Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 19, 2009, Pages 6914-6925

  Perez, Daniel I ^a   Conde, Santiago ^a   Pérez, Concepción ^a   Gil, Carmen ^a   Simon, Diana ^b,c   Wandosell, Francisco ^b,c   Moreno, Francisco J ^c   Gelpí, José L ^d   Luque, Francisco J ^d   Martínez, Ana ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Alzheimer's disease; GSK 3 inhibitors; Halomethylketones; Tau phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIBODY; CYSTEINE; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; KETONE DERIVATIVE; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; TAU PROTEIN; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL MEMBRANE PERMEABILITY; CHEMICAL REACTION; DRUG DESIGN; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MOLECULAR MODEL; MOUSE; NERVE CELL CULTURE; NONHUMAN; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ANIMALS; BINDING SITES; CELL MEMBRANE PERMEABILITY; GLYCOGEN SYNTHASE KINASE 3; HUMANS; KETONES; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949184443     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.042     Document Type: Article

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