Synthesis, structure and antiarrhythmic properties evaluation of new basic derivatives of 5,5-diphenylhydantoin

European Journal of Medicinal Chemistry

Volumn 38, Issue 6, 2003, Pages 555-566

  Kieć Kononowicz, Katarzyna ^a   Stadnicka, Katarzyna ^b   Mitka, Agnieszka ^b   Pekala, Elzbieta ^a   Filipek, Barbara ^a   Sapa, Jacek ^a   Zygmunt, Małgorzata ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Antiarrhythmic activity; Anticonvulsant properties; Diphenylhydantoin derivatives; X ray structure determination

Indexed keywords

1 (3 CYCLOHEXYLAMINO 2 PROPANOLO) 3 CARBMETHOXYMETHYL 5,5 DIPHENYLHYDANTOIN; 1 (3 N MORPHOLINO 2 PROPANOLO) 3 ETHYL 5,5 DIPHENYLHYDANTOIN; 1 [3 (2 PROPYL)AMINO 2 PROPANOLO] 3 CARBMETHOXYMETHYL 5,5 DIPHENYLHYDANTOIN; 1 [4 (2 HYDROXYETHYL) 1 PIPERAZINE 2 PROPANOLO] 3 ETHYL 5,5 DIPHENYLHYDANTOIN; 3 [(4 PHENYL 1 PIPERAZINE) 2 PROPANOLO] 5,5 DIPHENYLHYDANTOIN; 3 [4 (2 HYDROXYETHYL) 1 PIPERAZINE 2 PROPANOLO] 5,5 DIPHENYLHYDANTOIN; ALKYL GROUP; ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; PENTETRAZOLE; PHENYTOIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DERIVATIZATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROCARDIOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT; REPERFUSION INJURY; SEIZURE; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; X RAY ANALYSIS;

EID: 0038460904     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00075-8     Document Type: Article

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