Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3517-3521

  Barta, Thomas E ^a   Veal, James M ^a   Rice, John W ^a   Partridge, Jeffrey M ^a   Fadden, R Patrick ^a   Ma, Wei ^a   Jenks, Matthew ^a   Geng, Lifeng ^a   Hanson, Gunnar J ^a   Huang, Kenneth H ^a   Barabasz, Amy F ^a   Foley, Briana E ^a   Otto, James ^a   Hall, Steven E ^a  

^a Serenex Inc   (United States)

Author keywords

ATP; Benzamide; Cancer inhibitor; Cancer therapeutic; Carbazol 4 one; Heat shock protein 90; Her2; Hsp70; Hsp90; X ray structure

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBAZOLE DERIVATIVE; HEAT SHOCK PROTEIN 90;

ARTICLE; BINDING SITE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG STRUCTURE; HUMAN; HUMAN CELL; PROTEIN STABILITY; X RAY ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CARBAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44649202705     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.023     Document Type: Article

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