메뉴 건너뛰기




Volumn 47, Issue 2, 2006, Pages 542-550

Purification and characterization of Mycobacterium tuberculosis 1d-myo-inosityl-2-acetamido-2-deoxy-α-d-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme

Author keywords

Mca; Metalloamidase; MshB; Mycobacterium tuberculosis; Mycothiol biosynthesis; Substrate specificity

Indexed keywords

AMIDASE; BACTERIAL PROTEIN; CYSTEINE; DISACCHARIDE; GLYCOPEPTIDE; INOSITOL; METALLOPROTEIN; MYCOTHIOL; N ACETYL 1 D INOSITYL 2 AMINO 2 DEOXY ALPHA D GLUCOPYRANOSIDE DEACETYLASE; N-ACETYL-1-D-INOSITYL-2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE DEACETYLASE; PYRAZOLE DERIVATIVE; RECOMBINANT PROTEIN; THIOL DERIVATIVE;

EID: 33646546739     PISSN: 10465928     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pep.2006.03.003     Document Type: Article
Times cited : (41)

References (29)
  • 2
    • 0038662691 scopus 로고    scopus 로고
    • The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA)
    • Newton G.L., Koledin T., Gorovitz B., Rawat M., Fahey R.C., and Av-Gay Y. The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). J. Bacteriol. 185 (2003) 3476-3479
    • (2003) J. Bacteriol. , vol.185 , pp. 3476-3479
    • Newton, G.L.1    Koledin, T.2    Gorovitz, B.3    Rawat, M.4    Fahey, R.C.5    Av-Gay, Y.6
  • 3
    • 0034460953 scopus 로고    scopus 로고
    • N-Acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis
    • Newton G.L., Av-Gay Y., and Fahey R.C. N-Acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. J. Bacteriol. 182 (2000) 6958-6963
    • (2000) J. Bacteriol. , vol.182 , pp. 6958-6963
    • Newton, G.L.1    Av-Gay, Y.2    Fahey, R.C.3
  • 4
    • 0037018946 scopus 로고    scopus 로고
    • ATP-dependent l-cysteine:1d-myo-inosityl 2-amino-2-deoxy-α-d-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases
    • Sareen D., Steffek M., Newton G.L., and Fahey R.C. ATP-dependent l-cysteine:1d-myo-inosityl 2-amino-2-deoxy-α-d-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Biochemistry 41 (2002) 6885-6890
    • (2002) Biochemistry , vol.41 , pp. 6885-6890
    • Sareen, D.1    Steffek, M.2    Newton, G.L.3    Fahey, R.C.4
  • 5
    • 0036401562 scopus 로고    scopus 로고
    • Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes
    • Koledin T., Newton G.L., and Fahey R.C. Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. Arch. Microbiol. 178 (2002) 331-337
    • (2002) Arch. Microbiol. , vol.178 , pp. 331-337
    • Koledin, T.1    Newton, G.L.2    Fahey, R.C.3
  • 6
    • 0036840388 scopus 로고    scopus 로고
    • Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals and antibiotics
    • Rawat M., Newton G.L., Ko M., Martinez G.J., Fahey R.C., and Av-Gay Y. Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals and antibiotics. Antimicrob. Agents Chemother. 46 (2002) 3348-3355
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3348-3355
    • Rawat, M.1    Newton, G.L.2    Ko, M.3    Martinez, G.J.4    Fahey, R.C.5    Av-Gay, Y.6
  • 7
    • 0242407452 scopus 로고    scopus 로고
    • Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman
    • Sareen D., Newton G.L., Fahey R.C., and Buchmeier N.A. Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman. J. Bacteriol. 185 (2003) 6736-6740
    • (2003) J. Bacteriol. , vol.185 , pp. 6736-6740
    • Sareen, D.1    Newton, G.L.2    Fahey, R.C.3    Buchmeier, N.A.4
  • 9
    • 0034609546 scopus 로고    scopus 로고
    • A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase
    • Newton G.L., Av-Gay Y., and Fahey R.C. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry 39 (2000) 10739-10746
    • (2000) Biochemistry , vol.39 , pp. 10739-10746
    • Newton, G.L.1    Av-Gay, Y.2    Fahey, R.C.3
  • 10
    • 0037347862 scopus 로고    scopus 로고
    • Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics
    • Buchmeier N.A., Newton G.L., Koledin T., and Fahey R.C. Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics. Mol. Microbiol. 47 (2003) 1723-1732
    • (2003) Mol. Microbiol. , vol.47 , pp. 1723-1732
    • Buchmeier, N.A.1    Newton, G.L.2    Koledin, T.3    Fahey, R.C.4
  • 11
    • 0345306583 scopus 로고    scopus 로고
    • The crystal structure of 1-d-myo-inosityl 2-acetamido-2-deoxy-α-d-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold
    • Maynes J.T., Garen C., Cherney M.M., Newton G.L., Arad D., Av-Gay Y., Fahey R.C., and James M.N. The crystal structure of 1-d-myo-inosityl 2-acetamido-2-deoxy-α-d-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J. Biol. Chem. 278 (2003) 47166-47170
    • (2003) J. Biol. Chem. , vol.278 , pp. 47166-47170
    • Maynes, J.T.1    Garen, C.2    Cherney, M.M.3    Newton, G.L.4    Arad, D.5    Av-Gay, Y.6    Fahey, R.C.7    James, M.N.8
  • 12
    • 0346493029 scopus 로고    scopus 로고
    • Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis
    • McCarthy A.A., Peterson N.A., Knijff R., and Baker E.N. Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. J. Mol. Biol. 335 (2004) 1131-1141
    • (2004) J. Mol. Biol. , vol.335 , pp. 1131-1141
    • McCarthy, A.A.1    Peterson, N.A.2    Knijff, R.3    Baker, E.N.4
  • 13
    • 0142040351 scopus 로고    scopus 로고
    • Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase
    • Steffek M., Newton G.L., Av-Gay Y., and Fahey R.C. Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry 42 (2003) 12067-12076
    • (2003) Biochemistry , vol.42 , pp. 12067-12076
    • Steffek, M.1    Newton, G.L.2    Av-Gay, Y.3    Fahey, R.C.4
  • 14
    • 2942532643 scopus 로고    scopus 로고
    • Synthesis of a bromotyrosine-derived natural product inhibitor of mycothiol-S-conjugate amidase
    • Fetterolf B., and Bewley C.A. Synthesis of a bromotyrosine-derived natural product inhibitor of mycothiol-S-conjugate amidase. Bioorg. Med. Chem. Lett. 14 (2004) 3785-3788
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 3785-3788
    • Fetterolf, B.1    Bewley, C.A.2
  • 15
    • 0037763888 scopus 로고    scopus 로고
    • Synthesis of 2-deoxy-2-C-alkylglucosides of myo-inositol as possible inhibitors of a N-deacetylase enzyme in the biosynthesis of mycothiol
    • Gammon D.W., Hunter R., Steenkamp D.J., and Mudzunga T.T. Synthesis of 2-deoxy-2-C-alkylglucosides of myo-inositol as possible inhibitors of a N-deacetylase enzyme in the biosynthesis of mycothiol. Bioorg. Med. Chem. Lett. 13 (2003) 2045-2049
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 2045-2049
    • Gammon, D.W.1    Hunter, R.2    Steenkamp, D.J.3    Mudzunga, T.T.4
  • 17
    • 0037414508 scopus 로고    scopus 로고
    • Solution conformations of mycothiol bimane, 1-d-GlcNAc-α-(1 → 1)-d-myo-Ins and 1-d-GlcNAc-α-(1 → 1)-l-myo-Ins
    • Mahadevan J., Nicholas G.M., and Bewley C.A. Solution conformations of mycothiol bimane, 1-d-GlcNAc-α-(1 → 1)-d-myo-Ins and 1-d-GlcNAc-α-(1 → 1)-l-myo-Ins. J. Org. Chem. 68 (2003) 3380-3386
    • (2003) J. Org. Chem. , vol.68 , pp. 3380-3386
    • Mahadevan, J.1    Nicholas, G.M.2    Bewley, C.A.3
  • 18
    • 0037245381 scopus 로고    scopus 로고
    • Inhibition and kinetics of Mycobacterium tuberculosis and Mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors
    • Nicholas G.M., Eckman L.L., Newton G.L., Fahey R.C., Ray S., and Bewley C.A. Inhibition and kinetics of Mycobacterium tuberculosis and Mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors. Bioorg. Med. Chem. Lett. 11 (2003) 601-608
    • (2003) Bioorg. Med. Chem. Lett. , vol.11 , pp. 601-608
    • Nicholas, G.M.1    Eckman, L.L.2    Newton, G.L.3    Fahey, R.C.4    Ray, S.5    Bewley, C.A.6
  • 20
