High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin

Journal of Biological Chemistry

Volumn 287, Issue 12, 2012, Pages 8792-8802

  Fueller, Florian ^a   Jehle, Britta ^b   Putzkers, Kerstin ^b   Lewiss, Joe D ^b   Krauth Siegel, R Luise ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AFRICAN TRYPANOSOMES; ANTI-CANCER THERAPEUTICS; ANTICANCER DRUG; BROAD SPECTRUM; COMPLETE SYSTEM; DETAILED KINETICS; DRUG TARGETS; GEL SHIFT ASSAYS; GLUTATHIONES; HELA CELL; HIGH THROUGHPUT SCREENING; HYDROPEROXIDES; IN-VITRO ASSAYS; MOLAR EXCESS; OXIDOREDUCTASES; TARGET PROTEINS; THIOREDOXINS; TIME-DEPENDENT; TRYPANOSOMA BRUCEI; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE;

AMINO ACIDS; DETOXIFICATION;

PROTEINS;

ANTIPARASITIC AGENT; PEROXIDASE; THIOREDOXIN; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE; TRYPAREDOXIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HELA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; TRYPANOSOMA BRUCEI;

ANTIPROTOZOAL AGENTS; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PEROXIDASE; PROTOZOAN PROTEINS; THIOREDOXINS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

TRYPANOSOMA BRUCEI;

EID: 84858596191     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.338285     Document Type: Article

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