메뉴 건너뛰기




Volumn 12, Issue 4, 2012, Pages 491-501

Denosumab for treatment of breast cancer bone metastases and beyond

Author keywords

Bone metastasis; Breast cancer; Denosumab; RANK; RANKL

Indexed keywords

CLODRONIC ACID; DENOSUMAB; ETIDRONIC ACID; OSTEOCLAST DIFFERENTIATION FACTOR; PAMIDRONIC ACID; PLACEBO; ZOLEDRONIC ACID;

EID: 84858683384     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2012.664634     Document Type: Review
Times cited : (4)

References (92)
  • 1
    • 0023137823 scopus 로고
    • The clinical course of bone metastases from breast cancer
    • Coleman RE, Rubens RD. The clinical course of bone metastases from breast cancer. Br J Cancer 1987;55:61-6 (Pubitemid 17234155)
    • (1987) British Journal of Cancer , vol.55 , Issue.1 , pp. 61-66
    • Coleman, R.E.1    Rubens, R.D.2
  • 2
    • 71949095197 scopus 로고    scopus 로고
    • The science and practice of bone health in oncology: Managing bone loss and metastasis in patients with solid tumors
    • quiz S30
    • Lipton A, Uzzo R, Amato RJ, et al. The science and practice of bone health in oncology: managing bone loss and metastasis in patients with solid tumors. J Natl Compr Canc Netw 2009;7(Suppl 7):S1-29; quiz S30
    • (2009) J. Natl. Compr. Canc Netw. , vol.7 , Issue.SUPPL. 7
    • Lipton, A.1    Uzzo, R.2    Amato, R.J.3
  • 3
    • 80052575583 scopus 로고    scopus 로고
    • Breast cancer metastasis to the bone: Mechanisms of bone loss
    • Chen YC, Sosnoski DM, Mastro AM. Breast cancer metastasis to the bone: mechanisms of bone loss. Breast Cancer Res 2010;12:215
    • (2010) Breast Cancer Res. , vol.12 , pp. 215
    • Chen, Y.C.1    Sosnoski, D.M.2    Mastro, A.M.3
  • 5
    • 22744455581 scopus 로고    scopus 로고
    • Breast cancer metastasis to bone: Mechanisms of osteolysis and implications for therapy
    • DOI 10.1007/s10911-005-5399-8
    • Kozlow W, Guise TA. Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy. J Mammary Gland Biol Neoplasia 2005;10:169-80 (Pubitemid 41031006)
    • (2005) Journal of Mammary Gland Biology and Neoplasia , vol.10 , Issue.2 , pp. 169-180
    • Kozlow, W.1    Guise, T.A.2
  • 6
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Roodman GD. Mechanisms of bone metastasis. N Engl J Med 2004;350:1655-64
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1655-1664
    • Roodman, G.D.1
  • 7
    • 0022535311 scopus 로고
    • Metastatic breast cancer confined to the skeletal system. An indolent disease
    • DOI 10.1016/0002-9343(86)90286-X
    • Sherry MM, Greco FA, Johnson DH, Hainsworth JD. Metastatic breast cancer confined to the skeletal system. An indolent disease. Am J Med 1986;81:381-6 (Pubitemid 16003855)
    • (1986) American Journal of Medicine , vol.81 , Issue.3 , pp. 381-386
    • Sherry, M.M.1    Greco, F.A.2    Johnson, D.H.3    Hainsworth, J.D.4
  • 8
    • 84858679064 scopus 로고    scopus 로고
    • NCCN clinical practice guidelines in oncology: Breast cancer
    • National Comprehensive Cancer Network Available from: [Accessed on 1 April 2011
    • National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: breast cancer. Version 2.2011. Available from: http://www.nccn.org/ professionals/ physician-gls/pdf/breast.pdf [Accessed on 1 April 2011]
    • (2011) Version , vol.2
  • 9
    • 79952743744 scopus 로고    scopus 로고
    • American society of clinical oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer
    • Van Poznak CH, Temin S, Yee GC, et al. American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. J Clin Oncol 2011;29:1221-7
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1221-1227
    • Van Poznak, C.H.1    Temin, S.2    Yee, G.C.3
  • 10
    • 33947109369 scopus 로고    scopus 로고
    • Bisphosphonates: Mode of Action and Pharmacology
    • DOI 10.1542/peds.2006-2023H
    • Russell RG. Bisphosphonates: mode of action and pharmacology. Pediatrics 2007;119(Suppl 2):S150-62 (Pubitemid 46397937)
    • (2007) Pediatrics , vol.119 , Issue.SUPPL. 2
    • Russell, R.G.G.1
  • 13
    • 0027874994 scopus 로고
    • Double-blind trial of oral clodronate in breast cancer patients with bone metastases
