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Volumn 55, Issue 1, 2002, Pages 3-16

Antiarrhythmic drug development: Historical review and future perspective

Author keywords

Antiarrhythmics; Ischemia; Proarrhythmia; Sicilian Gambit; Vaughan Williams

Indexed keywords

1 NAPHTHALENEACETIC ACID 2 MORPHOLINOCYCLOHEXYL ESTER; AMIODARONE; ANTIARRHYTHMIC AGENT; ATENOLOL; AZIMILIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; DISOPYRAMIDE; DOFETILIDE; DRONEDARONE; ENCAINIDE; ESMOLOL; FLECAINIDE; IBUTILIDE; LIDOCAINE; METOPROLOL; MEXILETINE; MORACIZINE; PHENYTOIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROCAINAMIDE; PRONETALOL; PROPRANOLOL; QUINIDINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SOTALOL; TRANSCAINIDE; UNINDEXED DRUG; VERAPAMIL;

EID: 0036215014     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10036     Document Type: Review
Times cited : (16)

References (121)
  • 12
    • 0020613124 scopus 로고
    • Importance of physico-chemical properties in determining the kinetics of the effects of class I antiarrhythmic drugs on maximum rate of depolarization in guinea-pig ventricle
    • (1983) Br J Pharmacol , vol.80 , pp. 33-40
    • Campbell, T.J.1
  • 13
    • 0020644769 scopus 로고
    • Kinetics of onset and rate-dependent effects of class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea pig ventricle, and provide a theoretical basis for their subclassification
    • (1983) Cardiovasc Res , vol.17 , pp. 344-352
    • Campbell, T.J.1
  • 17
    • 0024321898 scopus 로고
    • Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction
    • (1989) N Engl J Med , vol.321 , pp. 406-412
  • 18
    • 0026752875 scopus 로고
    • Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction
    • The Cardiac Arrhythmia Suppression Trial II Investigators
    • (1992) N Engl J Med , vol.327 , pp. 227-233
  • 21
    • 0021285665 scopus 로고
    • Electrophysiological evidence that local anesthetics and antiarrhythmic drugs bind to a specific receptor site in cardiac sodium channels: Displacement of bupivacaine by lidocaine
    • (1984) Proc West Pharmacol Soc , vol.27 , pp. 23-25
    • Clarkson, C.W.1    Hondeghem, L.M.2
  • 30
    • 0025992447 scopus 로고
    • Experimental models of reentry, antiarrhythmic, and proarrhythmic actions of drugs. Complexities galore!
    • (1991) Circulation , vol.84 , pp. 1871-1875
    • El Sherif, N.1
  • 32
    • 0008798558 scopus 로고
    • Effects of diphenylhydantoin sodium and phenobarbital sodium upon ectopic ventricular tachycardia in acute myocardial infarction
    • (1950) Am J Physiol , vol.163 , pp. 505-516
    • Harris, A.S.1    Kokernot, R.H.2
  • 33
    • 0021820003 scopus 로고
    • Antiarrhythmic drug classification: New science and practical application
    • (1985) Am J Cardiol , vol.56 , pp. 185-187
    • Harrison, D.C.1
  • 35
    • 85047680648 scopus 로고
    • The Sicilian Gambit: Reasons for maintaining the present antiarrhythmic drug classification
    • (1992) Cardiovasc Res , vol.26 , pp. 566-567
    • Harrison, D.C.1
  • 38
    • 0017332486 scopus 로고
    • Local anaesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
    • (1977) J Gen Physiol , vol.69 , pp. 497-515
    • Hille, B.1
  • 55
    • 0021684972 scopus 로고
    • International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings
    • Impact Research Group
    • (1984) J Am Coll Cardiol , vol.4 , pp. 1148-1163
  • 57
    • 0026490947 scopus 로고
    • To prolong refractoriness or to delay conduction (or both)?
    • (1992) Eur Heart J , vol.13 , Issue.SUPPL. F , pp. 14-18
    • Janse, M.J.1
  • 66
    • 0029848068 scopus 로고    scopus 로고
    • From first class to third class: Recent upheaval in antiarrhythmic therapy - Lessons from clinical trials
    • (1996) Am J Cardiol , vol.78 , pp. 28-33
    • Lazzara, R.1
  • 67
    • 0026748851 scopus 로고
    • Ibutilide, a new compound with potent class III antiar-rhythmic activity, activates a slow inward Na+ current in guinea pig ventricular cells