    • 0035902239 scopus 로고    scopus 로고
    • Novel bromotyrosine alkaloids: inhibitors of mycothiol S-conjugate amidase
    • Nicholas G.M., Newton G.L., Fahey R.C., and Bewley C.A. Novel bromotyrosine alkaloids: inhibitors of mycothiol S-conjugate amidase. Org. Lett. 3 (2001) 1543-1545
    • (2001) Org. Lett. , vol.3 , pp. 1543-1545
    • Nicholas, G.M.1    Newton, G.L.2    Fahey, R.C.3    Bewley, C.A.4
  • 21
    • 0346651485 scopus 로고    scopus 로고
    • Crystallization and preliminary X-ray analysis of N-acetyl-1-d-myo-inosityl-2-deoxy-α-d-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis
    • McCarthy A.A., Knijff R., Peterson N.A., and Baker E.N. Crystallization and preliminary X-ray analysis of N-acetyl-1-d-myo-inosityl-2-deoxy-α-d-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis. Acta Crystallogr. D Biol. Crystallogr. 59 (2003) 2316-2318
    • (2003) Acta Crystallogr. D Biol. Crystallogr. , vol.59 , pp. 2316-2318
    • McCarthy, A.A.1    Knijff, R.2    Peterson, N.A.3    Baker, E.N.4
  • 22
    • 0031839173 scopus 로고    scopus 로고
    • An immunoassay for the detection and quantitative determination of mycothiol
    • Unson M.D., Newton G.L., Davis C., and Fahey R.C. An immunoassay for the detection and quantitative determination of mycothiol. J. Immunol. Methods 214 (1998) 29-39
    • (1998) J. Immunol. Methods , vol.214 , pp. 29-39
    • Unson, M.D.1    Newton, G.L.2    Davis, C.3    Fahey, R.C.4
  • 23
    • 0032728879 scopus 로고    scopus 로고
    • Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase pknB
    • Av-Gay Y., Jamil S., and Drews S.J. Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase pknB. Infect. Immun. 67 (1999) 5676-5682
    • (1999) Infect. Immun. , vol.67 , pp. 5676-5682
    • Av-Gay, Y.1    Jamil, S.2    Drews, S.J.3
  • 24
    • 0032515068 scopus 로고    scopus 로고
    • Mycothiol biosynthesis and metabolism: cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol
    • Anderberg S.J., Newton G.L., and Fahey R.C. Mycothiol biosynthesis and metabolism: cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol. J. Biol. Chem. 273 (1998) 30391-30397
    • (1998) J. Biol. Chem. , vol.273 , pp. 30391-30397
    • Anderberg, S.J.1    Newton, G.L.2    Fahey, R.C.3
  • 25
    • 0027267127 scopus 로고
    • Low molecular weight thiols in streptomycetes and their potential role as antioxidants
    • Newton G.L., Fahey R.C., Cohen G., and Aharonowitz Y. Low molecular weight thiols in streptomycetes and their potential role as antioxidants. J. Bacteriol. 175 (1993) 2734-2742
    • (1993) J. Bacteriol. , vol.175 , pp. 2734-2742
    • Newton, G.L.1    Fahey, R.C.2    Cohen, G.3    Aharonowitz, Y.4
  • 27
    • 0024448151 scopus 로고
    • Calculation of protein extinction coefficients from amino acid sequence data
    • Gill S.C., and von Hippel P.H. Calculation of protein extinction coefficients from amino acid sequence data. Anal. Biochem. 189 (1989) 319-326
    • (1989) Anal. Biochem. , vol.189 , pp. 319-326
    • Gill, S.C.1    von Hippel, P.H.2
  • 28
    • 0029062905 scopus 로고
    • Removal and replacement of metal ions in metallopeptidases
    • Auld D.S. Removal and replacement of metal ions in metallopeptidases. Methods Enzymol. 248 (1995) 228-242
    • (1995) Methods Enzymol. , vol.248 , pp. 228-242
    • Auld, D.S.1
  • 29
    • 0037853400 scopus 로고    scopus 로고
    • Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis
    • Rawat M., Kovacevic S., Billman-Jacobe H., and Av-Gay Y. Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis. Microbiology 149 (2003) 1341-1349
    • (2003) Microbiology , vol.149 , pp. 1341-1349
    • Rawat, M.1    Kovacevic, S.2    Billman-Jacobe, H.3    Av-Gay, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.