PARP-1 inhibition induces a late increase in the level of reactive oxygen species in cells after ionizing radiation

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 732, Issue 1-2, 2012, Pages 9-15

  Cieślar Pobuda, Artur ^a   Saenko, Yuriy ^a,b   Rzeszowska Wolny, Joanna ^a  

^a SILESIAN UNIVERSITY OF TECHNOLOGY   (Poland)

^b ULYANOVSK STATE UNIVERSITY   (Russian Federation)

Author keywords

DNA repair; DNA strand breaks; PARP 1 inhibition; ROS production

Indexed keywords

8 HYDROXY 2 METHYL 4(3H) QUINAZOLINONE; CASPASE 3; CASPASE 8; DICHLOROFLUORESCEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; POLY(ADENOSINE DIPHOSPHATE RIBOSE); REACTIVE OXYGEN METABOLITE; 1,5-DIHYDROXYISOQUINOLINE; 5-IODO-6-AMINO-1,2-BENZOPYRONE; COUMARIN DERIVATIVE; ISOQUINOLINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN; QUINAZOLINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL DEATH; COMET ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IONIZING RADIATION; LEUKEMIA CELL; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DOUBLE STRANDED DNA BREAK; G2 PHASE CELL CYCLE CHECKPOINT; K562 CELL LINE; METABOLISM; X RAY;

APOPTOSIS; COUMARINS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; ISOQUINOLINES; K562 CELLS; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; QUINAZOLINES; REACTIVE OXYGEN SPECIES; X-RAYS;

EID: 84858800021     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2012.01.005     Document Type: Article

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