey, Robert C ^b   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CRYSTAL STRUCTURE; DETOXIFICATION; HYDROGEN BONDS; HYDROLYSIS; SUBSTRATES; X RAY CRYSTALLOGRAPHY;

ELECTROPHILIC ASSISTANCE; PRECURSORS;

ENZYMES;

BACTERIAL ENZYME; HYDROLASE; LACTATE DEHYDROGENASE; MYCOTHIOL DEACETYLASE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DETOXIFICATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HYDROGEN BOND; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN HYDROLYSIS; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMIDOHYDROLASES; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROLASES; L-LACTATE DEHYDROGENASE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; WATER; ZINC;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 0345306583     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308914200     Document Type: Article

References (34)

1. Dye, C., Scheele, S., Dolin, P., Pathania, V., and Raviglione, M. C. (1999) JAMA (J. Am. Med. Assoc.) 282, 677-686
2. WHO (1998) Global Tuberculosis Control, pp. 1-3, WHO, Geneva, Switzerland
3. Amaral, L., Viveiros, M., and Kristiansen, J. E. (2001) Trop. Med. Int. Health 6, 1016-1022
4. Newton, G. L., Arnold, K., Price, M. S., Sherrill, C., Delcardayre, S. B., Aharonowitz, Y., Cohen, G., Davies, J., Fahey, R. C., and Davis, C. (1996) J. Bacteriol. 178, 1990-1995
5. Misset-Smits, M., van Ophem, P. W., Sakuda, S., and Duine, J. A. (1997) FEBS Lett. 409, 221-222
6. Norin, A., Van Ophem, P. W., Piersma, S. R., Persson, B., Duine, J. A., and Jornvall, H. (1997) Eur. J. Biochem. 248, 282-289
7. Newton, G. L., Unson, M. D., Anderberg, S. J., Aguilera, J. A., Oh, N. N., delCardayre, S. B., Av-Gay, Y., and Fahey, R. C. (1999) Biochem. Biophys. Res. Commun. 266, 239-244
8. Newton, G. L., Av-Gay, Y., and Fahey, R. C. (2000) Biochemistry 39, 10739-10746
9. Rawat, M., Newton, G. L., Ko, M., Martinez, G. J., Fahey, R. C., and Av-Gay, Y. (2002) Antimicrob. Agents Chemother. 46, 3348-3355
10. Newton, G. L., Koledin, T., Gorovitz, B., Rawat, M., Fahey, R. C., and Av-Gay, Y. (2003) J. Bacteriol. 185, 3476-3479
11. Newton, G. L., Av-Gay, Y., and Fahey, R. C. (2000) J. Bacteriol. 182, 6958-6963
12. Sareen, D., Steffek, M., Newton, G. L., and Fahey, R. C. (2002) Biochemistry 41, 6885-6890
13. Koledin, T., Newton, G. L., and Fahey, R. C. (2002) Arch. Microbiol. 178, 331-337
14. Buchmeier, N. A., Newton, G. L., Koledin, T., and Fahey, R. C. (2003) Mol. Microbiol. 47, 1723-1732
15. Newton, G. L., and Fahey, R. C. (2002) Arch. Microbiol. 178, 388-394
16. Leslie, A. G. W. (1992) Joint CCP4 + ESF-EAMCB Newsletter on Protein Crystallography, No. 26, CCP4, York, UK
17. Evans, P. R. (1993) Proceedings of the CCP4 Study Weekend on Data Collection and Processing, pp. 114-122, CCP4, York, UK
18. Bailey, S. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
19. Terwilliger, T. C. (2001) Acta Crystallogr. Sect. D Biol. Crystallogr. 57, 1763-1775
20. Terwilliger, T. C. (2002) Acta Crystallogr. Sect. D Biol. Crystallogr. 58, 1937-1940
21. Perrakis, A., Morris, R., and Lamzin, V. S. (1999) Nat. Struct. Biol. 6, 458-463
22. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect. D Biol. Crystallogr. 53, 240-255
23. McRee, D. E. (1999) J. Struct. Biol. 125, 156-165
24. Delano, W. L. (2002) The Pymol Molecular Graphics System, Delano Scientific, San Carlos, CA
25. White, J. L., Hackert, M. L., Buehner, M., Adams, M. J., Ford, G. C., Lentz, P. J., Smiley, I. E., Steindel, S. J., and Rossmann, M. G. (1976) J. Mol. Biol. 102, 759-779
26. Holm, L., and Sander, C. (1993) J. Mol. Biol. 233, 123-138
27. Quiocho, F. A. (1993) Biochem. Soc. Trans. 21, 442-448
28. Rees, D. C., Lewis, M., and Lipscomb, W. N. (1983) J. Mol. Biol. 168, 367-387
29. Brown, I. D. (1996) J. Appl. Crystallogr. 29, 479-480
30. Roe, R. R., and Pang, Y. P. (1999) J. Mol. Model 5, 134-140
31. Chang, T., Milne, K. G., Guther, M. L., Smith, T. K., and Ferguson, M. A. (2002) J. Biol. Chem. 277, 50176-50182
32. Vogt, R. N., Steenkamp, D. J., Zheng, R., and Blanchard, J. S. (2003) Biochem. J. 374, 657-666
33. Schwede, T., Kopp, J., Guex, N., and Peitsch, M. C. (2003) Nucleic Acids Res. 31, 3381-3385
34. Handa, N., Terada, T., Kamewari, Y., Hamana, H., Tame, J. R., Park, S. Y., Kinoshita, K., Ota, M., Nakamura, H., Kuramitsu, S., Shirouzu, M., and Yokoyama, S. (2003) Protein Sci. 12, 1621-1632