    • Paterson AH, Powles TJ, Kanis JA, et al. Double-blind trial of oral clodronate in breast cancer patients with bone metastases. Bull Cancer 1993;80(10 Suppl):50-6
    • (1993) Bull. Cancer , vol.80 , Issue.SUPPL. , pp. 50-6
    • Paterson, A.H.1    Powles, T.J.2    Kanis, J.A.3
  • 15
    • 41949138597 scopus 로고    scopus 로고
    • Preclinical evidence for nitrogen-containing bisphosphonate inhibition of farnesyl diphosphate (FPP) synthase in the kidney: Implications for renal safety
    • Luhe A, Kunkele KP, Haiker M, et al. Preclinical evidence for nitrogen-containing bisphosphonate inhibition of farnesyl diphosphate (FPP) synthase in the kidney: implications for renal safety. Toxicol In Vitro 2008;22:899-909
    • (2008) Toxicol. In Vitro. , vol.22 , pp. 899-909
    • Luhe, A.1    Kunkele, K.P.2    Haiker, M.3
  • 19
    • 20644449488 scopus 로고    scopus 로고
    • Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: A randomized, placebo-controlled trial
    • Kohno N, Aogi K, Minami H, et al. Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trial. J Clin Oncol 2005;23:3314-21
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3314-3321
    • Kohno, N.1    Aogi, K.2    Minami, H.3
  • 21
    • 0036898482 scopus 로고    scopus 로고
    • Efficacy of zoledronic acid and pamidronate in breast cancer patients: A comparative analysis of randomized phase III trials
    • DOI 10.1097/00000421-200212001-00005
    • Coleman RE. Efficacy of zoledronic acid and pamidronate in breast cancer patients: a comparative analysis of randomized phase III trials. Am J Clin Oncol 2002;25(6 Suppl 1):S25-31 (Pubitemid 35453653)
    • (2002) American Journal of Clinical Oncology: Cancer Clinical Trials , vol.25 , Issue.SUPPL. 1
    • Coleman, R.E.1
  • 22
    • 0030474026 scopus 로고    scopus 로고
    • Clodronate decreases the frequency of skeletal metastases in women with breast cancer
    • DOI 10.1016/S8756-3282(96)00285-2, PII S8756328296002852
    • Kanis JA, Powles T, Paterson AH, et al. Clodronate decreases the frequency of skeletal metastases in women with breast cancer. Bone 1996;19:663-7 (Pubitemid 27035848)
    • (1996) Bone , vol.19 , Issue.6 , pp. 663-667
    • Kanis, J.A.1    Powles, T.2    Paterson, A.H.G.3    McCloskey, E.V.4    Ashley, S.5
  • 24
    • 2642521168 scopus 로고    scopus 로고
    • Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors: A randomized, phase III, double-blind, placebo-controlled trial
    • DOI 10.1002/cncr.20308
    • Rosen LS, Gordon D, Tchekmedyian NS, et al. Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors: a randomized, Phase III, double-blind, placebo-controlled trial. Cancer 2004;100:2613-21 (Pubitemid 38715767)
    • (2004) Cancer , vol.100 , Issue.12 , pp. 2613-2621
    • Rosen, L.S.1    Gordon, D.2    Tchekmedyian, N.S.3    Yanagihara, R.4    Hirsh, V.5    Krzakowski, M.6    Pawlicki, M.7    De Souza, P.8    Zheng, M.9    Urbanowitz, G.10    Reitsma, D.11    Seaman, J.12
  • 25
    • 33847623326 scopus 로고    scopus 로고
    • Assessment of renal toxicity and osteonecrosis of the jaws in patients receiving zoledronic acid for bone metastasis
    • DOI 10.1093/annonc/mdl408
    • Aguiar Bujanda D, Bohn Sarmiento U, Cabrera Suarez MA, Aguiar Morales J. Assessment of renal toxicity and osteonecrosis of the jaws in patients receiving zoledronic acid for bone metastasis. Ann Oncol 2007;18:556-60 (Pubitemid 46359639)
    • (2007) Annals of Oncology , vol.18 , Issue.3 , pp. 556-560
    • Aguiar Bujanda, D.1    Bohn Sarmiento, U.2    Cabrera Suarez, M.A.3    Aguiar Morales, J.4
  • 26
    • 77952646938 scopus 로고    scopus 로고
    • Renal toxicity in patients with multiple myeloma receiving zoledronic acid vs ibandronate: A retrospective medical records review
    • Weide R, Koppler H, Antras L, et al. Renal toxicity in patients with multiple myeloma receiving zoledronic acid vs. ibandronate: a retrospective medical records review. J Cancer Res Ther 2010;6:31-5
    • (2010) J. Cancer Res. Ther. , vol.6 , pp. 31-35
