The Parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies

Journal of Molecular Neuroscience

Volumn 46, Issue 1, 2012, Pages 109-121

  Parelkar, Sangram S ^a   Cadena, Juan G ^a   Kim, Chul ^a   Wang, Zhaohui ^a   Sugal, Rachel ^a   Bentley, Brooke ^b   Moral, Luis ^c   Ardley, Helen C ^d   Schwartz, Lawrence M ^a,b  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b Pioneer Valley Life Sciences Institute   (United States)

^c BAYSTATE MEDICAL CENTER   (United States)

^d ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Aggresomes; Dopaminergic neurons; Lewy body; Parkinson's disease; Proteasome; Ubiquitin

Indexed keywords

CASK PROTEIN; CDCREL 1 PROTEIN; HUMAN HOMOLOG OF DROSOPHILA ARIADNE 1; LIGASE; PARKIN; PROTEASOME; RING FINGER PROTEIN; SYNPHILIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AGGRESOME; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEWY BODY; MALE; MAMMAL CELL; MICROTUBULE; MORPHOLOGY; NONHUMAN; PARKINSON DISEASE; PROTEIN BINDING; PROTEIN FUNCTION; ANIMAL CELL; ANIMAL CELL CULTURE; BRAIN; GENE MUTATION; GENETIC TRANSFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

MAMMALIA;

ADULT; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; CARRIER PROTEINS; CERCOPITHECUS AETHIOPS; COS CELLS; DROSOPHILA PROTEINS; FEMALE; HUMANS; LEWY BODIES; LEWY BODY DISEASE; MALE; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; RABBITS; UBIQUITIN-PROTEIN LIGASES;

EID: 84858860684     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9535-1     Document Type: Article

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