Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with α 1-adrenoceptor affinities

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2290-2303

  Handzlik, Jadwiga ^a   Bajda, Marek ^a   Zygmunt, Małgorzata ^a   MacIg, Dorota ^a,b   Dybała, Małgorzata ^a   Bednarski, Marek ^a   Filipek, Barbara ^a   Malawska, Barbara ^a   Kieć Kononowicz, Katarzyna ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Antiarrhythmic activity; hERG; Hydantoin; Phenylpiperazine

Indexed keywords

1 (3 BROMOPROPYL) 3 METHYL 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 1 (4 BROMOBUTYL) 3 METHYL 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 1 [2 HYDROXY3 (4 PHENYLPIPERAZIN 1 YL) PROPYL] 2,4 DIOXO 3 METHYL 5,5 DIPHENYLIMIDAZOLIDINE HYDROCHLORIDE; 1 [3 [4 (2 CHLOROPHENYL) PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 3 METHYL 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDINE HYDROCHLORIDE; 1 [3 [4 (2 FLUOROPHENYL) PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 3 METHYL 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDINE HYDROCHLORIDE; 1 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL] 3 METHYL 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE HYDROCHLORIDE; 1 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL] 3 METHYL 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE HYDROCHLORIDE; [1 [2 HYDROXY 3 (4 PHENYLPIPERAZINE 1 YL) PROPYL] 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDIN 3 YL] ACETIC ACID; [1 [3 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDIN 3 YL] ACETIC ACID ETHYL ESTER HYDROCHLORIDE; [1 [3 [4 (2 FLUORPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDIN 3 YL] ACETIC ACID ETHYL ESTER HYDROCHLORIDE; ALPHA 1 ADRENERGIC RECEPTOR; METHYL 2 [1 (3 BROMOPROPYL) 3 METHYL 5,5 DIPHENYLIMIDAZOLIDINE 3 YL]PROPIONATE; METHYL 2 [2,4 DIOXO 5,5 DIPHENYL 1 [3 [4 (2 ETHOXYPHENYL)PIPERAZIN 1 YL]PROPYL]IMIDAZOLIDIN 3 YL]PROPIONATE; METHYL 2 [2,4 DIOXO 5,5 DIPHENYL 1 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL]IMIDAZOLIDIN 3 YL]ACETATE HYDROCHLORIDE; N1 PHENYLPIPERAZINEHYDROXYPROPYL 5,5 DIPHENYLHYDANTOIN DERIVATIVE; PHENYLPIPERAZINE DERIVATIVE; PHENYTOIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ARRHYTHMIA; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; RADIOASSAY; RAT; STRUCTURE ACTIVITY RELATION; TREATMENT RESPONSE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOOD PRESSURE; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART RATE; IMIDAZOLIDINES; MALE; PHENYTOIN; PIPERAZINES; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84858280306     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.009     Document Type: Article

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