    • Weide, R.1    Koppler, H.2    Antras, L.3
  • 29
    • 0034784606 scopus 로고    scopus 로고
    • Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity
    • DOI 10.1172/JCI200113890
    • Lam J, Nelson CA, Ross FP, et al. Crystal structure of the TRANCE/ RANKL cytokine reveals determinants of receptor-ligand specificity. J Clin Invest 2001;108:971-9 (Pubitemid 32946071)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.7 , pp. 971-979
    • Lam, J.1    Nelson, C.A.2    Ross, F.P.3    Teitelbaum, S.L.4    Fremont, D.H.5
  • 33
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda H, Shima N, Nakagawa N, et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 1998;95:3597-602
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3597-602
    • Yasuda, H.1    Shima, N.2    Nakagawa, N.3
  • 34
    • 42749083246 scopus 로고    scopus 로고
    • Functions of RANKL/RANK/OPG in bone modeling and remodeling
    • Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 2008;473:139-46
    • (2008) Arch. Biochem. Biophys. , vol.473 , pp. 139-146
    • Boyce, B.F.1    Xing, L.2
  • 35
    • 42049110350 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor κB ligand and osteoprotegerin regulation of bone remodeling in health and disease
    • DOI 10.1210/er.2007-0014
    • Kearns AE, Khosla S, Kostenuik PJ. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev 2008;29:155-92 (Pubitemid 351519689)
    • (2008) Endocrine Reviews , vol.29 , Issue.2 , pp. 155-192
    • Kearns, A.E.1    Khosla, S.2    Kostenuik, P.J.3
  • 36
    • 33947583822 scopus 로고    scopus 로고
    • Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems
    • DOI 10.1038/nri2062, PII NRI2062
    • Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 2007;7:292-304 (Pubitemid 46480961)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.4 , pp. 292-304
    • Takayanagi, H.1
  • 37
    • 30644469500 scopus 로고    scopus 로고
    • RANKL-RANK signaling in osteoclastogenesis and bone disease
    • DOI 10.1016/j.molmed.2005.11.007, PII S1471491405002674
    • Wada T, Nakashima T, Hiroshi N, Penninger JM. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med 2006;12:17-25 (Pubitemid 43089652)
    • (2006) Trends in Molecular Medicine , vol.12 , Issue.1 , pp. 17-25
    • Wada, T.1    Nakashima, T.2    Hiroshi, N.3    Penninger, J.M.4
  • 38
    • 0035054126 scopus 로고    scopus 로고
    • Determination of three isoforms of the receptor activator of nuclear factor-κB ligand and their differential expression in bone and thymus
    • DOI 10.1210/en.142.4.1419
    • Ikeda T, Kasai M, Utsuyama M, Hirokawa K. Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus. Endocrinology 2001;142:1419-26 (Pubitemid 32299669)
    • (2001) Endocrinology , vol.142 , Issue.4 , pp. 1419-1426
    • Ikeda, T.1    Kasai, M.2    Utsuyama, M.3    Hirokawa, K.4
  • 39
    • 79952518815 scopus 로고    scopus 로고
    • Physiology and pathophysiology of the RANKL/RANK system
    • Hanada R, Hanada T, Penninger JM. Physiology and pathophysiology of the RANKL/RANK system. Biol Chem 2010;391:1365-70
    • (2010) Biol. Chem. , vol.391 , pp. 1365-1370
    • Hanada, R.1    Hanada, T.2    Penninger, J.M.3
  • 40
    • 56549098575 scopus 로고    scopus 로고
    • RANK/ RANKL: Regulators of immune responses and bone physiology
    • Leibbrandt A, Penninger JM. RANK/ RANKL: regulators of immune responses and bone physiology. Ann NY Acad Sci 2008;1143:123-50
    • (2008) Ann. N.Y. Acad. Sci. , vol.1143 , pp. 123-150
    • Leibbrandt, A.1    Penninger, J.M.2
  • 41
    • 0034730327 scopus 로고    scopus 로고
    • The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    • Fata JE, Kong YY, Li J, et al. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 2000;103:41-50
    • (2000) Cell , vol.103 , pp. 41-50
    • Fata, J.E.1    Kong, Y.Y.2    Li, J.3
  • 42
    • 0035839450 scopus 로고    scopus 로고
    • A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation
    • Arron JR, Vologodskaia M, Wong BR, et al. A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation. J Biol Chem 2001;276:30011-17
