Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives

European Journal of Medicinal Chemistry

Volumn 39, Issue 12, 2004, Pages 1013-1027

  Dyla̧g, Tomasz ^a   Zygmunt, Małgorzata ^a   Macia̧g, Dorota ^a   Handzlik, Jadwiga ^a   Bednarski, Marek ^a   Filipek, Barbara ^a   Kieć Kononowicz, Katarzyna ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Antiarrhythmic activity; Anticonvulsant activity; Diphenylhydantoin derivatives; Hypotensive activity; Microwave

Indexed keywords

1 [3 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 3 ETHYL 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDINE; 1 [3 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 3 ETHYL 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDINE; 1 [3 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 3 ETHYL 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDINE; 2 [3 [2 HYDROXY 3 (4 PHENYLPIPERAZIN 1 YL)PROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]PROPIONIC ACID ETHYL ESTER; 2 [3 [2 HYDROXY 3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]PROPIONIC ACID ETHYL ESTER; 2 [3 [3 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]PROPIONIC ACID ETHYL ESTER; 3 ETHYL 1 [2 HYDROXY 3 (4 PHENYLPIPERAZIN 1 YL)PROPYL] 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDINE; 3 ETHYL 1 [2 HYDROXY 3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 2,4 DIOXO 5,5 DIPHENYLIMIDAZOLIDINE; [3 [2 HYDROXY 3 (4 PHENYLPIPERAZIN 1 YL)PROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID ETHYL ESTER; [3 [2 HYDROXY 3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID ETHYL ESTER; [3 [3 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID ETHYL ESTER; [3 [3 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID ETHYL ESTER; [3 [3 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID ETHYL ESTER; ACETIC ACID ETHYL ESTER; ADRENALIN; ALKYL GROUP; ANTIARRHYTHMIC AGENT; BARIUM CHLORIDE; CHLORIDE; ETHYL 2 PROPIONATE; HYDANTOIN; HYDANTOIN DERIVATIVE; PIPERAZINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; HEART ARRHYTHMIA; IN VIVO STUDY; MALE; NONHUMAN; PROPHYLAXIS; RAT; SOLUBILITY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTICONVULSANTS; ANTIHYPERTENSIVE AGENTS; ELECTROCARDIOGRAPHY; HEART RATE; MALE; MICE; MOLECULAR STRUCTURE; MUSCULOSKELETAL EQUILIBRIUM; PHENYTOIN; RATS; RATS, WISTAR;

EID: 9644273902     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.05.008     Document Type: Article

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