Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2550-2554

  Huang, Kenneth H ^a,b   Barta, Thomas E ^a   Rice, John W ^a   Smith, Emilie D ^a   Ommen, Andy J ^a   Ma, Wei ^a   Veal, James M ^a   Fadden, R Patrick ^a   Barabasz, Amy F ^a   Foley, Briana E ^a   Hughes, Philip F ^a   Hanson, Gunnar J ^a   Markworth, Christopher J ^a   Silinski, Melanie ^a   Partridge, Jeffrey M ^a   Steed, Paul M ^a   Hall, Steven E ^a  

^a Serenex Inc   (United States)

^b Pamlico Pharmaceutical Inc   (United States)

Author keywords

Aminoquinazoline; Cancer; Chaperone; Her2; Hsp90; Indolone; Inhibitors; Quinazoline

Indexed keywords

1 (2 AMINO 4 METHYLQUINAZOLIN 7 YL) 3,6,6 TRIMETHYL 6,7 DIHYDRO 1H INDOL 4 (5H) ONE; 1 (4 AMINOQUINAZOLINE 7 YL) 2,6,6 TRIMETHYL 6,7 DIHYDRO 1H INDOL 4(5H) ONE; 4 (2,6,6 TRIMETHYL 4 OXO 4,5,6,7 TETRAHYDRO 1H INDOL 1 YL) BENZAMIDE; BENZAMIDE DERIVATIVE; ERLOTINIB; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; MOLINDONE; QUINAZOLINE DERIVATIVE; SNX 2112; SNX 6883; SNX 7081; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; DRUG ACTIVITY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INDOLES; MODELS, MOLECULAR; PROTEIN BINDING; QUINAZOLINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858702836     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.137     Document Type: Article

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