    • (2001) J. Biol. Chem. , vol.276 , pp. 30011-30017
    • Arron, J.R.1    Vologodskaia, M.2    Wong, B.R.3
  • 44
    • 33745821237 scopus 로고    scopus 로고
    • Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation
    • DOI 10.1002/cncr.21978
    • Chen G, Sircar K, Aprikian A, et al. Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation. Cancer 2006;107:289-98 (Pubitemid 44036558)
    • (2006) Cancer , vol.107 , Issue.2 , pp. 289-298
    • Chen, G.1    Sircar, K.2    Aprikian, A.3    Potti, A.4    Goltzman, D.5    Rabbani, S.A.6
  • 45
    • 33645453481 scopus 로고    scopus 로고
    • Regulation of cancer cell migration and bone metastasis by RANKL
    • Jones DH, Nakashima T, Sanchez OH, et al. Regulation of cancer cell migration and bone metastasis by RANKL. Nature 2006;440:692-6
    • (2006) Nature , vol.440 , pp. 692-696
    • Jones, D.H.1    Nakashima, T.2    Sanchez, O.H.3
  • 48
    • 17844363974 scopus 로고    scopus 로고
    • Canonical Wnt/β-catenin signaling prevents osteoblasts from differentiating into chondrocytes
    • DOI 10.1016/j.devcel.2005.02.013, PII S1534580705000870
    • Hill TP, Spater D, Taketo MM, et al. Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 2005;8:727-38 (Pubitemid 40585295)
    • (2005) Developmental Cell , vol.8 , Issue.5 , pp. 727-738
    • Hill, T.P.1    Spater, D.2    Taketo, M.M.3    Birchmeier, W.4    Hartmann, C.5
  • 55
    • 29244476052 scopus 로고    scopus 로고
    • Functional dissection of osteoprotegerin and its interaction with receptor activator of NF-κB ligand
    • DOI 10.1074/jbc.M506366200
    • Schneeweis LA, Willard D, Milla ME. Functional dissection of osteoprotegerin and its interaction with receptor activator of NF-kappaB ligand. J Biol Chem 2005;280:41155-64 (Pubitemid 41832168)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.50 , pp. 41155-41164
    • Schneeweis, L.A.1    Willard, D.2    Milla, M.E.3
  • 56
    • 0025821071 scopus 로고
    • Localization of parathyroid hormone-related protein in breast cancer metastases: Increased incidence in bone compared with other sites
    • Powell GJ, Southby J, Danks JA, et al. Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res 1991;51:3059-61
    • (1991) Cancer Res. , vol.51 , pp. 3059-3061
    • Powell, G.J.1    Southby, J.2    Danks, J.A.3
  • 59
    • 0042707678 scopus 로고    scopus 로고
    • Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease
    • DOI 10.1016/S8756-3282(03)00086-3
    • Bendre MS, Montague DC, Peery T, et al. Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease. Bone 2003;33:28-37 (Pubitemid 36952685)
    • (2003) Bone , vol.33 , Issue.1 , pp. 28-37
    • Bendre, M.S.1    Montague, D.C.2    Peery, T.3    Akel, N.S.4    Gaddy, D.5    Suva, L.J.6
  • 60
    • 0032586714 scopus 로고    scopus 로고
    • 2 cooperates with TRANCE in osteoclast induction from hemopoietic precursors: Synergistic activation of differentiation, cell spreading, and fusion
    • Wani MR, Fuller K, Kim NS, et al. Prostaglandin E2 cooperates with TRANCE in osteoclast induction from hemopoietic precursors: synergistic activation of differentiation, cell spreading, and fusion. Endocrinology 1999;140:1927-35 (Pubitemid 29149267)
    • (1999) Endocrinology , vol.140 , Issue.4 , pp. 1927-1935
    • Wani, M.R.1    Fuller, K.2    Kim, N.S.3    Choi, Y.4    Chambers, T.J.5
  • 61
    • 0000391746 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
    • Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000;2:737-44
    • (2000) Nat. Cell Biol. , vol.2 , pp. 737-744
    • Bergers, G.1    Brekken, R.2    McMahon, G.3
  • 62
    • 23044448510 scopus 로고    scopus 로고
    • Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3
    • DOI 10.1038/sj.emboj.7600729
    • Kang JS, Alliston T, Delston R, Derynck R. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J 2005;24:2543-55 (Pubitemid 41076311)
    • (2005) EMBO Journal , vol.24 , Issue.14 , pp. 2543-2555
    • Kang, J.S.1    Alliston, T.2    Delston, R.3    Derynck, R.4
  • 63
    • 60349128880 scopus 로고    scopus 로고
    • Xgeva Thousand Oaks, CA. Amgen, Inc. Available from:Last accessed 9 February 2012]