    • (1992) J Pharmacol Exp Ther , vol.262 , pp. 99-108
    • Lee, K.S.1
  • 70
    • 0025936173 scopus 로고
    • Quinidine-related mortality in the short-to medium-term treatment of ventricular arrhythmias: A meta analysis
    • (1991) Circulation , vol.84 , pp. 1977-1983
    • Morganroth, J.1    Goin, J.E.2
  • 73
  • 74
    • 0025857263 scopus 로고
    • Antiarrhythmic drug classifications. A critical appraisal of their history, present status, and clinical relevance
    • (1991) Drugs , vol.41 , pp. 672-701
    • Nattel, S.1
  • 76
    • 0032730428 scopus 로고    scopus 로고
    • Mortality reduction by antiadrenergie modulation of arrhythmogenic substrate: Significance of combining beta blockers and amiodarone
    • (1999) Am J Cardiol , vol.84
    • Ogunyankin, K.O.1    Singh, B.N.2
  • 80
  • 84
    • 0020513561 scopus 로고
    • Amiodarone: Historical development and pharmacological profile
    • (1983) Am Heart J , vol.106 , pp. 788-799
    • Singh, B.N.1
  • 88
    • 0014828868 scopus 로고
    • A third class of antiarrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474
    • (1970) Br J Pharmacol , vol.39 , pp. 675-687
    • Singh, B.N.1    Vaughan Williams, E.M.2
  • 89
    • 0015122469 scopus 로고
    • Effect of altering potassium concentration of the action of lidocaine and diphenylhydantoin on rabbit atrial and ventricular muscle
    • (1971) Circ Res , vol.24 , pp. 286-295
    • Singh, B.N.1    Vaughan Williams, E.M.2
  • 90
    • 85004340459 scopus 로고
    • A fourth class of anti-dysrhythmic action? EfFect of verapamil on ouabain toxicity, on atrial and ventricular intracellular potentials, and on other features of cardiac function
    • (1972) Cardiovasc Res , vol.6 , pp. 109-119
    • Singh, B.N.1    Vaughan Williams, E.M.2
  • 91
    • 0033094631 scopus 로고    scopus 로고
    • The relevance of sympathetic activity in the pharmacological treatment of chronic stable angina
    • (1999) Can J Cardiol , vol.15 , Issue.SUPPL. A
    • Singh, B.N.1
  • 94
    • 0025060196 scopus 로고
    • Effects of quinidine on the sodium current of guinea pig ventricular myocytes. Evidence for a drug-associated rested state with altered kinetics
    • (1990) Circ Res , vol.66 , pp. 565-579
    • Snyders, D.J.1    Hondeghem, L.M.2
  • 96
    • 0010120886 scopus 로고
    • Theoretical characterization of ion channel blockade. Competitive binding to periodically accessible receptors
    • (1987) Biophys J , vol.52 , pp. 405-412
    • Starmer, C.F.1
  • 100
    • 0015784454 scopus 로고
    • The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine
    • (1973) J Gen Physiol , vol.62 , pp. 37-57
    • Strichartz, G.R.1
  • 101
    • 0017413024 scopus 로고
    • Effects of tertiary local anesthetics and their quaternary derivatives on sodium channels of nerve membranes
    • (1977) Biophys J , vol.18 , pp. 353-354
    • Strichartz, G.R.1
  • 103
    • 0025137922 scopus 로고
    • Barium-induced nondriven action potentials as a model of triggered potentials from early after depolarizations: Significance of slow channel activity and differing effects of quinidine and amiodarone
    • (1990) J Am Coll Cardiol , vol.15 , pp. 213-221
    • Takanaka, C.1    Singh, B.N.2
  • 104
    • 0026050195 scopus 로고
    • The Sicilian Gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms
    • (1991) Circulation , vol.84 , pp. 1832-1851
  • 116
    • 84931785324 scopus 로고
    • Effects of calcium ions and local anesthetics on electrical properties of Purkinje fibers
    • (1955) J Physiol (Lond) , vol.129 , pp. 568-582
    • Weidmann, S.1
  • 117
    • 0021132403 scopus 로고
    • Methods in the detection and assessment of antiarrhythmic activity
    • (1984) Pharmacol Ther , vol.24 , pp. 401-433
    • Winslow, E.1
  • 121
    • 0026075868 scopus 로고
    • The long QT interval syndrome. A Rosetta Stone for sympathetic related ventricular tachyarrhythmias
    • (1991) Circulation , vol.84 , pp. 1414-1419
    • Zipes, D.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.