    • Xgeva. Prescribing Information. Thousand Oaks, CA. Amgen, Inc. 2010. Available from: http://www.xgeva.com [Last accessed 9 February 2012]
    • (2010) Prescribing Information
  • 65
    • 43549116878 scopus 로고    scopus 로고
    • Phase 1 trial of denosumab safety, pharmacokinetics, and pharmacodynamics in Japanese women with breast cancer-related bone metastases
    • DOI 10.1111/j.1349-7006.2008.00803.x
    • Yonemori K, Fujiwara Y, Minami H, et al. Phase 1 trial of denosumab safety, pharmacokinetics, and pharmacodynamics in Japanese women with breast cancer-related bone metastases. Cancer Sci 2008;99:1237-42 (Pubitemid 351676637)
    • (2008) Cancer Science , vol.99 , Issue.6 , pp. 1237-1242
    • Yonemori, K.1    Fujiwara, Y.2    Minami, H.3    Kitagawa, K.4    Fujii, H.5    Arai, T.6    Sohn, W.7    Ohkura, M.8    Ohtsu, T.9
  • 67
    • 77956388219 scopus 로고    scopus 로고
    • Population pharmacokinetics of therapeutic monoclonal antibodies
    • Dirks NL, Meibohm B. Population pharmacokinetics of therapeutic monoclonal antibodies. Clin Pharmacokinet 2010;49:633-59
    • (2010) Clin. Pharmacokinet. , vol.49 , pp. 633-659
    • Dirks, N.L.1    Meibohm, B.2
  • 68
    • 75149145545 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of monoclonal antibodies: Concepts and lessons for drug development
    • Mould DR, Green B. Pharmacokinetics and pharmacodynamics of monoclonal antibodies: concepts and lessons for drug development. BioDrugs 2010;24:23-39
    • (2010) BioDrugs , vol.24 , pp. 23-39
    • Mould, D.R.1    Green, B.2
  • 69
    • 19944432878 scopus 로고    scopus 로고
    • Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors
    • Brown JE, Cook RJ, Major P, et al. Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors. J Natl Cancer Inst 2005;97:59-69
    • (2005) J. Natl. Cancer Inst. , vol.97 , pp. 59-69
    • Brown, J.E.1    Cook, R.J.2    Major, P.3
  • 70
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-κ ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • DOI 10.1158/1078-0432.CCR-05-1933
    • Body JJ, Facon T, Coleman RE, et al. A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res 2006;12:1221-8 (Pubitemid 43342512)
    • (2006) Clinical Cancer Research , vol.12 , Issue.4 , pp. 1221-1228
    • Body, J.-J.1    Facon, T.2    Coleman, R.E.3    Lipton, A.4    Geurs, F.5    Fan, M.6    Holloway, D.7    Peterson, M.C.8    Bekker, P.J.9
  • 71
    • 58149198581 scopus 로고    scopus 로고
    • Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapy
    • Lipton A, Steger GG, Figueroa J, et al. Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapy. Clin Cancer Res 2008; 14:6690-6
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6690-6696
    • Lipton, A.1    Steger, G.G.2    Figueroa, J.3
  • 72
    • 79551568488 scopus 로고    scopus 로고
    • Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study
    • Stopeck AT, Lipton A, Body JJ, et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol 2010;28:5132-9
    • (2010) J. Clin. Oncol. , vol.28 , pp. 5132-5139
    • Stopeck, A.T.1    Lipton, A.2    Body, J.J.3
  • 73
    • 63749094012 scopus 로고    scopus 로고
    • Randomized Phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates
    • Fizazi K, Lipton A, Mariette X, et al. Randomized Phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol 2009;27:1564-71
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1564-1571
    • Fizazi, K.1    Lipton, A.2    Mariette, X.3
  • 74
    • 84858691750 scopus 로고    scopus 로고
    • Study of denosumab as adjuvant treatment for women with high risk early breast cancer receiving neoadjuvant or adjuvant therapy (D-CARE
    • Amgen Daiichi Sankyo Inc gov NCT01077154 Available from:
    • Amgen, Daiichi Sankyo, Inc. Study of Denosumab as Adjuvant Treatment for Women With High Risk Early Breast Cancer Receiving Neoadjuvant or Adjuvant Therapy (D-CARE). ClinicalTrial.gov NCT01077154 Available from: http://clinicaltrials.gov/ ct2/show/NCT01077154? term=NCT01077154&rank=1
    • Clinical. Trial.
  • 75
    • 84856007763 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled multicenter phase III study comparing denosumab with placebo as adjuvant treatment for women with early-stage breast cancer who are at high risk of disease recurrence (D-CARE
    • abstract TPS152
    • Goss PE, Barrios CH, Bell R, et al. A randomized, double-blind, placebo-controlled multicenter phase III study comparing denosumab with placebo as adjuvant treatment for women with early-stage breast cancer who are at high risk of disease recurrence (D-CARE). J Clin Oncol 2011;29(Suppl):abstract TPS152
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL.
    • Goss, P.E.1    Barrios, C.H.2    Bell, R.3
  • 76
    • 84858691752 scopus 로고    scopus 로고
    • Amgen study on prolonging bone metastasis-free survival in men with hormone refractory prostate cancer
    • gov NCT00286091 Available from:
    • Amgen. Study on Prolonging Bone Metastasis-Free Survival in Men With Hormone Refractory Prostate Cancer. ClinicalTrial.gov NCT00286091 Available from: http://clinicaltrials.gov/ ct2/show/NCT00286091? term= NCT00286091&rank=1
    • Clinical. Trial.
  • 77
    • 60549097419 scopus 로고    scopus 로고
    • Endocrine therapy plus zoledronic acid in premenopausal breast cancer
    • Gnant M, Mlineritsch B, Schippinger W, et al. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med 2009; 360:679-91
    • (2009) N. Engl. J. Med. , vol.360 , pp. 679-691
    • Gnant, M.1    Mlineritsch, B.2    Schippinger, W.3
  • 78
    • 46949100735 scopus 로고    scopus 로고
    • Exploring the anti-tumour activity of bisphosphonates in early breast cancer
    • Winter MC, Holen I, Coleman RE. Exploring the anti-tumour activity of bisphosphonates in early breast cancer. Cancer Treat Rev 2008;34:453-75
    • (2008) Cancer Treat. Rev. , vol.34 , pp. 453-475
    • Winter, M.C.1    Holen, I.2    Coleman, R.E.3
  • 79
    • 77957332433 scopus 로고    scopus 로고
    • Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits tumor metastasis in mouse melanoma through suppression of the Rho/ROCK pathway
    • Tanimori Y, Tsubaki M, Yamazoe Y, et al. Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits tumor metastasis in mouse melanoma through suppression of the Rho/ROCK pathway. Clin Exp Metastasis 2010; 27:529-38
    • (2010) Clin. Exp. Metastasis. , vol.27 , pp. 529-538
    • Tanimori, Y.1    Tsubaki, M.2    Yamazoe, Y.3
  • 82
    • 77649259667 scopus 로고    scopus 로고
    • Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
    • Beleut M, Rajaram RD, Caikovski M, et al. Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci USA 2010;107:2989-94
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 2989-2994
    • Beleut, M.1    Rajaram, R.D.2    Caikovski, M.3
  • 83
    • 61349178831 scopus 로고    scopus 로고
    • The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse
    • Fernandez-Valdivia R, Mukherjee A, Ying Y, et al. The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Dev Biol 2009;328:127-39
    • (2009) Dev. Biol. , vol.328 , pp. 127-139
    • Fernandez-Valdivia, R.1    Mukherjee, A.2    Ying, Y.3
  • 84
    • 78149284767 scopus 로고    scopus 로고
    • RANK ligand mediates progestin-induced mammary epithelial proliferationand carcinogenesis
    • Gonzalez-Suarez E, Jacob AP, Jones J, et al. RANK ligand mediates progestin-induced mammary epithelial proliferationand carcinogenesis. Nature 2010;468:103-7
    • (2010) Nature , vol.468 , pp. 103-107
    • Gonzalez-Suarez, E.1    Jacob, A.P.2    Jones, J.3
  • 85
    • 0035990985 scopus 로고    scopus 로고
    • Differential gene expression of TGF-β family members and osteopontin in breast tumor tissue: Analysis by real-time quantitative PCR
    • DOI 10.1023/A:1016339120506
    • Reinholz MM, Iturria SJ, Ingle JN, Roche PC. Differential gene expression of TGF-beta family members and osteopontin in breast tumor tissue: analysis by real-time quantitative PCR. Breast Cancer Res Treat 2002; 74:255-69 (Pubitemid 34848353)
    • (2002) Breast Cancer Research and Treatment , vol.74 , Issue.3 , pp. 255-269
    • Reinholz, M.M.1    Iturria, S.J.2    Ingle, J.N.3    Roche, P.C.4
  • 86
    • 30444459116 scopus 로고    scopus 로고
    • Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor κB ligand (RANKL) in human breast tumours
    • DOI 10.1136/jcp.2005.026534
    • Van Poznak C, Cross SS, Saggese M, et al. Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor kappaB ligand (RANKL) in human breast tumours. J Clin Pathol 2006; 59:56-63 (Pubitemid 43076239)
    • (2006) Journal of Clinical Pathology , vol.59 , Issue.1 , pp. 56-63
    • Van Poznak, C.1    Cross, S.S.2    Saggese, M.3    Hudis, C.4    Panageas, K.S.5    Norton, L.6    Coleman, R.E.7    Holen, I.8
  • 87
    • 78650671134 scopus 로고    scopus 로고
    • Expression pattern of receptor activator of NFkappaB (RANK) in a series of primary solid tumors and related bone metastases
    • Santini D, Perrone G, Roato I, et al. Expression pattern of receptor activator of NFkappaB (RANK) in a series of primary solid tumors and related bone metastases. J Cell Physiol 2011;226:780-4
    • (2011) J. Cell Physiol. , vol.226 , pp. 780-784
    • Santini, D.1    Perrone, G.2    Roato, I.3
  • 88
    • 84858646933 scopus 로고    scopus 로고
    • Association of receptor activator of NF-kb (RANK) expression with bone metastasis in breast carcinomas
    • abstract 1053
    • Santini D, Vincenzi B, Russo A, et al. Association of receptor activator of NF-kb (RANK) expression with bone metastasis in breast carcinomas. J Clin Oncol 2010;28:abstract 1053
    • (2010) J. Clin. Oncol. , vol.28
    • Santini, D.1    Vincenzi, B.2    Russo, A.3
  • 89
    • 78149284013 scopus 로고    scopus 로고
    • Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
    • Schramek D, Leibbrandt A, Sigl V, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 2010;468:98-102
    • (2010) Nature , vol.468 , pp. 98-102
    • Schramek, D.1    Leibbrandt, A.2    Sigl, V.3
  • 90
    • 79952193038 scopus 로고    scopus 로고
    • Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
    • Tan W, Zhang W, Strasner A, et al. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature 2011;470:548-53
    • (2011) Nature , vol.470 , pp. 548-553
    • Tan, W.1    Zhang, W.2    Strasner, A.3
  • 91
    • 77953384898 scopus 로고    scopus 로고
    • Control of mammary stem cell function by steroid hormone signalling
    • Asselin-Labat ML, Vaillant F, Sheridan JM, et al. Control of mammary stem cell function by steroid hormone signalling. Nature 2010;465:798-802
    • (2010) Nature , vol.465 , pp. 798-802
    • Asselin-Labat, M.L.1    Vaillant, F.2    Sheridan, J.M.3
  • 92
    • 77953388315 scopus 로고    scopus 로고
    • Progesterone induces adult mammary stem cell expansion
    • Joshi PA, Jackson HW, Beristain AG, et al. Progesterone induces adult mammary stem cell expansion. Nature 2010;465:803-7
    • (2010) Nature , vol.465 , pp. 803-807
    • Joshi, P.A.1    Jackson, H.W.2    Beristain, A.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.